Review
Oncology
Nadeem Abu-Rustum, Catheryn Yashar, Rebecca Arend, Emma Barber, Kristin Bradley, Rebecca Brooks, Susana M. Campos, Junzo Chino, Hye Sook Chon, Christina Chu, Marta Ann Crispens, Shari Damast, Christine M. Fisher, Peter Frederick, David K. Gaffney, Robert Giuntoli II, Ernest Han, Jordan Holmes, Brooke E. Howitt, Jayanthi Lea, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Mirna Podoll, Ritu Salani, John Schorge, Jean Siedel, Rachel Sisodia, Pamela Soliman, Stefanie Ueda, Renata Urban, Stephanie L. Wethington, Emily Wyse, Kristine Zanotti, Nicole R. McMillian, Shaili Aggarwal
Summary: Adenocarcinoma of the endometrium is the most common malignancy of the female genital tract in the United States, with an estimated 65,950 new cases in 2022 and 12,550 deaths. It includes pure endometrioid cancer and carcinomas with high-risk endometrial histology. Stromal or mesenchymal sarcomas are rare subtypes accounting for approximately 3% of all uterine cancers. This article focuses on the diagnosis, staging, and management of pure endometrioid carcinoma from the NCCN Guidelines for Uterine Neoplasms.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Review
Oncology
Camilla Nero, Francesca Tronconi, Elena Giudice, Giovanni Scambia, Domenica Lorusso
Summary: The prognosis of patients with advanced endometrial cancer is poor, but integrating molecular features into the clinico-pathological classification has significantly improved prognostic risk groups. This has led to breakthroughs in disease management and treatment perspectives.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeremy Dana, Simon Gauvin, Michelle Zhang, Jose Lotero, Christopher Cassim, Giovanni Artho, Sahir Rai Bhatnagar, Simon Tanguay, Caroline Reinhold
Summary: This study compared the diagnostic performance and inter-reader agreement of the 2005 and 2019 versions of the CT-based Bosniak classification systems for risk stratification of cystic renal lesions. The results showed that there was no significant improvement in diagnostic performance and inter-reader agreement between the two versions. However, the inter-reader agreement decreased when the 2019 version was dichotomized according to management strategy.
EUROPEAN RADIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Shiho Yokoo, Feibi Zeng, Munenobu Nogami, Yoshiko R. Ueno, Takamichi Murakami
Summary: A 52-year-old woman suspected of uterine sarcoma underwent F-18-FDG PET/MRI, which revealed a myometrial mass and an endometrial lesion, suggesting dual primary neoplasms. Based on the PET/MRI findings, the intraoperative procedure was modified to determine the necessity of pelvic lymphadenectomy. PET/MRI was more useful than PET/CT in diagnosing and differentiating between the two malignant neoplasms in the uterus, due to the high contrast resolution and precise fusion of MRI.
CLINICAL NUCLEAR MEDICINE
(2022)
Review
Oncology
Donna Marie Edwards, Shruti Jolly
Summary: This review article focuses on the treatment paradigms for early-stage endometrial cancer, particularly the role of external beam radiation therapy. Surgical resection is the main treatment, and adjuvant radiation therapy after surgery aims to prevent local recurrence. Observation is a possible approach for low-risk patients, while vaginal cuff brachytherapy is recommended for high-intermediate risk patients. Pelvic radiation therapy is reserved for deeply invasive disease and non-endometrioid histologies. Definitive treatment for medically inoperable patients includes brachytherapy +/- pelvic external beam radiation therapy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Pathology
Shan Ye, Jing Wu, Lingli Yao, Jie He
Summary: UTROSCT is a rare mesenchymal tumor with unique clinical and pathological characteristics. Diagnosis requires a combination of immunohistochemistry and molecular testing. BCL-2 has potential diagnostic value in UTROSCT, and this tumor type may be sensitive to platinum/poly (ADP-ribose) polymerase inhibitors.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-ying Jia, Yang Gui, Xue-qi Chen, Xiao-qian Zhang, Jia-hui Zhang, Meng-hua Dai, Jun-chao Guo, Xiao-yan Chang, Li Tan, Chun-mei Bai, Yue-juan Cheng, Jian-chu Li, Ke Lv, Yu-xin Jiang
Summary: This study found that the diagnostic performance for pancreatic ductal adenocarcinoma (PDAC) can be improved by adding iso-enhancement and very fast/fast washout as supplementary diagnostic criteria.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Yuki Nitta, Hiroto Murata, Noriyuki Okonogi, Kazutoshi Murata, Masaru Wakatsuki, Kumiko Karasawa, Shingo Kato, Shigeru Yamada, Takashi Nakano, Hiroshi Tsuji
Summary: This retrospective study assessed the incidence of secondary cancers in patients with cervical cancer who received carbon-ion radiotherapy (CIRT) and photon radiotherapy (RT). The results showed that the incidence of secondary cancers was similar between the two treatment groups.
