Article
Multidisciplinary Sciences
Marco Vidotto, Andrea Bernardini, Marco Trovatelli, Elena De Momi, Daniele Dini
Summary: The study analyzes the hydraulic permeability of two white matter areas and finds significant anisotropic behavior and permeability differences, indicating the importance of considering white matter heterogeneity in brain drug transport modeling. These findings not only contribute to drug delivery modeling but also shed light on interstitial transport mechanisms in the brain's extracellular space.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geosciences, Multidisciplinary
Victor H. P. Souza, Francisco H. R. Bezerra, Lucieth C. Vieira, Caroline L. Cazarin, Jose A. Brod
Summary: Hydrothermal silicification plays a significant role in carbonate reservoirs, with sedimentary facies and stratigraphy influencing the process. The Cristal Cave study in Brazil reveals differences in silicification degrees and vertical distribution within the stratigraphic units, contributing to the understanding of silicified carbonate reservoirs.
MARINE AND PETROLEUM GEOLOGY
(2021)
Article
Chemistry, Physical
Xiaoqian Ge, Xueqi Xu, Qi Cai, Hejian Xiong, Chen Xie, Yi Hong, Xiaofei Gao, Yao Yao, Robert Bachoo, Zhenpeng Qin
Summary: The pan-ECM method enables live imaging of the entire brain extracellular matrix, providing insights into its heterogeneity and changes in neurological disorders. This novel approach has the potential to advance our understanding of brain function and neurological diseases.
Article
Medicine, General & Internal
Guomei Zhao, Hongbin Han, Wei Wang, Kaiying Jia
Summary: The study demonstrated that propofol accelerates interstitial fluid drainage in the deep rat brain, leading to shortened half-life of ISF, increased ECS volume fraction, and decreased ECS tortuosity, in contrast to isoflurane.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Neurosciences
Jan Tonnesen, Sabina Hrabetova, Federico N. Soria
Summary: The brain extracellular space (ECS) is a complex interstitial reticulum that plays a crucial role in intercellular communication. Diffusion is the primary mechanism for the transportation of neuroactive substances within the ECS. Recent nanoscopic imaging techniques have revealed the dynamic nature of the ECS and its heterogeneous diffusivity across brain regions. The geometry of the ECS and the properties of the interstitial fluid and extracellular matrix determine the diffusivity, which can be regulated independently.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Jing Yu, Pingqiang Cai, Xiaoqian Zhang, Tiankai Zhao, Linlin Liang, Sulin Zhang, Hong Liu, Xiaodong Chen
Summary: In multicellular assembly, the transition from fluid to solid is crucial for tissue morphogenesis, and is regulated by confinement size and surface tension. Experimental observations suggest that epithelial tensional stress and traction forces are dependent on confinement size, and correlate with cellular nanomechanics profile.
Article
Materials Science, Multidisciplinary
Hongxia Li, Guohua Bai, Rongzhi Zhao, Hua Yang, Ziwen Lu, Mingliang Cheng, Rui Su, Sateesh Bandaru, Yanan Zhang, Xiaolian Liu, Zhong Li, Erpan Zhang, Zhenhua Zhang, Mingji Zhang, Xianguo Liu, Xuefeng Zhang
Summary: In this study, FeSiAl soft magnetic composites with low power loss and high permeability were successfully fabricated by confined solid-state reaction between TiO2 and FeSiAl matrix. The homogeneous and lattice-matched Al2O3 layer formed by this reaction effectively insulated the FeSiAl particles. The resulting SMC exhibited low power loss and high permeability, making it suitable for energy-saving and high-efficiency devices.
Article
Electrochemistry
Kaitlynn P. Olczak, Kevin J. Otto
Summary: During neural stimulation, it is important to consider the impact of electrical stimulation on biological molecules, especially those with low oxidation potentials like ascorbic acid (AA). Research findings indicate that significant AA oxidation occurs even at stimulation levels typically deemed safe.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Geriatrics & Gerontology
Xianjie Cai, Qingyuan He, Wei Wang, Chunlin Li, Hui Wang, Feng Yin, Tong Li, Dongsheng Kong, Yanxing Jia, Hongfeng Li, Junhao Yan, Xunbin Wei, Qiushi Ren, Yajuan Gao, Shuangfeng Yang, Huaiyu Tong, Yun Peng, Hongbin Han
Summary: In this study, a new method was developed to accelerate the drainage of brain interstitial fluid (ISF) in the extracellular space (ECS). The method involved a minimally invasive surgery that implanted a branch of the external carotid artery in the epidural space, resulting in a pulsation effect on cerebrospinal fluid (CSF). The results showed that the drainage of ISF from the caudate nucleus to the ipsilateral cortex was significantly accelerated, along with increases in the volume fraction of the ECS and molecular diffusion rate. This study provides a new perspective on the treatment of brain diseases through the brain ECS.
Article
Engineering, Biomedical
Tian Yuan, Wenbo Zhan, Daniele Dini
Summary: This study reveals the impact of interactions between neurons and surrounding fluid on the macroscopic transport behavior of brain tissue, shedding light on unresolved issues related to brain functions and medical treatments. For the first time, a microstructure-informed permeability tensor was established to accurately model the transport properties of brain tissue. This study is important for improving the prediction accuracy of brain tissue transport properties and neural tissue engineering.
