Article
Medicine, General & Internal
Monika Zawadka-Kunikowska, Lukasz Rzepinski, Malgorzata Tafil-Klawe, Jacek J. Klawe, Pawel Zalewski, Joanna Slomko
Summary: This study aimed to evaluate the cardiac and autonomic function in patients with myasthenia gravis (MG) and investigate its relationship with disease outcomes. The results showed that MG patients exhibited altered systolic blood pressure variability, reduced heart rate response to deep breathing test, increased sympathovagal balance after tilt, lower baroreflex sensitivity, and decreased hemodynamic parameters compared to controls. Disease severity was found to be associated with diminished vagal tone and increased sympathetic response. Age and sex were the main predictors of hemodynamic parameters. These findings highlight the importance of evaluating autonomic balance in MG patients, especially those at risk for cardiovascular disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Alkame Akguemues, Ahmet Balun, Tezcan Peker, Bedrettin Boyraz
Summary: Heart rate variability (HRV) is impaired in many diseases and reflects the autonomic functions of the heart. This study aimed to investigate the relationship between HRV and marital status. The study included 104 patients aged 20 to 40 years, divided into married and unmarried groups. The results showed that HRV was significantly lower in the unmarried group, suggesting a dominant effect of the sympathetic system on the heart in unmarried individuals.
Article
Nutrition & Dietetics
Eo Jin Park, Seung Don Yoo
Summary: This study aimed to examine the relationship between nutritional biomarkers and heart rate variability (HRV) parameters in stroke patients. The results showed that HRV parameters were significantly lower in the nutritional biomarker-deficient groups. Serum albumin, prealbumin, and transferrin levels were associated with autonomic nervous system (ANS) function, as measured by HRV, and their deficiency may be a predictive factor for the severity of ANS dysfunction in stroke patients.
Article
Neurosciences
Martin Iniguez, Antonio Jimenez-Marin, Asier Erramuzpe, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocio Del Pino, Tamara Fernandez, Mar Carmona-Abellan, Alberto Cabrera-Zubizarreta, Juan Carlos Gomez-Esteban, Jesus M. Cortes, Inigo Gabilondo
Summary: Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD), and this study analyzed the synchronization between HRV and brain activity in PD patients using resting-state functional brain MRI. The findings suggest a desynchronization between heart and brain in PD, which has an impact on clinically relevant autonomic outcomes.
NPJ PARKINSONS DISEASE
(2022)
Article
Medicine, General & Internal
Lukasz Rzepinski, Monika Zawadka-Kunikowska, Julia L. Newton, Pawel Zalewski
Summary: This study found that myasthenia gravis patients exhibited parasympathetic deficiency and sympathetic predominance during head-up tilt test, whereas relapsing-remitting multiple sclerosis patients showed dysfunction in both sympathetic and parasympathetic systems. There were no significant differences in cardiac autonomic parameters between the two patient groups.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Shijing Jia, Wang Lu, Minghui Hang, Chu Zhang, Zilin Ma, Kun Xue, Yunqi Lu, Shenghong Zhang, Yijin Guo, Jiabao Zhang, Xinyu Zhang, Yimeng Wang, Haiyin Zhao
Summary: This study aims to investigate the immediate impact of manual acupuncture on autonomic dysfunction in stroke patients during the convalescence phase. Heart rate variability detection and clinical feature scale will be utilized to evaluate the outcomes. It provides a new approach for the treatment of stroke patients.
Review
Psychology, Multidisciplinary
Ana Myriam Lavin-Perez, Daniel Collado-Mateo, Xian Mayo, Gary Liguori, Liam Humphreys, Alfonso Jimenez
Summary: This study analyzed the effects of exercise programs on the autonomic modulation, measured by HRV, of patients with cancer and its survivors. The results showed that exercise can improve both time-domain and frequency-domain HRV measures, indicating positive effects on autonomic modulation in patients.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Physiology
Zhiwei Fan, Yoko Suzuki, Like Jiang, Satomi Okabe, Shintaro Honda, Junki Endo, Takahiro Watanabe, Takashi Abe
Summary: Pulse rate variability (PRV), derived from Laser Doppler flowmetry (LDF) or photoplethysmography, has become widely used for sleep state assessment. However, peripheral blood flow (BF), also estimated by LDF, has not been extensively studied for sleep state assessment. This study aimed to investigate the potential of peripheral BF to provide information about sleep stages and improve sleep state assessment. The results showed that peripheral BF can provide complementary information to PRV for different sleep stages, and the combination of peripheral BF and PRV may be advantageous in assessing sleep states and related autonomic nervous activity.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Malgorzata Maciorowska, Pawel Krzesinski, Robert Wierzbowski, Beata Uzieblo-Zyczkowska, Grzegorz Gielerak
Summary: This study assessed the correlation between heart rate variability (HRV) and the hemodynamic profile of arterial hypertension (AH) patients. The results showed that HRV parameters were correlated with arterial blood pressure, left ventricular function, and afterload.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yung-Sheng Chen, Yi-Ying Lin, Chun-Che Shih, Cheng-Deng Kuo
Summary: The study demonstrated that pulse rate variability measures of both hands show moderate to good agreements and high correlations with heart rate variability measures in patients after coronary artery bypass graft surgery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Eo Jin Park
Summary: Autonomic dysfunction is common in patients with ischemic stroke. This study aimed to investigate the relationship between HRV and vitamin B12 status in patients with ischemic stroke and found that serum vitamin B12 status is a significant predictor of autonomic dysfunction.
