Article
Clinical Neurology
Mei-Xue Dong, Qing Wang, Jun-Feng Xu, Ling Hu, Ying Yu, Tao Li
Summary: Abusing laughing gas can lead to peripheral neuropathy, resulting in symptoms such as wheelchair dependence and nerve damage. The patient experienced significant improvement in symptoms after appropriate treatment.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Cinta Lleixa, Lorena Martin-Aguilar, Elba Pascual-Goni, Teresa Franco, Marta Caballero, Noemi de Luna, Eduard Gallardo, Xavier Suarez-Calvet, Laura Martinez-Martinez, Jordi Diaz-Manera, Ricard Rojas-Garcia, Elena Cortes-Vicente, Joana Turon, Carlos Casasnovas, Christian Homedes, Gerardo Gutierrez-Gutierrez, Maria Concepcion Jimeno-Montero, Jose Berciano, Maria Jose Sedano-Tous, Tania Garcia-Sobrino, Julio Pardo-Fernandez, Celedonio Marquez-Infante, Inigo Rojas-Marcos, Ivonne Jerico-Pascual, Eugenia Martinez-Hernandez, German Moris de la Tassa, Cristina Dominguez-Gonzalez, Candido Juarez, Isabel Illa, Luis Querol
Summary: This study found that GBS patients have a heterogeneous repertoire of autoantibodies targeting nerve cells and structures. Gangliosides are the most frequent antigens in GBS patients and have prognostic value. Further antigen-discovery experiments may elucidate other potential antigens in GBS.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Andreea-Raluca Hanganu, Alexandru Constantin, Elena-Sonia Moise, Cristian-Mihail Niculae, Ioana Diana Olaru, Cristian Baicus, Adriana Hristea
Summary: There is increasing evidence that COVID-19 can affect both the central and peripheral nervous systems, with a particular impact on the cranial nerves. Facial, vestibulo-cochlear, and olfactory nerves are the most frequently involved. Patients with peripheral nervous system involvement are more likely to be hospitalized and experience post-COVID-19 sequelae. Overall, the importance of this study is rated at 8 out of 10.
Article
Immunology
Netanel Karbian, Yael Eshed-Eisenbach, Marian Zeibak, Adi Tabib, Natasha Sukhanov, Anya Vainshtein, B. Paul Morgan, Yakov Fellig, Elior Peles, Dror Mevorach
Summary: This study revealed the localization and role of complement regulatory proteins in the peripheral nervous system of CD59a-deficient mice and CD59-deficient patients. The lack of CD59 in the Nodes of Ranvier makes them vulnerable to complement attack, while the myelin unit in the human PNS is protected by CD59 and CD55.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Johanna I. Hamel, Eric L. Logigian
Summary: This study retrospectively reviewed cases from 1999 to 2020 to describe the clinical, micronutrient, and electrophysiologic spectra and prognosis of acute nutritional axonal neuropathy (ANAN). The results showed that ANAN has a wide spectrum of manifestations and specific micronutrient deficiencies or risk factors do not predict neuropathy subtype. The prognosis of ANAN is guarded due to slow recovery of independent ambulation and residual neuropathic pain.
Editorial Material
Clinical Neurology
Sina Marzoughi, Laura Marulanda, Dian Ngo, Tychicus Chen
Summary: This case presents an atypical motor axonal neuropathy with asymmetric paralysis, initially preserved reflexes, rapid progression, and cardiac dysfunction independent of dysautonomia.
Editorial Material
Clinical Neurology
Jonah P. Zuflacht, Aimee K. Boegle
Summary: CIDP may present acutely, resembling GBS.
Article
Clinical Neurology
Jiting Zhu, Yuanyuan Zhang, Runyun Li, Yi Lin, Ying Fu, Yaping Yan, Wenli Zhu, Ning Wang, Zaiqiang Zhang, Guorong Xu
Summary: This study investigated the diagnostic efficiency of a novel immunoblotting detection assay for anti-ganglioside antibodies (AGAs) in Guillain-Barre syndrome (GBS). The results showed a high detection rate of AGAs in GBS patients, with specific assistance in diagnosing the AMAN subtype.
