Journal
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
Volume 7, Issue 6, Pages 659-665Publisher
HARBORSIDE PRESS
DOI: 10.6004/jnccn.2009.0046
Keywords
Renal cell cancer; non-clear cell; papillary; chromophobe; collecting duct; sunitinib; sorafenib; temsirolimus; c-MET
Categories
Ask authors/readers for more resources
The treatment of metastatic renal cell carcinoma (RCC) has changed dramatically with the introduction of targeted therapies against vascular endothelial growth factor and the mammalian target of rapamycin. Because patients with clear cell histology account for more than 80% of patients with RCC, little evidence is available on treating patients with non-clear cell histologies. Most clinical trials have excluded them from enrollment, except for a randomized study investigating temsirolimus. Many retrospective studies on the use of sunitinib, sorafenib, and temsirolimus in patients with non-clear cell histology have shown response rates ranging from 3.7% to 16%. Prospective studies in non-clear cell histologies are ongoing. Although response rates may not be as high as those in patients with clear cell histologies, targeted therapy may provide a clinically meaningful response. New investigational therapies are on the horizon for papillary RCC-the most-common non-clear cell RCC histology-targeting pathways specific to this histology, such as the c-MET pathway. (JNCCN 2009;7:659-665)
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available