Article
Nutrition & Dietetics
Eduardo Prado, Anibal Magalhaes-Netto, Jose Rezende Neto, Adriana Bassini, Luiz-Claudio Cameron
Summary: The study found that caffeine consumption may attenuate the increase in ammonemia during prolonged exercise, leading to improved exercise performance.
Article
Nutrition & Dietetics
Debora Romualdo Lacerda, Albena Nunes-Silva, Ana Leticia Malheiros Silveira, Katia Anunciacao Costa, Debora Fernandes Rodrigues, Michele Macedo Moraes, Vanessa Pinho, Gustavo Batista Menezes, Mauro Martins Teixeira, Samuel Penna Wanner, Danusa Dias Soares, Adaliene Versiani Matos Ferreira
Summary: This study investigated the effect of acute exercise on the inflammatory response in adipose tissue of lean and obese mice. Acute exercise enhanced the levels of IL-6 and tumor necrosis factor-a in the adipose tissue of lean mice, while no changes were observed in proinflammatory cytokines in obese mice. However, the levels of IL-13, IL-4, and IL-10 were increased in obese mice after exercise. These findings suggest that acute exercise promotes an inflammatory response in adipose tissue of lean mice, but elicits an anti-inflammatory response in adipose tissue of obese mice.
Review
Biochemistry & Molecular Biology
Philipp von Hundelshausen, Kanin Wichapong, Hans-Joachim Gabius, Kevin H. Mayo
Summary: The trafficking and local activity of leukocytes are essential for various physiological processes. Microenvironments are complex due to the multiple mediators from diverse cell types playing regulated roles. Chemokines and galectins represent important effector molecules involved in inflammatory processes and have the capacity to form various molecular interactions in response to inflammation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Raquel Freitas Zambonatto, Renata Nakata Teixeira, Sarah de Oliveira Poma, Eliane Borges da Silva, Mariana Mendes de Almeida, Gerson dos Santos Leite, Cesar Miguel Momesso dos Santos, Heloisa Helena de Oliveira Alves, Renata Gorjao, Tania Cristina Pithon-Curi, Celso R. F. Carvalho, Rui Curi, Adriana Cristina Levada-Pires
Summary: The study found that neutrophils from atopic elite runners exhibited lower responses to LPS stimulation compared to non-atopic runners. Both groups responded similarly to fMLP stimulation. Training hours and volume were not associated with neutrophil function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Francesca Motta, M. Eric Gershwin, Carlo Selmi
Summary: Mushrooms have been believed to have effects on immunity, cancer, and autoimmunity for centuries, with glucans and specific proteins being the key to their biological activity. Despite various influencing factors, rigorous research is needed to determine the potential of mushroom compounds for human health.
JOURNAL OF AUTOIMMUNITY
(2021)
Article
Hematology
Sarah Skinner, Elie Nader, Emeric Stauffer, Melanie Robert, Camille Boisson, Agnes Cibiel, Clement Foschia, Leonard Feasson, Paul Robach, Guillaume Y. Millet, Philippe Connes
Summary: This study showed that a 171 km ultra-trail race results in greater modulations in cytokine profiles than a traditional trail race. Both races led to significant increases in leukocyte concentrations, but certain cytokines showed more significant changes after the ultra-trail race.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Microbiology
Carlos J. Ramirez-Flores, Billy Joel Erazo Flores, Andres M. Tibabuzo Perdomo, Katie L. Barnes, Sarah K. Wilson, Carolina Mendoza Cavazos, Laura J. Knoll, Melissa Bruckner Lodoen
Summary: Linoleic acid signals sexual development in the feline host, and TgLOXL1 plays a role in the IFN-gamma signaling cascade and changes localization in response to host immune activation.
Article
Biochemistry & Molecular Biology
Heikki V. Sarin, Eija Pirinen, Kirsi H. Pietilainen, Ville Isola, Keijo Hakkinen, Markus Perola, Juha J. Hulmi
Summary: This study on 42 healthy athletic females revealed that prolonged energy deficit can lead to metabolic adaptations, including suppression of mitochondrial and ribosome biogenesis gene expression. These findings suggest that adaptation to energy deficit in humans is broader than previously believed.
Article
Cell Biology
Daniela A. Paira, Carolina Olivera, Andrea D. Tissera, Rosa Molina, Jose J. Olmedo, Virginia E. Rivero, Hector A. Saka, Ruben D. Motrich
Summary: U. urealyticum and M. hominis infections are associated with inflammation and decreased sperm quality in male urogenital system. A comprehensive analysis of urogenital infections caused by U. urealyticum and M. hominis reveals the association with urogenital inflammation and impaired sperm quality in men. These findings suggest that screening for these infections and analyzing leukocyte subsets and inflammatory cytokines in semen could be clinically useful for the diagnosis and management of male urogenital infections.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Correction
Sport Sciences
Ian Rollo, Javier T. Gonzalez, Cas J. Fuchs, Luc J. C. van Loon, Clyde Williams
Summary: A correction to the paper has been published.
