Review
Engineering, Biomedical
Fangxing Wang, Florian Metzner, Georg Osterhoff, Leyu Zheng, Stefan Schleifenbaum
Summary: Bone marrow plays an important role in the mechanical properties of trabecular bone, with its contribution varying depending on different loading types and test settings. To accurately obtain the mechanical properties of trabecular bone, both the bone marrow and the solid matrix should be considered simultaneously.
BIOMEDICAL ENGINEERING ONLINE
(2022)
Article
Multidisciplinary Sciences
F. Metzner, C. Neupetsch, J. -P. Fischer, W. -G. Drossel, C. -E. Heyde, S. Schleifenbaum
Summary: The study focused on collecting mechanical parameters from compressive tests on proximal femora samples to predict bone strength, with distal density being the most relevant parameter. It found no significant mechanical differences between osteopenic and osteoporotic bones. Therefore, actions should be taken even if osteopenia is detected.
SCIENTIFIC REPORTS
(2021)
Article
Orthopedics
Jonathan Kusins, Nikolas Knowles, Nicole Martensson, Melanie P. Columbus, George S. Athwal, Louis M. Ferreira
Summary: This study experimentally measured the local strain and ultimate strength of trabecular bone cores from the humeral head, finding that bone volume fraction and bone mineral content strongly influence the apparent ultimate strength of these cores collected from patients with end-stage osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Endocrinology & Metabolism
Huiru Wang, Tianming Du, Rui Li, Russell P. Main, Haisheng Yang
Summary: This study investigated the interactive effects of different loading parameters on fluid velocity and shear stress within the osteocyte lacunar-canalicular system (LCS). The results showed that strain magnitude and rate were the main factors affecting velocity and shear stress, and their combination was not directly additive. The addition of a short rest between cycles enhanced the combined effect of these factors.
Article
Materials Science, Multidisciplinary
A. A. R. Rabiatul, Devi Rianti, S. J. Fatihhi, Amir Putra Md Saad, Zulfadzli Zakaria, Anita Yuliati, M. N. Harun, M. R. A. Kadir, Andreas Ochsner, Tunku Kamarul, Khalid M. Saqr, Ardiyansyah Syahrom
Summary: This study investigates the effect of bone marrow on the mechanical environment and structure of trabecular bone during normal walking loading using a Fluid-Structure Interaction (FSI) approach. The findings show that the shear stress value during normal walking is sufficient to minimally regulate cell response. This study provides insights into the mechanobiological response related to nutrient supply to bone cells.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART L-JOURNAL OF MATERIALS-DESIGN AND APPLICATIONS
(2022)
Article
Multidisciplinary Sciences
Pinkal D. Patel, Yen-Lin Chen, Ramesh B. Kasetti, Prabhavathi Maddineni, William Mayhew, J. Cameron Millar, Dorette Z. Ellis, Swapnil K. Sonkusare, Gulab S. Zode
Summary: TRPV4 channels play a crucial role in regulating intraocular pressure and can be activated by increased fluid flow. Impaired TRPV4 channel activity in glaucomatous patients contributes to elevated intraocular pressure, highlighting the importance of TRPV4-eNOS signaling in IOP regulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biophysics
A. A. R. Rabiatul, S. J. Fatihhi, Amir Putra Md Saad, Zulfadzli Zakaria, M. N. Harun, M. R. A. Kadir, Andreas ochsner, Tunku Kamarul Zaman, Ardiyansyah Syahrom
Summary: The study investigated the fluid characteristic and mechanical properties of trabecular bone using the FSI approach, finding moderate correlations between permeability and porosity, surface area in both longitudinal and transverse orientations. Transverse orientation limits fluid flow through trabeculae due to high shear stress. Compared to the longitudinal orientation, transverse orientation exhibits higher permeability.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Orthopedics
Wenting Xu, Cheng Ni, Yuxuan Wang, Guoqing Zheng, Jinshan Zhang, Youjia Xu
Summary: The study revealed a decline in serum Gal-1 levels in mice and men with age-related trabecular bone loss, indicating its potential as a biomarker for BMSC senescence, early osteoporosis diagnosis, and trabecular bone loss monitoring. Gal-1 was positively correlated with bone mineral density and showed differential secretion by BMSC, HSC, and MP in aged mice.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Polymer Science
Sefiu Adekunle Bello, Oluwatosin Eunice Egbanubi, Abdul Ganiyu Funsho Alabi
Summary: This study utilizes snail shell and pumpkin pods to produce nanoparticles for biomedical materials. The nanoparticles were incorporated into high-density polyethylene and examined. The results show that the nanoparticles can improve certain properties of the materials but have some drawbacks. Both nanocomposites are suitable for replacing trabecular bones, but compatibility screening is recommended.
