Article
Nanoscience & Nanotechnology
Zhongbin Zhang, Jinqing Chen, Linghui Zou, Jing Tang, Jiaxin Zheng, Meijiao Luo, Gang Wang, Dan Liang, Yuyang Li, Ben Chen, Hongjun Yan, Wenya Ding
Summary: CD-CS-BA-NPs were successfully prepared and demonstrated enhanced elimination of S. aureus biofilm, providing a potential reference for the development of anti-biofilm agents.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Polymer Science
Fernanda Petzold Pauli, Cyntia Silva Freitas, Patricia Ribeiro Pereira, Alvicler Magalhaes, Fernando de Carvalho da Silva, Vania M. F. Paschoalin, Vitor Francisco Ferreira
Summary: In this study, chemically-modified chitosan (CS), namely 1,4-NQ-CS and 1,2-NQ-CS, were synthesized using 2,3-dichloro-1,4-naphthoquinone and the sodium salt of 1,2-naphthoquinone-4-sulfonic acid. The synthesized compounds exhibited excellent antimicrobial activities and cytotoxicity, making them suitable for safe application to human tissue. However, caution should be exercised due to the cytotoxicity of 1,4-NQ-CS against breast cancer cells.
Article
Materials Science, Multidisciplinary
Monisha Joy Williams, Sudhaker Raboni Grace, Varnitha Manikantan, Aleyamma Alexander, Govindaraj Sri Varalakshmi, Sivaraj Ramasamy, Archana Sumohan Pillai, Israel V. M. V. Enoch, Dariela Nunez
Summary: In this study, lanthanum-doped carbon dots were developed as a nanocomposite for delivering the anticancer drug camptothecin. The nanocomposite showed promising results as a drug delivery agent, with a high encapsulation efficiency and slow release of the drug.
Review
Polymer Science
Nimish Moramkar, Purvi Bhatt
Summary: Cancer is a complex chronic disease with limitations in current treatment methods, but nanotechnology based on chitosan has emerged as a potential drug delivery vector for tumor therapy. Chitosan-based nanocomplexes offer advantages such as biocompatibility and targeted drug delivery, improving treatment efficiency.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Chemistry, Applied
Stylianos Panagiotakis, Barbara Mavroidi, Alexandros Athanasopoulos, Antonio Ricardo Goncalves, Loic Bugnicourt-Moreira, Theo Regagnon, Nikos Boukos, George Charalambidis, Athanasios G. Coutsolelos, Mantas Grigalavicius, Theodossis A. Theodossiou, Kristian Berg, Catherine Ladaviere, Maria Pelecanou, Konstantina Yannakopoulou
Summary: In order to target cancer cell lysosomes for drug transport and light-controlled release, we synthesized new conjugates of beta-cyclodextrin with highly hydrophobic triphenylporphyrin. These conjugates self-assemble into similar nanoparticles in water and selectively target the lysosomes of breast adenocarcinoma cells. The nanoparticles exhibit photoactivity and can bind with different anticancer drugs.
CARBOHYDRATE POLYMERS
(2023)
Article
Pharmacology & Pharmacy
Mahsa Shahriari, Prashant Kesharwani, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Cancer is a widespread disease with various treatment modalities and challenges. Chemotherapy has limitations due to toxicity and drug resistance. Curcumin, a natural compound with multiple therapeutic properties, has poor solubility and limited bioavailability. Cyclodextrin complexes of curcumin improve its properties, and beta-cyclodextrin is commonly used. This review focuses on comparing different curcumin-cyclodextrin formulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Yixin Wang, Wen Li, Zhaoting Li, Fanyi Mo, Yu Chen, Mari Iida, Deric L. Wheeler, Quanyin Hu
Summary: Immune checkpoint inhibitors (ICIs) have potential in treating various tumors by reinvigorating T cells. Researchers propose a delivery strategy to enhance tumor-selective ICI accumulation by utilizing platelet responsiveness to coagulation signals. A fused protein tTF-RGD targets tumor blood vessels and initiates local coagulation, attracting platelets conjugated with anti-PD-1 antibodies to release them for improved immunotherapy. The study also demonstrates enhanced accumulation and efficacy of chemotherapeutics using platelet membrane-coated nanoparticles. This versatile platform utilizes platelet responsiveness for improved local accumulation of ICIs and chemodrugs.
