Article
Chemistry, Physical
Mengyu Li, Xin Han, Zewen Fan, Hao Chen, Yu Zhang, Lin Zhang, Dan Guo, Guoxin Xie
Summary: This study reports a self-repairing polyurethane material that can target repair large-scale damage with a width of over 1 mm. The self-repair effect of the material is controlled by the disordered hydrogen bonds within the polyurethane chain segments. The targeted repair effect, induced by temperature, is caused by the difference between the internal and external chemical components of the polyurethane. The molecular configuration changes caused by the synergistic dynamic bond structure result in targeted and large-scale damage self-repairing effects.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Polymer Science
Klaudia Ordon, Piotr Szatkowski, Wojciech Piekarczyk, Elzbieta Pamula, Kinga Pielichowska
Summary: Novel polyurethane-based materials were synthesized using a two-step process with poly(epsilon-caprolactone) diol (PCL) and 1,3-propanediol/starch (PDO/ST) systems as chain extenders/cross-linkers. Poly(ethylene glycol)/starch (PEG/ST) system as a phase change material (PCM) decreased the maximum setting temperature, and hydroxyapatite (HAp) was used as a bioactive nanofiller. The synthesized polyurethanes showed good energy storage effect and potential application for bone cements.
Article
Engineering, Electrical & Electronic
Suphassa Pringpromsuk, Hong Xia, Qing-Qing Ni
Summary: A tube actuator was successfully fabricated by incorporating SMPU with DBA plasticizer, producing softness and glass transition temperature close to human body temperature. The addition of DBA plasticizer to SMPU resulted in a faster recovery rate and a shape recovery ratio of up to 83%. The biocompatibility and non-toxicity of the tube make it a promising candidate for clinical applications.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Thermodynamics
Monika Szlachta, Klaudia Ordon, Katarzyna Nowicka, Kinga Pielichowska
Summary: The thermal properties of PU materials depend on the load of polysaccharides and bioceramics, with an increase in chitosan fraction leading to higher glass transition temperature and onset temperature of degradation. However, the presence of ceramics did not significantly impact the thermal properties of PU composites.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2021)
Article
Materials Science, Multidisciplinary
Giovanni Carlo Miceli, Annalisa Martorana, Francesco Cancilla, Giovanna Pitarresi, Mariano Licciardi, Fabio Salvatore Palumbo
Summary: A solid biodegradable elastomer with strong adhesion capability was successfully synthesized by incorporating a dopamine-based adhesive moiety into segmented polyurethanes. The material displayed a low melting point, high adhesion strength, and showed potential applications in various fields. Moreover, the degradation products of the material after 6 months of hydrolytic degradation were found to be non-toxic to cells.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Polymer Science
Liyun Yuan, Wei Zhou, Yong Shen, Zhibo Li
Summary: The large-scale production and disposal of petroleum-derived commercial polyurethane materials have caused severe environmental problems. While bio-based or biodegradable polyols have attracted attention for preparing sustainable polyurethanes, the chemical recycling of polyurethanes to recover monomers or value-added building blocks remains a major challenge. This study addresses this challenge by preparing biodegradable and chemically recyclable polyurethanes using bio-based telechelic hydroxyl terminated poly(gamma-butyrolactone) diols as precursors. The resulting polyurethanes exhibit thermoplastic or elastomeric properties depending on the molar mass of the used diol precursors. The thermal, mechanical, and hydrolytic properties of the polyurethanes based on poly(gamma-butyrolactone) are systematically investigated. Remarkably, these polyurethanes can be chemically recycled to recover gamma-butyrolactone with high purity in almost quantitative yield through a simple vacuum distillation procedure.
