☆ 4.4 Editorial Material

Can We Identify Predictive Biomarkers for Antiangiogenic Therapy of Cancer Using Mathematical Modeling?

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2013)

Journal

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

Volume 105, Issue 11, Pages 762-765

Publisher

OXFORD UNIV PRESS INC

DOI: 10.1093/jnci/djt114

Keywords

-

Categories

Oncology

Funding

NCI NIH HHS [R01-CA149285, R01-CA126642, R21-CA139168, P01 CA080124, P01-CA080124, R01-CA115767, R01-CA159258, R01-CA085140] Funding Source: Medline

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Review Biochemistry & Molecular Biology

Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?

Ignacio F. San Francisco, Pablo A. Rojas, Juan C. Bravo, Jorge Diaz, Luis Ebel, Sebastian Urrutia, Benjamin Prieto, Javier Cerda-Infante

Summary: The incidence of prostate cancer has been increasing annually. Metastatic disease is the main cause of mortality. It is important to develop better tools for predicting which patients will progress to non-localized clinical disease or already have micrometastatic disease. Currently, there are few biomarkers for predicting metastatic prostate cancer and more research is needed. Predicting metastasis is crucial as it significantly affects quality of life and survival.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Review Pharmacology & Pharmacy

New insights into antiangiogenic therapy resistance in cancer: Mechanisms and therapeutic aspects

Maohua Huang, Yuning Lin, Chenran Wang, Lijuan Deng, Minfeng Chen, Yehuda G. Assaraf, Zhe-Sheng Chen, Wencai Ye, Dongmei Zhang

Summary: Angiogenesis is essential for tumor growth, but resistance to antiangiogenic therapy is a major challenge. This review describes the cellular and molecular mechanisms behind tumor resistance to antiangiogenic therapy and potential biomarkers for predicting treatment response. It also discusses recent advances in combination strategies to enhance therapeutic efficacy.

DRUG RESISTANCE UPDATES (2022)

Add to Collection

Article Oncology

Predictive biomarkers for personalized medicine in breast cancer

Sylvie Rodrigues-Ferreira, Clara Nahmias

Summary: Breast cancer is a common malignancy among women worldwide, and different treatment options have significantly improved patient outcomes. However, further research on predictive biomarkers is needed to combat treatment resistance and identify the most suitable patients for personalized treatment, aiming to avoid unnecessary overtreatment.

CANCER LETTERS (2022)

Add to Collection

Review Biochemistry & Molecular Biology

Targeting the Tumor Microenvironment in Breast Cancer: Prognostic and Predictive Significance and Therapeutic Opportunities

Maria A. Dominguez-Cejudo, Ana Gil-Torralvo, Monica Cejuela, Sonia Molina-Pinelo, Javier Salvador Bofill

Summary: Breast cancer prognosis and treatment outcomes depend on tumor microenvironment (TME), which plays a critical role in its development, progression, and treatment response. This review examines the different components of TME as prognostic and predictive biomarkers in breast cancer. Techniques for assessing TME, such as immunohistochemistry or gene expression profiling, and their clinical utility in therapeutic decision-making are also discussed. Lastly, therapeutic strategies targeting TME are reviewed, highlighting their potential clinical benefits.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

Add to Collection

Article Computer Science, Interdisciplinary Applications

Can we identify prominent scholars using ChatGPT?

Frode Eika Sandnes

Summary: A small experiment was conducted to validate the use of ChatGPT for learning about scholars, but it showed that ChatGPT (GPT-3.5) only recognized a subset of scholars without obvious connection to their citation attributes or internet presence, and the recognized details were often erroneous.

SCIENTOMETRICS (2023)

Add to Collection

Article Oncology

Prostac: A New Composite Score With Potential Predictive Value in Prostate Cancer

E. O. Asante-Asamani, Gargi Pal, Leslie Liu, Olorunseun O. Ogunwobi

Summary: Prostate cancer is the most commonly diagnosed solid organ cancer in men globally, and current diagnosis methods have limitations. The creation of a new composite score, Prostac, based on recently discovered PCa biomarkers, shows promise for improving PCa diagnosis accuracy.

