Article
Engineering, Environmental
Sarra Karoui, Wala Abou Saoud, Achraf Ghorbal, Florence Fourcade, Abdeltif Amrane, Aymen Amin Assadi
Summary: Wastewater treatment is a global concern and the search for advanced oxidation processes with minimal waste generation remains a challenge. The study investigated the photodegradation of Ciprofloxacin using the Dielectric-Barrier-Discharge process, showing high degradation efficiency and mineralization yields. The research demonstrated that the combination of DBD and photocatalysis processes could be a promising technology for efficient and environmentally friendly removal of pollutants in wastewater.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Fan Bu, Gaurav Nayak, Peter Bruggeman, George Annor, Baraem P. Ismail
Summary: The impact of different plasma-produced reactive oxygen and nitrogen species on pea protein isolate was studied, with O-3 and OH treatments enhancing protein hydrophobicity and beta-sheet content, leading to improved gelling and emulsification properties. These specific changes in structure and functionality suggest potential for optimizing cold atmospheric plasma treatment for desired modifications in pea protein isolate.
Article
Dermatology
Monireh Golpour, Mina Alimohammadi, Farshad Sohbatzadeh, Sadegh Fattahi, Sander Bekeschus, Alireza Rafiei
Summary: Despite advances in therapy, malignant melanoma remains a fatal disease. Cold atmospheric pressure plasma (CAP), which releases reactive oxygen and nitrogen species (ROS/RNS), has shown promising results as a novel antitumor agent in preclinical models. In addition, malignant melanoma can be targeted by mild starvation. This study investigated the combined effect of starvation and CAP treatment on melanoma in vitro and in vivo, finding that the combination exhibited enhanced antitumor effects.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Sander Bekeschus
Summary: The combined cytotoxicity of gas plasma treatment and nanoparticle exposure has shown significant effectiveness against melanoma cells, especially for silica, silver, iron oxide, and cerium oxide nanoparticles.
Article
Physics, Applied
Vincenza Armenise, Valeria Veronico, Savino Cosmai, Danilo Benedetti, Roberto Gristina, Pietro Favia, Francesco Fracassi, Eloisa Sardella
Summary: Reactive oxygen and nitrogen species (RONS) can be generated in liquids through various cold plasma processes. These species can have significant effects on cell biology and pathology and can be utilized in wound healing, disinfection, and cancer treatments. The configuration and conditions of plasma sources play a crucial role in determining the production of RONS in liquids.
PLASMA PROCESSES AND POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Review
Materials Science, Biomaterials
Phuong Le Thi, Dieu Linh Tran, Thai Thanh Hoang Thi, Yunki Lee, Ki Dong Park
Summary: The dual role of reactive oxygen and nitrogen species (RONS) in physiological and pathological processes has been widely studied. Injectable hydrogels have emerged as promising biomaterials for controlling RONS levels and have shown potential in regenerative medicine and tissue engineering applications.
REGENERATIVE BIOMATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Plant Sciences
Samantha Cannazzaro, Silvia Traversari, Sonia Cacini, Sara Di Lonardo, Catello Pane, Gianluca Burchi, Daniele Massa
Summary: Research has shown that applying non-thermal plasma technology to nutrient solution can promote the fresh leaf and flower biomass of gerbera plants grown in peat, while reducing dry plant matter. However, it may decrease the leaf and flower biomasses of plants grown in compost due to substrate-dependent effects.
Article
Physics, Multidisciplinary
Vikas Rathore, Sudhir Kumar Nema
Summary: This study investigates the impact of plasma-forming gases on the properties of plasma-activated water (PAW) and characterizes the plasma and plasma radicals/species using electrical diagnosis and optical emission spectroscopy. The results show that different plasma-forming gases and plasma-water exposure time significantly affect the physicochemical properties and RONS concentration in PAW.
Article
Chemistry, Applied
Xiangyong Meng, Chang Chen, Teng Song, Jingwen Xu, Xiaobin Zhang, Jing Wang, Zhongli Pan, Huien Zhang, Huijuan Zhang
Summary: The use of nano-silica coating and pressurized Ar significantly delayed senescence in sweet cherries by suppressing decay rate, inhibiting the generation and accumulation of ROS, and mitigating lipid peroxidation. Combined treatment maintained higher levels of ascorbic acid and glutathione, enhancing antioxidase activities to retain cherry quality during cold storage.
