Article
Oncology
Qing-Qing Xu, Qing-Jie Li, Liu Chen, Xin-Yi Su, Jing-Xia Song, Juan Du, Lei Chen, Li-Xia Lu
Summary: A nomogram was developed to predict the prognosis of patients with mucosal melanoma of the head and neck, with high diagnostic accuracy. Patients were stratified into different risk groups based on their nomogram scores, allowing for individualized treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Pathology
Costantino Ricci, Maria V. Altavilla, Barbara Corti, Ernesto Pasquini, Livo Presutti, Anna M. Baietti, Luca Amorosa, Tiziana Balbi, Chiara Baldovini, Francesca Ambrosi, Marco Grillini, Antonia D'Errico, Michelangelo Fiorentino, Maria P. Foschini
Summary: PRAME is a cancer-testis antigen that can be used to differentiate between benign and malignant melanocytic lesions. In this study, PRAME stain was performed on mucosal melanocytic tumors of the head and neck region to evaluate the most reliable diagnostic score. The best-performing cutoff of PRAME-positive cells (<60%/= 60%) showed high accuracy in differentiating between benign and malignant tumors. However, some PRAME-negative malignant tumors were identified, particularly in the palatal area.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Immunology
Qing-Qing Xu, Qing-Jie Li, Cheng-Long Huang, Mu-Yan Cai, Mei-Fang Zhang, Shao-Han Yin, Li-Xia Lu, Lei Chen
Summary: The research found that through the IHC signature, the survival rate of patients with head and neck mucosal melanoma can be predicted, and better prognostic predictions can be made through group classification. Multivariable analysis showed that IHC score, T stage, and primary tumor site were independent variables in predicting survival rate.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Arash Abiri, Tyler M. Yasaka, Brandon M. Lehrich, Khodayar Goshtasbi, Peter Papagiannopoulos, Bobby A. Tajudeen, Maie A. St. John, Jeremy P. Harris, Edward C. Kuan
Summary: The study found that in patients with head and neck mucosal melanoma, surgery with immunotherapy (SI) had better overall survival than surgery alone, while SI and surgery with adjuvant radiotherapy and immunotherapy (SRI) were more beneficial for overall survival than surgery with adjuvant radiotherapy. Factors such as age, gender, tumor localization, stage, and surgical margins were associated with increased mortality risk in patients.
Article
Otorhinolaryngology
Kelsey M. Roman, Sina J. Torabi, Benjamin F. Bitner, Khodayar Goshtasbi, Yarah M. Haidar, Tjoson Tjoa, Edward C. Kuan
Summary: This study evaluated the differences in treatment outcomes for head and neck mucosal melanoma (HNMM) patients seen at academic versus nonacademic centers and high versus low volume facilities. The results showed that patients treated at academic centers had longer wait times for surgery, higher rates of negative surgical margins, and higher readmission rates within 30 days of surgery. Kaplan-Meier analysis demonstrated that patients treated at academic centers and high volume facilities had higher 5-year overall survival rates. Multivariate analysis showed that facility type and surgical volume were not significant predictors of overall survival in HNMM patients.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jiong Lyu, Yuwen Miao, Fang Yu, Chengdong Chang, Wei Guo, Huiyong Zhu
Summary: The study found high frequencies of CDK4 and TERT amplification in oral mucosal melanoma (OMM). The amplifications tended to occur together in OMM and were associated with higher protein expression levels. Knockdown of CDK4 led to cell cycle delays, and OMM cells were sensitive to the CDK4 inhibitor abemaciclib, which showed synergistic effects with dacarbazine in inhibiting cell viability.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Surgery
Laurence Pincet, Karma Lambercy, Philippe Pasche, Martin Broome, Sofiya Latifyan, Antoine Reinhard
Summary: Head and Neck Mucosal Melanoma (HNMM) is a rare malignancy that mainly occurs in the nasal cavity, paranasal sinuses, and oral cavity. Traditional treatment involves surgery followed by radiotherapy, but new systemic therapies like immunotherapy and targeted therapy have shown some benefits for patients with advanced stages. A small sample study showed that surgical resection with negative margins can improve overall survival for HNMM patients.
FRONTIERS IN SURGERY
(2021)
Editorial Material
Otorhinolaryngology
Brandon M. Lehrich, Arash Abiri, Theodore V. Nguyen, Benjamin F. Bitner, Charles C. L. Tong, Edward C. Kuan
Summary: Head and neck mucosal melanomas have a diverse and low mutational burden. A subset of patients (approximately 13%) have ROS1 mutations, which are actionable driver mutations. ROS1-mutated patients have improved overall survival, potentially due to their higher mutational burden.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2023)
Article
Otorhinolaryngology
Antoine Moya-Plana, David Mangin, Pierre Blanchard, Rais Obongo, Odile Casiraghi, Francois Bidault, Stephane Temam, Caroline Robert, Philippe Gorphe
Summary: The study found that the cN status is not a prognostic factor in patients with resectable head and neck mucosal melanoma. Elective lymph node dissection should not be routinely performed in cN0 patients.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Medicine, Research & Experimental
Axel Sahovaler, Hedyeh Ziai, Felipe Cardemil, Shao Hui Huang, Jie Su, David P. Goldstein, Ralph Gilbert, Ali Hosni, Andrew Hope, John Waldron, Anna Spreafico, Eric Monteiro, Ian Witterick, Jonathan Irish, Patrick Gullane, Wei Xu, Brian O'Sullivan, John R. de Almeida
Summary: Achieving negative surgical margins is important for disease control in mucosal melanoma of the head and neck. Radiotherapy may enhance surgical outcomes, and immunotherapy shows therapeutic benefit in recurrent and/or metastatic disease.
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Motoo Nomura
Summary: This study aims to discuss future directions for multimodal definitive treatment of head and neck mucosal melanoma, a rare clinical subtype of melanoma or head and neck cancer. Surgery is considered as the main treatment for locally advanced cases, with adjuvant radiotherapy playing a role in local disease control.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alice Indini, Fausto Roila, Francesco Grossi, Daniela Massi, Mario Mandala
Summary: Mucosal melanoma is a rare and aggressive subtype of melanoma that has shown poor response to novel treatment approaches. Recent molecular studies have revealed potential therapeutic targets and the potential benefits of immunotherapy in this disease. However, further research is needed to confirm these findings in different studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Jad Wehbe, Dominic Jaikaransingh, Abigail Walker
Summary: This paper discusses the use of immunotherapy in mucosal melanoma of the head and neck. Studies have shown that immunotherapy can improve survival rates. However, larger clinical trials are needed to accurately assess the efficacy of immunotherapy due to the rarity of the disease.
Article
Otorhinolaryngology
Wei Guo, Gaofei Yin, Chuanliang Cui, Yan Kong, Zhigang Huang, Xiaohong Chen
Summary: Gene phenotypes of mucosal melanoma in different locations vary, with NRAS mutation being an independent factor for distant metastasis and more commonly found in nasal cavity/paranasal sinuses, while BRAF mutation is associated with local recurrence and more common in locations other than the nasal cavity/paranasal sinus.
ACTA OTO-LARYNGOLOGICA
(2022)