FRONTIERS IN ONCOLOGY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Can We Identify the Salt-Cocrystal Continuum State Using XPS?

Srinu Tothadi, Tabrez Rafique Shaikh, Sharad Gupta, Rambabu Dandela, Chathakudath P. Vinod, Ashwini K. Nangia

Summary: X-ray photoelectron spectroscopy (XPS) was used to investigate the intermediate states of proton transfer from a carboxylic acid to nitrogen. The study successfully differentiated between salts and cocrystals using N 1s XPS spectra, confirming the predictive ability of XPS in distinguishing intermediate states.

CRYSTAL GROWTH & DESIGN (2021)

Add to Collection

Review Pharmacology & Pharmacy

Mechanisms of the antiangiogenic effects of aspirin in cancer

Shiyuan Xie, Youqiong Wang, Yixuan Huang, Bin Yang

Summary: Aspirin, an old drug extracted from willow bark, is widely used for the prevention and treatment of cardiovascular diseases, and may also significantly reduce angiogenesis in cancer. Studies have revealed that aspirin targets not only COX-1, but also other antiangiogenic targets, and can produce antiangiogenic effects in different cell types.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Editorial Material Geosciences, Multidisciplinary

Modeling Denitrification: Can We Report What We Don't Know?

B. Grosz, A. Matson, K. Butterbach-Bahl, T. Clough, E. A. Davidson, R. Dechow, S. DelGrosso, E. Diamantopoulos, P. Dorsch, E. Haas, H. He, C. V. Henri, D. Hui, K. Kleineidam, D. Kraus, M. Kuhnert, J. Leonard, C. Mueller, S. O. Petersen, D. Sihi, I. Vogeler, R. Well, J. Yeluripati, J. Zhang, C. Scheer

Summary: Biogeochemical models simulate soil nitrogen turnover and are often used to assess nitrogen losses through denitrification. However, only a subset of nitrogen pools and fluxes are typically published due to the inability to validate the full nitrogen budget with measured data. This limitation in publication restricts the opportunity to improve understanding of modeled processes. The authors propose that the modeler community should support the publication of all simulated nitrogen pools and processes in future studies.

AGU ADVANCES (2023)

Add to Collection

Review Oncology

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen

Summary: Combining antiangiogenic therapy with immunotherapy may disrupt the crosstalk between abnormal tumor vasculature and immunosuppression, increase effector immune cell infiltration, improve immunotherapy effectiveness, and reduce the risk of immune-related adverse events. This combination could serve as a potential therapeutic strategy for breast cancer treatment, promoting tumor vasculature normalization and enhancing the efficiency of immunotherapy.

BIOMARKER RESEARCH (2021)

Add to Collection

Article Allergy

Real-life management of patients with severe asthma in the biologics era: Can we do better?

Jeremy Charriot, Milka Maravic, Michael Huguet, Isabelle Vachier, Carey Suehs, Arnaud Bourdin

Summary: This study investigated the treatment profile of severe asthma patients in France in 2018, revealing discrepancies between guidelines and real-life practice. The findings emphasized the need for improved patient phenotyping and provided insight into the positioning of current and forthcoming biologics.

WORLD ALLERGY ORGANIZATION JOURNAL (2021)

Add to Collection

Article Oncology

Novel computational biology modeling system can accurately forecast response to neoadjuvant therapy in early breast cancer

Joseph R. Peterson, John A. Cole, John R. Pfeiffer, Gregory H. Norris, Yuhan Zhang, Dorys Lopez-Ramos, Tushar Pandey, Matthew Biancalana, Hope R. Esslinger, Anuja K. Antony, Vinita Takiar

Summary: In this study, a biophysical simulation platform was used to predict the response of breast cancer patients to neoadjuvant therapy (NAT) and assess the stability of the platform. The study showed a prediction accuracy of 91.2% for pathological complete response. The aim of this research is to address the gap in predicting the response to NAT in early-stage and locally advanced breast cancer patients in current clinical practice.