POLYMER DEGRADATION AND STABILITY
(2022)
Article
Polymer Science
Amin Babaie, Mostafa Rezaei, Donya Razzaghi, Hossein Roghani-Mamaqani
Summary: Thermally and magnetically stimulated shape memory polyurethane nanocomposites were synthesized for intravascular stent applications. The addition of modified magnetic nanoparticles improved the affinity between the nanocomposites and the PU matrix, resulting in enhanced mechanical properties and shape memory behavior.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yuvaraj Arun, Radhakanta Ghosh, Abraham J. Domb
Summary: Biodegradable, hydrophobic, and injectable liquid polymers are able to achieve sustained, local drug release, with potential applications in regenerative medicine.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Green & Sustainable Science & Technology
Hyeonseo Joo, Sujeong Gwak, Mun Hwan Lee, Hyosik Park, Cheoljae Lee, Ju Hun Lee, Sang A. Han, Ju-Hyuck Lee
Summary: This study presents the design of a biodegradable TPU for the development of high-powered TENGs with controlled biodegradability. The modified TPU-based TENG exhibited significantly increased output performance, reaching a voltage of 74.03V and a current of 1.98 mu A. The maximum power density was increased by approximately 1423 times compared to the native TPU-based TENG.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2023)
Article
Polymer Science
Amal Patel, Bhausaheb S. Rajput, Thien An Phung Hai, Daniel Zhen, Natasha R. Gunawan, Marissa Tessman, Jaysen Reindel, Jenna Shepherd, Ryan Simkovsky, Robert S. Pomeroy, Naser Pourahmady, Stephen P. Mayfield, Michael D. Burkart
Summary: Non-biodegradable petroleum-based plastic wastes are a major environmental concern. New efforts are being made to develop biobased and biodegradable alternatives. In this study, waterborne, biodegradable adhesives with over 70% biocontent were developed, avoiding viscosity challenges and the use of volatile organic solvents. The resulting polyurethane dispersions showed good material properties and met the desired mechanical and biodegradability targets, indicating their viability as lamination adhesives.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Polymer Science
Reihaneh Farajollah, Mir Mohammad Alavi Nikje, Ebrahim Saadat, Farid Abedin Dorkoosh
Summary: In this study, a novel three-dimensional waterborne polymer network containing a pentol star core was designed and synthesized. The polymer showed increased hydrophilicity, degradability, and biocompatibility compared to the core material. These results suggest that the prepared polymer has potential for biomedical applications in the future.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Physical
Mohamed Alaa Mohamed, Clayton L. Rumsey, Martin Trebbin, Stelios T. Andreadis
Summary: Multifunctional supramolecular polyurethane elastomers with high toughness and fast autonomous self-healing capacity at room temperature were developed. The elastomers exhibited high strength, notch insensitivity, and high fracture energy, and recovered almost 90% of their original toughness within 6 hours post-injury.
CHEMISTRY OF MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Herbert Canziani, Benedikt Hanschmann, Florentin Tischer, Alexander Sommereyns, Thomas Distler, Jonas Schramm, Nicolas Hesse, Jochen Schmidt, Alina Gruenewald, Rainer Detsch, Aldo Boccaccini, Michael Maskos, Michael Schmidt, Nicolas Vogel
Summary: This study introduces a supraparticle-based approach to manufacture biodegradable poly(lactic acid) and composite powders for additive manufacturing of bone replacement materials. The supraparticle powders, prepared through a scalable spray-drying process, exhibit controlled particle size, shape, and composition. The optimized supraparticle powders are successfully used in laser powder bed fusion of polymers, demonstrating relevant functional properties such as biodegradation and bioactivity.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Alina Kirillova, Taylor R. Yeazel, Darya Asheghali, Shannon R. Petersen, Sophia Dort, Ken Gall, Matthew L. Becker
Summary: The goal of this review is to provide a guide for the fabrication of biodegradable polymer-based scaffolds that includes the complete pathway starting from selecting materials, choosing the correct fabrication method, and considering the requirements for tissue specific applications of the scaffold.
