Article
Biology
Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Cesar Augusto Roque-Borda, Fernando Rogerio Pavan, Andreia Bagliotti Meneguin, Marlus Chorilli, Ana Melero, Antonio Jose Guillot, Caroline Magnani Spagnol, Marcos Antonio Correa
Summary: This study aimed to prepare chitosan biodegradable microparticles containing ascorbic acid and nicotinamide for topical delivery. The microparticles were characterized chemically and their release profile, skin permeation, and retention were evaluated. The results showed that the microparticles successfully delivered the drugs and exhibited antibacterial activity.
Article
Pharmacology & Pharmacy
Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Nikolaos Bouropoulos, Emmanuel Panteris, Melpomeni Akrivou, Ioannis S. Vizirianakis, Zeeshan Ahmad, Dimitrios G. Fatouros
Summary: In this study, a multi-component system for pulmonary delivery was developed, including engineered microparticles and investigation of two active pharmaceutical ingredients. All formulations exhibited satisfactory performance and drug release. Physicochemical properties evaluation showed appropriate morphology and aerodynamic performance of the microparticles, with release of the active ingredients monitored in simulated lung fluid.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Jaewon Choi, Jugal Kishore Sahoo, Onur Hasturk, Thomas Falcucci, Ya Yao, David L. Kaplan
Summary: This study presents a new strategy to fabricate silk protein-based aerosols and silk fibers instantaneously in situ using a spray device, without the need for complicated and costly advanced manufacturing techniques. The key to success lies in the conformational transition of silk fibroin from random coil to beta-sheet before spraying, achieved by mixing silk and polyethylene glycol solutions in the spray device. The system utilizes green solvents and shear and elongational flow to provide a portable and user-friendly method for drug delivery carriers and surface coatings.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
Xiaojie Xing, Yu Han, Hui Cheng
Summary: Natural polymers derived from animals and plants have been widely used in biomedical applications due to their similarities with biomacromolecules in the human body. Chitosan, an alkaline polysaccharide, has attracted much attention in tissue regeneration and drug delivery. By combining chitosan with silk fibroin, the mechanical properties and degradation behavior drawbacks of chitosan can be overcome. Additionally, other natural and synthetic biopolymers have also been incorporated to improve the performance of chitosan/silk fibroin composites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Polymer Science
Anna Tuwalska, Sylwia Grabska-Zielinska, Alina Sionkowska
Summary: This review summarizes recent advances in the field of chitosan and silk fibroin blends as new biomaterials. These blends have attracted attention from both academia and industry, but have not been summarized in a review paper yet.
Article
Materials Science, Multidisciplinary
Tianshuo Jia, Dajiang Kuang, Zhenzhen Qi, Guohongfang Tan, Xiaojing Yang, Subhas C. Kundu, Shenzhou Lu
Summary: This paper investigated the preparation of silk fibroin/chitosan hydrogel microneedles and their pH-sensitive drug release characteristics. The results showed that the microneedles can intelligently regulate the transdermal release of insulin based on the acidity or alkalinity of the environment.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Engineering, Chemical
Lorena Pasero, Francesca Susa, Riccardo Chiavarino, Tania Limongi, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Summary: Spray freeze-drying is a viable alternative to traditional spray drying for producing therapeutic dry microparticles, particularly suitable for pulmonary drug delivery. This study used ultrasonic spray freeze-drying to generate dry microparticles composed of mannitol or a combination of mannitol and salbutamol sulphate. The particle size, morphology, surface area, porosity, and crystallinity were influenced by solid concentration and feed flow rate. The aerodynamic properties for drug deposition were found to depend on solid concentration and feed flow rate.
Article
Biophysics
Mohammad Akrami-Hasan-Kohal, Mahnaz Eskandari, Atefeh Solouk
Summary: The study developed a sustained release formulation using dexamethasone sodium phosphate-loaded chitosan nanoparticles embedded in silk fibroin hydrogel. The scanning electron microscopy showed the prepared drug delivery system had a properly interconnected porous structure, indicating potential for drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Applied
Sushma Indrakumar, Santanu Ghosh, Tapan Kumar Dash, Vivek Mishra, Bharat Tandon, Kaushik Chatterjee
Summary: Researchers have developed a bilayered foam that can quickly clot blood, reduce bleeding, and be easily removed without causing rebleeding.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Hyo-Jung Lee, Yong-Bin Kwon, Ji-Hyun Kang, Dong-Won Oh, Eun-Seok Park, Yun-Seok Rhee, Ju-Young Kim, Dae-Hwan Shin, Dong-Wook Kim, Chun-Woong Park
Summary: The feasibility of using inhalable bosentan microparticles as an alternative treatment for PAH was validated in this study, showing promising results in vitro and in vivo. The microparticles exhibited superior aerodynamic performance and dissolution rate compared to raw bosentan hydrate, with no evidence of lung toxicity. The intratracheal administration of SDBM 1:1 significantly improved pharmacokinetic parameters, pulmonary arterial remodeling, and right ventricular hypertrophy in a rat model of PAH.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Food Science & Technology
Maria Isabel Landim Neves, Mayara de Souza Queiros, Rodolfo Lazaro Soares Viriato, Ana Paula Badan Ribeiro, Mirna Lucia Gigante
Summary: This study investigated the stability of LMP made with AMF and FHSBO during storage at different temperatures, finding that storage temperature and lipid base influenced the polymorphic form of LMP, and an increase in FHSBO concentration can enhance polymorphic stability.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Engineering, Chemical
Aijun Di, Shengyu Zhang, Xuan Liu, Zhenbo Tong, Siping Sun, Zengchao Tang, Xiao Dong Chen, Winston Duo Wu
Summary: This study developed microparticles with improved solubility and antioxidant activity using resveratrol as a model drug. Chitosan played a key role in adjusting drug release behavior and enhancing mucoadhesion properties.