BREAST CANCER RESEARCH (2023)

Add to Collection

Article Mathematics

Mathematical Modeling Reveals Mechanisms of Cancer-Immune Interactions Underlying Hepatocellular Carcinoma Development

Juan Shen, Xiao Tu, Yuanyuan Li

Summary: Understanding the relationship between hepatocellular carcinoma (HCC) and immunity is crucial for HCC immunotherapy. Continuous immune activation can facilitate the transition of HCC quantity from a high steady-state to a low state. Immune system activation plays a critical role in cancer therapy and can potentially impact HCC treatment.

MATHEMATICS (2023)

Add to Collection

Article Multidisciplinary Sciences

Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons

Eui Min Jeong, Miri Kwon, Eunjoo Cho, Sang Hyuk Lee, Hyun Kim, Eun Young Kim, Jae Kyoung Kim

Summary: In metazoan organisms, circadian rhythms are regulated by pacemaker neurons organized in a master-slave hierarchy. This study reveals the heterogeneity in molecular clockworks between master pacemakers and slave oscillators, with higher PER synthesis and turnover, as well as lower CLK levels in the master pacemakers. The distinct molecular clockwork of the master pacemakers allows them to generate strong rhythms and adapt flexibly to environmental changes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection

Article Biochemistry & Molecular Biology

CRISPReader System Sensing the Ets-1 Transcription Factor Can Effectively Identify Cancer Cells

Kang Yang, Yan Zhou, Hongcai Zhong

Summary: The CRISPReader system can effectively target and inhibit bladder cancer cells by sensing transcription factors such as c-Myc and Get-1, and has the potential to exert anti-cancer abilities against various tumors by sensing the broad-spectrum transcription factor Ets-1. The constructed CRISPReader system that senses the Ets-1 transcription factor can effectively identify and induce apoptosis in cancer cells, confirming the effectiveness of Ets-1 as a broad-spectrum cancer-related signal and providing a new anti-cancer tool based on the CRISPReader system.

FRONTIERS IN MOLECULAR BIOSCIENCES (2021)

Add to Collection

Article Gastroenterology & Hepatology

Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma

Shuichi Aoki, Koetsu Inoue, Sebastian Klein, Stefan Halvorsen, Jiang Chen, Aya Matsui, Mohammad R. Nikmaneshi, Shuji Kitahara, Tai Hato, Xianfeng Chen, Kazumichi Kawakubo, Hadi T. Nia, Ivy Chen, Daniel H. Schanne, Emilie Mamessier, Kohei Shigeta, Hiroto Kikuchi, Rakesh R. Ramjiawan, Tyge C. E. Schmidt, Masaaki Iwasaki, Thomas Yau, Theodore S. Hong, Alexander Quaas, Patrick S. Plum, Simona Dima, Irinel Popescu, Nabeel Bardeesy, Lance L. Munn, Mitesh J. Borad, Slim Sassi, Rakesh K. Jain, Andrew X. Zhu, Dan G. Duda

Summary: Elevated levels of placental growth factor (PIGF) in human ICC stromal cells and circulating blood plasma were associated with disease progression. Inhibition of PIGF led to reduction in intratumorous hypoxia and metastatic dissemination, enhanced chemotherapy sensitivity, and increased survival in mice-bearing aggressive ICC.

GUT (2022)

Add to Collection

Editorial Material Gastroenterology & Hepatology

Refining genetic and molecular classifications to facilitate breakthrough treatments in intrahepatic cholangiocarcinoma: are we there yet?

Satoru Morita, Dan G. Duda

GUT (2023)

Add to Collection

Article Gastroenterology & Hepatology

Characterization of Morreton virus as an oncolytic virotherapy platform for liver cancers

Bolni Marius Nagalo, Yumei Zhou, Emilien J. Loeuillard, Chelsae Dumbauld, Oumar Barro, Alexander T. Baker, Mansi Arora, James M. Bogenberger, Natalie Meurice, Joachim Petit, Pedro Luiz Serrano Uson, Faaiq Asiam, Elizabeth Raupach, Musa Gabere, Alexei Basnakian, Camila C. Simoes, Martin J. Cannon, Steven R. Post, Kenneth Buetow, Jean Christopher Chamcheu, Michael T. Barrett, Dan G. Duda, Bertram Jacobs, Richard Vile, Michael A. Barry, Lewis R. Roberts, Sumera Llyas, Mitesh J. Borad

Summary: This study demonstrates that wild-type Morreton virus has potential therapeutic effects on cholangiocarcinoma and hepatocellular carcinoma in vitro models. It can induce immune responses and lead to tumor regression. These findings support further development and clinical translation of Morreton virus as an oncolytic virotherapy platform.