FRONTIERS IN NEUROLOGY
(2021)
Article
Gastroenterology & Hepatology
Ankit Malik, Jean M. Brudvig, Barbie J. Gadsden, Alexander D. Ethridge, Linda S. Mansfield
Summary: This study demonstrates the link between Campylobacter jejuni and the autoimmune disease Guillain-Barré syndrome and identifies the roles of Siglec-1 and IL-4 in its development. The mouse model developed in this study provides potential therapeutic interventions for this disease.
Article
Orthopedics
Hisao Ishii, Shigeru Kurimoto, Masahiro Tatebe, Michiro Yamamoto, Katsuyuki Iwatsuki, Hitoshi Hirata
Summary: This study revealed the presence of postoperative neuropathy induced by surgical stress, with most patients fully recovering within one year. Surgeons should recognize the existence of postoperative idiopathic neuropathy to understand its pathogenesis and reduce litigation risks.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Immunology
Margherita Bellucci, Francesco Germano, Stefano Grisanti, Chiara Castellano, Francesco Tazza, Emanuela Maria Mobilia, Davide Visigalli, Giovanni Novi, Federico Massa, Silvia Rossi, Paolo Durando, Corrado Cabona, Angelo Schenone, Diego Franciotta, Luana Benedetti
Summary: This article reports a case in which a patient developed GBS symptoms after COVID-19 infection, recovered after treatment, but experienced a recurrence of GBS after receiving the COVID-19 vaccine. Based on this case and previous observations, there may be a possible causal link between SARS-CoV-2 and GBS.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Clinical Neurology
Jeffrey A. Allen
Summary: With every influenza vaccination, the question of previous Guillain-Barre syndrome (GBS) history is asked, and vaccination is typically advised against for those with GBS. The topic is widely discussed with strong opinions for or against vaccination within patient and physician networks. The COVID-19 pandemic has heightened concerns among the inflammatory neuropathy community and clinicians caring for GBS and CIDP patients, given the global scale of SARS-CoV-2 vaccinations.
Article
Clinical Neurology
Stephane Mathis, Antoine Soulages, Gwendal Le Masson, Jean-Michel Vallat
Summary: The history of mankind is affected by numerous epidemics, some of which involve diseases of the peripheral nervous system, whether infectious or autoimmune in nature. This article describes the three main infectious causes of epidemics affecting the peripheral nervous system, as well as discussing epidemics of autoimmune origin.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Stephen Keddie, Duncan Smyth, Ryan Y. S. Keh, Michael K. L. Chou, Donna Grant, Sunaina Surana, Amanda Heslegrave, Henrik Zetterberg, Luuk Wieske, Milou Michael, Filip Eftimov, Roberto Bellanti, Simon Rinaldi, Melanie S. Hart, Axel Petzold, Michael P. Lunn
Summary: Valid blood biomarkers specific to peripheral nerve damage would greatly improve management of peripheral nervous system diseases. This study found that peripherin, an intermediate filament protein, could serve as a promising biomarker for peripheral nerve axonal damage. An immunoassay using single molecule array technology was developed to detect serum peripherin levels, and longitudinal analysis showed its potential clinical application in certain diseases.
Article
Pediatrics
Alisa Corrado, Grace Yoshiba, Megan Buranosky, Zakary Woods, Julie Wohrley, Lubov Romantseva, Ashley Wolf
Summary: A 43-day-old male infant presented with decreased activity and oral intake, initially diagnosed with bronchiolitis. However, as his condition worsened, he developed neurological deficits and underwent an extensive workup, leading to a surprising diagnosis.