Review
Biochemistry & Molecular Biology
Christoph Federer, Markus Kurpiers, Andreas Bernkop-Schnurch
Summary: Thiolation of chitosan allows for customization of various properties to meet specific needs in a wide range of application areas, with advantageous characteristics such as adhesion, adjustable cross-linking and swelling behavior, controllable drug release, cellular uptake enhancement, complexation of metal ions, and antioxidative properties, while remaining biodegradable without increased toxicity.
Article
Biochemistry & Molecular Biology
Yujin Lee, Nanhee Song, Nuri Kim, Manseok Yang, Gayoung Kwon, Hyejin Hyeon, Eunkyeong Jung, Seong-Cheol Park, Chunho Kim, Dongwon Lee
Summary: A ROS-generating polyprodrug of cinnamaldehyde (CA) has been developed, which serves as a drug carrier and synergizes with drug payloads. The polyprodrug can self-assemble with a tumor-targeting lipopeptide and encapsulate doxorubicin to exert synergistic anticancer actions.
Article
Chemistry, Multidisciplinary
Shahbaz Ahmed, Masood Nadeem, Irfan Hussain, Sana Fatima, M. Moshahid A. Rizvi, Mohammad Tabish
Summary: Cancer damages healthy cells and organs, and the toxic effects of anticancer drugs on these cells is a major concern. This study focused on the encapsulation of the well-studied anticancer drug chlorambucil into nanosized formulations, which improved its delivery system. Various characterization studies were conducted to optimize the size, charge, efficiency, release profile, stability, and interaction of the chlorambucil nanosized formulations. The study also investigated the cytotoxicity, uptake, and interaction of the nanosized formulations with cancer cells.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Hua Guo, Huimin Wang, Hong Deng, Yiyi Zhang, Xue Yang, Weiqi Zhang
Summary: Photodynamic therapy (PDT) is an effective treatment for cancer, and the use of nanocarriers can improve the toxicity of photosensitizers (PSs) and enhance treatment outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Roberto Zagami, Anna Barattucci, Luigi Monsu Scolaro, Maurizio Viale, Giuseppina Raffaini, Paola Maria Bonaccorsi, Antonino Mazzaglia
Summary: This article introduces the potential application of non-ionic cyclodextrin-based nanoassemblies as nanocomplex adjuvants in anticancer therapy. The nanoassemblies were prepared by solvent evaporation method and characterized by spectroscopic techniques. Theoretical studies were performed to understand the formation and stability of the nanoassemblies. Experimental results showed that the nanoassemblies exhibited similar anticancer activity to free curcumin in different cancer cell lines.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Multidisciplinary Sciences
Fereshteh Vajhadin, Mohammad Mazloum-Ardakani, Mahdie Hemati, Seyed Mohammad Moshtaghioun
Summary: Circulating tumor cells (CTCs) are important markers for early detection of metastasis, tumor recurrence, and treatment effectiveness. This study explored the use of ZnFe2O4 magnetic nanoparticles for capturing CTCs that express specific cell surface markers. Functionalization of ZnFe2O4 nanoparticles with folic acid allowed for specific binding to folate bioreceptors on MCF-7 breast cancer cells. The study also demonstrated the effectiveness of a cost-effective ZnFe2O4-based biosensing platform for cancer cell detection and quantification.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Hossein Hosseinzadeh, Ziba Jahanbakhsh, Bakhshali Masoumi, Vahid Hooshangi
Summary: A novel beta-CD-based magnetic nanocarrier with superparamagnetic and molecular recognition properties was synthesized for controlled drug release. The nanocarrier showed efficient loading and releasing behaviors of doxorubicin, with drug loading efficiency dependent on initial drug concentration, beta-CD content, and temperature. The in vitro release rate of doxorubicin was found to be pH-dependent, and the nanocarrier exhibited high performance in killing cancerous cells.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Chemistry, Physical