Article
Oncology
Tracy Sherertz, Anuja Jhingran, Matthew Biagioli, David Gaffney, Mohamed Elshaikh, Robert L. Coleman, Matthew Harkenrider, Elizabeth A. Kidd, Shruti Jolly, Catheryn Yashar, Lorraine Portelance, Andrew Wahl, Aradhana Venkatesan, Linna Li, William Small, American Radium Society
Summary: The American Radium Society has summarized evidence-based guidelines for the management of uterine clear cell and serous carcinomas, which have a high risk of locoregional and distant spread, worse prognosis than endometrioid cancers, and may benefit from multimodal adjuvant therapies. Complete surgical staging is recommended as the primary treatment, and counseling patients about combined-modality treatment with systemic chemotherapy and radiotherapy could be reasonable. Further research is needed to determine optimal sequencing of therapy and appropriate management based on individual risk factors.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Article
Oncology
Sarah S. Lee, Christopher R. Weil, Leslie R. Boyd, Cristina DeCesaris, David Gaffney, Gita Suneja
Summary: The use of combined chemoradiotherapy in GOG 258 study increased before, during, and after the study, despite the absence of benefit in the experimental arm.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Adela Richtarova, Barbora Boudova, Pavel Dundr, Zdenka Lisa, Kristyna Hlinecka, Zdenek Zizka, Filip Fruhauf, David Kuzel, Jiri Slama, Michal Mara
Summary: This study analyzed the clinical and reproductive outcomes of patients with uterine smooth muscle tumor of uncertain malignant potential (STUMP) who underwent myomectomy. The results showed that uterus-saving procedures and fertility-preservation strategies in STUMP patients are feasible, safe, and associated with a low risk of malignant recurrence. Additionally, laparoscopic surgery can be considered as the preferred surgical approach.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Sunyoung Lee, Jaeseung Shin, Won Jeong Son, Hyejung Shin, Ji Eun Lee, Jeong Ah Hwang, Yong Eun Chung, Jin-Young Choi, Mi-Suk Park
Summary: The study systematically compared the performance of CT/MRI LI-RADS category 5 (LR-5) for diagnosing HCC between 2017 and 2018 versions, finding no significant difference in sensitivity and specificity between the two versions. The most common underlying liver disease (hepatitis B or hepatitis C) was a significant factor contributing to the heterogeneity of sensitivities among studies for both versions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Medicine, General & Internal
Hideki Kobara, Kunihisa Uchita, Noriya Uedo, Jun Kunikata, Kenji Yorita, Naoya Tada, Noriko Nishiyama, Yuriko Shigehisa, Chihiro Kuroiwa, Noriko Matsuura, Yohei Takahashi, Yuka Kai, Uiko Hanaoka, Yumiko Kiyohara, Shoji Kamiura, Kenji Kanenishi, Tsutomu Masaki, Koki Hirano
Summary: This multicenter prospective study aimed to investigate the diagnostic ability of magnifying endoscopy with narrow band imaging (ME-NBI) for cervical intraepithelial neoplasia grade 2 or worse (CIN2+). The study found that ME-NBI exhibited a better sensitivity than colposcopy in detecting CIN2+ lesions, while also demonstrating a higher patient acceptability.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Reitan Ribeiro, Glauco Baiocchi, Renato Moretti-Marques, Jose Clemente Linhares, Caroline Nadai Costa, Rene Pareja
Summary: Uterine transposition is a feasible procedure for preserving gonadal and uterine function in patients requiring pelvic radiotherapy for non-gynecological cancer, with the potential for achieving spontaneous pregnancy and successful delivery.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao-qing Lv, Yuan Feng, Jing-ru Li, Xin-qiong Zhang, Ru Xiang, Jing-fang Hong
Summary: The study developed a short form of the Cataldo lung cancer stigma scale for Chinese people with lung cancer, which showed reliability and validity. The short version demonstrated good performance in factor structure and measurement properties, and has practical application in Chinese lung cancer populations.
