Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Biochemistry & Molecular Biology
Malgorzata Edyta Wojtys, Kajetan Kielbowski, Michal Kunc, Seweryn Adam Skrzyniarz, Piotr Lisowski, Rafal Becht, Paulina Zukowska, Konrad Ptaszynski, Janusz Wojcik
Summary: Basal cell carcinoma (BCC) is the most common skin cancer, but metastasizing BCC (MBCC) is rare, occurring in approximately 0.0028% to 0.55% of BCC patients. We report two cases of pulmonary MBCC. The first case is a 72-year-old male with multiple recurrences who underwent surgical resection and adjuvant radiotherapy. Immunohistochemistry showed the expression of Ber-EP4, CK5/6, p63, EMA (focal), BCL-2, and CD10 in neoplastic cells, while they were negative for CK7, CK20, S100, estrogen and progesterone receptors, and TTF-1. The second case is a 64-year-old female treated with vismodegib. Clinicopathological features and differential diagnoses are described.
Article
Oncology
Imene Mansouri, Boris Schwartz, Giao Vu-Bezin, Daniel Bejarano-Quisoboni, Brice Fresneau, Chiraz El-Fayech, Christelle Dufour, Stephanie Bolle, Aurore Surun, Daniel Orbach, Rodrigue S. Allodji, Ibrahima Diallo, Charlotte Demoor-Goldschmidt, Florent de Vathaire, Nadia Haddy
Summary: This study aimed to determine the long-term risks of hospitalization related to renal and urinary diseases among 5-year childhood cancer survivors (CCS). The results showed that CCS had a higher risk of renal hospitalization compared to the general population, and radiation therapy with certain dose-volume indicators increased the risk. It also identified specific risk factors associated with hospitalization for renal causes among CCS.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Taku Kimura, Ken-ichiro Sakata, Jun Sato, Chisato Ouchi, Noritaka Ohga, Aya Yanagawa-Matsuda, Kyoko Hida, Yoshimasa Kitagawa
Summary: Metastatic basal cell carcinoma poses challenges in current treatment and requires consideration of treatment history and pathohistological features in posttreatment planning.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, General & Internal
Rusha Bhandari, Saro H. Armenian, Shana Mccormack, Rama Natarajan, Sogol Mostoufi-Moab
Summary: Due to advancements in cancer treatment and supportive care, there is an increasing number of childhood cancer survivors who face a significant burden of comorbidities associated with their treatment. One of the notable late effects is an increased risk of developing diabetes mellitus (DM), which is a major risk factor for cardiovascular disease. The underlying pathophysiology of DM in cancer survivors is multifactorial and includes both treatment-related exposures and genetic factors.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Suman Shrestha, James E. Bates, Qi Liu, Susan A. Smith, Kevin C. Oeffinger, Eric J. Chow, Aashish C. Gupta, Constance A. Owens, Louis S. Constine, Bradford S. Hoppe, Wendy M. Leisenring, Ying Qiao, Rita E. Weathers, Laurence E. Court, Chelsea C. Pinnix, Stephen F. Kry, Daniel A. Mulrooney, Gregory T. Armstrong, Yutaka Yasui, Rebecca M. Howell
Summary: This study reevaluated survivors in the CCSS cohort using an improved HHybrid model, finding associations between heart RT doses and late cardiac disease risk. Updated risk estimates were generally consistent with prior estimates, but there were significant increases in cardiac disease risk in certain dose and volume categories with the updated dosimetry.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Wassim Chemaitilly, Zhenghong Li, Tara M. Brinkman, Angela Delaney, Sujuan Huang, Kari L. Bjornard, Catherine G. Lam, Carmen L. Wilson, Nicole Barnes, Karen L. Clark, Matthew J. Krasin, Monika L. Metzger, Anthony Sheyn, Michael W. Bishop, Noah D. Sabin, Rebecca M. Howell, Sara Helmig, Barry L. Shulkin, Brandon M. Triplett, Ching-Hong Pui, Amar Gajjar, Deo Kumar Srivastava, Daniel M. Green, Gregory T. Armstrong, Leslie L. Robison, Melissa M. Hudson, Kristen K. Ness, Charles A. Sklar, Kevin R. Krull
Summary: This study examined the prevalence and risk factors of primary hypothyroidism in childhood cancer survivors, and found associations with physical frailty, dyslipidemia, impaired physical quality of life, and having health care insurance. The impact of thyroid hormone replacement practices on these outcomes should be further investigated.