Article
Chemistry, Applied
Antonia Goncalves, Berta N. Estevinho, Fernando Rocha
Summary: Oil-in-water emulsions were utilized to produce RA-loaded biopolymer-based delivery systems using spray-drying technology, with different rheological properties and droplet size distributions. The use of a spray-dryer at an inlet air temperature of 130 degrees C significantly improved RA encapsulation efficiency in modified chitosan-based microparticles. The release time of RA from microparticles varied depending on the biopolymers used, with xanthan and arabic gums showing faster release (48 and 94 min, respectively) and alginic acid sodium prolonging the release time to almost 8 hours.
FOOD HYDROCOLLOIDS
(2022)
Article
Materials Science, Multidisciplinary
Xueping Liu, Hui Wu, Peng Pan, Mengmeng Wang, Wenjing Zhang, Cheng Hu, Shenzhou Lu, Mingzhong Li, Yu Liu
Summary: In this study, thermosensitive hydroxybutyl chitosan (HBC)/silk fibroin (SF) hybrid hydrogels were prepared by physical interaction. The HBC/SF hybrids showed rapid sol-gel transition at physiological temperature and had the potential to be used as injectable tissue engineering scaffolds and soft tissue fillers. The introduction of SF component effectively reduced the cytotoxicity of HBC hydrogel.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Polymer Science
Shang-Ta Wang, Yi-Ying Lu, Min-Lang Tsai
Summary: This study introduced different excipients to improve the spray drying process of chitosan/NaCl/maltodextrin microparticles, resulting in spherical particles with sizes ranging from 6.29 to 7.64 μm. The addition of microcrystalline cellulose and waxy starch significantly reduced hygroscopicity and caking strength, showing potential for reducing sodium intake in the food industry.
Article
Materials Science, Biomaterials
Chih-Yu Wu, Chao-Wei Huang, Zhen-Yu Guan, Jyun-Ting Wu, Shu-Yun Yeh, Chiao-Tzu Su, Chih-Hao Chang, Shih-Torng Ding, Hsien-Yeh Chen
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Multidisciplinary Sciences
Chih-Hao Chang, Shu-Yun Yeh, Bing-Heng Lee, Chia-Jie Chen, Chiao-Tzu Su, Yen-Ting Lin, Chien-Lin Liu, Hsien-Yeh Chen
Article
Multidisciplinary Sciences
Chih-Hao Chang, Chih-Yang Lin, Fwu-Hsing Liu, Mark Hung-Chih Chen, Chun-Pin Lin, Hong-Nerng Ho, Yunn-Shiuan Liao
Article
Medicine, Research & Experimental
Yu-Jen Huang, Chih-Yuan Lee, Jerry Cao, Hsuan-Shu Lee, Chih-hao Chang, Po-Da Chen, Yao-Ming Wu
MOLECULAR PHARMACEUTICS
(2019)
Article
Automation & Control Systems
Jian-Yuan Huang, Chih-Hao Chang, Wei-Ching Wang, Ming-Ju Chou, Chun-Chieh Tseng, Pei-Weng Tu
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Chih-Hao Chang, Yu-Hsuan Lee, Zhen-Hao Liao, Mark Hung-Chih Chen, Fu-Chuo Peng, Jiang-Jen Lin
Summary: The study evaluated the effects of composition of Ag-NP supported by silicate nanoplatelet on cytotoxicity and genotoxicity, finding that NSP effectively maintained the antimicrobial activity of Ag-NP. The high-surface area of NSP served as an excellent support for associating Ag-NP and reducing its toxicity in clinical applications.
Letter
Medicine, General & Internal
Yi-Hsiang Lai, Kuan-Yin Lin, Chih-Hao Chang, Shan-Chwen Chang
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Polymer Science
Hsuan-Yu Chen, Tzu-Chieh Lin, Chih-Yung Chiang, Shiuan-Li Wey, Feng-Huei Lin, Kai-Chiang Yang, Chih-Hao Chang, Ming-Hsiao Hu
Summary: The study fabricated a sponge material to inhibit scar tissue formation post laminectomy surgery, which was validated for its effectiveness and biocompatibility through cell experiments and rat experiments.
