Review
Neurosciences
Shazia Malik, Omar Alnaji, Mahnoor Malik, Teresa Gambale, Michel Piers Rathbone
Summary: This study found through a systematic review that neuroinflammatory cytokines associated with mild traumatic brain injuries are related to emotional impairments such as depression, anxiety, and post-traumatic stress disorder (PTSD). IL-6, TNF alpha, IL-10, and CRP are the most common cytokines associated with poor psychological outcomes involving PTSD and/or depression in the chronic mTBI population.
Review
Clinical Neurology
Mackenzie M. Aychman, David L. Goldman, Joshua S. Kaplan
Summary: Cannabidiol (CBD) has potential therapeutic effects against the secondary injury cascade from traumatic brain injury (TBI) by initiating anti-inflammatory, antioxidative, and antiepileptic properties. The lack of effective broad treatment strategies for TBI highlights the importance of CBD's mechanistic support in countering the damaging mechanisms and providing neuroprotective benefits. Future clinical research and ongoing clinical trials are necessary to further examine CBD's efficacy in TBI treatment protocols.
FRONTIERS IN NEUROLOGY
(2023)
Article
Critical Care Medicine
Stephen Breazeale, Samantha Conley, Sangchoon Jeon, Susan G. Dorsey, Joan Kearney, Brad Yoo, Nancy S. Redeker
Summary: The research identified distinct symptom cluster profiles among TOI survivors, with sociodemographic characteristics and serum BDNF concentrations being associated with membership in specific clusters.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Clinical Neurology
Christina Devoto, Rany Vorn, Sara Mithani, Timothy B. Meier, Chen Lai, Steven P. Broglio, Thomas Mcallister, Christopher C. Giza, Daniel Huber, Jaroslaw Harezlak, Kenneth L. Cameron, Gerald Mcginty, Jonathan Jackson, Kevin Guskiewicz, Jason P. Mihalik, Alison Brooks, Stefan Duma, Steven Rowson, Lindsay D. Nelson, Paul Pasquina, Christine Turtzo, Lawrence Latour, Michael A. Mccrea, Jessica M. Gill, CARE Consortium Investigators
Summary: This study aimed to investigate plasma phosphorylated tau (p-tau181) protein in mild traumatic brain injury (mTBI) patients and concussed athletes. The study found that plasma p-tau181 concentrations were significantly elevated within 48 hours of injury in both groups, with the highest levels observed in patients with neuroimaging evidence of injury. These findings suggest that plasma p-tau181 concentrations may be related to brain injury and could potentially serve as an early diagnostic biomarker for mTBI/concussions.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Grant L. Iverson, Ryan Van Patten, Douglas P. Terry, Christopher R. Levi, Andrew J. Gardner
Summary: This study found that depression in retired elite level rugby league players was not significantly associated with lifetime history of concussions or number of years playing professional collision sport, but was instead correlated with current anxiety, stress, resilience, and life interference due to chronic pain.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Medicine, General & Internal
Rossella Tomaiuolo, Martina Zibetti, Chiara Di Resta, Giuseppe Banfi
Summary: Traumatic brain injury (TBI) affects 69 million people annually, but the lack of diagnostic criteria and standardized assessment methods hampers efficient management. Current first-choice examination, computerized axial tomography, has limitations and drawbacks. Immediate and accurate diagnosis and management of TBIs, especially in sports-related cases, are critically needed. Fluid biomarkers may serve as prognostic indicators, improving risk stratification and clinical decision making. This review focuses on blood-based protein biomarkers that can be readily and directly measured in the field, aiming to enhance mild TBI management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Jill Daugherty, Kelly Sarmiento, Matthew Breiding
Summary: This study examines how the wording of questions can influence the reporting of traumatic brain injury (TBI). The results show that a greater percentage of respondents reported a lifetime history of concussion compared to mild TBI, suggesting that the terminology used can impact reporting.
Article
Clinical Neurology
Ann Scher, James S. McGinley, R. J. Wirth, Richard B. Lipton, Heidi Terrio, Lisa A. Brenner, Wesley R. Cole, Karen Schwab
Summary: The study found that post-traumatic headaches differ from other headaches in terms of symptom complexity, with post-traumatic headache patients more likely to seek medical care for headaches.
