Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 340, Issue 1-2, Pages 144-149Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2014.03.014
Keywords
Parkinson disease; Quality of life (QoL); Non-motor symptoms (NMS); Motor severity; Determinants; PDQ-39
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Funding
- National Science Fund of China [30973149]
- Science and Technology Bureau Fund of Sichuan Province [2010SZ0069]
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Background: The determinants of the quality of life (QoL) of patients with Parkinson's disease (PD) in Chinese population remain largely unknown. Methods: A total of 649 PD patients from Southwest China participated in this cross-sectional study. Non-motor Symptoms Scale (NMSS) was used to evaluate the non-motor symptoms (NMS), whereas PD Quality of Life Questionnaire (PDQ-39) was used to assess the QoL of the PD patients. Multiple stepwise regression analysis was conducted to identify the determinants of the QoL. Results: NMS, H-Y stage, female, disease duration, UPDRS III score, single/divorced/widowed, and motor complications accounted for 66.3% of the variables in the multiple regression analysis and were the negative determinants of the QoL. Among these variables, NMS and H-Y stage accounted for 46.7% and 14.5%, respectively. NMS were closely associated with each domain of PDQ-39. Female sex especially predicted poor emotional well-being and bodily discomfort, whereas single/divorced/widowed especially predicted poor stigma and social support of PD patients. Comorbidity, motor complications and rural living predicted poor mobility, activities of daily living and emotional well-being, respectively. Conclusion: Both demographic and disease-specific factors influence the QoL in PD patients. NMS are the strongest independent negative determinant of the overall QoL and closely associated with each domain of PDQ-39. The treatment of NMS may help to improve the QoL of PD patients. (C) 2014 Elsevier B.V. All rights reserved.
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