Article
Infectious Diseases
Marisa Haenni, Laetitia Du Fraysseix, Pauline Francois, Antoine Drapeau, Tristan Bralet, Jean-Yves Madec, Thierry Boulinier, Olivier Duriez
Summary: This study investigated whether griffon vultures (Gyps fulvus) from two populations in the French Alps carry antibiotic-resistant bacteria. Results showed that 11.8% of the bacteria exhibited resistance to extended-spectrum beta-lactamases (ESBL), with transmission primarily occurring within the same vulture population. These findings highlight the need for measures to mitigate the spread of multidrug-resistant bacteria through commensal species.
Article
Infectious Diseases
Lin Sun, Nan Meng, Zecheng Wang, Jiaxin Hong, Yuqi Dai, Zhenyu Wang, Jing Wang, Xinan Jiao
Summary: This study provides a comprehensive overview of resistance profiles and genomic characteristics in ESBL/AmpC-producing E. coli from stray dogs in Yangzhou, China, highlighting the potential role of stray dogs as a reservoir for antibiotic resistance genes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Microbiology
Laura Patricia Weber, Sylvia Dreyer, Maike Heppelmann, Katharina Schaufler, Timo Homeier-Bachmann, Lisa Bachmann
Summary: This study investigated the prevalence of ESBL/AmpC-E. coli in young pre-weaned calves and their dams on large dairy farms in Germany. The highest prevalence observed in Europe was reported, with notable risk factors including feeding with waste milk and the overall health of dams and calves. The findings suggest the need for new or improved approaches to animal health management and farm hygiene practices in order to address this issue.
Article
Infectious Diseases
Timo Homeier-Bachmann, Jette F. Kleist, Anne K. Schuetz, Lisa Bachmann
Summary: The study found that ESBL/AmpC-producing E. coli are prevalent on a dairy farm, especially in calf populations. Recommendations for reducing transmission include improving hygiene management and questioning the use of antibiotics.
Article
Infectious Diseases
Isabella A. Tickler, Diane Kawa, Anne E. Obradovich, Ferric C. Fang, Fred C. Tenover
Summary: A total of 199 Gram-negative bacterial isolates from urinary tract infections and 162 from bloodstream infections were collected from 12 healthcare systems throughout the United States between May 2021 and August 2022. The study characterized the isolates that were resistant to cephalosporins or carbapenems through antimicrobial susceptibility testing and whole genome sequencing. The results showed a wide range of carbapenemase-mediated resistance, with blaKPC-3 and blaKPC-2 being the most common carbapenemase genes identified. Additionally, extended-spectrum beta-lactamase genes and AmpC genes were also detected in a significant number of isolates. Importantly, some of the carbapenemase-producing organisms were still susceptible to certain antibiotics.
Article
Agriculture, Dairy & Animal Science
M. A. Gonggrijp, A. E. Heuvelink, C. C. ter Bogt-Kappert, A. G. J. Velthius, T. J. G. M. Lam
Summary: The prevalence of extended-spectrum β-lactamase and AmpC-type β-lactamase-resistant bacteria in young dairy calves on farms is significantly higher compared to young stock and dairy cows. However, it was previously unknown at what age these antimicrobial resistant bacteria first appear in the gut of calves and how long the infections persist. This study examined the prevalence, numbers, and genotypes of these resistant bacteria in young dairy calves aged 0-21 days and observed a transient colonization in these calves, which does not lead to long-term shedding of these bacteria.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Chemistry, Medicinal
Manish Kaushik, Aditi Kaushik, Akash Jain, Jasmine Chaudhary, Vrinda Gupta
Summary: Multi-drug resistance and its transmission is a global health issue. The production of AmpC beta-lactamases by bacteria is hindering the development of new antibiotics. The lack of comprehensive data makes it difficult to choose appropriate beta-lactam antibiotics for treatment.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Olivia M. Gruenzweil, Lauren Palmer, Adriana Cabal, Michael P. Szostak, Werner Ruppitsch, Christian Kornschober, Maciej Korus, Dusan Misic, Tanja Bernreiter-Hofer, Anna D. J. Korath, Andrea T. Fessler, Franz Allerberger, Stefan Schwarz, Joachim Spergser, Elke Mueller, Sascha D. Braun, Stefan Monecke, Ralf Ehricht, Chris Walzer, Hrvoje Smodlaka, Igor Loncaric
Summary: The study aimed to investigate the presence of ESBL- and AmpC-producing Enterobacterales, as well as Salmonella, in marine mammals. Results revealed a high prevalence of multidrug-resistant bacteria and pandemic high-risk clones, indicating anthropogenic antimicrobial pollution in these animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Joao Pires, Laura Huber, Rachel A. Hickman, Simon Dellicour, Kamonwan Lunha, Thongpan Leangapichart, Jatesada Jiwakanon, Ulf Magnusson, Marianne Sunde, Josef D. Jarhult, Thomas P. Van Boeckel
Summary: Thailand is experiencing differences in antimicrobial use and the composition of antimicrobial resistance genes (ARGs) between small and medium farms. Pig isolates from small farms are more associated with genes conferring resistance to colistin and fluoroquinolones, while pig isolates from medium farms are associated with genes conferring resistance to drugs commonly used on medium farms. ARGs conferring resistance to critically important antimicrobials are more frequently co-carried on plasmids from small farms compared to plasmids from medium farms. Actions to curb the spread of these ARGs are urgently needed.
