Why Do Phase III Clinical Trials in Oncology Fail so Often?

Drug Development: Portals of Discovery

(2012) S. E. Bates et al.   CLINICAL CANCER RESEARCH

Assumptions of Expected Benefits in Randomized Phase III Trials Evaluating Systemic Treatments for Cancer

(2012) H. K. Gan et al.   JNCI-Journal of the National Cancer Institute

Benefits, challenges and obstacles of adaptive clinical trial designs

(2011) Shein-Chung Chow et al.   Orphanet Journal of Rare Diseases

Statistical Considerations for the Next Generation of Clinical Trials

(2011) Wenting Wu et al.   SEMINARS IN ONCOLOGY

Is response rate increment obtained by molecular targeted agents related to survival benefit in the phase III trials of advanced cancer?

(2010) K. Tsujino et al.   ANNALS OF ONCOLOGY

Stable Disease Is Not Preferentially Observed With Targeted Therapies and as Currently Defined Has Limited Value in Drug Development

(2010) Tatiana Vidaurre et al.   CANCER JOURNAL

Stable Disease Is a Valid End Point in Clinical Trials

(2010) Anthony W. Tolcher   CANCER JOURNAL

Adaptive Methods: Telling “The Rest of the Story”

(2010) Scott S. Emerson et al.   Journal of Biopharmaceutical Statistics

A Modeling and Simulation Framework to Support Early Clinical Drug Development Decisions in Oncology

(2010) Rene Bruno et al.   JOURNAL OF CLINICAL PHARMACOLOGY

When Are "Positive" Clinical Trials in Oncology Truly Positive?

(2010) A. Ocana et al.   JNCI-Journal of the National Cancer Institute

Rapidly rising clinical trial costs worry researchers

(2009) R. Collier   CANADIAN MEDICAL ASSOCIATION JOURNAL

Clinical benefit in oncology trials: Is this a patient-centred or tumour-centred end-point?

(2009) Pavlo Ohorodnyk et al.   EUROPEAN JOURNAL OF CANCER

Call for Clarity in the Reporting of Benefit Associated With Anticancer Therapies

(2009) Christopher M. Booth et al.   JOURNAL OF CLINICAL ONCOLOGY

Model-Based Prediction of Phase III Overall Survival in Colorectal Cancer on the Basis of Phase II Tumor Dynamics

(2009) Laurent Claret et al.   JOURNAL OF CLINICAL ONCOLOGY

Randomized Phase III Clinical Trial Designs for Targeted Agents

(2008) A. Hoering et al.   CLINICAL CANCER RESEARCH