Article
Oncology
Takumi Tsuji, Atsuki Hosoda, Yuuki Toriyama, Yuya Yoshida, Takeyuki Kohno
Summary: This study found that the combination treatment of CDDP and renin-angiotensin system inhibitors, particularly ENA and TEL, may exacerbate CDDP-induced nephrotoxicity. It highlights the need for large-scale clinical studies to establish treatment regimens that do not interfere with the therapeutic intensity of CDDP.
TRANSLATIONAL ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Negar Khoshghamat, Niloufar Jafari, Vajiheh Toloue-pouya, Shakiba Azami, Seyyedeh Helya Mirnourbakhsh, Majid Khazaei, Gordon A. Ferns, Majid Rajabian, Amir Avan
Summary: Pancreatic cancer is a lethal malignancy with poor prognosis, and patients often become resistant to current therapies. Research suggests that RAS blockers may have anti-carcinogenic effects and could improve clinical outcomes in the management of pancreatic cancer.
Article
Medicine, General & Internal
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
Summary: This study aimed to evaluate patient survival with the use of renin-angiotensin system blockers (RASBs) in maintenance hemodialysis (HD) patients, and found that the use of RASBs was associated with higher patient survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Medicinal
Daisuke Iijima, Hiroshi Sugama, Nobumasa Awai, Yoichi Takahashi, Yuko Togashi, Tohru Takebe, Jianshu Xie, Jingkang Shen, Ying Ke, Hidenori Akatsuka, Takayuki Kawaguchi, Kei Takedomi, Akiko Kashima, Masashi Nishio, Yosuke Inui, Hikaru Yoneda, Guangxin Xia, Toru Iijima
Summary: The renin-angiotensin-aldosterone system (RAAS) is crucial in blood pressure regulation, with renin being the initial and rate-limiting enzyme. A novel class of direct renin inhibitors (DRIs) composed of a 2-carbamoyl morpholine scaffold showed potent antihypertensive efficacy via oral administration in double transgenic mice.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Hua Miao, Yan-ni Wang, Wei Su, Liang Zou, Shou-gang Zhuang, Xiao-yong Yu, Fei Liu, Ying-yong Zhao
Summary: This study investigates the regulatory mechanisms of Sirt in podocyte injury in membranous nephropathy (MN) patients, CBSA-induced MN rats, and ZAS-stimulated podocytes. The results demonstrate that Sirt6 ameliorates podocyte injury by blocking RAS signaling via the Wnt1/β-catenin pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pharmacology & Pharmacy
Jeong Yee, Tae-Jin Song, Ha-Young Yoon, Junbeom Park, Hye-Sun Gwak
Summary: The purpose of this study was to identify genetic factors related to the renin-angiotensin system (RAS) and its association with bleeding, and to develop a risk scoring system for bleeding in patients receiving direct oral anticoagulants (DOACs). The study found that older age and moderate to severe renal impairment were independent risk factors for bleeding, and certain RAS-related gene polymorphisms were also associated with increased bleeding risk. According to the risk scoring system, the risk of bleeding increased exponentially with a higher score.
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Sebastian Andone, Zoltan Bajko, Anca Motataianu, Smaranda Maier, Laura Barcutean, Rodica Balasa
Summary: This article reviews the role of the renin-angiotensin system in stroke neuroprotection. The effects of the renin-angiotensin system on receptors were observed, and the neuroprotective properties seem to be independent of the blood pressure reduction mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Persoulla A. Nicolaou
Summary: Sex-related differences in clinical manifestations, risk factors, and treatment drug use in patients with heart failure are significant, particularly in the regulation of the renin-angiotensin-aldosterone system (RAAS). While current evidence suggests potential differences in the efficacy of RAAS drugs between men and women, further research is needed to determine the optimal treatment strategies for both genders.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Sizhu Gong, Fang Deng
Summary: Emotional disorders, such as depression and anxiety, have a significant impact on global morbidity. The renin-angiotensin system (RAS) plays a role in hypertension and emotional disorders, and elevated RAS activity is associated with depression and anxiety through neuroinflammation, stress, and oxidative stress. Blocking the RAS could potentially be a future treatment approach for anxiety and depression. The positive effects of RAS blockers on these disorders are reviewed, aiming to provide a promising target for novel medications and to improve the efficacy of current treatments independent of blood pressure management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chan Soon Park, Han-Mo Yang, Jeehoon Kang, Jung-Kyu Han, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Ki-Bae Seung, Kwang Soo Cha, In-Whan Seong, Seung-Woon Rha, Myung Ho Jeong, Hyo-Soo Kim, KAMIR-NIH Registry
Summary: The use of Renin-angiotensin-system inhibitors (RASi) medication at 1-year follow-up did not show any improvement in 2-year all-cause mortality or cardiac mortality for patients after acute myocardial infarction (MI). This study provides valuable information for tailored medication strategies after acute MI.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cell Biology
Maksymilian Ziaja, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The renin-angiotensin system (RAS) is not only involved in regulating cardiovascular function, but also plays a complex role in various processes such as memory and cancer. Maintaining the balance between individual elements of the RAS system is crucial for achieving homeostasis, and any disturbance in their expression or activity can lead to pathological processes.
