Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 260, Issue 2, Pages 290-293Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2009.06.010
Keywords
Maximum parsimony; Ancestral state reconstruction; Two-state symmetric model
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Funding
- Allan Wilson Centre for Molecular Ecology and Evolution, New Zealand
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In this paper we investigate mathematical questions concerning the reliability( reconstruction accuracy) of Fitch's maximum parsimony algorithm for reconstructing the ancestral state given a phylogenetic tree and a character. In particular, we consider the question whether the maximum parsimony method applied to a subset of taxa can reconstruct the ancestral state of the root more accurately than when applied to all taxa, and we give an example showing that this in deed is possible. A surprising feature of our example is that ignoring a tax on closer to the root improves the reliability of the method. On the other hand, in the case of the two-state symmetric substitution model, we answer affirmatively a conjecture of Li, Steel and Zhang which states that under a molecular clock the probability that the state at a single taxon is a correct guess of the ancestral state is a lower bound on the reconstruction accuracy of Fitch's method applied to all taxa. (C) 2009 Elsevier Ltd. All rights reserved.
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