Article
Food Science & Technology
Xianliang Luo, Wangxin Liu, Minjie Zhao, Tao Liu, Feifei Xiong, Lei Lei, Fuhuai Jia, Fengqin Feng
Summary: This study revealed that Atlantic salmon bone-derived collagen peptide (CPs) has potential in inhibiting osteoarthritis development and promoting anti-inflammatory and cartilage regeneration effects. CPs can reduce the expression of inflammatory factors, decrease chondrocytes apoptosis, and has good biocompatibility. However, further research is needed to explore the mechanism of CPs' positive effect on osteoarthritis.
FOOD RESEARCH INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Ziwei Ouyang, Lei Dong, Feng Yao, Ke Wang, Yong Chen, Shufang Li, Renpeng Zhou, Yingjie Zhao, Wei Hu
Summary: Collagen plays an important role in maintaining the mechanical properties of articular cartilage and the stability of the extracellular matrix. The degradation of collagen is involved in the progressive destruction of cartilage in diseases such osteoarthritis and rheumatoid arthritis. Collagen degradation can generate new biochemical markers and collagen can also be used as a biomaterial with excellent properties. This review provides a comprehensive understanding of collagen and its role in cartilage repair, offering insights and techniques for clinical diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Yibo Zhang, Liu He, Yiqi Yang, Jieqiong Cao, Zijian Su, Bihui Zhang, Huiying Guo, Zhenyu Wang, Peiguang Zhang, Junye Xie, Jieruo Li, Jinshao Ye, Zhengang Zha, Hengyi Yu, An Hong, Xiaojia Chen
Summary: Triclocarban (TCC), a widely used EDC, has been found to cause osteoarthritis (OA) in zebrafish by stimulating the expression of DNMT1 and initiating DNA hypermethylation. This leads to the suppression of type II collagen and other extracellular matrices, resulting in decreased cartilage tissue and narrowing of the intraarticular space, characteristic of OA pathogenesis. The regulation of OA occurrence by TCC is conserved in both zebrafish cartilage tissue and human chondrocytes. DNMT1 is highlighted as a potential therapeutic target for TCC-induced OA.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Cell & Tissue Engineering
Md Shafiullah Shajib, Kathryn Futrega, Travis Jacob Klein, Ross W. Crawford, Michael Robert Doran
Summary: Achieving high-quality integration between repair tissue and native cartilage is a major challenge in cartilage defect repair. Enzyme treatment of the tissue interface has been explored to facilitate remodeling and integration, but simpler models are needed to evaluate its effectiveness.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Chemistry, Medicinal
Zara Ahmed, Lydia C. Powell, Navid Matin, Andrew Mearns-Spragg, Catherine A. Thornton, Ilyas M. Khan, Lewis W. Francis
Summary: The study found that jellyfish collagen exhibited comparable scaffold structural properties and stability to mammalian collagen, and showed similar immunogenic responses in vitro. Jellyfish collagen supported invasion of bovine chondroprogenitor cells in scaffold structures, promoting chondrogenesis in the presence of TGF beta 1, highlighting its potential as a safe and biocompatible biomaterial.
