Article
Biochemistry & Molecular Biology
Huan Xu, Lv Ke, Mengke Tang, Han Shang, Zi-Lin Zhang, Wenxuan Xu, Ya-Nan Fu, Yanqing Wang, Daoyuan Tang, Donghui Huang, Shenghui Zhang, Hao-Ran Yang, Xinjian He, Jiefeng Gao
Summary: The anisotropic hierarchical structures of naturally derived materials have been used as design principles to fabricate high-strength and functional materials. In this study, a structure-by-bionics approach was used to create pea pod-mimicking architecture for poly(lactic acid) (PLA) composites incorporated with hydroxyapatite nanowhiskers (HANWs). The resulting structured PLA composites showed improved mechanical properties and bioactivity, making them promising for guided bone/tissue regeneration therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Naishun Guo, Mengen Zhao, Sijing Li, Jiahui Hao, Zhaoying Wu, Chao Zhang
Summary: This study developed a HA/PLA nanocomposite by surface modification of n-HA, which improved the dispersion of n-HA in the PLLA matrix and formed a stereocomplex crystal at the interface, leading to greatly enhanced mechanical performance. The composite material exhibited excellent mechanical properties and promoted osteogenic differentiation of bone marrow stromal cells.
Article
Biochemistry & Molecular Biology
Xiaohong Hu, Xiaofeng Song, Mengfei Xu, Yanhe Wang, Chuanming Zhu, Wanting Yu, Yuze Zhao
Summary: In this study, a shape memory composite was constructed by blending poly(epsilon-caprolactone) with TiO2 nanomaterial. The composite showed excellent shape fixing and recovery ratio, with a short recovery time at a low temperature. Moreover, the composite exhibited good antibacterial properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Honglei Kang, Xudong Jiang, Zhiwei Liu, Fan Liu, Guoping Yan, Feng Li
Summary: Biodegradable scaffolds based on biomedical polymeric materials were prepared using composite materials of PTMC/PLA/HA and PTMC/HA, showing low toxicity, good biodegradability, and biocompatibility while enhancing the cell multiplication ability of osteoblast cells.
Article
Chemistry, Physical
Kentaro Ayasaka, Mrunalini Ramanathan, Ngo Xuan Huy, Ankhtsetseg Shijirbold, Tatsuo Okui, Hiroto Tatsumi, Tatsuhito Kotani, Yukiho Shimamura, Reon Morioka, Takahiro Kanno
Summary: This study evaluated the application of four generations of bioresorbable biomaterials in maxillofacial surgery through an animal experiment. The results showed that the first-generation biomaterials did not have advantages in bone fixation compared to other generations. Second-generation biomaterials degraded faster and were potentially suitable for non-stress regions. Third and fourth-generation biomaterials exhibited improved bioactivity and strength, making them suitable for panfacial use.
Article
Polymer Science
Elisa Capuana, Francesco Lopresti, Manuela Ceraulo, Vincenzo La Carrubba
Summary: This review focuses on the properties and applications of poly-l-lactic acid (PLLA) as a biomaterial in the field of tissue engineering. The structure and main properties of PLLA are discussed, along with the recent advances in overcoming its hydrophobic and synthetic nature. Additionally, various fabrication technologies and the in vitro and in vivo applications of PLLA in tissue repair strategies are reviewed.
Article
Chemistry, Multidisciplinary
Yun Chen, Liying Wang, Weishuo Chen, Channa Zhong, Shuangcheng Li, Jun Shao, Gao Li, Haoqing Hou
Summary: This study investigated the crystallization kinetics of PLLA and PLLA blocks in PEG-PLLA copolymers with different block lengths. The results showed that the crystallization rate of the PLLA block strongly depends on the copolymer architecture and block length. The crystallization rate first decreased and then increased with the increase in crystallization temperature (Tc). Moreover, higher crystallization rates were observed at lower Tc values and for copolymers with longer PEG block lengths.
Article
Chemistry, Physical
Mehmet Topuz
Summary: In this research, a hydroxyapatite-Al2O3 reinforced poly (lactic acid) hybrid coating was synthesized on magnesium to improve interface strength, corrosion properties, and dissolution rate. The coatings were produced using the spin-coating technique of the synthesized solutions. The characterization, mechanical properties, and in-vitro bioactivity of the hybrid coatings were investigated.