Article
Physiology
Jian Liu, Shiqi Liu, Longfei Gao, Guangqiao Li, Jie Xu, Yilin Sun, Jingfeng Wang, Bo Shi
Summary: This study aimed to evaluate the feasibility of using pre-operative heart rate variability (HRV) parameters to predict post-operative blood inflammatory biomarkers in patients with cervical cancer. Results showed that pre-operative SD2 was significantly associated with post-operative PLR, while LF/HF was significantly correlated with NLR. These findings suggest that pre-operative HRV parameters may potentially predict post-operative inflammation and help in clinical treatment decisions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Clinical Neurology
Woojun Kim, Hyunjo Lee, Kyung Won Lee, Eunjin Yang, Seonghoon Kim
Summary: This study found that nocturnal seizures can lead to autonomic dysfunction during sleep in patients with epilepsy. This may be attributed to abnormalities in the brain-heart autonomic axis. However, there were no significant differences in central and cardiac autonomic variables between the NFLE and DFLE groups during wakefulness.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Medicine, General & Internal
Simone Bellavia, Irene Scala, Marco Luigetti, Valerio Brunetti, Maurizio Gabrielli, Lorenzo Zileri Dal Verme, Serenella Servidei, Paolo Calabresi, Giovanni Frisullo, Giacomo Della Marca
Summary: This study investigated the prevalence of autonomic dysfunction in 20 non-critically-ill COVID-19 patients in the acute phase of the disease. The COVID+ group showed higher values of pupillary dilatation velocities and baseline pupil diameter compared to the COVID- group. The study observed the occurrence of autonomic dysfunction in the early stage of the disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Anne T. Berg, Keith Coffman, Deborah Gaebler-Spira
Summary: The study revealed a correlation between functional impairments and autonomic symptoms in young people with DEEs, with these symptoms also contributing to parental stress. This correlation poses challenges for caregivers of children with DEEs.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Editorial Material
Surgery
Chong-Chi Chiu, Po-Huang Lee, Chen-Fuh Lam, Li-Ren Yeh, Cheuk-Kwan Sun
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Review
Anesthesiology
Kuo-Chuan Hung, Ching-Chung Ko, Chih-Wei Hsu, Yu-Li Pang, Jen-Yin Chen, Cheuk-Kwan Sun
Summary: This systematic review and meta-analysis investigated the impact of peripheral nerve blocks (PNBs) on patient-reported quality of recovery (QoR) following breast cancer surgery. The results showed that patients who received PNBs had higher QoR scores at 24 hours after surgery, as well as higher scores on all subscales of the QoR-40 scale except for psychological support. Sensitivity analysis confirmed the stability of the results. The use of PNBs was associated with lower opioid consumption and a lower risk of postoperative nausea and vomiting.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Letter
Immunology
Renin Chang, Hui Yuan Chen, Yao-Min Hung, Cheuk Kwan Sun
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Anesthesiology
I-Chia Teng, Cheuk-Kwan Sun, Chun-Ning Ho, Li-Kai Wang, Yao-Tsung Lin, Ying-Jen Chen, Jen-Yin Chin, Chin-Chen Chu, Chung-Hsi Hsing, Kuo-Chuan Hung
Summary: This meta-analysis found that combined epidural anaesthesia/analgesia (EAA) did not have a significant impact on the incidence of postoperative delirium/cognitive dysfunction (POD/POCD) in patients following major non-cardiac surgery. However, it was associated with lower pain scores at postoperative 24 hours and a decreased risk of postoperative nausea/vomiting (PONV).