Review
Neurosciences
Naif H. Ali, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Ali K. Albuhadily, Rabab S. Hamad, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad, Gaber El-Saber Batiha
Summary: This article discusses the pathophysiology of depression and the role of the brain renin-angiotensin system (RAS) in it. It is found that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers may be effective in the treatment of depression. By regulating serotonin, brain-derived neurotrophic factor, mitochondrial dysfunction, oxidative stress, and neuroinflammation, these drugs can ameliorate the pathophysiology of depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Lucas M. Kangussu, Natalia P. Rocha, Priscila A. C. Valadao, Thatiane C. G. Machado, Kivia B. Soares, Julliane V. Joviano-Santos, Leigh B. Latham, Gabriela D. Colpo, Ana Flavia Almeida-Santos, Erin Furr Stimming, Ana Cristina Silva, Antonio L. Teixeira, Aline Silva Miranda, Cristina Guatimosim
Summary: The imbalance of the Renin-Angiotensin System in the central nervous system may play a role in the pathophysiology of Huntington's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Junda Hu, Yan Xu, Sebastian Bachmann, Kerim Mutig
Summary: The inhibition of COX-2 caused by CsA is due to RAS activation, which can override the stimulatory effects of calcineurin inhibition. Antagonism of angiotensin II alleviates CsA nephrotoxicity by normalizing creatinine clearance and sodium excretion through COX-2 pathway. Candesartan can effectively mitigate the renal side effects induced by CsA, while celecoxib may prevent the improvements brought by candesartan.
Article
Instruments & Instrumentation
Tinku, Mohd. Mujeeb, Abdul Ahad, Mohd. Aqil, Waseem Ahmad Siddiqui, Abul Kalam Najmi, Mymoona Akhtar, Apeksha Shrivastava, Abdul Qadir, Thasleem Moolakkadath
Summary: This study successfully optimized rubiadin-loaded niosomes using Box-Behnken design for the management of diabetic nephropathy in Wistar rats. The optimized formulation showed significant anti-diabetic activity and improvement in biochemical parameters in Wistar rats. The findings suggest that the prepared RLN formulation has potential for the management of STZ-NA-induced DN.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mahtab Alam, Md Noushad Javed, Abul Kalam Najmi, Farhan Jalees Ahmad, Syed Sarim Imam, Mohd Akhtar
Summary: Thymoquinone (TQ) suspension and its SLN (TQSLN) show advantages in neuronal signaling mechanism and neuroprotective effects compared to the standard antidepressant drug fluoxetine. TQSLN may attenuate neuroinflammatory transmitters and promote BDNF to modulate depressive neurobehavioral states.
CURRENT DRUG METABOLISM
(2021)
Review
Endocrinology & Metabolism
Sana Khan, Soumya Pati, Shailja Singh, Mohd. Akhtar, Piush Khare, Saba Khan, Sadat Shafi, Abul Kalam Najmi
Summary: This study aims to understand the role of hypercoagulation in triggering the progression of neurodegeneration in MetS. It also offers a few interventions to prevent the progression of AD in MetS targeting hypercoagulation.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Neurosciences
Noorul Hasan, Saima Zameer, Abul Kalam Najmi, Suhel Parvez, Mohd Akhtar
Summary: This study investigated the therapeutic potential of the PDE-4 inhibitor roflumilast in Alzheimer's disease. The results showed that roflumilast improved learning and memory capacities in rats, reduced neuroinflammation and amyloid deposition, and activated the cAMP/BDNF signaling pathway.
NEUROTOXICITY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Juheb Akhter, Jasim Khan, Madhu Baghel, Mirza Masroor Ali Beg, Poonam Goswami, Mohd Amir Afjal, Shahzad Ahmad, Haroon Habib, Abul Kalam Najmi, Sheikh Raisuddin
Summary: This study investigated the therapeutic effects of rosmarinic acid (RA) against inflammation-induced acute kidney injury (AKI) and found that RA can effectively prevent cisplatin-induced AKI by inhibiting the activation of the NLRP3 signaling pathway and other related signal molecules.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Asad Ali, Mohd Aqil, Syed Sarim Imam, Abdul Ahad, Arshiya Parveen, Abdul Qadir, Mohd Humair Ali, Mohd Akhtar
Summary: The study aimed to prepare and optimize Embelin-loaded liposomes, resulting in the promising formulation EMB-NLop with enhanced antioxidant activity and permeation. Experimental data indicated that EMB-NLop is a promising and effective formulation for intranasal delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Kashif Haider, Kamal Ahmad, Abul Kalam Najmi, Subham Das, Alex Joseph, M. Shahar Yar
Summary: A series of 2-aminobenzothiazole derivatives were synthesized and evaluated for their anticancer activity. Compound 8i showed the most potent inhibitory activity and high selectivity against PI3K alpha, inducing apoptosis in a dose-dependent manner.