Article
Clinical Neurology
Raj G. Kumar, Nimali Jayasinghe, Rod L. Walker, Laura E. Gibbons, Melinda C. Power, Eric B. Larson, Paul K. Crane, Kristen Dams-O Connor
Summary: In older males, traumatic brain injury with loss of consciousness (LOC) and past military employment are associated with late-life trajectories of depressive symptom severity. There is no such association in females. Recall bias may affect the retrospective assessment of lifetime history of TBI.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Orthopedics
Jose A. Canseco, R. Robert Franks, Brian A. Karamian, Srikanth N. Divi, Ariana A. Reyes, Jennifer Z. Mao, Fadi Al Saiegh, Chester J. Donnally, Gregory D. Schroeder, James S. Harrop, Matthew D. Pepe, Alexander R. Vaccaro
Summary: This review summarizes the epidemiology, clinical presentation, pathophysiology, and treatment of traumatic brain injury in collision athletes, particularly those participating in American football. The literature review yielded 147 references, with limited information on the epidemiology and management of severe traumatic brain injuries. Return-to-play decisions should be based on individual patient symptoms and recovery.
CLINICAL JOURNAL OF SPORT MEDICINE
(2022)
Review
Clinical Neurology
Martijn de Neeling, Dirk Liessens, Bart Depreitere
Summary: Mild traumatic brain injury (mTBI) has a high incidence worldwide, and long-term persistent postconcussion symptoms (PPCS) are predicted by psychological and psychiatric factors. Anxiety, depressive symptoms, and emotional distress early after injury can predict PPCS burden and functional outcome. Coping styles, preinjury psychiatric disorders and mental health also correlate with PPCS burden and functional outcome.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Orthopedics
Amelie Tremblay, Kathryn J. Schneider, Keith Owen Yeates, Geoff Schneider, Pierre Fremont
Summary: A comparative analysis was conducted on the SCAT5 and emergency room rules, showing that the SCAT5 has high sensitivity in identifying severe head and brain injuries, but there is still room for improvement.
JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY
(2023)
Article
Multidisciplinary Sciences
James Furness, Katherine McArthur, Debbie Remnant, Darcy Jorgensen, Catherine J. Bacon, Robert W. Moran, Wayne Hing, Mike Climstein
Summary: The survey conducted in New Zealand found that out of the approximately 315,000 surfers, one third of recreational surfers experienced a major traumatic injury in the previous 12 months. Competitive surfers and those capable of performing aerial maneuvers were at increased risk of injuries, with shoulder injuries having the longest duration. Competitive surfers were more likely to sustain neck, shoulder, lower back, and knee injuries compared to recreational surfers.
Article
Clinical Neurology
Grant L. Iverson, Zachary C. Merz, Douglas P. Terry
Summary: This study found that over half of middle-aged men met the symptom criteria for traumatic encephalopathy syndrome (TES), with neurotrauma exposure not being a significant predictor of meeting the criteria. Sleep difficulties and chronic pain were predictive of meeting the symptom criteria for TES.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Deepa M. Ramanathan, Britney M. Wardecker, Julia E. Slocomb, Frank G. Hillary
Article
Neurosciences
John D. Medaglia, Kathy S. Chiou, Julia Slocomb, Neal M. Fitzpatrick, Britney M. Wardecker, Deepa Ramanathan, Jeffrey Vesek, David C. Good, Frank G. Hillary
HUMAN BRAIN MAPPING
(2012)
Article
Critical Care Medicine
Deepa M. Ramanathan, Nathan McWilliams, Philip Schatz, Frank G. Hillary
JOURNAL OF NEUROTRAUMA
(2012)
Article
Computer Science, Artificial Intelligence
John D. Medaglia, Deepa M. Ramanathan, Umesh M. Venkatesan, Frank G. Hillary
NETWORK-COMPUTATION IN NEURAL SYSTEMS
(2011)
Article
Neurosciences
Deepa M. Ramanathan-Elion, Hind A. Baydoun, Brick Johnstone
Article
Psychology, Clinical
Deepa M. Ramanathan-Elion, Jessica Wolfman McWhorter, Stephen T. Wegener, Kathleen T. Bechtold
REHABILITATION PSYCHOLOGY
(2016)