Article
Biotechnology & Applied Microbiology
Hui Yu, Lingling Zheng, Jikuan Qiu, Jiayue Wang, Yaoke Xu, Baoshi Fan, Rui Li, Junxiu Liu, Chao Wang, Yubo Fan
Summary: This study investigated the influence of design parameters on the mechanical properties of a novel braided nasal stent. The results showed that wire diameter, braiding density, and external stent diameter had significant effects on the stent's reaction force and bending stiffness. The wire diameter was the most important determining parameter. The optimal combination of parameters was a stent with a 25mm external diameter, 30° braiding angle, and 0.13mm wire diameter.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Ran He, Liguo Zhao, Vadim V. Silberschmidt, Jiling Feng, Ferdinand Serracino-Inglott
Summary: The personalised nitinol stent designs show significant improvements in lumen gain, reduction of stress levels in the media layer, and enhancement of lumen shape compared to the commercial stent design. This pilot study highlights the potential of personalised stents in delivering desirable treatment outcomes.
JOURNAL OF BIOMECHANICS
(2022)
Article
Engineering, Civil
Tekcham Gishan Singh, Konjengbam Darunkumar Singh
Summary: This paper presents a numerical investigation on the performance and design of cold-formed steel hollow sections stub columns with circular perforations. Most of the currently available design equations for perforated stub columns are found to be overly conservative and highly scattered. A modified design equation is proposed based on regression analysis, which offers improved accuracy and reliability in predicting the design strengths.
THIN-WALLED STRUCTURES
(2021)
Article
Materials Science, Biomaterials
Ran He, Liguo Zhao, Vadim V. Silberschmidt, Helen Willcock, Felix Vogt
Summary: This paper focuses on designing personalized nitinol stents for femoropopliteal arteries using medical imaging and advanced computational mechanics, with the design process based on achieving a healthy lumen area, reducing stress, and improving lumen shape after stenting. The design protocols were effective in developing personalized stents for arteries with diffuse and focal plaques, providing benefits such as double lumen gain and reduced stress compared to commercial stents. The approach suggested in this study can be applied to development of personalized therapies involving stent technology in various medical procedures.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Mechanics
Andrew Montalbano, Georges M. Fadel, Gang Li
Summary: In this study, a surrogate model is developed using numerical models and finite element simulations to investigate the relationship between energy loss and design parameters of bistable beams. The surrogate model is also used to obtain optimal designs and material selections for maximum energy loss.
MECHANICS BASED DESIGN OF STRUCTURES AND MACHINES
(2023)
Article
Engineering, Biomedical
Christopher Noble, Kent D. Carlson, Erica Neumann, Sean Doherty, Dan Dragomir-Daescu, Amir Lerman, Ahmet Erdemir, Melissa Young
Summary: This study validated a workflow for in silico stenting on a patient-specific peripheral artery with heterogeneous plaque structure using finite element models and IVUS-VH images. The findings suggest that plaque geometry has a stronger effect on stent performance than plaque composition, supporting the use of simple homogeneous material models for predicting stent performance, with stress criteria being important for calculating stent fatigue.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Engineering, Biomedical
Yafei Li, Yan Wang, Zhenquan Shen, Fulong Miao, Jianfeng Wang, Yufeng Sun, Shijie Zhu, Yufeng Zheng, Shaokang Guan
Summary: In this study, a new structurally designed magnesium alloy stent was proposed and optimized to improve its plastic deformation, expansion, and compression resistance performance. Experimental results verified the simulation results, demonstrating that the optimized stent has higher radial strength and reduced stress concentration compared to the traditional sinusoidal stent.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Civil
Fernando Goncalves Garcia, Roberto Ramos Jr
Summary: This study utilizes parametric finite element models to generate design charts for predicting the local buckling behavior of integrally web-stiffened panels subjected to uniaxial compressive loads. The proposed models are validated through numerical and experimental comparisons, revealing a significant increase in local buckling stresses for filleted panels.
THIN-WALLED STRUCTURES
(2022)
Article
Engineering, Civil
Quantian Luo, Liyong Tong, Mani Khezri, Kim J. R. Rasmussen, Mike R. Bambach
Summary: This study presents an optimal design problem to maximize the airflow opening of a thin-walled structure for efficient ventilation, deriving a novel formulation for airflow opening in plates or shells with large deflections and solving the maximum airflow problem as a topology optimization problem. Numerical examples demonstrate that optimizing laminated plates in a similar shape to their critical buckling mode can greatly increase airflow opening compared to flat plates with the same material and thickness.
THIN-WALLED STRUCTURES
(2022)
Article
Mechanics
Ravi Kumar, Ajay Kumar, Divesh Ranjan Kumar
Summary: In this study, a C0 finite element model based on modified third-order shear deformation theory is used along with deep neural networks, extreme gradient boosting, and random forest models to predict the critical buckling load of a carbon nanotube-reinforced hybrid functionally graded plate structure. The finite element model is validated and found suitable for finding new results. A regression problem is expressed using machine learning methods to predict the buckling response of the CNT-reinforced hybrid FG plates, using random values of the material's elastic properties as input parameters.
