Review
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: The meta-analysis showed no significant association between the ACE I/D polymorphism and lung cancer risk, and subgroup analysis by ethnicity did not yield significant results.
Correction
Oncology
Junjian Chen, Mao Sun, Min Zhou, Renfu Lu
Summary: An amendment to this paper has been published and can be accessed via the original article.
Article
Medical Laboratory Technology
Jaroslav A. Hubacek, Ladislav Dusek, Ondrej Majek, Vaclav Adamek, Tereza Cervinkova, Dana Dlouha, Vera Adamkova
Summary: This study found that ACE I/D polymorphism has the potential to predict the severity of COVID-19, with I/I homozygotes being at increased risk of symptomatic COVID-19.
CLINICA CHIMICA ACTA
(2021)
Article
Behavioral Sciences
Fan Cheng, Xiao-Min Si, Gong-Li Yang, Lan Zhou
Summary: This meta-analysis investigated the association between PPAR-gamma gene polymorphisms and ischemic stroke risk. The results suggested that rs1801282 C/G polymorphism may be associated with an increased risk for ischemic stroke, while rs3856806 C/T polymorphism showed no significant association with ischemic stroke risk.
BRAIN AND BEHAVIOR
(2021)
Review
Health Care Sciences & Services
Aline Ruilowa de Pinho Coelho, Luciana Carvalho Silveira, Kamilla de Faria Santos, Rodrigo da Silva Santos, Angela Adamski da Silva Reis
Summary: This study used a systematic review and meta-analysis to investigate the relationship between the ACE gene (I/D) polymorphism and the development and progression of DR in type 2 diabetic patients. The results showed no significant association between the polymorphism and DR risk, indicating that the I/D polymorphism is not involved in the susceptibility to and progression of DR in type 2 diabetic patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Jie Chai, Xian-Ling Cao, Feng Lu
Summary: This meta-analysis found no significant association between IL-6 -174G/C(rs1800795) polymorphism and ischemic stroke (IS), but subgroup analysis showed that the relationship varied significantly according to ethnicity and geography.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Chunlin Ma, Wenbo Cao, Yang Huang, Qiuyue Tian, Yanfei Chen, Yabing Wang, Jian Chen, Peng Gao, Adam A. Dmytriw, Robert W. Regenhardt, Fei Chen, Qingfeng Ma, Liqun Jiao, Bin Yang
Summary: The study aimed to investigate the effect of two major etiologies (intracranial atherosclerotic stenosis and cardioembolism) on outcomes of acute ischemic stroke patients with large vessel occlusion undergoing endovascular thrombectomy. Clinical data of anterior circulation AIS patients receiving EVT were retrospectively analyzed, and the clinical outcomes were compared. The etiology was not considered as an important factor in functional outcome, despite the differences in baseline characteristics and technical approach.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Michelle C. Johansen
Summary: Accurate determination and diagnosis of ischemic stroke are crucial for providing excellent cerebrovascular care. It helps initiate appropriate prevention strategies, educate patients about specific risk factors, and predict patient outcomes. It also provides an opportunity for patients to participate in research studies and targeted treatments. Advances in research, imaging techniques, biomarkers, and genetic sequencing have challenged the traditional classification of stroke, leading to the identification of new entities and limitations in current diagnostic algorithms. This article reviews the steps for accurate classification and discusses emerging research and future directions in stroke diagnostics and classification.
Review
Clinical Neurology
Manabesh Nath, Priyanka Swarnkar, Shubham Misra, Pradeep Kumar
Summary: This meta-analysis aimed to evaluate the relationship between phosphodiesterase 4 D (PDE4D) gene polymorphism and the risk of ischemic stroke (IS). The results showed that SNP45, SNP83, and SNP89 polymorphisms were significantly associated with increased risk of IS in Asians, but not in the Caucasian population.
ACTA NEUROLOGICA BELGICA
(2023)
Review
Medicine, General & Internal
Yunnan Jing, Siya Hu, Jing Song, Xu Dong, Ying Zhang, Xiaowei Sun, Dongyan Wang
Summary: This Meta-analysis found that four miRNA polymorphisms were associated with the risk of ischemic stroke, although the overall and subgroup analyses were not entirely consistent.
Article
Genetics & Heredity
Aleksandra Ekkert, Aleksandra Sliachtenko, Julija Grigaite, Birute Burnyte, Algirdas Utkus, Dalius Jatuzis
Summary: The etiology of ischemic stroke is multifactorial, and genetic causes play a significant role in early-onset stroke. Several stroke classification systems based on genetic information have been proposed. Twin and family history studies, as well as candidate gene approach, are common methods to discover genetic causes of stroke. Genome-wide association studies and next generation sequencing are increasingly used. Some monogenic disorders cause well-known clinical manifestations, while polygenic disorders are more common. Current advances in human genetics provide opportunities for personalized prevention and novel treatment possibilities. Genetic risk scores and extended polygenic risk scores can contribute to better primary stroke prevention.
Article
Cardiac & Cardiovascular Systems
Robson Sarmento Teodoro, Gisele Sampaio Silva, Gabriel Pinheiro Modolo, Stella De Angelis Trivellato, Juli Thomaz de Souza, Gustavo Jose Luvizutto, Helio Rubens de Carvalho Nunes, Luis Cuadrado Martin, Rodrigo Bazan, Silmeia Garcia Zanati Bazan
Summary: Transthoracic echocardiography plays a key role in investigating the etiology of ischemic stroke and reducing the proportion of patients with an undetermined TOAST classification. Echocardiography during hospitalization for ischemic stroke can improve prognosis and reduce in-hospital mortality risk, while being classified as undetermined TOAST type increases the chance of mortality during hospitalization.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Cecilia Calabrese, Anna Annunziata, Antonietta Coppola, Pia Clara Pafundi, Salvatore Guarino, Valentina Di Spirito, Valeria Maddaloni, Nicola Pepe, Giuseppe Fiorentino
Summary: Recent studies suggest a high risk of thromboembolism in patients with severe COVID-19 pneumonia, with a potential link to ACE gene polymorphisms. In this pilot study, researchers found a significant difference in ACE I/D polymorphisms between COVID-19 patients with and without pulmonary embolism, indicating a possible genetic susceptibility to thromboembolism in COVID-19.
FRONTIERS IN MEDICINE
(2021)
Article
Neurosciences
Ankit Goyal, Alvee Saluja, Kallur N. Saraswathy, Priya Bansal, Rajinder K. Dhamija
Summary: The study demonstrates a strong association between ACE insertion/deletion polymorphism and the risk of acute ischemic stroke (AIS), with the DD genotype independently associated with an increased risk. This finding suggests the potential of ACE polymorphism as a genetic risk factor for AIS.
Article
Genetics & Heredity
Kathleen Y. de Almeida, Tiago Cetolin, Andrea Rita Marrero, Aderbal Silva Aguiar Junior, Pedro Mohr, Naoki Kikuchi
Summary: This study examines the associations between the ACTN3 R577X and ACE I/D gene polymorphisms and the incidence and severity of muscle injury in professional soccer athletes from Brazil. The findings suggest that individuals with the ACTN3 XX genotype are more susceptible to severe injuries, and those with the ACE II genotype have a higher number of injuries per season. Additionally, the combination of the ACTN3 577X allele and the ACE II genotype is associated with an increased number of injuries per season.
