Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 342, Issue 1-2, Pages 25-28Publisher
ELSEVIER
DOI: 10.1016/j.jns.2014.04.003
Keywords
Febrile seizures; Interleukin-6; Cytokine; Etiology; Pro-inflammatory; Single nucleotide polymorphisms
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Funding
- Tehran University of Medical Sciences and Health Services [18083]
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Febrile seizures (FSs) are the most common convulsive event in children. Inflammatory elements and genetics have major roles in their pathogenesis. As of the importance of interleukin-6 (IL-6) in FS, this study was performed to assess IL6 single nucleotide polymorphisms (SNPs) in a group of patients with FS. IL6 gene (-174 and +565) SNPs were studied on genomic DNAs of 90 children with FS, using PCR-SSP method. The results were compared to 139 healthy individuals. The presence of the G allele or the GG genotype at +565 position reduced risk of FS, while the A allele at +565 position of the promoter regions was a constituted risk factor for developing FS. This study could support the idea that IL6 SNPs play a role in the pathogenesis of FS. (C) 2014 Elsevier B.V. All rights reserved.
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