Article
Endocrinology & Metabolism
Samuel T. Robinson, Peter T. Shyu, X. Edward Guo
Summary: Intermittent injections of parathyroid hormone (PTH) and mechanical loading both lead to a net increase in bone mass, with PTH inducing bone accumulation indiscriminately and loading having a stronger effect on plates than rods. The interactions of PTH and loading show synergistic effects on anabolic modeling in trabecular bone and on catabolic modeling on cortical surfaces.
Article
Acoustics
Brent K. Hoffmeister, Evan N. Main, Will R. Newman, Sheldon C. Ebron, Jinsong Huang
Summary: This study investigated the effect of porosity on the frequency dependence of reflected power in cancellous bone. The results showed a moderate frequency dependence, with a maximum change of less than 6 dB over the entire frequency range. The porosity of the specimens had an influence on the reflected power.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Yusuke Osawa, Toshiko Tanaka, Richard D. Semba, Giovanna Fantoni, Ruin Moaddel, Julian Candia, Eleanor M. Simonsick, Stefania Bandinelli, Luigi Ferrucci
Summary: Bone fragility can worsen with age, but biomarkers for detecting emerging osteopenia are not fully understood. The study found a significant association between plasma GDF-15 levels and decline in cortical bone density and mMOI in women, suggesting that higher GDF-15 levels may lead to accelerated decline in bone health. Further research is needed to explore the underlying mechanisms of these gender differences.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Orthopedics
Caroline Ohman-Magi, Ondrej Holub, Dan Wu, Richard M. Hall, Cecilia Persson
Summary: The study aims to provide a comprehensive literature review on density and mechanical properties of human vertebral trabecular bone, finding a large variation in reported densities, mechanical properties, and relationships, with factors such as testing protocols and specimen geometry influencing the results. Standardized testing processes can reduce variability in data, emphasizing the importance of considering this variability when analyzing predictions and recommending the use of models suggested in the review to minimize data variability.
Article
Chemistry, Medicinal
Monika Martiniakova, Veronika Kovacova, Vladimira Mondockova, Karol Svik, Piotr Londzin, Joanna Folwarczna, Marta Soltesova Prnova, Milan Stefek, Radoslav Omelka
Summary: Cemtirestat, a drug with antioxidant ability as an aldose reductase inhibitor, shows potential for treating diabetic neuropathy. However, our study found that it had no significant effect on bone quality in non-diabetic rats, indicating its safety. In diabetic rats, cemtirestat supplementation slightly improved some bone parameters but did not effectively treat diabetic bone disease.
Article
Cell Biology
Min-Cong He, Jia-Qing Tian, Xiao-Ming He, Peng Yang, Tian-Ye Lin, Qing-Wen Zhang, Wei He, Qiu-Shi Wei
Summary: This study aims to investigate and compare the changes in osteocyte morphology and nanomechanical characteristics in different regions of necrotic femoral heads. The results showed that the protein level of SOST was lower in the sclerotic area. In the necrotic area, there was a decrease in bone volume fraction, trabecular thickness, and trabecular number, and an increase in trabecular separation. In the sclerotic area, there was an increase in bone volume fraction, trabecular number, and trabecular thickness, and a decrease in trabecular separation. The elastic modulus and hardness were higher in the sclerotic area compared to the necrotic, normal, and control areas, while they were lower in the necrotic area compared to the healthy area. The number of osteocytes tended to increase in the sclerotic area with more canalicular cells compared to the healthy area and control group.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Biomedical
Xinyao Zhu, Yifan Liu, Jing Ye, Wei Xu, Xuexia Zhao, Tianyan Liu
Summary: This study reveals the adverse effect of acid on dentin in terms of degradation of its fracture toughness. The peritubular dentin plays a significant role in enhancing the dentin's fracture resistance capability. The findings highlight the importance of structural integrity for dentin.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Priya Ranganathan, Vijayakumari Sugumaran, Bargavi Purushothaman, Ajay Rakkesh Rajendran, Balakumar Subramanian
Summary: The study aims to design and fabricate an ultra-easier multi-functional biomedical polymeric scaffold loaded with unique equimolar Ca:P phasic bioactive glass material. The results showed that the G:BG (1:2) ratio is the more appropriate composition for enhanced bio-mineralization and higher surface area. The scaffold can induce mitogenesis in osteoblast cells for hard tissue regeneration and rapid collagen secretion in fibroblast cells for soft tissue regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ziad Guerfi, Oum keltoum Kribaa, Hanane Djouama
Summary: Hydroxyapatite, a biocompatible and bioactive ceramic material, has been widely studied in fields such as orthopedics and plastic surgery. The use of computational tools, especially density functional theory, has become increasingly important in research. In this study, Hydroxyapatite was synthesized using the double decomposition method and quantum mechanical computations were performed using density functional theory. The experimental and computational results confirmed the successful synthesis of Hydroxyapatite and showed good agreement in spectroscopic characterizations.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Sally AbdulHussain Kadhum, Nassier A. Nassir
Summary: In this research, porous composites were successfully prepared and reinforced for bone scaffold applications. The functional groups, pore structure, and composition distribution of the materials were characterized using techniques such as FTIR, Atomic Force Microscopy (AFM), and Scanning Electron Microscopy (SEM).