Amy Oo, Panupong Mahalapbutr, Kuakarun Krusong, Ponsiri Liangsakul, Sariyarach Thanasansurapong, Vichai Reutrakul, Chutima Kuhakarn, Phornphimon Maitarad, Atit Silsirivanit, Peter Wolschann, Siyaporn Putthisen, Khanittha Kerdpol, Thanyada Rungrotmongkol
Summary: Encapsulation with beta-cyclodextrin (β-CD) has been explored to enhance the solubility of emodin (ED) for pharmaceutical applications. In this study, inclusion complexation of ED with β-CD and its derivatives was performed to identify the most promising drug carrier. The ED/DM-β-CD complex showed the highest stability and water solubility, followed by ED/SBE7-β-CD and ED/HP-β-CD complexes. The SEM micrographs and DSC thermograms confirmed the inclusion complex formation, and molecular docking suggested C-form insertion as the preferred binding mode. Moreover, the inclusion complexes, especially ED/DM-β-CD, showed significantly higher anti-proliferative effects on cancer cell lines compared to ED alone.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Fantahun Aklog Yihun, Shinsuke Ifuku, Hiroyuki Saimoto, Hironori Izawa, Minoru Morimoto
Article
Chemistry, Multidisciplinary
Hironori Izawa, Yuta Toyoshima, Minoru Morimoto, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The results show that oriented chitosan films prepared by elongation can be applied to surface wrinkling systems via a horseradish peroxidase-catalyzed surface reaction of ferulic acid and drying, resulting in different wrinkle morphologies influenced by drying compression stress.
Article
Chemistry, Multidisciplinary
Hironori Izawa, Fumika Yasufuku, Toshiki Nokami, Shinsuke Ifuku, Hiroyuki Saimoto, Toru Matsui, Kenji Morihashi, Masato Sumita
Summary: The study investigated the photo-induced colorimetric reaction mechanism of different cationic receptors, suggesting that substituents on the naphthalene ring can facilitate the generation of naphthalimide-based radical anions. Additionally, it was found that the trimethylammonium group plays a crucial role in stabilizing the radical anion species.
Article
Materials Science, Paper & Wood
Mizuki Kishimoto, Hironori Izawa, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The study successfully obtained chitin nanofibers of different colors using reactive dyes, which are resistant to hot water and detergents and can be mixed to produce a variety of colors. Through evaluation using reflection spectrum and color space, the optimal ratio of reactive dye to chitin was determined to be 5%, while maintaining the morphology of the nanofibers.
Article
Polymer Science
Dagmawi Abebe Zewude, Hironori Izawa, Shinsuke Ifuku
Summary: The alpha-chitin derived from crab shells was partially deacetylated with 30% sodium hydroxide to obtain a deacetylation degree of 36%. Partially deacetylated chitin nanofibers were successfully prepared using weak ultrasonic energy from a domestic ultrasonic cleaner. The optimal conditions for obtaining fine nanofibers with high yield were found to be ultrasonication at 45 kHz frequency for 20 minutes.
Article
Polymer Science
Koichi Tanabe, Hironori Izawa, Shinsuke Ifuku
Summary: Utilizing the emulsion-forming ability of partially deacetylated chitin nanofibers, a composite with polystyrene was prepared, significantly improving the mechanical and thermal properties of polystyrene. The optimal mixing ratio of chitin nanofibers for improving mechanical properties was 7%. The composite material showed good recyclability without a decrease in mechanical properties after hot pressing molding.
