Article
Computer Science, Interdisciplinary Applications
Weijian Lin, Qingen Meng, Junyan Li, Zhenxian Chen, Zhongmin Jin
Summary: This study developed a highly inhomogeneous fibril-reinforced biphasic model considering both depth-dependent and strain-dependent properties to illustrate the effect of highly inhomogeneous properties on the mechanical behavior of articular cartilage. The number of layers in models with depth-dependent properties should be chosen based on research questions and clinical demands. Models with strain-dependent permeability demonstrated enhanced fluid pressurization capability.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Sentong Wang, Kazunori Hase, Shunsuke Kita, Shinya Ogaya
Summary: This study investigates the biomechanical changes in the knee joint during walking caused by medial meniscal radial tears associated with knee osteoarthritis (OA). The results show that larger medial meniscal radial tears are prone to high stress concentrations and an increased risk of complete meniscal rupture. Furthermore, the tears disrupt the stress-transmitting function of the meniscus, greatly increasing the likelihood of developing knee OA. Complete postmeniscectomy also leads to a significant increase in tibial cartilage load, indicating a potential risk of OA flare-ups.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Multidisciplinary
Behrouz Arash, Wibke Exner, Raimund Rolfes
Summary: A finite deformation phase-field fracture model was developed to analyze the thermo-viscoelastic behavior of boehmite nanoparticle/epoxy nanocomposites, considering rate-dependent fracture evolution and the effect of nanoparticle contents and temperature on fracture behavior. The model's predictive capability was validated through comparing numerical results with experimental data, and numerical simulations were performed to study the effect of temperature and deformation rate on the force-displacement response of the nanocomposites in compact-tension tests.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Engineering, Biomedical
Weiqi Li, Duncan E. T. Shepherd, Daniel M. Espino
Summary: This study analyzed the compressive viscoelastic properties of brain tissue in both time and frequency domains using Finite Element models, and estimated the viscoelastic response in the time domain based on frequency-dependent mechanical moduli. The research demonstrates the feasibility of deriving time-domain viscoelastic parameters from frequency-dependent data for biological tissues through experimental tests and computational simulations.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Medicine, General & Internal
Alireza Karimi, Reza Razaghi, Steven Padilla, Seyed Mohammadali Rahmati, J. Crawford Downs, Ted S. Acott, Mary J. Kelley, Ruikang K. Wang, Murray Johnstone
Summary: This study revealed the differences in viscoelastic mechanical properties among different regions of the ocular conventional outflow pathway and between healthy and glaucomatous tissues using OCT imaging technology.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Anqi Xue, Zuming Mao, Xiaoyu Zhu, Qiang Yang, Peichen Wang, Zimu Mao, Mingze Du, Xu Ma, Dong Jiang, Yubo Fan, Feng Zhao
Summary: This study aimed to investigate the biomechanical effects of horizontal meniscal tears and different resection strategies on a rabbit knee joint using finite element analysis. The results showed that the horizontal meniscal tears had little biomechanical impact on the rabbit knee joint, and some of the partial meniscectomy strategies also had minimal effect on joint stress. It is recommended to preserve the posterior root and the remaining peripheral edge of the meniscus during surgery for a horizontal meniscal tear.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Mechanical
A. G. Cunha-Filho, Y. Briend, A. M. G. de Lima, M. Donadon
Summary: This paper discusses the application of fractional calculus combined with the finite element method in modeling viscoelastic systems, proposing a new and efficient three-dimensional fractional constitutive formulation based on a recurrence term to describe the behavior of viscoelastic materials, especially for complex systems. The efficiency and accuracy of this proposed formulation are demonstrated through an academic example compared to existing methods.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2021)
Article
Materials Science, Characterization & Testing
Zhihong Liang, Jian Li, Xuelian Zhang, Qianhua Kan
Summary: The mechanical properties of amorphous polymers from below to above glass transition temperature (Og) were described using a constitutive model based on the combination of multiple relaxation viscoelastic-viscoplastic model and the three-element viscoelastic model. The model successfully captured the strain-softening after yield as well as rate-dependent behaviors above and below Og, and also described the creep and relaxation behaviors of the material. The implemented model was able to reasonably predict the structural responses of amorphous polymers.
Article
Mathematics, Applied
Yiqun Li, Hong Wang, Xiangcheng Zheng
Summary: We propose a fully-discrete finite element scheme for modeling the mechanical responses of viscoelastic beams, thick beams, and beams subject to high-frequency excitations. The proposed scheme properly considers the effects of both transverse shear and rotational inertia. We prove high-order regularity of the solutions and provide error estimates for the numerical scheme. Numerical experiments are conducted to validate the analysis results and demonstrate the effectiveness of the fractional Timoshenko beam model compared to its integer-order analogue and the commonly-used Euler-Bernoulli beam models.
