Article
Multidisciplinary Sciences
Kyum-Yil Kwon, Suyeon Park, Eun Ji Lee, Mina Lee, Hyunjin Ju
Summary: The study revealed that fall-related risk factors in patients with early Parkinson's disease (PD) were highly associated with gastrointestinal dysautonomia.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Diego Santos-Garcia, Ariadna Laguna, Jorge Hernandez-Vara, Teresa de Deus Fonticoba, Carlos Cores Bartolome, Maria J. Feal Painceiras, Maria Cristina Iniguez-Alvarado, Iago Garcia Diaz, Silvia Jesus, Maria Teresa Boungiorno, Lluis Planellas, Marina Cosgaya, Juan Garcia Caldentey, Nuria Caballol, Ines Legarda, Iria Cabo, Lydia Lopez Manzanares, Isabel Gonzalez Aramburu, Maria A. Avila Rivera, Victor Gomez Mayordomo, Victor Nogueira, Victor Puente, Julio Dotor Garcia-Soto, Carmen Borrue, Berta Solano Vila, Maria Alvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martinez Castrillo, Pilar Sanchez Alonso, Maria G. Alonso G. Losada, Nuria Lopez Ariztegui, Itziar Gaston, Jaime Kulisevsky, Manuel Menendez Gonzalez, Manuel Seijo, Javier Ruiz Martinez, Caridad Valero, Monica Kurtis, Jessica Gonzalez Ardura, Ruben Alonso Redondo, Carlos Ordas, Luis M. Lopez M. Diaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir
Summary: This study analyzed sex difference manifestations in Spanish patients with Parkinson's disease (PD) and found important differences. Symptoms such as depression, fatigue, and pain were more frequent and/or severe in females, while symptoms such as hypomimia, speech problems, rigidity, and hypersexuality were more noted in males. Women received a lower levodopa equivalent daily dose and had worse perception of quality of life. After two years of follow-up, the NMS burden increased more significantly in males, while the functional capacity was more impaired in females.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Tarek Antar, Huw R. Morris, Faraz Faghri, Hampton L. Leonard, Mike A. Nalls, Andrew B. Singleton, Hirotaka Iwaki
Summary: The study identified potential risk factors for depression in Parkinson's disease patients, highlighting the importance of adjusting for multiple covariates when analyzing risk factors for depression. Risk factors included probable REM sleep behavior disorder (pRBD), age, duration of diagnosis, impairment in daily activities, mild constipation, and antidepressant use. Cox regression model found pRBD, impairment in daily activities, hyposmia, and mild constipation to be longitudinal predictors of sustained depressive symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Kyung Wook Kang, Seong-Min Choi, Byeong C. Kim
Summary: This study suggests that women with PD have milder motor symptoms compared to men, and gender differences in sexual function can be observed as non-motor symptoms. Men with PD had higher scores of sexual function, while women with PD had significantly higher scores of sleep disturbance.
Review
Chemistry, Medicinal
Yeojin Bang, Juhee Lim, Hyun Jin Choi
Summary: Parkinson's disease is a progressive neurodegenerative disease with non-motor symptoms such as olfactory dysfunction and depression, impacting the quality of life before motor symptoms appear. Studies suggest a correlation between olfactory dysfunction and an increased risk of developing PD, while depression is associated with abnormal neurotransmission and adult neurogenesis.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Frank C. Church
Summary: Parkinson's disease is a progressive neurodegenerative disorder that mainly affects older adults. Treatment options include rehabilitation, therapy, restorative programs, maintenance with complementary and alternative medicine, and surgery as a last resort. Currently, there is no cure for PD and the focus is on slowing disease progression and improving quality of life for patients.
Article
Clinical Neurology
Konstantin G. Heimrich, Aline Schonenberg, Hannah M. Muehlhammer, Sarah Mendorf, Diego Santos-Garcia, Tino Prell
Summary: This study aimed to determine the impact of non-motor symptoms on the progression of Parkinson's disease and revealed that the depressive symptoms of anhedonia and feeling sad had the strongest influence on the overall pattern of non-motor symptoms in PD.