Article
Immunology
Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Erik Martens, Bert Malengier-Devlies, Jennifer Vandooren, Jan Jeroen Vranckx, Patrick Matthys, Ghislain Opdenakker
Summary: This study found that using physiological fibrin hydrogels in skin wound healing in mice can modulate immune cells and molecules, leading to faster wound repair. The hydrogels can reduce neutrophil numbers, increase non-classical Ly6Clow monocytes and resolutive macrophage populations, and decrease the expression of pro-inflammatory cytokines. Additionally, the hydrogels can increase the counts of dermal endothelial cells, fibroblasts, and keratinocytes, promote keratinocyte migration, and accelerate wound healing.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Neurosciences
James Frampton, Jose Ivan Serrano-Contreras, Isabel Garcia-Perez, Georgia Franco-Becker, Jack Penhaligan, Abbigail S. Y. Tan, Ana Claudia Cepas de Oliveira, Annabelle J. Milner, Kevin G. Murphy, Gary Frost, Edward S. Chambers
Summary: Understanding the metabolic determinants of postexercise appetite regulation is important for developing therapeutics to suppress overeating behaviors and enhance the efficacy of exercise as a weight-loss treatment. This study found that dietary carbohydrate and exercise independently influenced gastrointestinal hormones associated with appetite regulation. Plasma acetate and succinate were identified as potential mediators of exercise-induced appetite and energy intake responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Psychology, Biological
James O. Ellis, Ben J. Lee, James E. Turner
Summary: Sleep fragmentation did not substantially alter exercise-induced leukocyte trafficking or mitogen-stimulated oxidative burst by leukocytes.
PHYSIOLOGY & BEHAVIOR
(2021)
Review
Immunology
Barbara Radovani, Ivan Gudelj
Summary: Chronic inflammation is a key feature of many inflammatory diseases, and changes in N-glycosylation play an important role in inflammation. Proinflammatory cytokines can alter the pathways involved in N-glycan synthesis and the expression of relevant enzymes, affecting immune cell functions and signal transduction. Understanding inflammation-induced N-glycosylation changes is crucial for elucidating disease mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Okba Selmi, Danielle E. Levitt, Filipe Manuel Clemente, Hadi Nobari, Giulia My, Antonella Muscella, Katsuhiko Suzuki, Anissa Bouassida
Summary: In this study, a perceived physical freshness (RPF) scale was developed and tested to monitor athletes' condition and prevent excessive fatigue and insufficient recovery. The results showed that the RPF scale had significant correlations with training load variables, recovery state, and well-being indices.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Maryam Molaeikhaletabadi, Reza Bagheri, Mohammad Hemmatinafar, Javad Nemati, Alexei Wong, Michael Nordvall, Maryam Namazifard, Katsuhiko Suzuki
Summary: This study examined the short-term effects of low-fat chocolate milk (LFCM) consumption on delayed onset muscle soreness (DOMS) and performance in female badminton players. The results indicate that LFCM consumption significantly enhances aerobic power, explosive power, and time to exhaustion, while reducing DOMS and rating of perceived exertion (RPE).
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Hamid Agha-Alinejad, Amir Hossein Ahmadi Hekmatikar, Ruheea Taskin Ruhee, Mahdieh Molanouri Shamsi, Masoud Rahmati, Kayvan Khoramipour, Katsuhiko Suzuki
Summary: Elite athletes face challenges in maintaining their immune system during high-intensity training, influenced by factors such as diet and vaccination. Low- and moderate-intensity training can improve immune function and overall physical health. Nutritional strategies can be employed to enhance immune function during high-intensity training.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Green & Sustainable Science & Technology
Hadi Nobari, Saber Saedmocheshi, Kelly Johnson, Katsuhiko Suzuki, Marcos Maynar-Marino
Summary: Research has shown that red beets and their active ingredients have various health benefits, and exercise and red beet consumption play a positive role in prostate cancer treatment. There is a significant relationship between an active lifestyle and proper diet with cancer incidence, making them important components of cancer treatment protocols for patients.
Article
Biochemistry & Molecular Biology
Damoon Ashtary-Larky, Sara Niknam, Meysam Alipour, Reza Bagheri, Omid Asbaghi, Mehrnaz Mohammadian, Salvador J. Jaime, Julien S. Baker, Alexei Wong, Katsuhiko Suzuki, Reza Afrisham
Summary: This study aimed to evaluate the cardiometabolic abnormalities in women with normal-weight obesity (NWO) in comparison with lean, overweight, and obese women. Significant differences were observed in HDL concentrations between NWO, lean, and obese participants. Individuals with NWO had a significantly higher incidence of cardiometabolic abnormalities when compared to lean participants.