Article
Oncology
John L. Jefferies, Wojciech M. Mazur, Carrie R. Howell, Juan C. Plana, Kirsten K. Ness, Zhenghong Li, Vijaya M. Joshi, Daniel M. Green, Daniel A. Mulrooney, Jeffrey A. Towbin, Hugo R. Martinez, Jason F. Goldberg, Rebecca M. Howell, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Gregory T. Armstrong
Summary: Limited data exist regarding left ventricular remodeling patterns observed in adult survivors of childhood cancer after therapy. Among survivors, chest radiation therapy increases the risk for concentric remodeling while it is associated with decreased exercise intolerance.
Article
Oncology
Kimberly W. Keefe, Andrea Lanes, Kayla Stratton, Daniel M. Green, Eric J. Chow, Kevin C. Oeffinger, Sara Barton, Lisa Diller, Yutaka Yasui, Wendy M. Leisenring, Gregory T. Armstrong, Elizabeth S. Ginsburg
Summary: Linking the Childhood Cancer Survivor Study database to the Society for Assisted Reproductive Technology Clinic Outcome Reporting System revealed that childhood cancer survivors are as likely to undergo treatment with assisted reproductive technology as their siblings. The success of assisted reproductive technology was not reduced after alkylator exposure.
Review
Biochemistry & Molecular Biology
Francesca Mainieri, Cosimo Giannini, Francesco Chiarelli
Summary: Cancer is a leading cause of death among children worldwide, and while survival rates have improved, survivors are at risk of metabolic abnormalities that may increase the risk of cardiovascular disease and premature mortality. Further research is needed to understand and improve long-term cardiometabolic outcomes for these patients.
Article
Oncology
Tara O. Henderson, Qi Liu, Lucie M. Turcotte, Joseph P. Neglia, Wendy Leisenring, David Hodgson, Lisa Diller, Lisa Kenney, Lindsay Morton, Amy Berrington de Gonzalez, Michael Arnold, Smita Bhatia, Rebecca M. Howell, Susan A. Smith, Leslie L. Robison, Gregory T. Armstrong, Kevin C. Oeffinger, Yutaka Yasui, Chaya S. Moskowitz
Summary: The study found that the risk of breast cancer in childhood cancer survivors has decreased over time, especially in those under 40 years old. This decline is mainly associated with the reduced use of chest radiation therapy, but is also influenced by other treatment modalities.