FRONTIERS IN NEUROLOGY
(2023)
Review
Psychology, Multidisciplinary
Francesca Mameli, Eleonora Zirone, Benedetta Capetti, Denise Mellace, Roberta Ferrucci, Giulia Franco, Alessio Di Fonzo, Sergio Barbieri, Fabiana Ruggiero
Summary: This review discusses the negative effects of the COVID-19 pandemic on the mental health of people with Parkinson's disease, highlighting the presence of depressive symptoms and reduced quality of life. However, there is limited evidence for the impact on anxiety disorders and sleep quality.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Fukiko Kitani-Morii, Takashi Kasai, Go Horiguchi, Satoshi Teramukai, Takuma Ohmichi, Makiko Shinomoto, Yuzo Fujino, Toshiki Mizuno
Summary: During the COVID-19 pandemic, the neuropsychiatric symptoms of patients with Parkinson's disease worsened, especially under social restrictions. More attention needs to be paid to PD patients with severe motor symptoms.
Article
Geriatrics & Gerontology
Qu Yi, Yu-Peng Chen, Jiang-Ting Li, Jing-Yi Li, Qi-Xiong Qin, Dan-Lei Wang, Jing-Wei Zhao, Zhi-Juan Mao, Yong-Jie Xiong, Min Zhe, Xue Zheng
Summary: Poor sleep is associated with more severe symptoms in Parkinson's disease (PD), and both insufficient and excessive time spent in bed and nocturnal sleep duration are correlated with higher non-motor symptom burdens. Non-motor symptoms play a mediating role in sleep quality, quality of life, PD severity, and motor symptoms.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Environmental Sciences
Shiwen Li, Beate Ritz, Yufan Gong, Myles Cockburn, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Emily Castro, Adrienne M. Keener, Jeff Bronstein, Kimberly C. Paul
Summary: This study examined the association between specific pesticides previously related to Parkinson's disease onset and the progression of PD symptoms. The findings suggest that ten agricultural pesticides are associated with faster symptom progression. Proximity to higher amounts of copper sulfate and MCPA was found to be associated with all three progression endpoints.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Neurosciences
Xiao-Zhong Jing, Xiang-Zhen Yuan, Xingguang Luo, Shu-Yun Zhang, Xiao-Ping Wang
Summary: Nondopaminergic neurotransmitters play a role in Parkinson's disease (PD) and their receptors are potential targets for developing new treatments. This review summarizes the recent findings on nondopaminergic treatments for PD, including drugs to reduce motor complications and improve non-motor symptoms. Several drugs have been approved for managing motor fluctuations and levodopa-induced dyskinesia, while ongoing research is focused on serotonergic and glutamatergic agents. Nondopaminergic drugs also show promise in treating non-motor symptoms such as hallucinations and delusions, daytime sleepiness, depression, and urinary tract symptoms.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Mariana Fernandes, Mariangela Pierantozzi, Alessandro Stefani, Carlo Cattaneo, Erminio A. Bonizzoni, Rocco Cerroni, Nicola Biagio Mercuri, Claudio Liguori
Summary: This study found a high prevalence of NMS in PD patients with motor fluctuations, with psychiatric disorders being more frequent in older patients and those with a longer PD diagnosis duration, while sleep problems were more common in younger patients with a shorter disease duration.
FRONTIERS IN NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Yi-Chieh Chen, Rou-Shayn Chen, Yi-Hsin Weng, Ying-Zu Huang, Chiung Chu Chen, June Hung, Yi-Ying Lin
Summary: In Taiwanese PD patients, the severity of NMSs worsens with disease duration, and the increase in medication dosage is independent of the progression of NMSs.