HEPATOLOGY (2023)

Add to Collection

Article Oncology

Inhibition of STAT3 Promotes Effector T Cell Infiltration But also Immunosuppression in the HCC Tumor Microenvironment

Taketo Sasaki, Kohei Shigeta, Shuji Kitahara, Yasuhiro Suzuki, Shimpei Matsui, Ryo Seishima, Koji Okabayashi, Dan G. Duda, Yuko Kitagawa

Summary: This study investigated the impact of a direct STAT3 inhibitor on the tumor microenvironment and the efficacy of PD-1 blockade in HCC models. The results showed that the STAT3 inhibitor enhanced CD8+ T cell infiltration, but also increased immunosuppression and vascular abnormalization in the tumor microenvironment.

ANTICANCER RESEARCH (2022)

Add to Collection

Article Gastroenterology & Hepatology

Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences

Shuling Chen, Cheng Huang, Guanrui Liao, Huichuan Sun, Yubin Xie, Changyi Liao, Jianping Wang, Minghui He, Huanjing Hu, Zihao Dai, Xiaoxue Ren, Xuezhen Zeng, Zhilong Lin, Guo-Pei Zhang, Wenxuan Xie, Shunli Shen, Shaoqiang Li, Sui Peng, Dong-Ming Kuang, Qiang Zhao, Dan G. Duda, Ming Kuang

Summary: Analyzing the single-cell immune ecosystems in recurrent hepatocellular carcinoma (HCC) can aid in the development of effective immunotherapies. The study identified de novo and true recurrences in HCC samples and found distinct immune characteristics in the tumor immune microenvironment (TIME) of these recurrences. The findings suggest the need for different immunotherapy strategies based on the type of HCC recurrence and the specific TIME.

GUT (2023)

Add to Collection

Article Oncology

Inhibition of CXCR4 Enhances the Efficacy of Radiotherapy in Metastatic Prostate Cancer Models

Nisha Gupta, Hiroki Ochiai, Yoshinori Hoshino, Sebastian Klein, Jozef Zustin, Rakesh R. Ramjiawan, Shuji Kitahara, Nir Maimon, Despina Bazou, Sarah Chiang, Sen Li, Daniel H. Schanne, Rakesh. K. Jain, Lance L. Munn, Peigen Huang, Sergey V. Kozin, Dan G. Duda

Summary: Radiotherapy is an important treatment for advanced prostate cancer. Inhibition of the SDF1 alpha/CXCR4 axis, which mediates metastasis and resistance to radiotherapy, may be a potential therapeutic target for prostate cancer patients. Inhibition of CXCR4 with AMD3100 enhances the effect of local radiotherapy and reduces lymph node metastasis. It also promotes the normalization of vasculature and reduces tissue hypoxia in bone metastatic prostate cancer.

CANCERS (2023)

Add to Collection

Article Oncology

Addition of Losartan to FOLFIRINOX and Chemoradiation Reduces Immunosuppression-Associated Genes, Tregs, and FOXP3+Cancer Cells in Locally Advanced Pancreatic Cancer

Yves Boucher, Jessica M. Posada, Sonu Subudhi, Ashwin S. Kumar, Spencer R. Rosario, Liqun Gu, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain

Summary: In this study, we found that adding losartan (LOS) to FOLFIRINOX (FFX) chemotherapy followed by chemoradiation (CRT) in patients with locally advanced pancreatic cancer (LAPC) resulted in a 61% R0 surgical resection rate. By evaluating the effects of neoadjuvant LOS on the tumor microenvironment, we identified potential mechanisms of benefit. The results showed that LOS+FFX+CRT reduced the expression of immunosuppression and pro-invasion genes and was associated with improved overall survival (OS).