Article
Polymer Science
Fanhao Zeng, Jingyi Ning, Yunyun Yang, Chong Tian, Lei Huang, Fuqi Zhao, Qiang Liu, Meiling Cui, Jiahao Lv, Yunfeng Jiang, Xufu Cai, Weibo Kong
Summary: This study proposes a strategy to fabricate photohealable polyurethanes (PHPUs) by molecule design, which exhibit superior mechanical robustness, high healing ratio, and shape programming under infrared control.
Review
Pharmacology & Pharmacy
Martyna Zagorska-Dziok, Marcin Sobczak
Article
Chemistry, Physical
Adam Kasinski, Monika Zielinska-Pisklak, Ewa Oledzka, Grzegorz Nalecz-Jawecki, Agata Drobniewska, Marcin Sobczak
Summary: A novel hydrogel drug delivery system capable of prolonged and controlled release of 5-FU was developed using CL-PEG and rac-LA-PEG copolymers, which were synthesized through the ring-opening polymerization process. The copolymers were chemically crosslinked and exhibited controlled release profiles with first-order or zero-order kinetics. The release mechanism was generally categorized as non-Fickian transport, showing potential for future applications in drug delivery.
Article
Biochemistry & Molecular Biology
Martyna Zagorska-Dziok, Patrycja Kleczkowska, Ewa Oledzka, Ramona Figat, Marcin Sobczak
Summary: Polymeric hydrogels play an increasingly important role in medicine, pharmacy, and cosmetology due to their favorable physicochemical properties and biocompatibility. This study synthesized new poly(chitosan-ester-ether-urethane) hydrogels and studied the kinetic release of genistein from these biomaterials. The developed hydrogels show non-toxicity to skin cells and a relatively highly controlled release profile of genistein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Adam Kasinski, Monika Zielinska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak
Summary: The paper developed injectable, thermosensitive smart hydrogel local drug delivery systems releasing the model antitumour drug 5-fluorouracil (5-FU). The biodegradable triblock copolymers synthesized through ring opening polymerization showed a sharp sol-gel transition at physiological temperature, with good mechanical properties at 37°C. In vitro release kinetics characterization indicated good control, with a total drug release time of approximately 12 hours.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Bialik, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: Rectal drug delivery offers a viable option for both local and systemic medication. Recent developments in thermosensitive liquid suppositories have shown promise, despite current limitations. Further research and development are necessary to fully uncover the potential of rectal drug delivery systems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Izabela M. Domanska, Anna Zgadzaj, Sebastian Kowalczyk, Aldona Zalewska, Ewa Oledzka, Krystyna Ciesla, Andrzej Plichta, Marcin Sobczak
Summary: Aliphatic polyesters are commonly used biodegradable synthetic polymers in pharmaceutical applications. This report investigates the ring-opening polymerization of L-lactide, epsilon-caprolactone, and glycolide using a simple and inexpensive catalytic system. The resulting polyesters have been characterized and their thermal properties have been determined. The study also examines the effects of temperature, reaction time, and catalyst content on the polymerization process. The obtained polyesters are non-cytotoxic and non-genotoxic, making them suitable for medical applications. The copolymers have a random distribution of comonomer units along the polymer chain.