Article
Oncology
Theodore M. Brasky, Ashley S. Felix, David E. Cohn, D. Scott McMeekin, David G. Mutch, William T. Creasman, Premal H. Thaker, Joan L. Walker, Richard G. Moore, Shashikant B. Lele, Saketh R. Guntupalli, Levi S. Downs, Christa I. Nagel, John F. Boggess, Michael L. Pearl, Olga B. Ioffe, Kay J. Park, Shamshad Ali, Louise A. Brinton
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2017)
Article
Oncology
Alexander R. Lucas, Brian C. Focht, David E. Cohn, Maryanna D. Klatt, Janet Buckworth
JOURNAL OF CANCER EDUCATION
(2018)
Article
Obstetrics & Gynecology
Kathleen R. Cho, Kumarasen Cooper, Sabrina Croce, Bojana Djordevic, Simon Herrington, Brooke Howitt, Pei Hui, Philip Ip, Martin Koebel, Sigurd Lax, Bradley J. Quade, Patricia Shaw, August Vidal, Anna Yemelyanova, Blaise Clarke, Lora Hedrick Ellenson, Teri A. Longacre, Ie-Ming Shih, W. Glenn McCluggage, Anais Malpica, Esther Oliva, Vinita Parkash, Xavier Matias-Guiu
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2019)
Article
Oncology
Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Suzanne George, Ernest Han, Susan Higgins, Warner K. Huh, John R. Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, Jillian L. Scavone
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2018)
Article
Obstetrics & Gynecology
Ashley S. Felix, David E. Cohn, Theodore M. Brasky, Richard Zaino, Kay Park, David G. Mutch, William T. Creasman, Premal H. Thaker, Joan L. Walker, Richard G. Moore, Shashikant B. Lele, Saketh R. Guntupalli, Levi S. Downs, Christa Nagel, John F. Boggess, Michael L. Pearl, Olga B. Ioffe, Marcus E. Randall, Louise A. Brinton
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2018)
Review
Oncology
Wui-Jin Koh, Nadeem R. Abu-Rustum, Sarah Bean, Kristin Bradley, Susana M. Campos, Kathleen R. Cho, Hye Sook Chon, Christina Chu, Rachel Clark, David Cohn, Marta Ann Crispens, Shari Damast, Oliver Dorigo, Patricia J. Eifel, Christine M. Fisher, Peter Frederick, David K. Gaffney, Ernest Han, Warner K. Huh, John R. Lurain, Andrea Mariani, David Mutch, Christa Nagel, Larissa Nekhlyudov, Amanda Nickles Fader, Steven W. Remmenga, R. Kevin Reynolds, Todd Tillmanns, Stefanie Ueda, Emily Wyse, Catheryn M. Yashar, Nicole R. McMillian, Jillian L. Scavone
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2019)
Article
Oncology
Lorena Lazo de la Vega, Mia C. Samaha, Kevin Hu, Nolan R. Bick, Javed Siddiqui, Daniel H. Hovelson, Chia-Jen Liu, Cody S. Carter, Kathleen R. Cho, Andrew P. Sciallis, Scott A. Tomlins
MOLECULAR CANCER RESEARCH
(2019)
Article
Oncology
Yisheng Wang, Michael S. Sessine, Yali Zhai, Courtney Tipton, Kevin McCool, Rork Kuick, Denise C. Connolly, Eric R. Fearon, Kathleen R. Cho
JOURNAL OF PATHOLOGY
(2019)
Article
Medicine, Research & Experimental
Jinyu Tang, Ying Feng, Rork Kuick, Megan Green, Maranne Green, Naoya Sakamoto, Yuki Kurosu, Jeffry Lin, Kathleen R. Cho, Eric R. Fearon
LABORATORY INVESTIGATION
(2019)
Article
Obstetrics & Gynecology