Article
Chemistry, Applied
Hironori Izawa, Tomoe Yonemura, Yumi Nakamura, Yuta Toyoshima, Momoka Kawakami, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: This study introduces hierarchical surface wrinkles and bumps fabricated through drying-induced shrinkage. The kappa-carrageenan system shows hierarchical wrinkles, while the iota-carrageenan system exhibits hierarchical bumps.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Hujun Li, Saori Yoshida, Naofumi Mitani, Mayumi Egusa, Momoko Takagi, Hironori Izawa, Teruyuki Matsumoto, Hironori Kaminaka, Shinsuke Ifuku
Summary: This study investigated the potential use of spent mushroom substrate (SMS) in agriculture and successfully isolated chitin/cellulose nanofiber complex (CCNFC) from SMS. Further research revealed that low concentration CCNFC water dispersion exhibited significant plant disease resistance and plant growth promotion activities.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Dagmawi Abebe Zewude, Takako Noguchi, Kimihiko Sato, Hironori Izawa, Shinsuke Ifuku
Summary: In this study, chitin nanoparticles were successfully prepared by alkaline treatment and regeneration, which showed small particle size, high dispersibility, and high heat resistance. Compared to nanofibers, nanoparticles had lower viscosity, allowing for preparation at higher concentrations, and can be easily redispersed in water after concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Organic
Hironori Izawa, Fumika Yasufuku, Tomoko Matsumoto, Shinsuke Ifuku, Hiroyuki Saimoto, Masato Sumita
Summary: A novel colorimetric sensor system utilizing the photo-induced colorimetric reaction of TENDI is demonstrated for the detection and quantification of carboxylate derivatives. The presence of CH3COONa induces a photo-induced colorimetric reaction in the TENDI solution under UV irradiation, enabling the detection of carboxylate derivatives. Additionally, TENDI has the ability to distinguish the structural features of carboxylate derivatives based on color tone.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Hironori Izawa, Shota Ishisaka, Hiroyuki Saimoto, Shinsuke Ifuku
Summary: The effects of the physical properties of skin layers and substrates on drying-induced surface wrinkling were investigated. It was found that the size of surface wrinkles formed by different polymers on skin layers varied. The hardness of the skin layers was the primary factor determining wrinkle size.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Materials Science, Composites
Dagmawi Abebe Zewude, Hironori Izawa, Shinsuke Ifuku
Summary: Chitin nanofibers were prepared by mechanically grinding chitin using a ball mill. The optimal conditions for efficient preparation were determined by analyzing the resulting water dispersion and cast film. The length and width of the nanofibers were measured, and it was found that the size of the balls, total ball weight, and milling time all had an impact on the grinding efficiency and fiber properties.
JOURNAL OF COMPOSITES SCIENCE
(2022)
Article
Materials Science, Composites
Kana Kishida, Toshifumi Mizuta, Hironori Izawa, Shinsuke Ifuku
Summary: Crickets are gaining attention as a low environmental impact nutrient source. In this study, chitin isolated from crickets was successfully converted into nanochitin, which had larger fiber width and smaller crystal size compared to crab shells. The shape differences affected the physical properties of the dispersion.
JOURNAL OF COMPOSITES SCIENCE
(2022)
Article
Polymer Science
Hironori Izawa, Ayaka Yagi, Ryo Umemoto, Shinsuke Ifuku
Summary: In this study, water-soluble guanidinylated chitosan (WGCS) is introduced as a potential material for protein delivery systems to improve the cellular internalization of protein/peptide drugs. WGCS, composed mainly of guanidinylated chitosan, chitosan, and chitin units, showed higher internalization into HeLa cells compared to common chitosan. The increased internalization was attributed to the guanidinylation and electrostatic interactions between WGCS and the protein.
Article
Engineering, Biomedical
Nowshin Farzana Khan, Hideaki Nakamura, Hironori Izawa, Shinsuke Ifuku, Daisuke Kadowaki, Masaki Otagiri, Makoto Anraku
Summary: Researchers evaluated the in vivo safety of GCS and observed no deleterious effects after a single oral administration of an excessive dose. They also found that GCS had a slower migration rate in the gastrointestinal tract and exhibited mucoadhesive properties. Future studies will focus on using GCS to improve absorption of poorly water-soluble and poorly membrane-permeable drugs.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