Article
Oncology
Cindy Im, Noha Sharafeldin, Yan Yuan, Zhaoming Wang, Yadav Sapkota, Zhanni Lu, Logan G. Spector, Rebecca M. Howell, Michael A. Arnold, Melissa M. Hudson, Kirsten K. Ness, Leslie L. Robison, Smita Bhatia, Gregory T. Armstrong, Joseph P. Neglia, Yutaka Yasui, Lucie M. Turcotte
Summary: This study evaluated SMNs among long-term childhood cancer survivors of European and African genetic ancestry, finding that a polygenic risk score (PRS) could significantly impact SMN risk in survivors who did not receive radiation therapy and were treated with specific chemotherapies.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Yan Teng, Yong Yu, Sujing Li, Youming Huang, Danfeng Xu, Xiaohua Tao, Yibin Fan
Summary: Ultraviolet radiation, particularly UVB, is a significant environmental risk factor for the development of basal cell carcinoma (BCC) by promoting uncontrolled cell replication. UVR can activate oncogenes, inhibit tumor suppressor genes, and lead to aberrant proliferation and survival of keratinocytes. In addition to DNA damage, inflammatory responses in the tumor microenvironment also play a crucial role in skin tumorigenesis induced by UVR.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Hematology
David Buchbinder, Neel S. Bhatt, Huiqi Wang, Yutaka Yasui, Saro Armenian, Smita Bhatia, Eric J. Chow, I. -Chan Huang, Anne C. Kirchoff, Wendy Leisenring, Elyse R. Park, K. Robin Yabroff, Gregory T. Armstrong, Paul C. Nathan, Nandita Khera
Summary: Long-term survivors of childhood cancer who received hematopoietic cell transplantation (HCT) do not report greater overall financial hardship compared to non-HCT survivors, but they do report greater overall financial hardship compared to sibling controls. Factors such as household income and chronic health conditions, rather than HCT, are associated with financial hardship among all survivors.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Urology & Nephrology
Esmee C. M. Kooijmans, Helena J. H. van der Pal, Saskia M. F. Pluijm, Margriet van der Heiden-van der Loo, Leontien C. M. Kremer, Dorine Bresters, Eline van Dulmen den Broeder, Marry M. van den Heuvel-Eibrink, Jacqueline J. Loonen, Marloes Louwerens, Sebastian J. C. Neggers, Cecile Ronckers, Wim J. E. Tissing, Andrica C. H. de Vries, Gertjan J. L. Kaspers, Margreet A. Veening, Arend Bokenkamp
Summary: This study aimed to evaluate glomerular dysfunction among childhood cancer survivors compared to a control group. It found a higher risk of chronic kidney disease and albuminuria in survivors, and identified several risk factors associated with these conditions. Therefore, lifelong monitoring of glomerular function is necessary for these survivors.
KIDNEY INTERNATIONAL
(2022)
Article
Oncology
Jennifer M. Yeh, Kathryn P. Lowry, Clyde B. Schechter, Lisa R. Diller, Grace O'Brien, Oguzhan Alagoz, Gregory T. Armstrong, John M. Hampton, Melissa M. Hudson, Wendy Leisenring, Qi Liu, Jeanne S. Mandelblatt, Diana L. Miglioretti, Chaya S. Moskowitz, Paul C. Nathan, Joseph P. Neglia, Kevin C. Oeffinger, Amy Trentham-Dietz, Natasha K. Stout
Summary: Early initiation of breast cancer screening in childhood leukemia or sarcoma survivors may reduce breast cancer deaths by half and is cost-effective, providing valuable insights for screening guidelines.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Hematology
Lucie M. Turcotte, Jillian A. Whitton, Wendy M. Leisenring, Rebecca M. Howell, Joseph P. Neglia, Rachel Phelan, Kevin C. Oeffinger, Kirsten K. Ness, William G. Woods, E. Anders Kolb, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow
Summary: The five-year survival rate for childhood acute myeloid leukemia (AML) has increased due to advancements in treatment and supportive care. However, the long-term health outcomes of AML survivors remain unclear. This study examined the incidence of late mortality and chronic health conditions (CHC) among 5-year AML survivors diagnosed between 1970 and 1999. The results showed that hematopoietic cell transplantation (HCT) was associated with higher late mortality, but the incidence of CHC has decreased over time for all treatment groups.