Review
Chemistry, Multidisciplinary
Yan Zhu, Tianjiao Zhao, Min Liu, Shuya Wang, Saili Liu, Yunrong Yang, Yuqi Yang, Yayun Nan, Qiong Huang, Kelong Ai
Summary: Rheumatoid arthritis (RA) is a disease with a significant medical burden and a tumor-like microenvironment. Traditional anti-inflammatory therapies are hindered by the buffer barrier of the RA microenvironment, while nanomaterials offer a potential solution by interfering with multiple pathogenic factors and achieving precise treatment. Recent advances in nanomaterials have greatly improved the therapeutic effect and reduced side effects in RA treatment.
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Article
Physics, Applied
Solmaz Saboohi, Bryan R. Coad, Robert D. Short, Andrew Michelmore, Hans J. Griesser
Summary: In order to improve the retention of desirable chemical structures during plasma polymerization, rational tailoring of plasma-phase conditions is necessary, with considerations of pressure, power, and the energy distribution of ions playing key roles. The abundance of intact molecular ions in plasmas can vary with pressure and power, but is not directly correlated with the functionality of plasma polymers. High ion flux and tailored ion energy distribution are important for achieving soft landing of ions on surfaces, with the optimal compromise between ion abundance and energy distribution near the transition between the alpha and gamma plasma phases.
PLASMA PROCESSES AND POLYMERS
(2021)
Article
Physics, Fluids & Plasmas
Bhagirath Ghimire, Endre J. Szili, Bethany L. Patenall, Pradeep Lamichhane, Nishtha Gaur, Alexander J. Robson, Dhruv Trivedi, Naing T. Thet, A. Toby A. Jenkins, Eun Ha Choi, Robert D. Short
Summary: This study investigates how to increase the production rate of hydrogen peroxide (H2O2) in deionised water (DIW) using an argon atmospheric-pressure plasma jet and explores the influence of operational parameters on H2O2 generation. Additionally, it demonstrates the synergistic action between H2O2 and other plasma generated molecules in DIW for effective decontamination of common wound pathogens.
PLASMA SOURCES SCIENCE & TECHNOLOGY
(2021)
Article
Physics, Applied
Endre J. Szili, Bhagirath Ghimire, Bethany Lee Patenall, Mohammed Rohaim, Dharmit Mistry, Adrian Fellows, Muhammad Munir, A. Toby A. Jenkins, Robert D. Short
Summary: This study presents a strategy utilizing cold plasma for the on-demand activation of acetyl donor molecules, generating an effective non-antibiotic antimicrobial formulation capable of eradicating common pathogens and inactivating viruses.
APPLIED PHYSICS LETTERS
(2021)
Article
Genetics & Heredity
Bethany L. Patenall, Hollie J. Hathaway, Maisem Laabei, Amber E. Young, Naing T. Thet, A. Toby A. Jenkins, Robert D. Short, Sarah L. Allinson
Summary: The main bactericidal components of cold atmospheric plasma are believed to be reactive oxygen and nitrogen species (RONS) along with UV-radiation, capable of causing DNA damage and mutations. CAP treatment may generate mutagenic effects on Escherichia coli, leading to resistance to the antibiotic ciprofloxacin.
Article
Physics, Applied
Bhagirath Ghimire, Bethany L. Patenall, Endre J. Szili, Nishtha Gaur, Pradeep Lamichhane, Naing T. Thet, Dhruv Trivedi, Andrew Toby A. Jenkins, Robert D. Short
Summary: This study investigates the influence of adding a 2nd ground electrode on the production of hydrogen peroxide (H2O2) in deionised water (DIW) in an argon plasma jet. It is found that the addition of a 2nd ground electrode leads to higher charge accumulation and increased discharge current and dissipated power, resulting in a higher electron temperature and more than twice the production of H2O2. The double ground electrode plasma jet is effective in reducing the growth of common wound pathogens and has low cytotoxicity in skin-like cells. These findings are valuable for optimizing plasma sources for clinical applications.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Physics, Applied
Bhagirath Ghimire, Endre J. Szili, Robert D. Short
Summary: A conical assembly of six plasma jets arranged in a rectangular pattern is proposed for biomedical applications. The conical configuration reduces interference and enables more uniform treatment. Experimental results show that the conical assembly achieves higher efficiency and is suitable for larger area treatments.