Article
Biotechnology & Applied Microbiology
Jerrell Felim, Chun-Kai Chen, David Tsou, Hsiang-Ping Kuo, Zwe-Ling Kong
Summary: Marine collagen has potential therapeutic effects for treating osteoarthritis. Collagen and glycine can inhibit the production of proinflammatory cytokines, attenuating cartilage degradation, while collagen peptides promote cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Food Science & Technology
Hye Jun Lee, Do Un Kim, Choon Ok Kim
Summary: The study suggests that low-molecular-weight collagen peptide can reduce knee pain in patients with osteoarthritis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Chengcheng Ma, Mingxiao Yu, Zhoujin Huang, Jingfeng Wang, Xue Zhao, Chunmei Kang, Hao Xu, Yanchao Wang, Hu Hou
Summary: The study demonstrates that administration of chicken sternal cartilage hydrolysates (CCH) can effectively prevent osteoarthritis by inhibiting abnormal subchondral bone formation, preventing osteophyte formation, and ameliorating cartilage damage through improving collagen metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Orthopedics
Benjamin Andress, Jason H. Kim, Hattie C. Cutcliffe, Annunziato Amendola, Adam P. Goode, Shyni Varghese, Louis E. DeFrate, Amy L. McNulty
Summary: The study established baseline expression profiles and dedifferentiation patterns of inner and outer zone primary meniscus cells, and evaluated the utility of PEGDA and GelMA polymer hydrogels to reverse dedifferentiation trends for long-term meniscus cell culture. The results showed that expression levels of meniscus cell phenotype genes were significantly modulated by varying the ratio of polymer components in the hydrogels, allowing for tunable materials for phenotype restoration, meniscus cell culture, and tissue engineering applications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Mathaeus Tschaikowsky, Sofia Brander, Vanessa Barth, Ralf Thomann, Bernd Rolauffs, Bizan N. Balzer, Thorsten Hugel
Summary: This study reveals changes in the thickness and composition of collagen fibers at the onset of osteoarthritis. Fibrocartilage-like tissue rich in type I collagen is formed in intact cartilage during the early stages of the disease, while thick fibers are completely absent in advanced osteoarthritis. The findings provide insights into the understanding of other native biological tissues and the development of sustainable biomaterials.
ACTA BIOMATERIALIA
(2022)
Article
Orthopedics
Emma N. Luke, Pahweenvaj Ratnatilaka Na Bhuket, Seungju M. Yu, Jeffrey A. Weiss
Summary: The objective of this study was to investigate the potential of collagen hybridizing peptides (CHPs) to extend the retention time of near-infrared fluorophores (NIRF) following intra-articular injection in rat knee joints. The study found that CHPs were retained within the joint for the full study period and significantly extended the retention time of NIRFs by binding to multiple collagenous tissues in the joint. These results support further research to develop CHP based therapeutics for the treatment of osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Medicine, General & Internal
Xiaowei Zhang, Shili Wu, Yong Zhu, Cong-Qiu Chu
Summary: The long-term in vivo study demonstrated that scSOX9 in combination with microfracture could induce reparative tissue with features of hyaline cartilage, showing durable effects in the prevention of progression to osteoarthritis in a rabbit model.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Environmental Sciences
Neelam Shivnath, Vineeta Rawat, Sahabjada Siddiqui, Sushma Verma, Pragya Gupta, Juhi Rais, Mohd Sajid Khan, Md Arshad
Summary: The study found that PGP can alleviate collagenase-induced OA in rats by reducing blood ALP levels, inhibiting cartilage erosion, increasing COL-2 gene expression, and decreasing MMP-3 and COX-2 gene expression. PGP's high phenolic and flavonoid content contribute to its strong antioxidant activity, making it a potential preventive treatment for OA that warrants further validation in clinical studies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Mun-Hoe Lee, Hyeong-Min Kim, Hee-Chul Chung, Do-Un Kim, Jin-Hee Lee
Summary: This study found that oral administration of low-molecular-weight collagen peptide can reduce cartilage damage and proteoglycan loss, promote cartilage repair, and suppress the progression of osteoarthritis.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Helena Port, Anne-Christine Bay-Jensen, Yi He, Morten A. A. Karsdal, Thorbjorn Gantzel, Christian S. S. Thudium, Signe Holm Nielsen
Summary: The development of a competitive chemiluminescence enzyme-linked immunosorbent assay, CALC2, targeting the type II collagen C-terminal pro-peptide as a marker of cartilage formation was evaluated. The CALC2 level was measured after in vitro cleavage of recombinant type II collagen and treatment of human osteoarthritis cartilage explant model with insulin-like growth factor-1. Serum CALC2 levels were found to be decreased in patients with rheumatoid arthritis and ankylosing spondylitis compared to controls. These results suggest that CALC2 may be a novel biomarker of type II collagen formation, but further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)