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Lin-Lin Pan, Hsiu-Chen Yu, Ching-Hui Lee, Kuo-Chuan Hung, I-Ting Tsai, Cheuk-Kwan Sun
Summary: The aim of this study was to identify the factors impacting the accuracy of reticulocyte enumeration and compare the results of different staining techniques. The results showed that the BCB stain was the most reliable, senior technologists had a higher bias in counting, and repeated counting also affected the results. However, inter-observer consistency was high, and inter-/intra-observer variations were non-significant.
Article
Medicine, General & Internal
Yu-Wen Chen, Wei-Chieh Lee, Hsiu-Yu Fang, Cheuk-Kwan Sun, Jiunn-Jye Sheu
Summary: This study compared the outcomes of percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease (CAD). The results showed that compared to PCI, CABG was associated with a lower incidence of heart failure (HF) hospitalization but worse survival outcomes.
Article
Health Care Sciences & Services
Hsien-Tsai Wu, Jian-Jung Chen
Summary: In this study, a refined stiffness index (SInew) was developed for assessing arterial stiffness based on decomposed radial pulse and digital volume pulse signals. High SInew-RP values were found to be the most significant risk factor for developing type 2 diabetes mellitus (T2DM).
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Psychology, Developmental
Kuo-Chuan Hung, Jen-Yin Chen, Chung-Hsi Hsing, Chih-Wei Hsu, Ping-Hsin Liu, Ying-Jen Chang, Jui-Yi Chen, Sheng-Fu Chiu, Cheuk-Kwan Sun
Summary: This meta-analysis investigated the association between labor epidural analgesia exposure and the risk of autism spectrum disorder in offspring. The results showed a slightly increased risk of autism spectrum disorder in children with exposure to labor epidural analgesia compared to those without. This finding was consistent in subgroup analysis focusing on sibling data and children delivered vaginally. However, no increased risk of autism spectrum disorder was observed in children exposed to labor epidural analgesia for less than 4 hours or more than 8 hours.
Review
Medicine, General & Internal
Kuo-Chuan Hung, Yu-Yu Li, Yen-Ta Huang, Ping-Hsin Liu, Chih-Wei Hsu, Chun-Ning Ho, I-Yin Hung, Fu-Sheng Chang, Cheuk-Kwan Sun
Summary: A meta-analysis found a positive correlation between blood urea nitrogen (BUN)/albumin ratio and poor outcome in patients with COVID-19. High BUN/Albumin ratio is associated with increased risk of poor prognosis.
Letter
Endocrinology & Metabolism
Yu-Hsuan Pai, Renin Chang, Cheuk-Kwan Sun, Wen-Bin Yeh
DIABETES & METABOLISM
(2023)
Review
Psychiatry
Hsien-Jane Chiu, Cheuk-Kwan Sun, Yu-Shian Cheng, Ming Yu Wang, Ruu-Fen Tzang, Feng-Li Lin, Ying-Chih Cheng, Weilun Chung
Summary: A meta-analysis of nine randomized controlled trials demonstrated that psychostimulants may be effective in treating symptoms of ADHD in preschool children, especially hyperactivity/impulsivity as observed by teachers. However, the quality of the evidence was low, and further research is needed to confirm the true magnitude of the effect.
EUROPEAN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Kuo-Chuan Hung, Chun-Ning Ho, Wei-Cheng Liu, Ming Yew, Ying-Jen Chang, Yao-Tsung Lin, I-Yin Hung, Jen-Yin Chen, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: This study aimed to provide updated evidence on the association between intraoperative lidocaine and the risk of postcardiac surgery cognitive deficit. The results suggested a prophylactic effect of intravenous lidocaine against cognitive deficit in the early postoperative period, but insufficient evidence to support this conclusion. In the late postoperative period, intravenous lidocaine did not reduce the risk of cognitive deficit. Intravenous lidocaine may be associated with a shortened length of stay in the intensive care unit/hospital, but the evidence is weak. Further large-scale studies are needed to evaluate the use of lidocaine for the prevention of cognitive deficit and enhancement of recovery.
Review
Medicine, General & Internal
I-Wen Chen, Yu-Yu Li, Kuo-Chuan Hung, Ying-Jen Chang, Jen-Yin Chen, Ming-Chung Lin, Kuei-Fen Wang, Chien-Ming Lin, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: By comparing the outcomes of video-stylets and conventional laryngoscopes in tracheal intubation of patients with cervical immobilization, the study found no significant differences in intubation success rate, time, and risk of tissue damage between the two, but video-stylets had a lower risk of causing sore throat.