Article
Food Science & Technology
Mohammad M. Obaidat, Wasan A. Gharaibeh
Summary: Limited data is available on the prevalence and antimicrobial resistance of ESBL and AmpC beta-lactamases E. coli in sheep and goats in Jordan. This study found a high prevalence of ESBL and AmpC beta-lactamases E. coli in milk samples from sheep and goats, with a significant resistance to multiple antimicrobial drugs. Therefore, good hygiene practices and judicious antimicrobial use are crucial in small ruminant farming.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Review
Food Science & Technology
Rafael M. P. Poeys-Carvalho, Alice G. M. Gonzalez
Summary: There is an increasing concern about the occurrence of antimicrobial-resistant Enterobacteriaceae in vegetables. Vegetables serve as vectors for the dissemination of resistance mechanisms previously observed in hospitals.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Infectious Diseases
Leah J. Toombs-Ruane, Jonathan C. Marshall, Jackie Benschop, Dragana Drinkovi, Anne C. Midwinter, Patrick J. Biggs, Zoe Grange, Michael G. Baker, Jeroen Douwes, Mick G. Roberts, Nigel P. French, Sara A. Burgess
Summary: This study aimed to assess whether having a pet in the home is a risk factor for community-acquired urinary tract infections associated with extended-spectrum β-lactamase (ESBL)-or AmpC β-lactamase (ACBL)-producing Enterobacterales. Through telephone questionnaire and logistic regression analysis, it was found that pet ownership was not associated with ESBL-or ACBL-producing Enterobacterales-related urinary tract infections, while the main risk factors included recent antimicrobial treatment, travel to Asia in the previous year, and a doctor's visit in the last 6 months.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Anna R. Holtmann, Diana Meemken, Anja Mueller, Diana Seinige, Kathrin Buettner, Klaus Failing, Corinna Kehrenberg
Summary: This study revealed the presence of ESBL-/AmpC-E. coli in wild boars, with a significant positive association with human population density. The E. coli isolates carried various β-lactamase genes and showed multiple drug resistances.
Article
Veterinary Sciences
Vangelis Economou, Georgios Delis, Dimitra Stavrou, Panagiota Gousia, Anestis Tsitsos, Tilemachos Mantzios, Eirini Chouliara, Nikolaos Kolovos, Nikolaos Soultos
Summary: Antimicrobial resistance (AMR) is a significant concern in both human and veterinary medicine, particularly among gram-negative bacteria like Escherichia coli. This study found that 64% of raw poultry skin samples collected from a university club in Greece were positive for extended-spectrum β-lactamase (ESBL)-producing E. coli. The isolates were further characterized, and the majority of them were classified as true ESBL or AmpC phenotypes.
VETERINARY SCIENCES
(2023)
Article
Pathology
Eddie Chan, Marcel Leroi
Summary: The VITEK 2 AES demonstrates high sensitivity and moderate specificity in detecting broad-spectrum 13-lactamases, but has poor specificity in classifying ESBLs. It can be a valuable screening aid, but requires adequate knowledge of resistance mechanisms for correct interpretation and acceptance of results.
Article
Veterinary Sciences
Elspeth Milne, Tim Nuttall, Katia Marioni-Henry, Chiara Piccinelli, Tobias Schwarz, Ali Azar, Jennifer Harris, Juliet Duncan, Michael Cheeseman
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2020)
Article
Dermatology
Deborah J. Gow, Hilary Jackson, Peter Forsythe, Tim Nuttall, Adam G. Gow, Richard J. Mellanby, David A. Hume
VETERINARY DERMATOLOGY
(2020)
Article
Veterinary Sciences
Ozana M. Hritcu, Vanessa M. Schmidt, Shebl E. Salem, Iuliana E. Maciuca, Ramona F. Moraru, Irina Lipovan, Mihai Mares, Gheorghe Solcan, Dorina Timofte
FRONTIERS IN VETERINARY SCIENCE
(2020)
Review
Dermatology
Ralf S. Mueller, Tim Nuttall, Christine Prost, Bianka Schulz, Petra Bizikova
Summary: The study reviewed evidence on the treatment of feline atopic syndrome and asthma, finding good efficacy of systemic glucocorticoids and ciclosporin, with limited evidence for other treatment options. More randomized controlled trials are needed to validate the efficacy of most treatment methods.
VETERINARY DERMATOLOGY
(2021)
Article
Dermatology
Richard Halliwell, Cherie M. Pucheu-Haston, Thierry Olivry, Christine Prost, Hilary Jackson, Frane Banovic, Tim Nuttall, Domenico Santoro, Petra Bizikova, Ralf S. Mueller
Summary: This study compared features of atopic diseases in humans and cats, suggesting similarities between feline allergic diseases and some human atopic diseases. The term Feline Atopic Syndrome and Feline Atopic Skin Syndrome were proposed to describe allergic conditions in cats, and a definition of Food Allergy was proposed for adverse food reactions in cats.