Article
Oncology
F. Lennie Wong, Janie M. Lee, Wendy M. Leisenring, Joseph P. Neglia, Rebecca M. Howell, Susan A. Smith, Kevin C. Oeffinger, Chaya S. Moskowitz, Tara O. Henderson, Ann Mertens, Paul C. Nathan, Yutaka Yasui, Wendy Landier, Gregory T. Armstrong, Leslie L. Robison, Smita Bhatia
Summary: This study evaluated the outcomes and cost-effectiveness of breast cancer screening using mammography and breast magnetic resonance imaging (MRI) in female chest-irradiated childhood Hodgkin lymphoma survivors. The results showed that annual mammography screening at age 30-74 years is effective and cost-effective in this population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paul C. Nathan, I-Chan Huang, Yan Chen, Tara O. Henderson, Elyse R. Park, Anne C. Kirchhoff, Leslie L. Robison, Kevin Krull, Wendy Leisenring, Gregory T. Armstrong, Rena M. Conti, Yutaka Yasui, K. Robin Yabroff
Summary: This study aimed to estimate the prevalence of financial hardship among adult survivors of childhood cancer compared with siblings and identify the correlates of hardship. The results showed that survivors were more likely to experience financial hardship compared to siblings.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Psychiatry
Donghao Lu, Yadav Sapkota, Unnur A. Valdimarsdottir, Karestan C. Koenen, Nan Li, Wendy M. Leisenring, Todd Gibson, Carmen L. Wilson, Leslie L. Robison, Melissa M. Hudson, Gregory T. Armstrong, Kevin R. Krull, Yutaka Yasui, Smita Bhatia, Christopher J. Recklitis
Summary: Genetic variants may be associated with traumatic exposures, and childhood cancer survivors are at risk for PTSD. Two specific genetic loci were found to be associated with PTSD in childhood cancer survivors and not in the general population.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Oncology
Chiara Papini, Ameera A. Fayad, Mingjuan Wang, Fiona S. M. Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M. Howell, Deokumar Srivastava, Wendy M. Leisenring, Gregory T. Armstrong, Todd M. Gibson, Leslie L. Robison, Kevin C. Oeffinger, Kevin R. Krull, Tara M. Brinkman
Summary: Young adult survivors of childhood cancer have an increased risk of loneliness, which can lead to physical and mental health issues in the future.
Article
Oncology
Danielle Novetsky Friedman, Pamela J. Goodman, Wendy M. Leisenring, Lisa R. Diller, Susan L. Cohn, Rebecca M. Howell, Susan A. Smith, Emily S. Tonorezos, Suzanne L. Wolden, Joseph P. Neglia, Kirsten K. Ness, Todd M. Gibson, Paul C. Nathan, Brent R. Weil, Leslie L. Robison, Kevin C. Oeffinger, Gregory T. Armstrong, Charles A. Sklar, Tara O. Henderson
Summary: This study examines the risk of late mortality, subsequent malignant neoplasms, and chronic health conditions in survivors of neuroblastoma diagnosed in infancy. The results show that the overall risk is relatively low, and there has been a decline in chronic health conditions with reduced exposure to radiation therapy in recent treatment eras.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Brent R. Weil, Andrew J. Murphy, Qi Liu, Rebecca M. Howell, Susan A. Smith, Christopher B. Weldon, Elizabeth A. Mullen, Arin L. Madenci, Wendy M. Leisenring, Joseph P. Neglia, Lucie M. Turcotte, Kevin C. Oeffinger, Amanda M. Termuhlen, Sogol Mostoufi-Moab, Jennifer M. Levine, Kevin R. Krull, Yutaka Yasui, Leslie L. Robison, Gregory T. Armstrong, Eric J. Chow, Saro H. Armenian
Summary: This study evaluated long-term morbidity and mortality rates among unilateral, nonsyndromic Wilms tumor (WT) survivors based on conventional treatment regimens. The results showed that survivors in different treatment groups were at risk for late mortality and chronic health conditions, especially an elevated risk for intestinal obstruction and kidney failure. The intensity of treatment was associated with an increased risk for severe chronic health conditions.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Paige A. Taylor, Elizabeth Miles, Lone Hoffmann, Sarah M. Kelly, Stephen F. Kry, Ditte Sloth Moller, Hugo Palmans, Kamal Akbarov, Marianne C. Aznar, Enrico Clementel, Coreen Corning, Rachel Effeney, Brendan Healy, Alisha Moore, Mitsuhiro Nakamura, Samir Patel, Maddison Shaw, Markus Stock, Joerg Lehmann, Catharine H. Clark
Summary: The Global Clinical Trials RTQA Harmonization Group (GHG) conducted a study to evaluate and prioritize clinical trial quality assurance, and identified high-risk errors in quality assurance tests for proton and photon therapy clinical trials. These findings can be used to improve the quality of radiotherapy and optimize clinical trial processes.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Cell Biology
Chayakrit Krittanawong, Nitin Kumar Singh, Richard A. A. Scheuring, Emmanuel Urquieta, Eric M. M. Bershad, Timothy R. R. Macaulay, Scott Kaplin, Carly Dunn, Stephen F. F. Kry, Thais Russomano, Marc Shepanek, Raymond P. P. Stowe, Andrew W. W. Kirkpatrick, Timothy J. J. Broderick, Jean D. D. Sibonga, Andrew G. G. Lee, Brian E. E. Crucian
Summary: The field of human space travel is undergoing a revolutionary change, with upcoming missions aiming to travel longer distances and durations than ever before. NASA and commercial space companies have started preparing for long-distance space exploration and plan to explore inner solar planets by the 2030s. Space travel has emerged as a potential new frontier in business, hospitality, medicine, and technology.