Article
Biology
Iain Hunter, Raz Leib
Summary: Natural movement is related to health, but it is difficult to measure. Existing methods cannot capture the full range of natural movement. Comparing movement across different species helps identify common biomechanical and computational principles. Developing a system to quantify movement in freely moving animals in natural environments and relating it to life quality is crucial. This study proposes a theoretical framework based on movement ability and validates it in Drosophila.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Andy Gardner
Summary: Fisher's geometric model is a useful tool for predicting key properties of Darwinian adaptation, and here it is applied to predict differences between the evolution of altruistic versus nonsocial phenotypes. The results suggest that the effect size maximizing probability of fixation is smaller in the context of altruism and larger in the context of nonsocial phenotypes, leading to lower overall probability of fixation for altruism and higher overall probability of fixation for nonsocial phenotypes.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Thomas F. Pak, Joe Pitt-Francis, Ruth E. Baker
Summary: Cell competition is a process where cells interact in multicellular organisms to determine a winner or loser status, with loser cells being eliminated through programmed cell death. The winner cells then populate the tissue. The outcome of cell competition is context-dependent, as the same cell type can win or lose depending on the competing cell type. This paper proposes a mathematical framework to study the emergence of winner or loser status, highlighting the role of active cell death and identifying the factors that drive cell competition in a cell-based modeling context.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Haruto Tomizuka, Yuuya Tachiki
Summary: Batesian mimicry is a strategy in which palatable prey species resemble unpalatable prey species to avoid predation. The evolution of this mimicry plays a crucial role in protecting the unpalatable species from extinction.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Jason W. Olejarz, Martin A. Nowak
Summary: Gene drive technology shows potential for population control, but its release may have unpredictable consequences. The study suggests that the failure of suppression is a natural outcome, and there are complex dynamics among wild populations.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Hamid Ravaee, Mohammad Hossein Manshaei, Mehran Safayani, Javad Salimi Sartakhti
Summary: Gene expression analysis is valuable for cancer classification and phenotype identification. IP3G, based on Generative Adversarial Networks, enhances gene expression data and discovers phenotypes in an unsupervised manner. By converting gene expression profiles into images and utilizing IP3G, new phenotype profiles can be generated, improving classification accuracy.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Beatrix Rahnsch, Leila Taghizadeh
Summary: This study forecasts the evolution of the COVID-19 pandemic in Germany using a network-based inference method and compares it with other approaches. The results show that the network-inference based approach outperforms other methods in short-to mid-term predictions, even with limited information about the new disease. Furthermore, predictions based on the estimation of the reproduction number in Germany can yield more reliable results with increasing data availability, but still cannot surpass the network-inference based algorithm.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Rongsheng Huang, Qiaojun Situ, Jinzhi Lei
Summary: Maintaining tissue homeostasis requires appropriate regulation of stem cell differentiation. Random inheritance of epigenetic states plays a pivotal role in stem cell differentiation. This computational model provides valuable insights into the intricate mechanism governing stem cell differentiation and cell reprogramming, offering a promising path for enhancing the field of regenerative medicine.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Patrick Vincent N. Lubenia, Eduardo R. Mendoza, Angelyn R. Lao
Summary: This study compares insulin signaling in healthy and type 2 diabetes states using reaction network analysis. The results show similarities and differences between the two conditions, providing insights into the mechanisms of insulin resistance, including the involvement of other complexes, less restrictive interplay between species, and loss of concentration robustness in GLUT4.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Nuverah Mohsin, Heiko Enderling, Renee Brady-Nicholls, Mohammad U. Zahid
Summary: Mathematical modeling is crucial in understanding radiobiology and designing treatment approaches in radiotherapy for cancer. This study compares three tumor volume dynamics models and analyzes the implications of model selection. A new metric, the point of maximum reduction of tumor volume (MRV), is introduced to quantify the impact of radiotherapy. The results emphasize the importance of caution in selecting models of response to radiotherapy due to the artifacts imposed by each model.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
Article
Biology
Armindo Salvador
Summary: Michael Savageau's Biochemical Systems Analysis papers have had a significant impact on Systems Biology, generating core concepts and tools. This article provides a brief summary of these papers and discusses the most relevant developments in Biochemical Systems Theory since their publication.
JOURNAL OF THEORETICAL BIOLOGY
(2024)
