Article
Public, Environmental & Occupational Health
Shri Kant Singh, Santosh Kumar Sharma, Sanjay K. Mohanty, Rakesh Mishra, Akash Porwal, Bal Kishan Gulati
Summary: In India, there is inconsistency and disproportion in self-reported hypertension compared to biomedically measured hypertension, with self-reports underestimating hypertension among men aged 15-54 years and women aged 35-49 years, while overestimating hypertension among women below the age of 35 years. False-positive hypertension prevalence was reported among women aged <35 years, while false-negative responses were observed among women aged >= 35 years and men aged 15-54 years.
SSM-POPULATION HEALTH
(2022)
Article
Mathematical & Computational Biology
Allison Meisner, Marco Carone, Margaret S. Pepe, Kathleen F. Kerr
Summary: Researchers propose a distribution-free method for constructing biomarker combinations, maximizing the true positive rate while constraining the false positive rate. The new method shows desirable properties in theoretical and simulation studies, suggesting potential for increased clinical adoption.
BIOMETRICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Daniel Mukadi-Bamuleka, Junior Bulabula-Penge, Bart K. M. Jacobs, Anja De Weggheleire, Francois Edidi-Atani, Fabrice Mambu-Mbika, Anais Legand, John D. Klena, Peter N. Fonjungo, Placide Mbala-Kingebeni, Sheila Makiala-Mandanda, Masahiro Kajihara, Ayato Takada, Joel M. Montgomery, Pierre Formenty, Jean-Jacques Muyembe-Tamfum, Kevin K. Arien, Johan van Griensven, Steve Ahuka-Mundeke, Study Grp
Summary: This study evaluated the performance of four rapid diagnostic tests (RDTs) for Ebola virus disease (EVD) detection. The sensitivity of the RDTs did not meet the desired levels set by the World Health Organization, but the specificity was satisfactory. Among the RDTs evaluated, QuickNavi-EbolaTM and OraQuick(R) Ebola Rapid Antigen Test showed the most favorable profiles and can be used as frontline tests for screening suspected cases.
Article
Oncology
Maaret Eskelinen, Jannica Meklin, Denise Peixoto Guimaraes, Tuomas Selander, Kari Syrjanen, Matti Eskelinen
Summary: This study evaluated the diagnostic accuracy of FIT ColonView and HemoccultSENSA in colorectal neoplasia screening in Brazil. The AA reading of the CV test showed higher diagnostic accuracy in bleed-positive patients than in bleed-negative patients.
ANTICANCER RESEARCH
(2023)
Article
Chemistry, Applied
Jaime A. Teixeira da Silva, Serhii Nazarovets
Summary: The objective of the study was to quantitatively assess the extent of the existence of ss-carotene in the literature. A search using the Web of Science Core Collection revealed 121 results, with the highest incidence of false positives occurring in 2021. Journal of the Science of Food and Agriculture had the highest incidence of ss-carotene, while Wiley journals had the most cases. A Scopus search found 552 false positives, with Acta Horticulturae having the highest number of cases.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Review
Parasitology
Andre Filipe Pastor, Maressa Rhuama Silva, Wagner Jose Tenorio dos Santos, Tamisa Rego, Eduardo Brandao, Osvaldo Pompilio de-Melo-Neto, Abraham Rocha
Summary: Lymphatic filariasis is a parasitic disease affecting approximately 67 million people worldwide, caused by worms like Wuchereria bancrofti. Improved diagnostic tools using recombinant antigens play a crucial role in preventing the spread of LF. Research on antigens is expected to lead to the development of cost-effective tests with high sensitivity and specificity, aiding in the Global Program to Eliminate Lymphatic Filariasis.
PARASITES & VECTORS
(2021)
Article
Statistics & Probability
Shi-Fang Qiu, Ying-Qiu Qu, Xiao-Liang Zhang, Chao Li
Summary: This study proposes likelihood-based and Bayesian methods for estimating disease prevalence, diagnostic-test sensitivity and specificity under two double-sampling models. Various methods are used to construct confidence intervals for these parameters, and their performance is evaluated and compared.
COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
(2023)
Article
Mathematical & Computational Biology
Matthew R. Schofield, Michael J. Maze, John A. Crump, Matthew P. Rubach, Renee Galloway, Katrina J. Sharples
Summary: In the absence of a gold standard, latent class models are proposed as a potential solution for estimating the sensitivity and specificity of diagnostic tests. A study using a real-world example highlights how violations of the assumptions underlying the latent class model can lead to substantial bias in parameter estimates. It suggests that the presence of additional latent states in fitting a two-state latent class model can affect the robustness of estimates of sensitivity, specificity, and prevalence.