Monica Hagan Vetter, Blair Smith, Jason Benedict, Erinn M. Hade, Kristin Bixel, Larry J. Copeland, David E. Cohn, Jeffrey M. Fowler, David O'Malley, Ritu Salani, Floor J. Backes
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2020)
Article
Oncology
David S. Miller, Virginia L. Filiaci, Robert S. Mannel, David E. Cohn, Takashi Matsumoto, Krishnansu S. Tewari, Paul DiSilvestro, Michael L. Pearl, Peter A. Argenta, Matthew A. Powell, Susan L. Zweizig, David P. Warshal, Parviz Hanjani, Michael E. Carney, Helen Huang, David Cella, Richard Zaino, Gini F. Fleming
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Minh Tung Phung, Alice W. Lee, Anna H. Wu, Andrew Berchuck, Kathleen R. Cho, Daniel W. Cramer, Jennifer Anne Doherty, Marc T. Goodman, Gillian E. Hanley, Holly R. Harris, Karen McLean, Francesmary Modugno, Kirsten B. Moysich, Bhramar Mukherjee, Joellen M. Schildkraut, Kathryn L. Terry, Linda J. Titus, Susan J. Jordan, Penelope M. Webb, Malcolm C. Pike, Celeste Leigh Pearce
Summary: The use of combined oral contraceptives and progestin-only contraceptives is associated with a decreased risk of ovarian cancer. Specifically, the injectable progestin-only contraceptive depot-medroxyprogesterone acetate (DMPA) was found to be associated with a 35% decreased risk of ovarian cancer, with a significant trend of decreasing risk with increasing duration of use. Some studies showed an inverse association between DMPA use and ovarian cancer risk, while others showed increased risk, indicating a need for further investigation into the mechanism of this association.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Lixing Chen, Yali Zhai, Yisheng Wang, Eric R. Fearon, Gabriel Nunez, Naohiro Inohara, Kathleen R. Cho
Summary: Bacteria play a role in the pathogenesis of ovarian cancer, with evidence from an in vivo mouse model. Altering the microbiome with antibiotics may enhance the response of HGSC to immunotherapy, as demonstrated in this study.
Article
Oncology
Monica D. Levine, Rachel Pearlman, Heather Hampel, Casey Cosgrove, David Cohn, Alexis Chassen, Adrian Suarez, David A. Barrington, Joseph P. McElroy, Steven Waggoner, John Nakayama, Caroline Billingsley, Kim Resnick, Stephen Andrews, Sareena Singh, Eric Jenison, Aine Clements, Robert Neff, Paul J. Goodfellow
Summary: This prospective multicenter study revealed actionable germline variants in 10% of unselected women with newly diagnosed EC, supporting the use of up-front MGPT for all EC patients. The discovery that BRCA1 or BRCA2 heterozygotes frequently had type II cancers points to therapeutic opportunities for women with aggressive histologic EC subtypes.
JCO PRECISION ONCOLOGY
(2021)
Article
Oncology
Jhalak Dholakia, David E. Cohn, J. Michael Straughn, Sarah E. Dilley
Summary: The study assessed the potential cost-effectiveness of prehabilitation in medically frail patients undergoing surgery for EOC, finding that prehabilitation was not only more effective but also cost-saving, by reducing complication rates and decreasing care facility requirements to save healthcare costs.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2021)