SURFACES AND INTERFACES
(2023)
Article
Polymer Science
Leonard Bauer, Anamarija Rogina, Marica Ivankovic, Hrvoje Ivankovic
Summary: The production of biocompatible composite scaffolds using additive manufacturing is growing in popularity. This study focuses on the effects of different grades of polymers and the addition of hydroxyapatite (HAp) on the degradation behavior and thermal stability of the scaffolds. The results show that a higher HAp content slows down the degradation of the polymer and improves its thermal stability, as evidenced by morphological changes and differences in glass transition temperatures throughout the samples.
Article
Polymer Science
Ofek Golan, Hila Shalom, Ifat Kaplan-Ashiri, Sidney R. Cohen, Yishay Feldman, Iddo Pinkas, Rakefet Ofek Almog, Alla Zak, Reshef Tenne
Summary: This study prepared films of PLLA and HA with small amounts of nontoxic WS2 nanotubes (INT-WS2) and investigated their structural aspects using various techniques. The mechanical properties were evaluated through tensile measurements, micro-hardness tests, and nanoindentation, while the thermal properties were studied via differential scanning calorimetry. The composite films showed improved mechanical and thermal properties compared to films made from PLLA and HA alone, making them advantageous for medical applications.
Article
Materials Science, Ceramics
M. Kasaeian-Naeini, M. Sedighi, R. Hashemi, H. Delavar
Summary: Employing ceramic particles like hydroxyapatite to fabricate magnesium-based bio-composite has attracted significant attention in orthopedic applications due to their bioactivity and biocompatibility. The combination of hydroxyapatite particles and the equal channel angular pressing (ECAP) process has shown improved microstructure, mechanical properties, and fracture toughness of the Mg/HA bio-composites. Through microstructural observation, mechanical tests, and digital image correlation (DIC) analysis, it was found that the addition of hydroxyapatite particles and the ECAP process led to decreased grain size, enhanced mechanical strength, and improved resistance against crack growth in the bio-composites. The four-pass ECAPed bio-composite showed the highest fracture toughness, approximately 28 MPa m0.5, 70% higher than pure Mg.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Environmental
Weishuo Chen, Channa Zhong, Shuangcheng Li, Die Wen, Dongdong Zhou, Jun Shao, Shuiliang Chen, Haoqing Hou, Sheng Xiang
Summary: The blends of poly(D-lactic acid) and poly(L-lactic acid) (PDLA/PLLA) exhibit higher crystallization rate and mechanical strength than individual PDLA or PLLA due to the formation of stereocomplex crystals (SC). SC serves as an effective nucleating agent for PLA homochiral crystals (HC). However, the morphology of SC in asymmetric blends and its effect on the crystallization behavior of HC remains unclear. In this study, PDLA/PLLA blends with different weight ratios were prepared using different methods to obtain SC with different morphologies. The results showed that SC morphology influenced the formation of HC, with fibrous and banded SC inhibiting HC formation, spherical SC enhancing HC formation, and network structure SC significantly accelerating the crystallization rate of HC.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Review
Chemistry, Physical
Huy Xuan Ngo, Yunpeng Bai, Jingjing Sha, Shinji Ishizuka, Erina Toda, Rie Osako, Akira Kato, Reon Morioka, Mrunalini Ramanathan, Hiroto Tatsumi, Tatsuo Okui, Takahiro Kanno
Summary: The forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted significant interest in bone tissue engineering and clinical applications in maxillofacial reconstructive surgery due to its bioactive osteoconductive ability and biocompatibility. Various studies have demonstrated the superiority of u-HA/PLLA as a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity.
Article
Polymer Science
Apisit Banpean, Shinichi Sakurai
Summary: The study found that under specific conditions, PEG can only crystallize in the preformed spherulites of PLLA and not in the amorphous phase of the mixed PLLA/PEG matrix.
Article
Polymer Science
Prasong Srihanam, Wiriya Thongsomboon, Yodthong Baimark
Summary: The aim of this study was to modify PLLA-b-PEG-b-PLLA copolymer using low-cost CaCO3 filler to improve its material properties. The addition of CaCO3 enhanced the crystallinity and thermal stability of PLLA-b-PEG-b-PLLA matrix. SEM analysis showed stronger interfacial adhesion between PLLA-b-PEG-b-PLLA and CaCO3 compared to PLLA and CaCO3. Tensile testing revealed increased stress and modulus for PLLA-b-PEG-b-PLLA matrix with CaCO3, while these properties significantly decreased for PLLA matrix. Therefore, CaCO3 shows promise as an inexpensive filler for improving PLLA-b-PEG-b-PLLA bioplastics.
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)