COMPOSITE STRUCTURES
(2023)
Article
Biophysics
Ran He, Liguo Zhao, Vadim V. Silberschmidt
Summary: Pre-dilation in femoropopliteal nitinol stent implantation may reduce stress in the stent but increase the risk of damage to the media layer. It also increases the risk of fatigue failure of the nitinol stent and has predictive value for in-stent restenosis.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Civil
Jelena Dobric, Aljosa Filipovic, Nancy Baddoo, Zlatko Markovic, Dragan Budevac
Summary: A comprehensive numerical investigation has been conducted to provide design recommendations for cold-formed stainless steel equal-leg angle columns, covering a wide range of crosssection sizes, slenderness values, and stainless steel grades. The proposed design procedures have been confirmed to be suitable through reliability assessment.
THIN-WALLED STRUCTURES
(2021)
Article
Chemistry, Multidisciplinary
Stelios K. Georgantzinos, Panagiotis A. Antoniou, Georgios I. Giannopoulos, Antonios Fatsis, Stylianos I. Markolefas
Summary: This study conducted a buckling analysis of laminated composite rectangular plates reinforced with multiwalled carbon nanotube inclusions using the finite element method. It revealed the effects of random dispersion, waviness, and agglomeration of carbon nanotubes on material properties, and numerically determined the critical buckling loads for various design parameters. The influence of carbon nanotube fillers on the critical buckling load of a nanocomposite rectangular plate was demonstrated, considering a modified Halpin-Tsai micromechanical model, with results in good agreement with experimental and theoretical data from other sources.
Article
Chemistry, Multidisciplinary
Ming-Yen Chang, Hsing-Hui Huang, Chia-Kai Lu
Summary: This study presents a design for a metal stent that expands under the influence of hydraulic pressure differentials, and uses simulations to explore the effects of various parameters on the stent joint, investigating differences in the stent design.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Zongchao Liu, Gongfa Chen, Chiwei Ong, Zhiyong Yao, Xiaoda Li, Jun Deng, Fangsen Cui
Summary: This study designed and verified an aortic stent-graft by optimizing a specially constructed commercial descending stent-graft. The optimization process, using surrogate modeling and multi-objective genetic algorithms, resulted in improved flexibility and radial support force of the stent-graft. The results provide guidelines and a feasible method for designing aortic arch stent-grafts.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Sarah Johnson, Ray McCarthy, Michael Gilvarry, Peter E. McHugh, J. Patrick McGarry
Summary: With mechanical thrombectomy becoming the new standard for stroke treatment, the mechanical behavior of clot analogues was studied in this research to provide valuable insights for the testing and design of thrombectomy devices. The composition of clot analogues was found to strongly influence their mechanical properties, with a hyper-viscoelastic constitutive law successfully capturing the experimental data. The study's findings are crucial for evaluating and developing mechanical thrombectomy devices and procedures.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Engineering, Biomedical
Gelareh Samandi, Vineet Gupta, Neethu Mohan, Peter McHugh, Cory Berkland, Michael Detamore, Stefan Lohfeld
Summary: The study introduces a new approach of using core-shell structure to alter the stiffness of microsphere units, which enables at least a five-fold increase in macroscopic stiffness of the scaffolds, addressing the limitation of stiffness in traditional microsphere-based scaffolds.
BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Reyhaneh N. Shirazi, Donnacha J. McGrath, Marie Clancy, Caroline Higgins, Ivan Mooney, Roger C. Dickenson, Peter E. McHugh, William Ronan
Summary: In this study, a finite element model was used to investigate the behavior of medical guidewires in an idealized tortuous path. The lag and whip phenomena in guidewires are mainly influenced by material properties, plastic deformation, and strain hardening behavior. Straight sections of the guidewire were found to increase the observed amount of whip in the study.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Medicine, General & Internal
Sahar Avazzadeh, Barry O'Brien, Ken Coffey, Martin O'Halloran, David Keane, Leo R. Quinlan
Summary: The study aimed to compare the optimal voltage thresholds for different cell types within the cardiovascular system and selective cell ablation. Results showed that neuronal and atrial cardiomyocyte lines had cell viabilities below 20% at 1000 V/cm, while cardiac fibroblasts showed an optimal threshold at 1250 V/cm.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Engineering, Biomedical
Kerstin van Gaalen, Felix Gremse, Felix Benn, Peter E. McHugh, Alexander Kopp, Ted J. Vaughan
Summary: This study develops an automated detection framework (PitScan) using Python-based algorithm to evaluate the severity and phenomenology of pitting corrosion. The framework analyzes microcomputer-tomography scans (mu CT) of corroded cylindrical specimens and identifies surface-based corrosion features, providing a spatial characterization of pitting parameters. The study also establishes relationships between key pitting parameters and mechanical performance in Rare Earth Magnesium alloy specimens. The results show that certain parameters described in ASTM G46-94 have little correlation with mechanical performance, while parameters directly linked to the reduction of cross-sectional area are more indicative of specimen's mechanical performance. The developed automated detection framework has the potential to standardize pitting corrosion measurements and predict mechanical strength degradation over time.