CLINICAL CANCER RESEARCH (2023)

Add to Collection

Article Oncology

Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer

Eleni Gkika, Elke Firat, Sonja Adebahr, Erika Graf, Ilinca Popp, Gianluca Radicioni, Simon S. Lo, Ursula Nestle, Nils H. Nicolay, Gabriele Niedermann, Dan G. Duda, Anca-L. Grosu

Summary: We conducted a prospective study to investigate the changes in circulating immune cells after stereotactic body radiotherapy (SBRT) in early-stage NSCLC patients. We found no significant increase in CD8(+) cytotoxic T lymphocytes at the first follow-up, but observed a significant expansion in Ki-67(+)CD8(+) and Ki-67(+)CD4(+) T-cell fractions in patients receiving 10 Gy or less per fraction. Our findings suggest that SBRT can induce immediate expansion of circulating effector T-cells.

NPJ PRECISION ONCOLOGY (2023)

Add to Collection

Review Oncology

The Gut Microbiome as a Biomarker and Therapeutic Target in Hepatocellular Carcinoma

Betul Gok Yavuz, Saumil Datar, Shadi Chamseddine, Yehia I. Mohamed, Michael LaPelusa, Sunyoung S. Lee, Zishuo Ian Hu, Eugene J. Koay, Hop S. Tran Cao, Prasun Kumar Jalal, Carrie Daniel-MacDougall, Manal Hassan, Dan G. Duda, Hesham M. Amin, Ahmed O. Kaseb

Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer, and the gut microbiome may play a role in its detection and treatment, particularly in immunotherapy. This review examines the gut microbiome's potential as a biomarker for HCC and its impact on immunotherapy. It also discusses the bidirectional interactions between the gut and liver and the role of gut microbiota in cancer treatment.

CANCERS (2023)

Add to Collection

Meeting Abstract Oncology

Addition of losartan to FOLFORINOX and chemoradiation downregulates proinvasion and immunosuppression-associated genes in locally advanced pancreatic cancer.

Yves Boucher, Jessica M. Posada, Sonu Subudhi, Spencer R. Rosario, Liqun Gu, Ashwin S. Kumar, Heena Kumra, Mari Mino-Kenudson, Nilesh P. Talele, Dan G. Duda, Dai Fukumura, Jennifer Y. Wo, Jeffrey W. Clark, David P. Ryan, Carlos Fernandez-Del Castillo, Theodore S. Hong, Mikael J. Pittet, Rakesh K. Jain

CANCER RESEARCH (2022)

Add to Collection

Meeting Abstract Oncology

Mechanistic model for booster doses effectiveness in healthy, cancer and immunosuppressed patients infected with SARS-CoV-2

Chrysovalantis Voutouri, Corey C. Hardin, Vivek Naranbhai, Mohammad R. Nikmaneshi, Melin J. Khandekar, Justin F. Gainor, Triantafyllos Stylianopoulos, Lance L. Munn, Rakesh K. Jain

CANCER IMMUNOLOGY RESEARCH (2022)

Add to Collection

Meeting Abstract Oncology

Distant lymphoid organs compensate for ICB efficacy after TDLN dissection

Hengbo Zhou, Meghan O'Melia, Pinji Lei, Johanna J. Rajotte, Mohammad Rizi Razavi, James Baish, Lance L. Munn, Timothy P. Padera

CANCER IMMUNOLOGY RESEARCH (2022)

Add to Collection

Meeting Abstract Oncology

Modulation of cancer immunotherapy by the microbiome: Insights from computational analyses of preclinical studies.

Constantinos Harkos, Andreas Hadjigeorgiou, Aditya K. Mishra, Golnaz Morad, Sarah Johnson, Nadim J. Ajami, Triantafyllos Stylianopoulos, Lance L. Munn, Jeniffer A. Wargo, Rakesh K. Jain

CANCER IMMUNOLOGY RESEARCH (2022)

Add to Collection

No Data Available

© Peeref 2019-2024. All rights reserved.