Article
Clinical Neurology
Kevin N. Alschuler, Daniel Whibley, Anna L. Kratz, Mark P. Jensen, Annette Wundes, Gloria von Geldern, Peiqing Qian, Charles H. Bombardier, Dawn M. Ehde
Summary: The study found that in the first year post-MS/CIS diagnosis, the average QOL was high and stable, with only a few variables predicting baseline QOL and changes over time. This suggests that early assessment of certain factors can help predict current and future QOL outcomes for patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Marco Pisa, Tommaso Croese, Gloria Dalla Costa, Simone Guerrieri, Su-Chun Huang, Annamaria Finardi, Lorena Fabbella, Francesca Sangalli, Bruno Colombo, Lucia Moiola, Vittorio Martinelli, Giancarlo Comi, Roberto Furlan, Letizia Leocani
Summary: Optical coherence tomography (OCT) is increasingly important in evaluating patients with multiple sclerosis, showing neuro-retinal changes indicative of inflammatory and disease burden. Subclinical optic nerve involvement and thinning of ganglion cell layer in eyes without acute optic neuritis are associated with greater disease burden, reflecting early disease phases.
Review
Clinical Neurology
Massimiliano Calabrese, Damiano Marastoni, Francesco Crescenzo, Antonio Scalfari
Summary: This review discusses the challenges in diagnosing patients with the first demyelinating attack or RIS, focusing on the updated diagnostic criteria, considering neuroinflammatory conditions in the differential diagnosis, and identifying factors that predict MS development. Accurate interpretation of demyelinating attacks, MRI results, and the importance of cerebrospinal fluid examination are emphasized for an early and precise MS diagnosis to start timely disease-modifying therapy and improve long-term outcomes.
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Behavioral Sciences
Matthias Grothe, Michael Opolka, Julia Berneiser, Alexander Dressel
Summary: This study compared two social cognition tests in multiple sclerosis patients and found that emotion recognition had better accuracy compared to theory of mind. Cognitive factors were associated with both social cognition tasks, with emotion recognition being more influenced. However, no relationship was found between social cognition and quality of life.
BRAIN AND BEHAVIOR
(2021)
Article
Medicine, Research & Experimental
Victor Chavarria, Guillermo Espinosa-Ramirez, Julio Sotelo, Jose Flores-Rivera, Omar Anguiano, Ana Campos Hernandez, Edgar Daniel Guzman-Rios, Aleli Salazar, Graciela Ordonez, Benjamin Pineda
Summary: This study investigates the predictors of conversion from Clinically Isolated Syndrome (CIS) to Clinical Definite Multiple Sclerosis (CDMS) in Mexican patients. Motor symptoms, multifocal syndromes, and alterations of somatosensory evoked potentials were associated with conversion to CDMS. The presence of at least one lesion on magnetic resonance imaging was the main factor associated with an increased risk of conversion to CDMS.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Clinical Neurology
Susana Otero-Romero, Luciana Midaglia, Pere Carbonell-Mirabent, Maria Zuluaga, Ingrid Galan, Jordi Rio, Georgina Arrambide, Marta Rodriguez-Barranco, Angela Vidal-Jordana, Joaquin Castillo, Breogan Rodriguez-Acevedo, Ana Zabalza, Carlos Nos, Manuel Comabella-Lopez, Patricia Mulero, Cristina Auger, Jaume Sastre-Garriga, Santiago Perez-Hoyos, Alex Rovira, Xavier Montalban, Mar Tintore
Summary: In this study, the effect of menopause on disability accumulation in women with clinically isolated syndrome (CIS) was evaluated. Results indicated that menopause did not increase the risk of disability in this population when considering Expanded Disability Status Scale (EDSS) trajectories along with age and disease duration. The annual increase in EDSS was higher in menopausal women compared to nonmenopausal women, but this difference disappeared when controlling for age and disease duration.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Lukas Haider, Ferran Prados, Karen Chung, Olivia Goodkin, Baris Kanber, Carole Sudre, Marios Yiannakas, Rebecca S. Samson, Stephanie Mangesius, Alan J. Thompson, Claudia A. M. Gandini Wheeler-Kingshott, Olga Ciccarelli, Declan T. Chard, Frederik Barkhof
Summary: The study found that after 30 years, the greatest differences in MRI measures between SPMS and RRMS were the higher number of cortical lesions in SPMS and the lower grey matter volume in SPMS. This suggests that cortical involvement, in terms of lesions and atrophy, is the main correlate of progressive disease and disability in individuals with very long follow-up, indicating it should be the target of therapeutic interventions.