Editorial Material
Clinical Neurology
Guillaume Taieb, Moglie Le Quintrec, Amandine Pialot, Ilan Szwarc, Helene Perrochia, Pierre Labauge, Jerome J. Devaux
Article
Medicine, Research & Experimental
Constance Manso, Luis Querol, Cinta Lleixa, Mallory Poncelet, Mourad Mekaouche, Jean-Michel Vallat, Isabel Illa, Jerome J. Devaux
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Clinical Neurology
Andrea Cortese, Raffaella Lombardi, Chiara Briani, Ilaria Callegari, Luana Benedetti, Fiore Manganelli, Marco Luigetti, Sergio Ferrari, Angelo M. Clerici, Girolama Alessandra Marfia, Andrea Rigamonti, Marinella Carpo, Raffaella Fazio, Massimo Corbo, Anna Mazzeo, Fabio Giannini, Giuseppe Cosentino, Elisabetta Zardini, Riccardo Curro, Matteo Gastaldi, Elisa Vegezzi, Enrico Alfonsi, Angela Berardinelli, Ludivine Kouton, Constance Manso, Claudia Giannotta, Pietro Doneddu, Patrizia Dacci, Laura Piccolo, Marta Ruiz, Alessandro Salvalaggio, Chiara De Michelis, Emanuele Spina, Antonietta Topa, Giulia Bisogni, Angela Romano, Sara Mariotto, Giorgia Mataluni, Federica Cerri, Claudia Stancanelli, Mario Sabatelli, Angelo Schenone, Enrico Marchioni, Giuseppe Lauria, Eduardo Nobile-Orazio, Jerome Devaux, Diego Franciotta
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
J. -M. Vallat, S. Mathis, E. Vegezzi, L. Richard, M. Duchesne, G. Gallouedec, P. Corcia, L. Magy, A. Uncini, J. Devaux
EUROPEAN JOURNAL OF NEUROLOGY
(2020)
Article
Immunology
Xuli Zhang, Peibing Zheng, Jerome J. Devaux, Yan Wang, Chen Liu, Jing Li, Shougang Guo, Yan Song, Qian Wang, Xungang Feng, Yuzhong Wang
JOURNAL OF NEUROIMMUNOLOGY
(2019)
Article
Clinical Neurology
Ludivine Kouton, Jose Boucraut, Jerome Devaux, Yusuf A. Rajabally, David Adams, Jean Christophe Antoine, Frederic Bourdain, Alexandre Brodovitch, Jean-Philippe Camdessanche, Cecile Cauquil, Jonathan Ciron, Thierry Dubard, Andoni Echaniz-Laguna, Aude-Marie Grapperon, Raul Juntas-Morales, Laurent Kremer, Thierry Kuntzer, Celine Labeyrie, Luca Lanfranco, Jean-Marc Leger, Thierry Maisonobe, Nicolas Mavroudakis, Sylvie Mecharles-Darrigol, Philippe Merle, Jean-Baptiste Noury, Violaine Rouaud, Celine Tard, Marie Theaudin, Jean-Michel Vallat, Karine Viala, Shahram Attarian, Emilien Delmont
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Neurosciences
Yael Eshed-Eisenbach, Jerome Devaux, Anna Vainshtein, Ofra Golani, Se-Jin Lee, Konstantin Feinberg, Natasha Sukhanov, Daniel S. Greenspan, Keiichiro Susuki, Matthew N. Rasband, Elior Peles
Letter
Clinical Neurology
Thierry Gendre, Jean-Pascal Lefaucheur, Jerome Devaux, Alain Creange
Letter
Clinical Neurology
S. Laroussi, S. Sakka, S. Belghuith, N. Farhat, O. Hdiji, S. Daoud, K. Moalla, J. Devaux, M. Damak, C. Mhiri
REVUE NEUROLOGIQUE
(2021)
Article
Urology & Nephrology
Moglie Le Quintrec, Maxime Teisseyre, Nicole Bec, Emilien Delmont, Ilan Szwarc, Helene Perrochia, Marie Christine Machet, Anthony Chauvin, Nicolas Mavroudakis, Guillaume Taieb, Luca Lanfranco, Claire Rigothier, Boucraut Jose, Catalano Concetta, Clair Geneste, Vincent Pernin, Christian Larroque, Jerome Devaux, Anais Beyze
Summary: Primary membranous nephropathy (MN) is an autoimmune glomerular disease with PLA2R1 as the main targeted antigen in 80% of cases, while the antigenic target remains undefined in 20% cases. A study discovered that contactin 1 is a novel common antigenic target in MN associated with chronic inflammatory demyelinating polyneuropathy.