JOURNAL OF SCIENTIFIC COMPUTING
(2023)
Article
Mechanics
Yufei Long, Orzuri Rique, Juan M. Fernandez, Andrew C. Bergan, Joshua E. Salazar, Wenbin Yu
Summary: In this study, finite element simulation of the column bending test (CBT) was conducted using shell elements with anisotropic viscoelastic section properties. The results showed that the model was capable of predicting most of the measured trends, but viscoplasticity should also be considered.
COMPOSITE STRUCTURES
(2022)
Article
Materials Science, Multidisciplinary
Raphael N. Glaesener, Jan-Hendrik Bastek, Frederick Gonon, Vignesh Kannan, Bastian Telgen, Ben Spottling, Stephan Steiner, Dennis M. Kochmann
Summary: Through theoretical, numerical, and experimental studies, a method using linear viscoelastic corotational beam description was deployed to conduct viscoelastic experiments on 3D-printed polymer samples, validating the effectiveness of applying this method to complex truss structures undergoing time-dependent stress relaxation. This offers a promising approach for modeling and optimizing 3D-printed truss metamaterials for engineering applications.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2021)
Article
Materials Science, Multidisciplinary
Aida Chaker, Amna Rekik, Andre Langlet, Ridha Hambli
Summary: This paper proposes a semi-numerical model that accurately estimates the mechanical behavior of viscoelastic microcracked masonry. The model consists of two steps: the approximation of the creep behavior of microcracked mortar and the simulation of the complete geometry of the masonry using finite elements method. The model takes into account the creep effects of both brick and mortar constituents, providing a comprehensive analysis.
MECHANICS OF MATERIALS
(2022)
Article
Mechanics
Valerii Matveenko, Nataliia Iurlova, Dmitrii Oshmarin, Natalya Sevodina
Summary: This paper focuses on optimizing the dissipative properties of smart-systems composed of elastic or viscoelastic bodies and piezoelectric bodies with connected electrodes. The parameters for maximal dissipative properties are sought by analyzing natural vibration frequencies. The mathematical formulation of the problem and basic relations for numerical simulation are presented, along with the use of finite-element matrices in the ANSYS software package for deformable elements. An algorithm based on Mueller's method and the argument principle is recommended for solving this problem. Examples are provided to illustrate the determination of parameters for maximum damping and the use of graphene composite elements for multimodal damping.
Article
Construction & Building Technology
Ricardo Morais Lanes, Marcelo Greco, Valerio da Silva Almeida
Summary: This paper presents a numerical methodology to analyze frame structures supported on footing foundations subjected to slow strains caused by consolidation settlements. The Boundary Element Method with the Mindlin fundamental solution has been applied to compute the displacement resulting from the interference between pressure bulbs on the foundation. The rheological Kelvin-Voigt model has also been used for soil-structure interactions. Terzaghi's Theory of Consolidation was used to fit the displacement-time curves. Finally, the rheological model was coupled through an iterative procedure, employing structural non-linear geometric effects. The results are consistent with settlement predicted effects and revealed that the slow distribution of efforts can cause relevant increases in some regions in the structure of the building.
Article
Materials Science, Multidisciplinary
Zhencai Xing, Huadong Yong
Summary: This paper investigates the finite deformation and instabilities of viscoelastic soft magnetic soft materials (HMSM). A numerical model is developed to analyze the buckling and snap-through instabilities of two typical HMSM structures (i.e. beam and spherical shell) with viscoelastic effects. The results show that the viscoelastic effects delay the onset of instability and suppress the snap-back phenomenon. This study provides an effective numerical model for analyzing the finite deformation and instabilities of viscoelastic HMSM and may guide the design of HMSM devices.
MECHANICS OF MATERIALS
(2023)
Article
Clinical Neurology
Fabio Galbusera, Andrea Cina, Tito Bassani, Matteo Panico, Luca Maria Sconfienza
Summary: This study demonstrates the use of natural language processing (NLP) and deep learning models to generate training data for detecting radiological findings in spine images. NLP classifiers based on the BERT model are able to accurately extract structured information from radiological reports. The ResNet-18 models showed varying performances for specific radiological findings, but overall performed well.