Article
Clinical Neurology
Catherine Bergmann, Shenira Becker, Adreanna Watts, Cynthia Sullivan, Jeffrey Wilken, Daniel Golan, Myassar Zarif, Barbara Bumstead, MariJean Buhse, Olivia Kaczmarek, Thomas J. Covey, Glen M. Doniger, Iris-Katharina Penner, Laura M. Hancock, Hans Bogaardt, Marissa A. Barrera, Sara Morrow, Mark Gudesblatt
Summary: This study aimed to determine relevant predictors of quality of life (QoL) in people with multiple sclerosis (MS). The study found that attention and executive functioning have a significant impact on QoL, even after controlling for other influencing factors.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Carlos R. Camara-Lemarroy, Claudia Silva, Luanne M. Metz, Graziela Cerchiaro, Jamie Greenfield, Reza Dowlatabadi, Hans J. Vogel, Chieh-Hsin Lee, Fabrizio Giuliani, Maryam Nakhaei-Nejad, David K. B. Li, Anthony Traboulsee, V. Wee Yong
Summary: In this study, blood levels of various biomarkers were measured in individuals with early MS and CIS, revealing differences in cytokines, MMPs, serum metabolomics, and immune cell immunophenotyping between early MS/CIS patients and healthy controls. One biomarker, MMP-1, was identified as being able to differentiate early MS from CIS and was found to correlate with lesion volume on MRI. The immunological and metabolic profiles of CIS and early MS were found to be remarkably similar, suggesting a common underlying pathophysiological process.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Clinical Neurology
Laura L. Laslett, Cynthia Honan, Jason A. Turner, Baye Dagnew, Julie A. Campbell, Tiffany K. Gill, Sarah Appleton, Leigh Blizzard, Bruce Taylor, Ingrid van der Mei
Summary: Poor sleep quality is common in people with multiple sclerosis (MS), and strongly associated with worse health-related quality of life. This association is independent of other MS symptoms and does not cluster with other common MS symptoms.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Mickael Ferrand, Jonathan Epstein, Marc Soudant, Francis Guillemin, Sophie Pittion-Vouyovitch, Marc Debouverie, Guillaume Mathey
Summary: This study aimed to evaluate the probability of diagnosing relapsing-remitting multiple sclerosis (MS) at different timepoints using different versions of the McDonald criteria and the time-to-diagnosis reduction with the 2017 McDonald criteria compared to the 2001, 2005, and 2010 versions in real life. The results showed that the 2017 McDonald criteria indeed shortened the time-to-diagnosis.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Christopher Martin Allen, Ellen Mowry, Mar Tintore, Nikos Evangelou
Summary: Clinically isolated syndrome (CIS) is a single attack of inflammatory demyelination of the central nervous system, which can predict the development of multiple sclerosis. MRI scanning remains the most influential prognostic investigation during diagnosis, while multiple testing methods and medical history information also contribute to the diagnosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Steven C. Pike, Francesca Gilli, Andrew R. Pachner
Summary: Multiple sclerosis (MS) is a clinically heterogeneous disease and it is currently difficult to identify patients who may benefit from earlier interventions. Previous data showed that the CXCL13 index (I-CXCL13) can predict future disease activity in MS patients two years after diagnosis. This study confirms that the predictive ability of I-CXCL13 extends to CIS and RIS patients for at least five years, suggesting its potential use in guiding immunomodulatory therapy in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Ozge Arici Duz, Ozlem Saatci, Ece Zeynep Karakulak, Erkingul Birday, Lutfu Hanoglu
Summary: Olfactory dysfunction can be observed in RIS patients similar to RRMS patients. Cognitive and olfactory dysfunction together may indicate degeneration in demyelinating diseases.
