Inhibition of Breast Cancer Metastases by a Novel Inhibitor of TGFβ Receptor 1

Plumbagin Inhibits Breast Tumor Bone Metastasis and Osteolysis by Modulating the Tumor-Bone Microenvironment

(2012) Z. Li et al.   CURRENT MOLECULAR MEDICINE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Outgrowth of Drug-Resistant Carcinomas Expressing Markers of Tumor Aggression after Long-term T RI/II Kinase Inhibition with LY2109761

(2011) E. C. Connolly et al.   CANCER RESEARCH

Blockade of TGF-  Signaling by the TGF R-I Kinase Inhibitor LY2109761 Enhances Radiation Response and Prolongs Survival in Glioblastoma

(2011) M. Zhang et al.   CANCER RESEARCH

PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3

(2011) Fangyan Dai et al.   EMBO REPORTS

The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer

(2011) Shogo Yamamura et al.   INTERNATIONAL JOURNAL OF CANCER

The Notch and TGF-β Signaling Pathways Contribute to the Aggressiveness of Clear Cell Renal Cell Carcinoma

(2011) Jonas Sjölund et al.   PLoS One

The Transcription Factors Snail and Slug Activate the Transforming Growth Factor-Beta Signaling Pathway in Breast Cancer

(2011) Archana Dhasarathy et al.   PLoS One

Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCα/Raf/MAPKs and NF-κB/AP-1-dependent mechanisms

(2010) Yong Pil Hwang et al.   BIOCHEMICAL PHARMACOLOGY

Inhibitory effect of a TGFβ receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells

(2010) O Shinto et al.   BRITISH JOURNAL OF CANCER

TGF- -RI Kinase Inhibitor SD-208 Reduces the Development and Progression of Melanoma Bone Metastases

(2010) K. S. Mohammad et al.   CANCER RESEARCH

Connective tissue growth factor induction by lysophosphatidic acid requires transactivation of transforming growth factor type β receptors and the JNK pathway

(2010) Claudio Cabello-Verrugio et al.   CELLULAR SIGNALLING

Metabolism, Excretion, and Pharmacokinetics of [14C]INCB018424, a Selective Janus Tyrosine Kinase 1/2 Inhibitor, in Humans

(2010) A. D. Shilling et al.   DRUG METABOLISM AND DISPOSITION

Maslinic acid suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss by regulating RANKL-mediated NF-κB and MAPK signaling pathways

(2010) Chenghai Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-κB signaling pathway in colon cancer cells

(2010) Zhengfeng Yang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor α by inhibiting NF-κB signaling pathway

(2010) Chenghai Li et al.   Molecular Cancer

Pharmacological Inhibition of Transforming Growth Factor   Signaling Decreases Infection and Prevents Heart Damage in Acute Chagas' Disease

(2009) M. C. Waghabi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis

(2009) Minoru Hasegawa et al.   ARTHRITIS AND RHEUMATISM

Regulation of bone formation and remodeling by G-protein-coupled receptor 48

(2009) J. Luo et al.   DEVELOPMENT

Targeting the transforming growth factor-β signaling pathway in human cancer

(2009) Nagathihalli S Nagaraj et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Inhibition of the TGF-  receptor I kinase promotes hematopoiesis in MDS

(2008) L. Zhou et al.   BLOOD

TGF- receptor kinase inhibitor LY2109761 reverses the anti-apoptotic effects of TGF-1 in myelo-monocytic leukaemic cells co-cultured with stromal cells

(2008) Yuanyuan Xu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Improvement of the breaking strength of wound by combined treatment with recombinant human G-CSF, recombinant human M-CSF, and a TGF-β1 receptor kinase inhibitor in rat skin

(2008) Kenji Sugiyama et al.   CANCER SCIENCE

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

Roles of TGFβ in metastasis

(2008) David Padua et al.   CELL RESEARCH

TGFβ-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFβ switch

(2008) Irwin M Liu et al.   EMBO JOURNAL

LY2109761, a novel transforming growth factor   receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

(2008) D. Melisi et al.   MOLECULAR CANCER THERAPEUTICS