BIOACTIVE MATERIALS
(2022)
Article
Computer Science, Interdisciplinary Applications
Ana Gonzalez-Suarez, Ramiro M. Irastorza, Stuart Deane, Barry O'Brien, Martin O'Halloran, Adnan Elahi
Summary: This study aimed to assess the electric field distribution in the heart and its surroundings during epicardial monopolar PEF ablation. The results showed that the electric field was mainly limited to the target area in the heart, and negligible in adjacent organs. The limited-domain model provided similar results to the full torso model in evaluating the electric field distribution.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sahar Avazzadeh, Mahshid H. Dehkordi, Peter Owens, Amirhossein Jalali, Barry O'Brien, Ken Coffey, Martin O'Halloran, Howard O. Fernhead, David Keane, Leo. R. Quinlan
Summary: This study presents important findings on the differences in the susceptibility of neurons and cardiomyocytes to irreversible electroporation. Cell type alone yielded selective and different dynamics in terms of the evolution and signaling mechanism of cell death in response to electroporation.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Stefan Lohfeld, William Curtin, Peter E. McHugh
Summary: This study presents the development of a patient specific implant system for osteochondral defects, addressing the issues associated with current treatments. It utilizes computer aided design and manufacturing techniques to produce a perfectly fitting tissue replacement, allowing for precise and easy implantation.
Article
Engineering, Biomedical
Conall Quinn, Kerstin Van Gaalen, Peter E. McHugh, Alexander Kopp, Ted J. Vaughan
Summary: This study developed an enhanced phenomenological model for surface-based localised corrosion of magnesium alloys for medical applications. The model considers the role of beta-phase components, captures multi-directional pitting and various pit morphologies, eliminates mesh sizing effects, reduces computational cost, offers control of pit sizing, and produces independent corrosion rates.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Ana Gonzalez-Suarez, Barry O'Brien, Martin O'Halloran, Adnan Elahi
Summary: The study aimed to investigate the distribution of electric field in tissues (fat, ganglionated plexi, myocardium, and blood) during epicardial pulsed electric field (PEF) ablation. The findings showed that PEF ablation mainly affected the epicardial fat layer, with minimal impact on the myocardium. The presence of saline on the epicardial fat surface resulted in lateral spread of the PEF zone around the electrode. The thickness of the fat layer and the presence of ganglionated plexi altered the distribution of the electric field.
BIOENGINEERING-BASEL
(2022)
Article
Engineering, Biomedical
Kerstin van Gaalen, Conall Quinn, Felix Benn, Peter E. McHugh, Alexander Kopp, Ted J. Vaughan
Summary: This study presents a computational framework that investigates the effect of localised surface-based corrosion on the mechanical performance of a magnesium-based alloy. Using a verified corrosion modelling approach, a quantitative relationship between mechanical integrity and corrosion features was established, with the minimal cross-sectional area parameter being the strongest predictor.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Kerstin van Gaalen, Conall Quinn, Marek Weiler, Felix Gremse, Felix Benn, Peter E. McHugh, Ted J. Vaughan, Alexander Kopp
Summary: This study investigates the influence of a plasma electrolytic oxidation (PEO) surface treatment on a medical-grade WE43-based magnesium alloy. The research finds that the PEO modified group has significantly lower corrosion rate and higher mechanical properties compared to the unmodified group.
BIOACTIVE MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Ana Gonzalez-Suarez, Juan J. Perez, Barry O'Brien, Adnan Elahi
Summary: The effect of metal intracoronary stents on PEF ablation was assessed. The presence of the coronary artery distorts the E-field distribution, but has minimal impact on the PEF-zone. Despite the presence of E-field hot spots, the temperature increase in the tissue is moderate.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Medicine, General & Internal
Sherif Sultan, Jamie Concannon, Dave Veerasingam, Wael Tawfick, Peter McHugh, Fionnuala Jordan, Niamh Hynes
Summary: Due to the lack of randomized controlled trials or controlled clinical trials, the safety and effectiveness of endovascular repair versus conventional open surgical repair in patients with thoracoabdominal aortic aneurysms cannot be determined, and there is no evidence available for the optimal surgical intervention for this group of patients. Conducting high-quality studies addressing this objective will be challenging due to logistical and ethical considerations for this life-threatening disease.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Biodiversity Conservation
Jud F. Kratzer, Peter McHugh, Richard Kirn, William H. Eldridge
Summary: The study shows that the abundance and distribution of Brook Trout in Vermont have increased over the past half century, primarily driven by an increase in young of year. This increase in abundance is not affected by the presence of non-native trout. While non-native trout are present at fewer sites in the 2000s, their densities remain unchanged.
NORTHEASTERN NATURALIST
(2021)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