Article
Physiology
Noriaki Kawanishi, Takaki Tominaga, Katsuhiko Suzuki
Summary: This study found that resistance exercise, specifically electrical pulse stimulation-induced muscle contraction, resulted in changes in the miRNA and mRNA profiles of circulating extracellular vesicles. Muscle-specific miRNAs such as miR-1, miR-133, and miR-206 showed significant upregulation after 90 minutes of muscle contraction. Additionally, mRNA expression changes in circulating extracellular vesicles after muscle contraction were found to promote angiogenesis and regulate the immune response. These changes in extracellular vesicle properties may play a crucial role in resistance exercise-induced physiological adaptations.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takaki Tominaga, Jiapeng Huang, Shuo Wang, Miwa Noguchi, Yishan Tong, Momoko Asano-Oritani, Katsuhiko Suzuki
Summary: Several food components, including polyphenols and phytonutrients, have immunomodulatory effects. Collagen, known for its various bioactivities, can promote wound healing and relieve symptoms of bone/joint disease. This study investigated the immunomodulatory effects of collagen-derived dipeptides and amino acids on macrophages and peripheral blood mononuclear cells (PBMC), and found that there is no difference in cytokine secretion between dipeptides and amino acids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiori Wakasugi-Onogi, Sihui Ma, Ruheea Taskin Ruhee, Yishan Tong, Yasuhiro Seki, Katsuhiko Suzuki
Summary: This study found that sulforaphane has various effects on neutrophil functions, including inhibiting reactive oxygen species (ROS) production, degranulation, phagocytosis, and neutrophil extracellular trap (NET) formation. Sulforaphane also has direct antioxidant activity. It was observed that sulforaphane can decrease the release of inflammatory cytokines and myeloperoxidase from neutrophils. In addition, sulforaphane directly removes ROS, including hypochlorous acid (HOCl).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Michiko Hirata, Tsukasa Tominari, Ryota Ichimaru, Naruhiko Takiguchi, Yuki Tanaka, Masaru Takatoya, Daichi Arai, Shosei Yoshinouchi, Chisato Miyaura, Chiho Matsumoto, Sihui Ma, Katsuhiko Suzuki, Florian M. W. Grundler, Masaki Inada
Summary: In this study, the demethylated forms of citrus nobiletin and tangeretin, 4'-demethylnobiletin and 4'-demethyltangeretin, were found to inhibit osteoclast differentiation and function via the suppression of the NF-KB pathway. These compounds may have potential applications in maintaining bone health and preventing metabolic bone diseases such as osteoporosis.
Review
Medicine, General & Internal
Fatemeh Khodadadi, Reza Bagheri, Raoof Negaresh, Sajjad Moradi, Michael Nordvall, Donny M. Camera, Alexei Wong, Katsuhiko Suzuki
Summary: This systematic review and meta-analysis examined the effects of different types of high-intensity interval training (HIIT) on body composition changes. The results showed that HIIT, particularly cycling-based HIIT, led to reductions in fat mass and body fat percentage, as well as increased fat-free mass. These findings suggest that cycling-based HIIT may be the most effective for improving body composition.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hiroaki Sako, Mohieldin Youssef, Olga Elisseeva, Takayuki Akimoto, Katsuhiko Suzuki, Takashi Ushida, Tadashi Yamamoto
Summary: Slower translation rates reduce protein misfolding by allowing time for proper folding. MicroRNAs (miRNAs), which are absent in prokaryotes, can stall translating ribosomes, preventing misfolding with little effect on protein abundance. This eukaryote-specific mechanism provides insights into co-translational protein folding and has potential in targeting protein misfolding diseases.
Review
Nutrition & Dietetics
Cong Wu, Katsuhiko Suzuki
Summary: Flavonoids may have a great potential to treat sarcopenia by improving skeletal muscle mass, muscle strength, and physical performance in older adults.
Article
Nutrition & Dietetics
Javad Nemati, Mohammad Hemmatinafar, Alireza Niknam, Mohammad Nikahd, Narjes Zeighami, Babak Imanian, Kousar Safari, Nima Jahaniboushehri, Katsuhiko Suzuki
Summary: The study aimed to evaluate the effects of acute caffeine supplementation on collegiate volleyball players' specific performance and skills. Results showed significant improvements in agility, Sargent's jump, attacking, and serving skills with higher doses of caffeine. However, there were no significant differences in hand movement speed, handgrip, and medicine ball throwing among the different supplementation conditions.
Article
Nutrition & Dietetics
Mohammad Hemmatinafar, Leila Zaremoayedi, Maryam Koushkie Jahromi, Stacey Alvarez-Alvarado, Alexei Wong, Alireza Niknam, Katsuhiko Suzuki, Babak Imanian, Reza Bagheri
Summary: This study aimed to evaluate the effects of beetroot juice (BRJ) on recovery and muscle soreness indicators in female volleyball players after exercise-induced muscle damage (EIMD). The results showed that BRJ supplementation improved muscle endurance performance and reduced muscle soreness and tissue edema after EIMD, compared to placebo.
Article
Medicine, General & Internal
Mahsa Naghashpour, Dian Dayer, Hadi Karami, Mahshid Naghashpour, Mahin Taheri Moghadam, Seyed Mohammad Jafar Haeri, Katsuhiko Suzuki
Summary: This study demonstrates that magnolol has a significant anti-tumor effect on MKN-45 cells and can be used to overcome cisplatin resistance in gastric cancer cells when combined with cisplatin.
MEDICINA-LITHUANIA
(2023)