APPLIED PHYSICS LETTERS
(2022)
Article
Physics, Applied
John J. Lowke, Endre J. Szili
Summary: An unresolved issue in lightning physics is how lightning proceeds to the ground and the structure of the dark column connecting the streamer step with the cloud. It is proposed that these processes can be explained by the accumulation of excited oxygen molecules. Calculations support this explanation.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nishtha Gaur, Robert D. Short, Sarah L. Allinson
Summary: We propose a novel plasma treatment regime called plasma fractionation, which divides a single dose of plasma into multiple small dosages and administers them to cells in vitro. Our study shows that plasma fractionation produces lower levels of cell death compared to a single plasma treatment, highlighting its potential as a safer method for plasma-based cancer treatment. We also demonstrate that the squamous cell carcinoma line (A431) is more sensitive to a single acute plasma treatment than the immortalized keratinocyte line (HaCaT), suggesting the importance of other shorter-lived plasma components.
IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Nishtha Gaur, Bethany L. Patenall, Bhagirath Ghimire, Naing T. Thet, Jordan E. Gardiner, Krystal E. Le Doare, Gordon Ramage, Bryn Short, Rachel A. Heylen, Craig Williams, Robert D. Short, Toby A. Jenkins
Summary: We introduce a versatile drug-loaded composite hydrogel that can simultaneously deliver a drug and CAP-generated molecules in a tissue target when activated by an argon-based cold atmospheric plasma jet. We demonstrated this concept by encapsulating gentamicin in sodium polyacrylate particles dispersed within a poly(vinyl alcohol) hydrogel matrix. The resulting gentamicin-PAA-PVA composite hydrogel can release gentamicin and effectively eradicate bacteria, including those in planktonic state and biofilm, when activated by CAP. The concept of the composite hydrogel can also be applied to other antimicrobial agents like cetrimide and silver, and activated by any dielectric barrier discharge CAP device.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Multidisciplinary
Sumyea Sabrin, Debabrata K. Karmokar, Nemai C. Karmakar, Sung-Ha Hong, Habibullah Habibullah, Endre J. Szili
Summary: Low temperature plasma technology has the potential to overcome healthcare challenges, but improvements in efficacy and safety are needed. Integrating feedback control systems and advanced diagnostic sensors into medical plasma technologies could enhance treatment outcomes. Research on suitable sensors and their integration into autonomous plasma systems would bridge the technological gap and enable the development of superior medical plasma technologies.
Article
Physics, Fluids & Plasmas
Shunya Hashimoto, Hideo Fukuhara, Endre J. Szili, Chiaki Kawada, Sung-Ha Hong, Yuta Matsumoto, Tatsuru Shirafuji, Masayuki Tsuda, Atsushi Kurabayashi, Mutsuo Furihata, Hiroshi Furuta, Akimitsu Hatta, Keiji Inoue, Jun-Seok Oh
Summary: Low-temperature atmospheric-pressure plasma jets are generally considered safe in medical treatments, but recent studies have shown that they can cause skin burns under certain conditions. This study identifies joule heating as the cause of the burns and suggests that increasing treatment distance can mitigate these effects while retaining the beneficial properties of plasma treatment.
Article
Physics, Fluids & Plasmas
Endre J. Szili, Bethany L. Patenall, Adrian Fellows, Dharmit Mistry, A. Toby A. Jenkins, Robert D. Short, Bhagirath Ghimire
Summary: The study compares the effects of acetyl donor molecules TAED and PAG on the antibacterial efficacy of low-temperature atmospheric-pressure argon plasma jet activated solutions. Results show that both TAED and PAG increase the concentration of hydrogen peroxide in the solution, with TAED being more effective. However, PAG is more efficient in producing peracetic acid for bactericidal activity. Additionally, the solutions activated with acetyl donors show significantly improved bactericidal activity against common wound pathogens.