ACTA BIOMATERIALIA
(2023)
Review
Physiology
Martin Kaag Rasmussen, Humberto Mestre, Maiken Nedergaard
Summary: The brain has the ability to shift its gears between wakefulness and sleep, with information processing and behavior dominating in wakefulness and homeostatic functions prevailing during sleep. The brain relies on the glymphatic system, a fluid system comprised of the cerebrospinal fluid and perivascular spaces formed by astrocytic vascular endfeet, to clear waste products and maintain homeostasis. This system is especially active during sleep, driven by the cardiac cycle, respiration, and slow vasomotion.
PHYSIOLOGICAL REVIEWS
(2022)
Article
Geochemistry & Geophysics
Xi Chen, Wei Wang, Yajun Cao, Qizhi Zhu, Weiya Xu, Huaining Ruan
Summary: The study on hydromechanical coupling properties of rocks is crucial for rock engineering, with experimental results showing that various mechanical properties increase with increased confining pressure. Pore pressure weakens the effect of confining pressure, leading to a decline in rock mechanical properties.
Article
Chemistry, Physical
Shizhong Zhang, Gangwei Fan, Dongsheng Zhang, Wenping Li, Tao Luo, Shuaishuai Liang, Zhanglei Fan
Summary: In order to understand the permeability variation mechanism of weakly cemented rocks, the authors conducted triaxial permeability tests on weakly cemented sandstones collected from northwest China. They found that the initial high permeability of the sandstones decreased significantly due to pore convergence during the compaction stage. In the residual stage, the disintegration of clay minerals caused a slight increase in permeability.
Article
Medicine, Research & Experimental
Halimeh Mobarak, Mohammad Heidarpour, Reza Rahbarghazi, Mohammad Nouri, Mandi Mahdipour
Summary: This study aimed to investigate the therapeutic effects of AF-Exos on sperm production capacity in a rat model of azoospermia, showing significant improvement in spermatogenesis and sperm parameters post-injection. The increase of OCT-3/4(+) cells, expression of DAZL and VASA, and restoration of testicular function were observed in NOA rats treated with AF-Exos.
Article
Biochemical Research Methods
Filipa Blasco Tavares Pereira Lopes, Daniela Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mehmet Koyuturk, Xin Qi, Mark R. Chance
Summary: Mouse models of Alzheimer's disease can be used to study the progression of the disease and identify factors that drive AD-related pathways. This study used proteomics to analyze the hippocampus tissue of mice at different time points and with different genetic backgrounds and sexes. The results showed that 5XFAD mice exhibited increases in known AD biomarkers and also identified new proteins associated with AD pathology. Pathway analysis revealed sex-linked differences in the 5XFAD model related to amyloid fibril formation, wound healing, lysosome biogenesis, and DNA damage.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Physics, Applied
A. G. Yew, D. Pinero, A. H. Hsieh, J. Atencia
APPLIED PHYSICS LETTERS
(2013)
Article
Biochemistry & Molecular Biology
Laura L. Hyland, Julianne D. Twomey, Savannah Vogel, Adam H. Hsieh, Y. Bruce Yu
Article
Cell & Tissue Engineering
Alvin G. Yew, Javier Atencia, Adam H. Hsieh
CELLULAR AND MOLECULAR BIOENGINEERING
(2014)
Article
Engineering, Biomedical
Michael A. Hawks, Hyunchul Kim, Joseph E. Strauss, Bryant W. Oliphant, Robert D. Golden, Adam H. Hsieh, Jason W. Nascone, Robert V. O'Toole
CLINICAL BIOMECHANICS
(2013)
Article
Materials Science, Multidisciplinary
D. Shahmirzadi, H. A. Bruck, A. H. Hsieh
EXPERIMENTAL MECHANICS
(2013)
Article
Engineering, Biomedical
Danial Shahmirzadi, Hugh A. Bruck, Adam H. Hsieh
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2013)
Article
Critical Care Medicine
Sara Strebe, Hyunchul Kim, Joseph P. Russell, Adam H. Hsieh, Jason Nascone, Robert V. O'Toole
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2014)
Article
Biophysics
Kevin M. Labus, Sang Kuy Han, Adam H. Hsieh, Christian M. Puttlitz
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2014)
Article
Orthopedics
Christina L. Boulton, Hyunchul Kim, Swapnil B. Shah, Scott P. Ryan, Thomas A. Metzger, Adam H. Hsieh, Robert V. O'Toole
JOURNAL OF ORTHOPAEDIC TRAUMA
(2014)
Article
Critical Care Medicine
Robert D. Golden, Hyunchul Kim, Jeffrey D. Watson, Bryant W. Oliphant, Christopher Doro, Adam H. Hsieh, Greg M. Osgood, Robert V. O'Toole
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2013)
Article
Orthopedics
Hyunchul Kim, Joseph P. Russell, Adam H. Hsieh, Robert V. O'Toole
Article
Clinical Neurology
Christopher M. Zarro, Steven C. Ludwig, Adam H. Hsieh, Charles N. Seal, Daniel E. Gelb
Article
Rheumatology
Anshu Rastogi, Hyunchul Kim, Julianne D. Twomey, Adam H. Hsieh
ARTHRITIS RESEARCH & THERAPY
(2013)
Article
Cell & Tissue Engineering
J. D. Twomey, P. I. Thakore, D. A. Hartman, E. G. H. Myers, A. H. Hsieh
EUROPEAN CELLS & MATERIALS
(2014)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)