Article
Oncology
Caroline Hesko, Wei Liu, Deo K. K. Srivastava, Tara M. M. Brinkman, Lisa Diller, Todd M. M. Gibson, Kevin C. C. Oeffinger, Wendy M. M. Leisenring, Rebecca Howell, Gregory T. T. Armstrong, Kevin R. R. Krull, Tara O. O. Henderson
Summary: This study explores neurocognitive outcomes in survivors of neuroblastoma and finds that survivors have a higher risk of impairments in emotional regulation and task efficiency. Factors such as treatment exposures, era of diagnosis, and chronic conditions are associated with these impairments. The study highlights the importance of identifying and managing these factors to improve outcomes for neuroblastoma survivors.
Article
Oncology
Adam J. Esbenshade, Lu Lu, Debra L. Friedman, Kevin C. Oeffinger, Gregory T. Armstrong, Kevin R. Krull, Joseph P. Neglia, Wendy M. Leisenring, Rebecca Howell, Robyn Partin, Amy Sketch, Leslie L. Robison, Kirsten K. Ness
Summary: Using a geriatric rating scale, researchers found that childhood cancer survivors accumulate diseases at a faster rate compared to their siblings and the general population.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
James E. Bates, Suman Shrestha, Qi Liu, Susan A. Smith, Daniel A. Mulrooney, Wendy Leisenring, Todd Gibson, Leslie L. Robison, Eric J. Chow, Kevin C. Oeffinger, Gregory T. Armstrong, Louis S. Constine, Bradford S. Hoppe, Choonsik Lee, Yutaka Yasui, Rebecca M. Howell
Summary: Radiation-associated cardiac disease is a major concern for childhood cancer survivors, with potential risks to cardiac substructures from radiotherapy. There may be no threshold dose below which radiation to the cardiac substructures does not increase the risk of cardiac diseases, highlighting the need for careful treatment planning.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Hematology
Julian Lindsay, Carla S. Walti, Anna B. Halpern, Hu Xie, E. Lisa Chung, Kelda G. Schonhoff, Emily M. Huebner, Guang-Shing Cheng, Louise E. Kimball, Wendy M. Leisenring, Matthew Greenwood, Sharon C. -A. Chen, David C. M. Kong, Monica A. Slavin, Michael Boeckh, David N. Fredricks, Catherine Liu, Steven A. Pergam, Roland B. Walter, Joshua A. Hill
Article
Oncology
Fabien N. Belle, Christina Schindera, Marc Ansari, Gregory T. Armstrong, Maja Beck-Popovic, Rebecca Howell, Wendy M. Leisenring, Lillian R. Meacham, Jochen Rossler, Ben D. Spycher, Emily Tonorezos, Nicolas X. von der Weid, Yutaka Yasui, Kevin C. Oeffinger, Claudia E. Kuehni
Summary: The study compared the prevalence of overweight and obesity among childhood acute lymphoblastic leukemia survivors in North America and Switzerland, finding that survivors in North America had significantly higher rates of overweight and obesity compared to Swiss survivors and siblings. Risk factors for obesity among survivors included living in North America, being male, older age, non-Hispanic Black ethnicity, and younger age at diagnosis.