Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 11, Issue 97, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsif.2014.0326
Keywords
gene transcription; transcription reinitiation; eukaryotic transcription; noise analysis
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Funding
- Aihara Innovative Mathematical Modelling Project
- Japan Society for the Promotion of Science (JSPS) through the 'Funding Programme for World-Leading Innovative R&D on Science and Technology (FIRST Programme)'
- Council for Science and Technology Policy (CSTP)
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB13000000]
- National Programme on Key Basic Research Project [2014CB910504]
- Knowledge Innovation Programme of the Chinese Academy of Sciences [KSCX2-EW-R-01]
- 863 project [2012AA020406]
- NSFC [61134013, 91029301, 11326035]
- MEXT, Japan
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Gene transcription is a noisy process carried out by the transcription machinery recruited to the promoter. Noise reduction is a fundamental requirement for reliable transcriptional responses which in turn are crucial for signal transduction. Compared with the relatively simple transcription initiation in prokaryotes, eukaryotic transcription is more complex partially owing to its additional reinitiation mechanism. By theoretical analysis, we showed that reinitiation reduces noise in eukaryotic transcription independent of the transcription level. Besides, a higher reinitiation rate enables a stable scaffold complex an advantage in noise reduction. Finally, we showed that the coupling between scaffold formation and transcription can further reduce transcription noise independent of the transcription level. Furthermore, compared with the reinitiation mechanism, the noise reduction effect of the coupling can be of more significance in the case that the transcription level is low and the intrinsic noise dominates. Our results uncover a mechanistic route which eukaryotes may use to facilitate a more reliable response in the noisy transcription process.
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