Journal
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Volume 77, Issue 6, Pages 725-731Publisher
SERBIAN CHEMICAL SOC
DOI: 10.2298/JSC110715219A
Keywords
1,5-benzothiazepines; 2-aminothiophenol; chalcones; anti-breast cancer activity
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The title compounds 3a-j, substituted 1,5-benzothiazepines, were synthesized by the condensation of variously substituted chalcones 1 and 2-aminothiophenol 2 via conventional as well as non-conventional inorganic solid support microwave irradiation methods. The non-conventional protocol offers several advantages, such as simple procedure, fast reaction rate, mild reaction conditions and improved yields, compared to conventional methods. The structures of the products 3a-j were established by elemental analysis, FTIR, H-1-NMR, C-13-NMR and mass spectroscopic studies. The synthesized compounds were also evaluated for their cytotoxicity against the human breast cancer cell line MDA-MB-435, with some exhibiting in vitro anti-breast cancer activity.
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