Article
Biochemistry & Molecular Biology
Guan-Ting Liu, Yong-Liang Li, Jing Wang, Chang-Zhi Dong, Minggao Deng, Meiling Tai, Lili Deng, Biao Che, Li Lin, Zhi-Yun Du, Hui-Xiong Chen
Summary: Our study showed that Lycium barbarum extract can reduce ROS and matrix metalloproteinase levels, enhance antioxidant defense system, increase skin collagen content, and improve UV-induced skin issues, suggesting its potential as a natural and cost-effective treatment for skin diseases with defective barrier function.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Dermatology
Elise Boireau-Adamezyk, Arlette Baillet-Guffroy, Georgios N. Stamatas
Summary: The study showed that age and environmental exposure can affect the water content and composition of natural moisturizing factors in the stratum corneum. While the water content decreases with age, the concentrations of various amino acids show species-specific changes. The dynamics of NMF composition may partially explain the age-related changes in SC hydration.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2021)
Article
Food Science & Technology
Mahendra P. Kapoor, Hiroaki Yamaguchi, Hitomi Ishida, Yoichi Mizutani, Derek Timm, Aya Abe
Summary: The dose-response study of prebiotic partially hydrolyzed guar gum (PHGG) dietary fiber supports the gut microbiome and improves gastrointestinal health, which is crucial for healthy skin. The ingestion of 6 and 12 g/day PHGG helps maintain constant moisture levels in the surface skin stratum corneum, preventing dryness and textural disorder to the skin. This study suggests a link between improved gut environment and increased hydration level of the skin, emphasizing the importance of consuming prebiotic PHGG dietary fiber.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Iuliana Popa, Audrey Solgadi, Didier Pin, Adrian L. Watson, Marek Haftek, Jacques Portoukalian
Summary: Golden Retrievers may suffer from Pnpl1-related inherited ichthyosis, leading to an increase in the specific form of linoleic acid, 9-KODE, in the stratum corneum. The production of 9-KODE is mainly through dehydration of HpODE. This keto-derivative is significantly increased in ichthyotic dogs.
Article
Biochemistry & Molecular Biology
Miyeong Lee, Eunjoung Kim, Hyunwoo Ahn, Seokjun Son, Hyunjun Lee
Summary: Collagen hydrolysate, containing bioactive peptides, has been shown to improve the elasticity, hydration, desquamation, and wrinkling of aging human skin. In a double-blind, randomized, and placebo-controlled study, we found that daily intake of a collagen peptide (CPNS) with dipeptides Gly-Pro and Pro-Hyp, had significant positive effects on skin health. After 12 weeks of administration, skin desquamation, hydration, wrinkling, and elasticity were all improved compared to the placebo group.
Article
Dermatology
Elea Thibault Greugny, Jalil Bensaci, Francois Fages, Georgios N. Stamatas
Summary: This study explains the impact of skin surface pH on the structural and physiological properties of the skin using an agent-based model. A less acidic pH weakens the skin barrier function and intensifies skin inflammation.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Burcu Yeni, Alexander Dermietzel, Charalampos Varnava, Philipp Wiebringhaus, Matthias Aitzetmueller, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus
Summary: Researchers have successfully regenerated skin through combined gene and stem cell therapy, and demonstrated its excellent long-term stability. Analysis of biomechanical properties showed significant differences between the transgenic epidermis, non-transgenic skin, and healthy controls. The study suggests potential applications for this technology in treating burns and other conditions.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Burcu Yeni, Alexander Dermietzel, Charalampos Varnava, Philipp Wiebringhaus, Matthias Aitzetmueller, Marie-Luise Klietz, Tobias Hirsch, Maximilian Kueckelhaus
Summary: The study reported the successful regeneration of an entire epidermis through combined gene and stem cell therapy. It also showed the long-term stability of the transgenic epidermis and its potential application in other conditions. The biomechanical properties of the transgenic epidermis demonstrated comparable results to normal skin and healthy controls.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Geriatrics & Gerontology
Bin Yang, Mao-Qiang Man
Summary: As we age, both cutaneous and extracutaneous disorders may develop, and there is a certain degree of association between skin abnormalities and aging-associated disorders. Inflammatory dermatoses like psoriasis and atopic dermatitis are associated with the development of cardiovascular diseases, obesity, and type 2 diabetes. Chronologically aged skin and individuals with aging-associated systemic conditions exhibit altered epidermal function, such as reduced stratum corneum hydration levels, which can lead to cutaneous inflammation. The higher expression levels of inflammatory cytokines in aged skin play a pathogenic role in various aging-associated health conditions, suggesting that the association of skin with aging-associated disorders is likely mediated by inflammation.