SCIENTIFIC REPORTS
(2021)
Letter
Medicine, General & Internal
Marjolein A. van der Marck, Rene J. F. Melis, Marcel G. M. Olde Rikkert
Article
Geriatrics & Gerontology
M. S. Nieuwboer, A. Richters, M. A. van der Marck
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2017)
Article
Geriatrics & Gerontology
Adina Dreier-Wolfgramm, Bernhard Michalowsky, Mary Guerriero Austrom, Marjolein A. van der Marck, Steve Iliffe, Catherine Alder, Horst Christian Vollmar, Jochen Rene Thyrian, Diana Wucherer, Ina Zwingmann, Wolfgang Hoffmann
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2017)
Article
Clinical Neurology
Anke Richters, Rene J. F. Melis, N. Job van Exel, Marcel G. M. Olde Rikkert, Marjolein A. van der Marck
ALZHEIMERS RESEARCH & THERAPY
(2017)
Meeting Abstract
Health Care Sciences & Services
Minke Saskia Nieuwboer, Marieke Perry, Rob van der Sande, Irma Maassen, Marcel Olde Rikkert, Marjolein Van der Marck
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2017)
Meeting Abstract
Health Care Sciences & Services
Anke Richters, Minke Nieuwboer, Marieke Perry, Marcel Olde Rikkert, Rene Melis, Marjolein van der Marck
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2017)
Article
Nutrition & Dietetics
Rosa Burgos, Irene Breton, Emanuele Cereda, Jean Claude Desport, Rainer Dziewas, Laurence Genton, Filomena Gomes, Pierre Jesus, Andreas Leischker, Maurizio Muscaritoli, Kalliopi-Anna Poulia, Jean Charles Preiser, Marjolein Van der Marck, Rainer Wirth, Pierre Singer, Stephan C. Bischoff
CLINICAL NUTRITION
(2018)
Article
Primary Health Care
Minke S. Nieuwboer, Marieke Perry, Rob van der Sande, Irma T. H. M. Maassen, Marcel G. M. Olde Rikkert, Marjolein A. van der Marck
Article
Multidisciplinary Sciences
Anke Richters, Minke S. Nieuwboer, Marcel G. M. Olde Rikkert, Rene J. F. Melis, Marieke Perry, Marjolein A. van der Marck
Editorial Material
Education, Scientific Disciplines
Malaz A. Boustani, Marjolein A. Van der Marck, Nadia Adams, Jose M. Azar, Richard J. Holden, Horst C. Vollmar, Sophia Wang, Christopher Williams, Catherine Alder, Shelley Suarez, Babar Khan, Ben Zarzaur, Nicole R. Fowler, Ashley Overley, Craig A. Solid, Alfonso Gatmaitan
Review
Primary Health Care
Minke S. Nieuwboer, Rob van der Sande, Marjolein A. van der Marck, Marcel G. M. Olde Rikkert, Marieke Perry
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2019)
Meeting Abstract
Health Care Sciences & Services
Marjolein Scholten, Marieke Perry, Marjolein van der Marck, Rose-Marie Droes, Hanny Groenewoud
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2018)
Meeting Abstract
Health Care Sciences & Services
Anke Richters, Minke Nieuwboer, Marcel Olde Rikkert, Rene Melis, Marieke Perry, Marjolein van der Marck
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2018)
Meeting Abstract
Health Care Sciences & Services
Helen Schonenberg, Ane Fullaondo Zabala, Simone de Bruin, Manon Lette, Jenny Billings, Caroline Baan, Marjolein van der Marck, Minke Nieuwboer
INTERNATIONAL JOURNAL OF INTEGRATED CARE
(2018)
Article
Primary Health Care
Minke S. Nieuwboer, Rob van der Sande, Irma T. H. M. Maassen, Marcel G. M. Olde Rikkert, Marieke Perry, Marjolein A. van der Marck
EUROPEAN JOURNAL OF GENERAL PRACTICE
(2020)