Journal
JOURNAL OF THE ROYAL SOCIETY INTERFACE
Volume 6, Issue -, Pages S567-S573Publisher
ROYAL SOC
DOI: 10.1098/rsif.2009.0156.focus
Keywords
small-angle neutron scattering; reflectivity; deuteration; neutrons; diffraction
Categories
Funding
- Wellcome Trust
- BBSRC
- Orla Protein Technologies Ltd
- EPSRC [TS/G001561/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [TS/G001561/1] Funding Source: researchfish
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From the structures of isolated protein complexes to the molecular dynamics of whole cells, neutron methods can achieve a resolution in complex systems that is inaccessible to other techniques. Biology is fortunate in that it is rich in water and hydrogen, and this allows us to exploit the differential sensitivity of neutrons to this element and its major isotope, deuterium. Furthermore, neutrons exhibit wave properties that allow us to use them in similar ways to light, X-rays and electrons. This review aims to explain the basics of biological neutron science to encourage its greater use in solving difficult problems in the life sciences.
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