CLINICAL INTERVENTIONS IN AGING
(2023)
Article
Engineering, Environmental
Zhengyang Sun, Zhiyong Yang, Yusheng Jiang, Hongji Gao, Kuanda Fang, Minglun Yin
Summary: The research focused on the impact of particle size distribution, test time, and moisture content on the Laboratoire Central des Ponts et Chaussees (LCPC) abrasivity coefficient (LAC). An optimized effective size (ESop) index was established as a more accurate indicator for determining the LAC of soil samples. The study found that soil samples with moisture content lower than saturation had a higher LAC than dry soil samples, while samples with moisture content higher than saturation had a similar LAC to dry samples.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2021)
Article
Dermatology
Yuka Maeda, Chizuru Fujikura, Takashi Asama, Masayuki Yagi, Nobuaki Okumura, Ayanori Yamaki, Akio Ohkuma, Kayoko Numano
Summary: This study evaluated the moisturizing function and other effects of royal jelly extract on the skin. The results showed that applying an essence containing royal jelly extract to the cheeks can significantly increase the water content of the stratum corneum, confirming the improvement in the moisturizing function of royal jelly extract.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ferdinand Fandrei, Tomas Havrisak, Lukas Opalka, Oskar Engberg, Albert A. Smith, Petra Pullmannova, Norbert Kucerka, Veronika Ondrejcekova, Bruno Deme, Lucie Novakova, Milos Steinhart, Katerina Vavrova, Daniel Huster
Summary: In this study, we synthesized Cer[EOS] with selectively deuterated segments of the ultralong N-acyl chain or deuterated or C-13-labeled linoleic acid and investigated their molecular behavior in a skin lipid model. The results showed surprising molecular dynamics for the ultralong N-acyl chain of Cer[EOS] and high mobility of the sphingosine moiety at skin temperature. The arrangement of the skin barrier lipids with alternating fluid, rigid, and isotropic layers offers a straightforward way to remodel the lamellar body lipids into the final lipid barrier.
JOURNAL OF LIPID RESEARCH
(2023)
Review
Medicine, General & Internal
Mohammad Adnan, Roshan K. Jha, Priyanshu Verma, Harsh N. Shah, Parth Singh
Summary: Food supplements can modify skin functions and help manage skin aging, but there is a lack of clinical trials to support these claims. The stratum corneum plays a crucial role in the epidermis of land vertebrates, and antioxidants are chemicals that can slow down or prevent oxidation. Hydrolyzed collagen is thought to be an antioxidant. Skin aging is a complex process influenced by both internal and external factors, and sun exposure is the primary cause of skin cancer. The hydration of the skin affects its characteristics, and moisturizers are important tools for dermatologists, although their scientific functions are not fully understood.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Nursing
Vita Boyar, Tuisha Desai
Summary: This study investigated the effects of a no-sting liquid barrier film (NSLBF) on the skin condition and maturation of premature neonates. The results showed that on the treated side, the skin condition worsened and hydration decreased, indicating an altered or delayed process of skin maturation. Therefore, it is recommended to limit the use of NSLBF to skin under medical devices, dressings, tapes, and affected areas, and to allow adequate intervals for physiological stratum corneum maturation between applications of NSLBF.
JOURNAL OF WOUND OSTOMY AND CONTINENCE NURSING
(2023)
Article
Nutrition & Dietetics
Paul A. Roberson, C. Brooks Mobley, Matthew A. Romero, Cody T. Haun, Shelby C. Osburn, Petey W. Mumford, Christopher G. Vann, Rory A. Greer, Arny A. Ferrando, Michael D. Roberts
Summary: The study found that amino acid transporters and metabolic enzymes are influenced by resistance exercise training, but do not appear to determine muscle fiber hypertrophy; in cell experiments, overexpression of LAT1 protein caused a decrease in protein synthesis levels.
FRONTIERS IN NUTRITION
(2021)