STATISTICS IN MEDICINE
(2021)
Article
Medical Laboratory Technology
Tze Ping Loh, Sarah J. Lord, Katy Bell, Mary Kathryn Bohn, Chun Yee Lim, Corey Markus, Hernan Fares Taie, Khosrow Adeli, Giuseppe Lippi, Sverre Sandberg, Andrea Horvath
Summary: Choosing laboratory tests and testing strategies for SARS-CoV-2 involves delicate trade-offs between NPV and PPV based on prevalence, clinical sensitivity, and clinical specificity. Practitioners and health authorities should carefully consider the clinical scenarios under which the test result will be used and select the most appropriate testing strategy that fulfills the a priori defined clinical performance specification.
CLINICAL BIOCHEMISTRY
(2021)
Review
Infectious Diseases
Ashar Dhana, Yohhei Hamada, Andre P. Kengne, Andrew D. Kerkhoff, Tobias Broger, Claudia M. Denkinger, Molebogeng X. Rangaka, Ankur Gupta-Wright, Katherine Fielding, Robin Wood, Helena Huerga, Sekai Chenai Mathabire Ruecker, Stephanie Bjerrum, Isik S. Johansen, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, David A. Barr, Graeme Meintjes, Gary Maartens
Summary: This study assessed the performance of WHO screening criteria and alternative screening tests/strategies to guide LF-LAM testing in HIV-positive inpatients. The results showed limited utility of WHO criteria and alternative screening tests/strategies, suggesting the implementation of AlereLAM testing in all HIV-positive inpatients and the potential improvement in tuberculosis diagnosis through routine FujiLAM testing.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Mohammad Khaja Mafij Uddin, Md. Fahim Ather, Senjuti Kabir, Arfatur Rahman, Sabrina Choudhury, Rumana Nasrin, Tanjina Rahman, S. M. Mazidur Rahman, Shahriar Ahmed, Sayera Banu
Summary: Accurate and appropriate diagnosis of extrapulmonary tuberculosis (EPTB) remains challenging. This study investigated the diagnostic performance of different methods for EPTB diagnosis and found that the Xpert MTB/RIF assay showed the highest sensitivity. Considering its short turnaround time and promising findings, the Xpert MTB/RIF assay should be integrated into national TB guidelines as a routine diagnostic test.
Review
Radiology, Nuclear Medicine & Medical Imaging
Guina Liu, Yuntian Chen, A. Runa, Jiaming Liu
Summary: This study investigated the diagnostic performance of the COVID-19 Reporting and Data System (CO-RADS) for detecting COVID-19. The results showed that CO-RADS has favorable sensitivity and specificity, making it an effective tool for detecting COVID-19. However, more well-designed studies are needed to validate its effectiveness.
EUROPEAN RADIOLOGY
(2022)
Article
Veterinary Sciences
Maria Contreras Garcia, Emily Walshe, Pieter C. Steketee, Edith Paxton, Javier Lopez-Vidal, Michael C. Pearce, Keith R. Matthews, Fatima Ezzahra-Akki, Alec Evans, Karen Fairlie-Clark, Jacqueline B. Matthews, Finn Grey, Liam J. Morrison
Summary: Animal trypanosomiasis is a significant livestock disease that requires improved diagnostics. Research shows that the 7SL sRNA RT-qPCR assays have strong specificity, are more effective than current diagnostic methods, and display rapid reduction of the 7SL sRNA signal post-treatment, and excel in distinguishing between infected and treated animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
A. Kumaravel, T. Vijayan
Summary: Nowadays, researchers are cautious about the cost of building models to prevent false positive and false negative results. They are searching for measures to control these behaviors based on the datasets. Cost sensitive classifiers are used to check the total cost of misclassifications. This article introduces a new measure called 'cost ratio' for monitoring misclassifications in sensitive diagnostic studies. The article focuses on variations of different cost ratios and establishes the possibility of reducing prediction errors.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Microbiology
Choon-Mee Kim, Dong-Min Kim, Na Ra Yun
Summary: This study evaluated the accuracy of different antibody tests for scrub typhus, revealing that the sensitivity and specificity of each test were unsatisfactory. There is an urgent need to develop more highly sensitive and specific tests.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)