GLOBAL SPINE JOURNAL
(2023)
Article
Engineering, Biomedical
Matthias Rueger, Andreas Martin Seitz, Katja Nuss, Brigitte von Rechenberg, Daniel Seitz, Cris Kostmann, Peter Quadbeck, Olaf Andersen, Caitlyn Collins
Summary: This study introduces a fiber-based biometal with adjustable anisotropic mechanical properties. The material demonstrates high compressive strength and stiffness similar to bone, and exhibits excellent osseointegration in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Orthopedics
Andreas M. Seitz, Janina Leiprecht, Jonas Schwer, Anita Ignatius, Heiko Reichel, Thomas Kappe
Summary: The purpose of this study was to investigate the potential of a doubled semitendinosus (ST) and a single gracilis tendon (GT) lateral meniscus autograft to restore knee joint kinematics and tibiofemoral contact after total lateral meniscectomy (LMM). The results showed that the ST autograft significantly improved knee joint kinematics and restored tibiofemoral contact mechanics, while the GT autograft had limited effectiveness.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Immunology
Melanie Haffner-Luntzer, Birte Weber, Kazuhito Morioka, Ina Lackner, Verena Fischer, Chelsea Bahney, Anita Ignatius, Miriam Kalbitz, Ralph Marcucio, Theodore Miclau
Summary: Clinical and preclinical data suggest accelerated bone fracture healing in subjects with an additional traumatic brain injury (TBI). Mechanistically, altered metabolism and neuro-endocrine regulations have been shown to influence bone formation after combined fracture and TBI, thereby increasing the bone content in the fracture callus. However, the early inflammatory response towards fracture and TBI has not been investigated in detail so far.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jana Riegger, Helga Joos, Valentin Moehler, Frank Leucht, Katrin Rading, Christian Kubisch, Anita Ignatius, Markus Huber-Lang, Rolf E. Brenner
Summary: The study suggests that the terminal complement complex (TCC) plays a role in the pathogenesis of posttraumatic osteoarthritis (PTOA). However, the absence of TCC may protect against OA progression and have minor effects on the micro-structure of the subchondral bone.
Editorial Material
Clinical Neurology
Fabio Galbusera, Andrea Cina, Dino Samartzis
Article
Orthopedics
Matthias Sukopp, Maoz Shemesh, Elena Pruech, Eran Linder-Ganz, Scott Hacker, Vincenzo Condello, Jonas Schwer, Anita Ignatius, Lutz Duerselen, Andreas Martin Seitz
Summary: The purpose of this in-vitro study was to examine the kinematics of an artificial, free-floating medial meniscus replacement device under dynamic loading situations and different knee joint states. A dynamic knee simulator was used to perform dynamic loading exercises on left human cadaveric knee joints to investigate the knee joint and implant kinematics. The results showed that the non-anchored free-floating device remains within the medial knee joint gap under challenging dynamic loading situations without indicating any luxation tendencies.
JOURNAL OF EXPERIMENTAL ORTHOPAEDICS
(2023)
Article
Endocrinology & Metabolism
Lena Steppe, Benjamin Krueger, Miriam Eva Angelica Tschaffon-Mueller, Jan-Moritz Ramge, Astrid Schoppa, Anita Ignatius, Melanie Haffner-Luntzer
Summary: External mechanostimulation induced by LMHFV has different effects on fracture healing in estrogen-competent and estrogen-deficient rodents. ER alpha signaling in osteoblasts is required for these effects, with ligand-dependent and -independent ER alpha signaling playing different roles. The AF-2 domain of the ER alpha receptor is crucial for the negative effects of vibration during bone fracture healing in estrogen-competent mice, suggesting that the osteoanabolic effects of vibration are mediated by ligand-independent ER alpha signaling.
Article
Clinical Neurology
Frank Niemeyer, Fabio Galbusera, Youping Tao, Frank M. Phillips, Howard S. An, Philip K. Louie, Dino Samartzis, Hans-Joachim Wilke
Summary: The purpose of this study is to develop a reliable method for automatically classifying sagittal MRI image stacks of cervical spinal segments with respect to degenerative phenotypes. This classification can provide insight into the extent of disease, predict future pathological developments, and inform surgical outcomes and complications.
EUROPEAN SPINE JOURNAL
(2023)
Article
Clinical Neurology
Jacopo Vitale, Luca Maria Sconfienza, Fabio Galbusera
Summary: This study assessed the cross-sectional area (CSA) and fat infiltration (FI) of lumbar spine muscles in a large cohort of subjects with back disorders using a validated deep learning model.
EUROPEAN SPINE JOURNAL
(2023)
Article
Orthopedics
Luisa de Roy, Kerstin Eichhorn, Martin Faschingbauer, Klaus Schlickenrieder, Anita Ignatius, Andreas Martin Seitz
Summary: The purpose of this in vitro study was to investigate the effect of hyaluronic acid supplementation on knee joint friction during osteoarthritis progression. The results showed that knee joint friction does not increase with degeneration, and hyaluronic acid supplementation does not lead to an initial decrease in friction.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Meeting Abstract
Dermatology
P. Maity, K. Singh, L. Krug, A. Koroma, W. Bloch, S. Kochanek, M. Wlaschek, M. Schorpp-Kistner, P. Angel, A. Ignatius, H. Geiger, K. Scharffetter-Kochanek
EXPERIMENTAL DERMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jana Riegger, Astrid Schoppa, Leonie Ruths, Melanie Haffner-Luntzer, Anita Ignatius
Summary: This article discusses oxidative stress as a major driver of pathophysiological processes in cartilage and bone, including aging, misdirected differentiation, cell death, mitochondrial dysfunction, and impaired mitophagy. It also elaborates on cellular defense mechanisms and therapeutic strategies to improve cell and tissue protection.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)