Review
Biochemistry & Molecular Biology
Marcin Sobczak
Summary: Fast advances in polymer science have led to the development of new hydrogels for drug delivery. Among them, stimuli-responsive hydrogels, also known as smart hydrogels, have shown great potential for pharmaceutical and biomedical applications. Enzyme-responsive hydrogels, in particular, have attracted much interest due to their ability to respond to various enzymes under mild conditions, leading to reversible or irreversible changes in their properties. This article reviews the current state of enzyme-responsive hydrogels designed for controlled drug delivery systems, including the enzymes used for their preparation and the strategies employed to produce them.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Marcin Sobczak, Karolina Kedra
Summary: With the development of polymeric biomaterials, drug delivery systems (DDSs) have become crucial in cancer therapy. Polyurethanes (PUs) are widely used in medicine and biomaterial engineering, and can be synthesized for anti-cancer DDSs by selecting suitable building blocks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Strzelecka, Urszula Piotrowska, Marcin Sobczak, Ewa Oledzka
Summary: We used biodegradable polyesters for the delivery of CPT and its analogues. The delivery systems can either adsorb the drug on the polymer's surface, encapsulate it within the polymer's macrostructure, or form a hydrolyzed chemical bond between the drug and the polymer chain. This delivery system can reduce the systemic toxicity and serious side effects associated with conventional cancer therapies and increase drug availability at the target site.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Bialik, Joanna Proc, Anna Zgadzaj, Karolina Mulas, Marzena Kuras, Marcin Sobczak, Ewa Oledzka
Summary: This study developed thermosensitive liquid suppositories carrying the antihypertensive drug metoprolol tartrate. It was the first to use biodegradable nanoparticles to produce liquid metoprolol suppositories and optimized their rheological and mechanical properties for rectal administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Adam Kasinski, Agata Swierczek, Monika Zielinska-Pisklak, Sebastian Kowalczyk, Andrzej Plichta, Anna Zgadzaj, Ewa Oledzka, Marcin Sobczak
Summary: The aim of this study was to develop a dual-stimuli-responsive smart hydrogel local drug delivery system (LDDS) that can be used for simultaneous chemotherapy and magnetic hyperthermia (MHT) antitumor treatment. The hydrogels were made from a biocompatible and biodegradable copolymer and characterized for their gel-forming and rheological properties. Magnetic iron oxide nanoparticles (MIONs) were created using the coprecipitation method and showed superparamagnetic properties when subjected to an alternating magnetic field (AMF). The MIONs/hydrogel matrices displayed controlled and prolonged release of paclitaxel (PTX), making them promising for combined chemotherapy and hyperthermia treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ewa Oledzka, Klaudia Pasnik, Izabela Domanska, Monika Zielinska-Pisklak, Urszula Piotrowska, Marcin Sobczak, Lukasz Szeleszczuk, Anna Laskowska
Summary: This study focuses on the encapsulation of camptothecin (CPT) in the poly(amidoamine) (PAMAM) dendrimer macromolecule to overcome its hydrophobicity, toxicity, and instability. The synthesized PAMAM dendrimer/CPT complex exhibited slow and controlled drug release, good hemocompatibility, and selective cytotoxicity against non-small-cell lung cancer cells. Molecular modeling studies showed that lactone form of CPT was more favorable for complex formation.
Article
Medicine, Research & Experimental
Karolina Banys, Joanna Giebultowicz, Marcin Sobczak, Rafal Wyrebiak, Wojciech Bielecki, Robert Wrzesien, Barbara Bobrowska-Korczak
Summary: The study found that dietary supplementation of genistein led to an increase in the excretion of methylated derivatives in the urine of rats. Animals on the control diet showed increasing or relatively low levels of methyl derivatives throughout the study, while those on diets supplemented with genistein had consistently high levels of methylated derivatives. High levels of methyl derivatives may have an influence on carcinogenesis.
Article
Pharmacology & Pharmacy
Kinga Byk, Filip Charuk, Ewa Oledzka, Marcin Sobczak, Monika Zielinska-Pisklak
Summary: Paclitaxel is a natural anti-cancer drug derived from the Pacific yew tree, known for its ability to block the cell cycle and inhibit mitosis through microtubule depolymerization, ultimately leading to cell necrosis.
BIULETYN WYDZIALU FARMACEUTYCZNEGO WARSZAWSKIEGO UNIWERSYTETU MEDYCZNEGO
(2021)
Article
Pharmacology & Pharmacy
Aleksandra Grodzka, Wiktoria Kuzaj, Monika Zielinska-Pisklak, Lukasz Szeleszczuk, Marcin Sobczak
Summary: Coffee contains various active substances, including caffeine, chlorogenic acid, kahweol and cafestol, and trigonelline. These substances have different pharmacological effects and potential side effects.
BIULETYN WYDZIALU FARMACEUTYCZNEGO WARSZAWSKIEGO UNIWERSYTETU MEDYCZNEGO
(2021)
