Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients

In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon 2 allele and less frequent in the carriers of epsilon 4 allele. (C) 2009 Elsevier B.V. All rights reserved