VETERINARY DERMATOLOGY
(2021)
Article
Veterinary Sciences
Cajsa M. Isgren, Nicola J. Williams, Owen D. Fletcher, Dorina Timofte, Richard J. Newton, Thomas W. Maddox, Peter D. Clegg, Gina L. Pinchbeck
Summary: The study described the antimicrobial resistance patterns of bacteria from clinical samples in the UK in 2018, revealing high rates of multidrug resistance in SSI/CRI/orthopaedic infections. Analysis of resistance in pathogens like E. coli and Staphylococcus species showed that some bacteria lacked readily available treatments for adult horses in the UK.
EQUINE VETERINARY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Leonardos Mageiros, Guillaume Meric, Sion C. Bayliss, Johan Pensar, Ben Pascoe, Evangelos Mourkas, Jessica K. Calland, Koji Yahara, Susan Murray, Thomas S. Wilkinson, Lisa K. Williams, Matthew D. Hitchings, Jonathan Porter, Kirsty Kemmett, Edward J. Feil, Keith A. Jolley, Nicola J. Williams, Jukka Corander, Samuel K. Sheppard
Summary: This study identifies genetic elements associated with pathogenicity in avian E. coli using population genomics and pangenome-wide association studies, revealing the underlying mechanisms of pathogenicity in poultry.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Lynette Cole, Tim Nuttall
Summary: Myringotomy is performed in cases of otitis media, abnormal tympanic membranes, etc.; it should be done under general anesthesia, preferably using a video otoscope; postoperative care includes keeping the tympanic membrane clean to prevent infection.
VETERINARY DERMATOLOGY
(2021)
Article
Microbiology
David A. Singleton, Pisut Pongchaikul, Shirley Smith, Rebecca J. Bengtsson, Kate Baker, Dorina Timofte, Stephen Steen, Matthew Jones, Larry Roberts, Fernando Sanchez-Vizcaino, Susan Dawson, P-J M. Noble, Alan D. Radford, Gina L. Pinchbeck, Nicola J. Williams
Summary: This study aimed to monitor antimicrobial resistance in companion animals in the UK, finding that the most commonly isolated bacteria in dogs and cats were Escherichia coli, with some bacteria showing resistance to multiple drugs. Genotypic characterization proved to be an efficient method for identifying important resistance trends in companion animals on a national scale.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
E. F. Groat, N. J. Williams, G. Pinchbeck, B. Warner, A. Simpson, V. M. Schmidt
Summary: Dogs fed raw meat are more likely to carry antimicrobial-resistant Escherichia coli and Salmonella species compared to dogs fed non-raw diets. This poses a potential public health issue, especially for households with vulnerable members.
JOURNAL OF SMALL ANIMAL PRACTICE
(2022)
Article
Veterinary Sciences
Alexandra Royden, Robert Christley, Alison Prendiville, Nicola J. Williams
Summary: Campylobacter is a leading cause of human bacterial diarrhoeal disease globally, with poultry meat products contributing significantly to the cases. Farmers recognize the importance of biosecurity but have concerns about the current measures and heavy burden of responsibility placed on them.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Genever Morgan, Nicola Williams, Vanessa Schmidt, Daisy Cookson, Carrie Symington, Gina Pinchbeck
Summary: Food selection is an area of dog ownership where owners have direct control over their pet's wellbeing. This study aimed to provide further data regarding feeding practices and diet choice for UK dog owners with a focus on raw meat diets. The results showed that factors such as dog breed, neuter status, and age are associated with feeding raw meat diets. Owners who feed raw meat diets are more likely to prioritize a "more natural" diet and seek dietary advice from sources other than veterinary professionals. They perceive their diet choice to provide a wide range of health benefits, while non-raw meat diet feeders have different perceptions.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Microbiology
Flavia Zendri, Cajsa M. Isgren, Jane Devaney, Vanessa Schmidt, Rachel Rankin, Dorina Timofte
Summary: The widespread occurrence of ESKAPE gram-negative organisms in veterinary ICU patients and hospital environments is described in this study. The most prevalent ESC-R GN isolates were found to be Enterobacter cloacae complex, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii complex, followed by Escherichia coli, and most of them carried a combination of genes encoding for beta-lactamases and ESBLs. Some genotypes showed likely intra-hospital transmission, suggesting possible transfer mediated via movement of staff and students. Importantly, isolates carrying transmissible resistance to last-resort antimicrobials were identified within the hospital environments, indicating the urgent need for infection control policies.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Genetics & Heredity
Natalie Ring, Alison S. Low, Bryan Wee, Gavin K. Paterson, Tim Nuttall, David Gally, Richard Mellanby, J. Ross Fitzgerald
Summary: Antimicrobial resistance is a major threat to human and animal health. This article presents a rapid diagnostic pipeline for identifying bacterial pathogens in clinical urine and skin samples of dogs using metagenomic nanopore sequencing. The pipeline can identify the pathogen within 5 hours and predict antibiotic sensitivity in urine samples.
MICROBIAL GENOMICS
(2023)