Journal
JOURNAL OF THE OPTICAL SOCIETY OF AMERICA A-OPTICS IMAGE SCIENCE AND VISION
Volume 27, Issue 12, Pages 2648-2659Publisher
OPTICAL SOC AMER
DOI: 10.1364/JOSAA.27.002648
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Funding
- National Science Foundation (NSF) [CBET-0546113, CBET-0854430]
- National Institutes of Health (NIH) [EB009715, CA136102, HL091017]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1135068] Funding Source: National Science Foundation
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Phase-contrast imaging methods exploit variations in an object's refractive index distribution to permit the visualization of subtle features that may have very similar optical absorption properties. Although phase-contrast is often viewed as being desirable in many biomedical applications, its relative influence on signal detectability when both absorption- and phase-contrast are present remains relatively unexplored. In this work, we investigate the ideal Bayesian observer signal-to-noise ratio in phase-contrast imaging for a signal-known-exactly/background-known exactly detection task involving a weak signal. We demonstrate that this signal detectability measure can be decomposed into three contributions that have distinct interpretations associated with the imaging physics. (C) 2010 Optical Society of America
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