EUROPEAN NEUROLOGY
(2021)
Article
Clinical Neurology
Jing Wu, Tomas Olsson, Jan Hillert, Lars Alfredsson, Anna Karin Hedstrom
Summary: This study aimed to investigate the influence of smoking habits, exposure to passive smoking and snuff use on disease progression, cognitive performance and quality of life in patients with multiple sclerosis (MS). The study found that smoking and passive smoking have negative effects on MS, and smoking cessation post diagnosis may be an important secondary preventive measure. Snuff use was associated with slower disease progression.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Genetics & Heredity
Carly Murphy, Sharyn Lincoln, Stephanie Meredith, Elizabeth M. Cross, David Rintell
JOURNAL OF GENETIC COUNSELING
(2016)
Article
Clinical Neurology
Natalie F. Baruch, Ellen H. O'Donnell, Bonnie I. Glanz, Ralph H. B. Benedict, Alexander J. Musallam, Brian C. Healy, David Rintell, Tanuja Chitnis
MULTIPLE SCLEROSIS JOURNAL
(2016)
Article
Clinical Neurology
Natalie F. Baruch, Ellen H. O'Donnell, Bonnie I. Glanz, Ralph H. B. Benedict, Alexander J. Musallam, Brian C. Healy, David Rintell, Tanuja Chitnis
MULTIPLE SCLEROSIS JOURNAL
(2016)
Review
Clinical Neurology
Riley Bove, Allison McHenry, Kerstin Hellwig, Maria Houtchens, Neda Razaz, Penelope Smyth, Helen Tremlett, A. D. Sadovnick, D. Rintell
JOURNAL OF NEUROLOGY
(2016)
Article
Clinical Neurology
Lauren B. Krupp, David Rintell, Leigh E. Charvet, Maria Milazzo, Evangeline Wassmer
Article
Clinical Neurology
Emily E. Greeke, Alicia S. Chua, Brian C. Healy, David J. Rintell, Tanuja Chitnis, Bonnie I. Glanz
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Psychiatry
D. J. Rintell, D. Frankel, S. L. Minden, B. I. Glanz
GENERAL HOSPITAL PSYCHIATRY
(2012)
Article
Clinical Neurology
Cristina Fernandez Carbonell, Leslie Benson, David Rintell, Jefferson Prince, Tanuja Chitnis
JOURNAL OF CHILD NEUROLOGY
(2014)
Article
Clinical Neurology
S. L. Minden, L. Ding, P. D. Cleary, D. Frankel, B. I. Glanz, B. C. Healy, D. J. Rintell
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2013)
Article
Clinical Neurology
Line E. Hviid, Brian C. Healy, David J. Rintell, Tanuja Chitnis, Howard L. Weiner, Bonnie I. Glanz
MULTIPLE SCLEROSIS JOURNAL
(2011)
Article
Health Care Sciences & Services
Brian C. Healy, Irene R. Degano, Ana Schreck, David Rintell, Howard Weiner, Tanuja Chitnis, Bonnie I. Glanz
QUALITY OF LIFE RESEARCH
(2012)
Article
Economics
Bonnie I. Glanz, Irene R. Degano, David J. Rintell, Tanuja Chitnis, Howard L. Weiner, Brian C. Healy
Article
Family Studies
Theodore P. Cross, Alane K. Shanks, Lisa Duffy, David J. Rintell
JOURNAL OF CHILD & ADOLESCENT TRAUMA
(2019)
Article
Psychiatry
TA Glass, B Dym, S Greenberg, D Rintell, C Roesch, LF Berkman
AMERICAN JOURNAL OF ORTHOPSYCHIATRY
(2000)