Article
Multidisciplinary Sciences
Kathryn L. Hopkins, Maya Jaffer, Khuthadzo E. Hlongwane, Kennedy Otwombe, Janan Dietrich, Mireille Cheyip, Jacobus Olivier, Tanya Doherty, Glenda E. Gray
Summary: A screening center in Soweto, South Africa investigated high-risk HPV, HIV, and cervical cancer risk among women. The study found high prevalence of HR-HPV infection in South African women, low coverage of cervical cancer screening, and that younger women are more susceptible to LSIL and other HR-HPV infections. It suggests implementing HPV-based primary screening starting from age 25.
Article
Oncology
Crispin Kahesa, Louise T. Thomsen, Ditte S. Linde, Bariki Mchome, Johnson Katanga, Patricia Swai, Rachel Manongi, Myassa Kjaerem, Thomas Iftner, Marianne Waldstrom, Julius Mwaiselage, Vibeke Rasch, Susanne K. Kjaer
Summary: This study from Tanzania compared nine HPV-based cervical cancer screening strategies and suggested that HPV testing alone, or HPV testing with extended genotyping or increased viral load cut-offs, may improve cervical cancer screening in Sub-Saharan Africa.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Melanie Gibson-Helm, Tania Slater, Evelyn J. J. MacDonald, Kendall Stevenson, Anna Adcock, Stacie Geller, Varsha Parag, Charles Lambert, Matthew Bennett, Merilyn Hibma, Peter Sykes, Marion Saville, David Hawkes, Jo-Ann Stanton, Mary-Ann Clueard, Grahame Jelley, Bev Lawton
Summary: New Zealand plans to introduce HPV testing as the primary screening method for cervical cancer. This implementation trial aims to assess if offering universal HPV self-testing achieves equal screening coverage compared to cervical cytology. The study will also explore the barriers and facilitators in the screening and diagnostic pathways.
Article
Public, Environmental & Occupational Health
Una Kojalo, Anna Tisler, Kersti Parna, Anda Kivite-Urtane, Jana Zodzika, Mindaugas Stankunas, Nicholas Baltzer, Mari Nygard, Anneli Uuskula
Summary: This study provides an overview of cervical cancer epidemiology and prevention efforts in Estonia, Latvia, and Lithuania. Key findings include high incidence and mortality rates, high prevalence of high-risk HPV, and suboptimal implementation of prevention strategies.
Article
Oncology
Ali Can Gunes, Nejat Ozgul, Murat Turkyilmaz, Fatih Kara, Fahriye Unlu, Ali Ayhan, Murat Gultekin
Summary: The study evaluated colposcopy performance in the HPV DNA screening program in Turkey and found high rates of unnecessary colposcopies, as well as a high percentage of multiple and random punch biopsies and endocervical curettage (ECC).
Article
Virology
Emel Yilmaz, Carina Eklund, Camilla Lagheden, Karin Dahlin Robertsson, Marina Lilja, Miriam Elfstrom, Laila Sara Arroyo Muhr, Joakim Dillner
Summary: This study provides the first global overview of the proficiency of HPV testing services for cervical cancer screening. The results indicate a high level of sensitivity and few false positives, but specificity still needs further improvement.
JOURNAL OF CLINICAL VIROLOGY
(2023)
Article
Oncology
Rianne van den Helder, Renske D. M. Steenbergen, Annina P. van Splunter, Constantijne H. Mom, Ming Y. Tjiong, Ivonne Martin, Fleur M. F. Rosier-van Dunne, Irene A. M. van der Avoort, Maaike C. G. Bleeker, Nienke E. van Trommel
Summary: Detection of hrHPV DNA and DNA methylation in urine offers a promising solution for the detection of cervical cancer and CIN2/3 lesions, especially for women who are currently not reached by conventional screening methods.
CLINICAL CANCER RESEARCH
(2022)
Review
Oncology
Biyuan Xing, Jianfeng Guo, Yuhan Sheng, Gang Wu, Yingchao Zhao
Summary: HPV-negative cervical cancers, predominantly adenocarcinomas, pose challenges in diagnosis and management due to unclear etiology and possible false negative results. It is important to pay greater attention to these cases as they are often diagnosed at advanced stages with poor prognoses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Matejka Rebolj, Christopher S. Mathews, Francesca Pesola, Alejandra Castanon, Henry Kitchener
Summary: International cervical screening guidelines suggest that high-risk human papillomavirus (HR-HPV) testing is more effective than liquid-based cytology (LBC) for diagnosing cervical cancer in women aged 24 to 29, as it not only accelerates cancer diagnosis, but also increases the detection of CIN2/3.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Louise T. Thomsen, Susanne K. Kjaer, Christian Munk, Dorthe Ornskov, Marianne Waldstrom
Summary: Compared to cytology-based screening, HPV-based screening resulted in a 90% increase in CIN3+ detection but also led to a threefold increase in colposcopy referrals. The findings support the implementation of HPV-based screening in Denmark, but adjustments to screening algorithms may be necessary to reduce unnecessary colposcopy referrals.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Review
Medicine, General & Internal
Paddy Ssentongo, Jennifer S. McCall-Hosenfeld, William A. Calo, Jennifer Moss, Eugene J. Lengerich, Vernon M. Chinchilli, Djibril M. Ba
Summary: This study found that HPV vaccination is associated with higher rates of cervical cancer screening, suggesting that vaccinated individuals are more likely to engage in preventive health behaviors.
Review
Oncology
Marc Arbyn, Marie Simon, Silvia de Sanjose, Megan A. Clarke, Mario Poljak, Remila Rezhake, Johannes Berkhof, Victoria Nyaga, Murat Gultekin, Karen Canfell, Nicolas Wentzensen
Summary: The cross-sectional accuracy of hrHPV mRNA testing is similar to DNA testing in detecting cervical intraepithelial neoplasia, but it is less sensitive for self-collected samples. Longitudinal follow-up studies show that hrHPV mRNA testing is comparable to DNA testing in preventing cervical intraepithelial neoplasia.
Article
Public, Environmental & Occupational Health
Jingran Li, Ruifang Wu, Xinfeng Qu, Xia Huang, Ling Li, Zhixin Lin, Zhijun Zhang, Jihong Deng, Rong Liu, Xiaofeng Zhao, Songling Zhang, Bei Lin, Ruifang An, Chao Zhao, Mingzhu Li, Yun Zhao, Lihui Wei
Summary: This study evaluated the feasibility of using self-sampling for HPV testing as a primary cervical cancer screening method, combined with the internet, in low-resource settings. The results showed that self-sampling was well accepted by the participants, with a high percentage of women willing to choose self-sampling for cervical cancer screening and to introduce it to others. Self-sampling can be used as a supplement to conventional screening, particularly in outlying areas with limited medical resources.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Kine Pedersen, Allison Portnoy, Stephen Sy, Bo T. Hansen, Ameli Trope, Jane J. Kim, Emily A. Burger
Summary: This study evaluated the impact and cost-effectiveness of switching from clinician-collected to self-collected HPV testing for cervical cancer screening among highly vaccinated and unvaccinated cohorts of Norwegian women. The results showed that HPV self-sampling strategies significantly reduced screening costs and were more cost-effective than clinician-collected HPV testing. Switching to self-collected HPV testing may be a cost-effective option for cervical screening in both vaccinated and unvaccinated cohorts.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
