Journal
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
Volume 95, Issue 4, Pages 828-835Publisher
WILEY-BLACKWELL
DOI: 10.1002/jsfa.6973
Keywords
carnosic acid; fatty acid; glucose tolerance; obesity; Rosmarinus officinalis
Funding
- SRC program (Center for Food & Nutritional Genomics) [2012-0000642]
- National Research Foundation (NRF) of Korea - Ministry of Education, Science, and Technology [2012R1A2A2A01046228]
- National Research Foundation of Korea [2008-0062618, 2012R1A2A2A01046228] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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BACKGROUNDCarnosic acid (CA), a major bioactive component of rosemary (Rosmarinus officinalis) leaves, is known to possess antioxidant and anti-adipogenic activities. In this study it was hypothesized that CA would ameliorate obesity-induced glucose intolerence and hepatic fat accumulation, and possible mechanisms are suggested. RESULTSIt was observed that a 0.02% (w/w) CA diet effectively decreased body weight, liver weight and blood triglyceride (TG) and total cholesterol levels (P < 0.05) compared with the control diet. CA at 0.02% significantly improved glucose tolerance, and hepatic TG accumulation was reduced in a dose-dependent manner. Hepatic lipogenic-related gene (L-FABP, SCD1 and FAS) expression decreased whereas lipolysis-related gene (CPT1) expression increased in animals fed the 0.02% CA diet (P < 0.05). Long-chain fatty acid content and the ratio of C18:1/C18:0 fatty acids were decreased in adipose tissue of animals fed the 0.02% CA diet (P < 0.05). Serum inflammatory mediators were also decreased significantly in animals fed the 0.02% CA diet compared with those of the obese control group (P < 0.05). CONCLUSIONThese results suggest that CA is an effective anti-obesity agent that regulates fatty acid metabolism in C57BL/6J-ob/ob mice. (c) 2014 Society of Chemical Industry
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