Article
Chemistry, Analytical
Yun-Liang Chang, Chia-Ying Hsieh, Chao-Yuan Yeh, Chih-Hao Chang, Feng-Huei Lin
Summary: This study investigated the use of Gel/HA-HAP and Gel/HA-HAP-SDF-1 composites in enhancing bone regeneration in a bone defect model. The results showed that both Gel/HA-HAP composite groups exhibited better bone generation compared to the control group, with the composite containing SDF-1 showing a trend of faster bone growth. This suggests that Gel/HA-HAP-SDF-1 composites may be a feasible material for filling traumatic bone defects.
Article
Polymer Science
Chih-Hao Chang, Chih-Hung Chang, Ya-Wen Yang, Hsuan-Yu Chen, Shu-Jyuan Yang, Wei-Cheng Yao, Chi-Yang Chao
Summary: This study successfully synthesized a novel polystyrene-block-quaternized polyisoprene amphipathic block copolymer and controlled the antibacterial activity by regulating the block composition, side chain length, and polymer morphology. The polymers with N,N-dimethyldodecylamine side chains formed polymersome structures in aqueous solutions, exhibiting the best inhibiting bacterial growth efficiency.
Article
Multidisciplinary Sciences
Chih-Hao Chang, Chih-Yang Lin, Chih-Hung Chang, Fwu-Hsing Liu, Yu-Tzu Huang, Yunn-Shiuan Liao
Summary: This study aims to investigate an appropriate ZrO2-SiO2 composite recipe for ceramic 3D printing processes that can strike a balance between the mechanical properties and cell affinity needed in clinical applications. The S5Z5 composite, which consists of 50 wt% ZrO2, 35 wt% SiO2 and 15 wt% SiO2 sol, showed an appropriate compressive strength and bending strength of 82.56 MPa and 55.98 MPa, respectively, at a sintering temperature of 1300 degrees C. The shrinkage rate of the S5Z5 composite was approximately 5% when the sintering temperature was increased from 900 to 1500 degrees C.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Shu-Jyuan Yang, Chih-Hao Chang, Tai-Horng Young, Chung-Hao Wang, Tzu-Hao Tseng, Man-Ling Wang
Summary: Raloxifene, encapsulated in human serum albumin-based nanoparticles, demonstrates potential for treating postmenopausal osteoporosis by increasing bioavailability and reducing dosage and administration time.
Article
Orthopedics
Tzu-Hao Tseng, Chih-Hao Chang, Chien-Lin Chen, Hongsen Chiang, Hao-Ying Hsieh, Jyh-Horng Wang, Tai-Horng Young
Summary: Passing Vicryl Rapide sutures through Simplex P cement beads significantly improves the elution profiles of antibiotics. This method is suitable for temporary spacer between two stages of a revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Chih-Hao Chang, Li-Hui Tsai, Yi-Chen Lee, Wei-Cheng Yao, Jiang-Jen Lin
Summary: In this study, a hybrid of AgNP/ZnONP/NSP was prepared by co-synthesizing zinc oxide nanoparticles and silver nanoparticles on a nano-silicate platelet. AgNP/ZnONP/NSP showed higher efficacy against Staphylococcus aureus compared to ZnONP/NSP and AgNP/NSP. In cell culture tests, 1/10/99 (weight ratio) of AgNP/ZnONP/NSP exhibited low cytotoxicity for mammalian cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Vivia Khosasih, Kai-Ming Liu, Chung-Ming Huang, Lieh-Bang Liou, Ming-Shium Hsieh, Chian-Her Lee, Chang-Youh Tsai, San-Yuan Kuo, Su-Yang Hwa, Chia-Li Yu, Chih-Hao Chang, Cheng-Jyh Lin, Song-Chou Hsieh, Chun-Ying Cheng, Wei-Ming Chen, Liang-Kuang Chen, Hui-Ping Chuang, Ying-Ting Chen, Pei-Chun Tsai, Liang-Suei Lu, Weng-Siong H'ng, Yanfei Zhang, Hsiang-Cheng Chen, Chien-Hsiun Chen, Ming Ta Michael Lee, Jer-Yuarn Wu
Summary: A genome-wide association study in the Han Chinese population identified six genetic variants associated with hand osteoarthritis, located at the 2p13.2 region downstream of the CYP26B1 gene. Among these variants, rs12713768 was found to be associated with susceptibility to and severity of hand osteoarthritis, suggesting the involvement of the retinoic acid signaling pathway in its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Xu Yang, Jieshi Xiao, Jian Huang, Kaixiang Peng
Summary: This study introduces an online convolutional adversarial autoencoder (AAE) model to learn representative industrial process information. By extracting features that reflect diverse information and follow a Gaussian distribution, the model improves the accuracy of fault detection and removes redundant information through a feature selection strategy.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
Article
Engineering, Chemical
Shao-Yang Wu, Meng-Tsun Lai, Chung-Hui Hsu, Kevin C. W. Wu, Yesong Gu
Summary: This study investigated the effectiveness of using Fe-based MOF or MIL-100(Fe) in conjunction with a PEDOT-modified Pt electrode for detecting the synthetic azo dye tartrazine. By modifying the electrode with two different methods, favorable lower reductive potentials, competitive sensitivities, and good repeatability and stability were achieved in all MIL-100(Fe)/PEDOT/Pt electrodes.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