KIDNEY INTERNATIONAL
(2021)
Article
Clinical Neurology
Cheng-Yin Tan, Khean-Jin Goh, Ai-Wen Oh, Jerome Devaux, Nortina Shahrizaila
Summary: This study reported a cohort of patients with CIDP who had a prevalence of 8% of autoimmune nodopathies and poor response to IVIG treatment. Patients with IgG4 anti-NF155 and anti-CNTN1 antibodies showed similar clinical features and treatment responses as previous reports.
NEUROMUSCULAR DISORDERS
(2022)
Article
Clinical Neurology
Jean-Michel Vallat, Nathalie Deschamps, Laurence Richard, Laurent Magy, Jerome Devaux, Stephane Mathis
Summary: We present a case report of a patient with severe sensorimotor polyneuropathy and immunoglobulin-M monoclonal gammopathy. Immunoglobulin-M targeting an unknown myelin antigen appears to be responsible for the nerve lesions similar to those observed in anti-myelin associated glycoprotein polyneuropathy. The combination of plasma exchanges and rituximab was effective in this patient, suggesting an autoimmune origin.
NEUROMUSCULAR DISORDERS
(2022)
Article
Clinical Neurology
Alexandre Jentzer, Arthur Attal, Clemence Roue, Julie Raymond, Cinta Lleixa, Isabel Illa, Luis Querol, Guillaume Taieb, Jerome Devaux
Summary: This study found that monospecific and bivalent anti-Nfasc155 IgG4 antibodies are present in patients and are pathogenic. Transforming these bivalent antibodies into monovalent Fab or IgG4 through FAE significantly reduces paranodal damage.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Marie Deck, Gerben Van Hameren, Graham Campbell, Nathalie Bernard-Marissal, Jerome Devaux, Jade Berthelot, Alise Lattard, Jean-Jacques Medard, Benoit Gautier, Sophie Guelfi, Scarlette Abbou, Patrice Quintana, Juan Manuel Chao de la Barca, Pascal Reynier, Guy Lenaers, Roman Chrast, Nicolas Tricaud
Summary: Lactate production through PKM2 enzyme and aerobic glycolysis is essential for the long-term maintenance of peripheral nerve axon physiology and function.
Article
Clinical Neurology
Elba Pascual-Goni, Janev Fehmi, Cinta Lleixa, Lorena Martin-Aguilar, Jerome Devaux, Romana Hoftberger, Emilien Delmont, Kathrin Doppler, Claudia Sommer, Aleksandar Radunovic, Alejandra Carvajal, Shane Smyth, Laura Williams, Radim Mazanec, Veronika Potockova, Nigel Hinds, Julien Cassereau, Karine Viala, Mathilde Lefilliatre, Guillaume Nicolas, Peter Foley, Frank Leypoldt, Stephen Keddie, Michael P. Lunn, Fritz Zimprich, Vharoon Sharma Nunkoo, Wolfgang N. Loscher, Laura Martinez-Martinez, Jordi Diaz-Manera, Ricard Rojas-Garcia, Isabel Illa, Simon Rinaldi, Luis Querol
Summary: In patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), a small percentage have antibodies targeting the Caspr1/CNTN1 complex, showing similar clinical and serological features, forming a distinct subgroup within the CIDP syndrome.