ARCHIV DER PHARMAZIE
(2022)
Article
Chemistry, Medicinal
Kashif Haider, Shivani Sharma, Yuba Raj Pokharel, Subham Das, Alex Joseph, Abul Kalam Najmi, Faiz Ahmad, Mohammad Shahar Yar
Summary: This report presents a new series of indole-tethered pyrazoline derivatives as potent anticancer agents. The compounds showed strong cytotoxicity against A431, HeLa, and MDAMB-231 cell lines. In addition, they exhibited inhibitory effects on colony formation, migration, and cell cycle arrest. The compounds also demonstrated potential as topoisomerase inhibitors and were found to be safe in vivo.
DRUG DEVELOPMENT RESEARCH
(2022)
Review
Immunology
Syed Sufian Ahmad, Faraha Ahmed, Ruhi Ali, Mohammed M. Ghoneim, Sultan Alshehri, Abul Kalam Najmi, Sayeed Ahmad, Mohammad Zaki Ahmad, Javed Ahmad, Mohammad Ahmed Khan
Summary: Osteoporosis, characterized by low bone mass and deteriorated bone microarchitecture, is a major cause of fractures and morbidity worldwide. Recent studies have identified the role of the immune system in the skeletal system, leading to the emergence of osteoimmunology. Immune dysregulation can cause inflammation and adversely affect bone integrity. T-lymphocyte subsets (Th17) play a significant role in the pathogenesis of osteoporosis. Therefore, studying osteoimmunology is important for understanding osteoporosis and developing immunotherapy strategies.
Review
Chemistry, Medicinal
Farazul Hoda, Afifa Khanam, Mehak Thareja, Mawrah Arshad, Mohd Ahtar, Abul Kalam Najmi
Summary: This systematic review summarizes the effects of Nigella sativa in the management of Type 2 Diabetes Mellitus (T2DM). The available evidence suggests that Nigella sativa can significantly improve glucose and insulin levels in patients with T2DM, and has a positive impact on the treatment outcomes of T2DM and its complications.
Article
Biochemistry & Molecular Biology
Sonal Gupta, Monika Saini, Nishant Joshi, Sadat Shafi, Abul Kalam Najmi, Shailja Singh
Summary: This study investigated the localization and druggability of serpentine receptors in Plasmodium, and demonstrated the strong binding interaction between PfSR12 and R138727. The findings suggest the importance of purinergic signaling and PfSR12 in the survival and development of the malaria parasite, and indicate that Prasugrel may serve as a potential antimalarial therapy targeting PfSR12.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Shaista Amin, Khursheed A. Sheikh, Ashif Iqubal, Mohammad Ahmed Khan, M. Shaquiquzzaman, Sharba Tasneem, Suruchi Khanna, A. K. Najmi, Mymoona Akhter, Anzarul Haque, Tarique Anwer, M. Mumtaz Alam
Summary: Despite advancements in Diabetes mellitus management, designing and synthesizing drug molecules that effectively improve hyperglycemia and associated complications in diabetic patients remains challenging. In this study, pyrimidine-thiazolidinedione derivatives were synthesized, characterized, and evaluated for their anti-diabetic properties. The synthesized compounds were analyzed using various techniques, including NMR, FTIR, and Mass Spectrometry. In-silico ADME studies confirmed the compounds met Lipinski's rule of five. In-vivo evaluation in diabetic rats showed that compounds 6e and 6m significantly reduced blood glucose levels without causing weight gain. Biochemical and histopathological analyses further supported the anti-diabetic effects of these compounds. Based on these findings, pyrimidine-based thiazolidinedione derivatives could be considered as novel anti-diabetic agents with minimal side effects.
BIOORGANIC CHEMISTRY
(2023)
Review
Oncology
Preeti Sharma, Mohammad Ahmed Khan, Abul Kalam Najmi, Shubhra Chaturvedi, Mohd Akhtar
Summary: Breast cancer is a major cause of malignant death in females, and triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis. Myricetin (MYR), a naturally occurring compound, has been found to have anti-cancer effects in various cancers, including TNBC. It regulates multiple signaling pathways to inhibit cell proliferation and invasion and promote cell apoptosis. The PI3K/AKT/mTOR pathway is identified as a potential therapeutic target for MYR in TNBC treatment.
Review
Chemistry, Medicinal
Ashif Iqubal, Farazul Hoda, Abul Kalam Najmi, Syed Ehtaishamul Haque
Summary: COVID-19, which originated in Wuhan, has now become a global pandemic with exponentially growing mortality rates. Patients with comorbid conditions experience higher clinical complications and fatality rates. The use of anti-cytokine and anti-inflammatory drugs to manage hyper inflammation in severe cases is being explored, but must be carefully considered to avoid worsening the situation.
