Journal
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
Volume 62, Issue 8, Pages 1108-1113Publisher
KOREAN PHYSICAL SOC
DOI: 10.3938/jkps.62.1108
Keywords
Osteoporosis; Trabecular bone; Bone density; Quantitative ultrasound; Speed of sound; Normalized broadband ultrasound attenuation; Nonlinear parameter B/A
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Funding
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Education, Science and Technology [2011-0014292]
- National Research Foundation of Korea [2011-0014292] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The purpose of the present study is to investigate the feasibility of assessing bone status and osteoporosis by using the nonlinear parameter B/A in bovine trabecular bone in vitro. The B/A values measured in 18 bovine femoral trabecular bone samples by using a finite-amplitude through-transmission method ranged from 63.3 to 122.6. The apparent bone density was highly correlated with the B/A and with the existing quantitative ultrasound parameters of the speed of sound (SOS) and the normalized broadband ultrasound attenuation (nBUA), with Pearson's correlation coefficients of r = 0.83 to 0.96. The best univariate predictor of the apparent bone density was the B/A, with an adjusted squared correlation coefficient of r (2) = 0.91. These results suggest that the B/A, in addition to the SOS and the nBUA, may have potential as an index for the assessment of bone status and osteoporosis.
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