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Veronika Geiger, Felicitas Mayinger, Moritz Hoffmann, Marcel Reymus, Bogna Stawarczyk
Summary: The study investigated the mechanical properties of four additively manufactured denture base resins in different measurement environments, and found that the measurement environment impacts the strength and fracture toughness of the materials.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Junxiao Wang, Amatjan Sawut, Rena Simayi, Huijun Song, Xueying Jiao
Summary: The development of cost-effective and eco-friendly conductive hydrogels with excellent mechanical properties, self-healing capabilities, and non-toxicity is of great significance in the field of biosensors.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Yijun Zhou, Lisa Ho, Ayan Samanta, Philip Procter, Cecilia Persson
Summary: In this study, soft, non-setting biomaterials based on Hyalectin gels and different morphological parameters of hydroxyapatite (HA) particles were evaluated as potential augmentation materials for orthopaedic implant fixation. The results showed that constructs reinforced with irregularly shaped nano-HA particles and spherically shaped micro-HA particles had significantly higher pull-out force compared to the control group.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Mehdi Jahandardoost, Donald Ricci, Abbas S. Milani, Mohsen Jahandardoost, Dana Grecov
Summary: Tubular flow diverters are important for treating cerebral aneurysms. A new design called VR-eCLIPs has been developed to cover the neck of challenging bifurcation aneurysms. A finite element model has been used to simulate the implantation processes of VR-eCLIPs and assess potential plastic deformation.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marek Traczynski, Adam Patalas, Katarzyna Roslan, Marcin Suszynski, Rafa l Talar
Summary: This article evaluates the forces acting on intravenous needles during insertion into the skin and selects the most suitable model for future research. The experimental results show that needle size, insertion angle, and insertion speed have an influence on the measured force values.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chester Jar, Andrew Archibald, Monica Gibson, Lindsey Westover
Summary: This study evaluates the ASIST technique for assessing the stability of dental implants. The results show that the ASIST technique can reliably measure the interfacial stiffness of dental implants, which is not significantly influenced by different abutment types. This method may provide an improved non-invasive way to measure the stability of dental implants.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Ali Kamali, Kaveh Laksari
Summary: In this paper, a UNet-based neural network model (El-UNet) is developed to infer the spatial distributions of mechanical parameters. The El-UNet shows superior performance in terms of accuracy and computational cost compared to other neural network models. A self-adaptive spatial loss weighting approach is proposed, which achieves the most accurate reconstructions in equal computation times.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Chunyan Yu, Yanju Lu, Jinhui Pang, Lu Li
Summary: In this study, a safe and effective hemostatic composite sponge was developed by combining chitosan and hydroxypropylmethylcellulose (HPMC). The sponge exhibited excellent flexibility and rapid hemostatic ability in vitro. In vivo assessments showed that the sponge had the shortest clotting time and minimal blood loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Zhongliang Yu, Lin Yu, Junjie Liu
Summary: The study proposes incorporating functionally graded tablets into nacreous composites to enhance both stiffness and damping properties. Analytical formulae and numerical experiments demonstrate the effectiveness of this design, surpassing existing homogeneous composites in performance.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Marc Graham, Sandra Klinge
Summary: This study investigates the macroscopic diffusion behavior of heterogeneous gels using a homogenization method in a finite element framework. Two materials, calcifying PDMA and PAAm, were studied, and the results show that the diffusivity of PDMA has a strong nonlinear dependence on the solute molecule radius.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
Article
Engineering, Biomedical
Abdur-Rasheed Alao
Summary: This study aimed to find the optimal sandblasting parameters for roughening YTZP surfaces. Through experimental and statistical analysis, the best setting was found to be IA = 45 degrees, AP = 110 μm, ST = 20 s, and P = 400 kPa, which resulted in the maximum surface roughness, phase transformation, and shear bond strength.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2024)
