Article
Clinical Neurology
Aliza P. Wingo, Selina M. Vattathil, Jiaqi Liu, Wen Fan, David J. Cutler, Allan Levey, Julie A. Schneider, David A. Bennett, Thomas S. Wingo
Summary: This study found that LDL-C is associated with various neuropathological manifestations of AD independent of APOE, suggesting that LDL-C may be a modifiable risk factor for AD.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Ioanna Katzourou, Ganna Leonenko, Dobril Ivanov, Alun Meggy, Rachel Marshall, Rebecca Sims, Julie Williams, Peter Holmans, Valentina Escott-Price
Summary: This study aimed to explore the genetic architecture of cognitive decline in AD patients, and found no significant association between APOE ε2 or ε4 alleles and the rate of cognitive decline. Further exploration is needed to uncover possible genetic variants that affect the rate of decline in patients with AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Pina-Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malu Gamez Tansey, T. C. W. Julia, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L. Worley, Henrik Zetterberg, Maria C. Carrillo
Summary: At the Alzheimer's Association's APOE and Immunity virtual conference, experts discussed recent research advances and insights into the roles of the APOE gene and immunity in neurodegenerative diseases like Alzheimer's. The meeting highlighted the importance of diverse research and presented new directions in drug development for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Yongqian Wang, Chenglong Li, Jie Liang, Darui Gao, Yang Pan, Wenya Zhang, Yang Zhang, Fanfan Zheng, Wuxiang Xie
Summary: This study aimed to investigate the relationship between age at diabetes diagnosis and the incidence of dementia. The results showed that an earlier onset of diabetes was significantly associated with a higher risk of dementia.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Chun Zhou, Yanjun Zhang, Sisi Yang, Ziliang Ye, Qimeng Wu, Mengyi Liu, Panpan He, Yuanyuan Zhang, Xianhui Qin
Summary: The habitual use of glucosamine supplements is significantly inversely associated with incident vascular dementia in the older population. The association with incident Alzheimer's disease and frontotemporal dementia is not significant. Concurrent use of calcium supplements strengthens the inverse association between glucosamine use and incident vascular dementia, while concurrent use of zinc supplements weakens this association. APOE genotypes and baseline cognitive function do not significantly modify the relationships between glucosamine use and incident vascular dementia or Alzheimer's disease.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Claire J. C. Huguenard, Adam Cseresznye, Teresa Darcey, Aurore Nkiliza, James E. E. Evans, Stanley L. L. Hazen, Michael Mullan, Fiona Crawford, Laila Abdullah
Summary: With age and the APOE E4 allele, there are disturbances in the lipid bioenergetics pathways in Alzheimer's disease (AD). This study found that in aging mice, the APOE genotype affected the L-carnitine system, which is important for lipid bioenergetics, in the brain and periphery. The presence of the E4 allele and aging may contribute to AD pathogenesis through alterations in the L-carnitine bioenergetic system and cerebrovascular dysfunctions.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Jochum J. Van 't Hooft, Wiesje Pelkmans, Jori Tomassen, Cas Smits, Nienke Legdeur, Anouk Den Braber, Frederik Barkhof, Bart Van Berckel, Maqsood Yaqub, Philip Scheltens, Yolande A. L. Pijnenburg, Pieter Jelle Visser, Betty M. Tijms
Summary: Hearing loss in older adults is associated with increased dementia risk, and the underlying mechanisms connecting the two remain unclear. This study found an association between hearing loss and biomarkers for dementia risk, and the association varied between different age groups. In older adults, hearing loss was associated with a decline in memory, global cognition, and language.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Christopher R. S. Belder, Charles R. Marshall, Jessica Jiang, Salvatore Mazzeo, Anthipa Chokesuwattanaskul, Jonathan D. Rohrer, Anna Volkmer, Chris J. D. Hardy, Jason D. Warren
Summary: This article reviews recent progress in the diagnosis and management of primary progressive aphasia, the language-led dementias. It poses six key unanswered questions and suggests that linking proteinopathies to phenotypes may help resolve the clinical complexity of this disease.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Astrid Suchy-Dicey, Barbara Howard, W. T. Longstreth, Eric M. Reiman, Dedra Buchwald
Summary: This study found no evidence of an association between the APOE epsilon 4 allele and neurodegenerative risk in American Indians. Further research is needed to explore potential protective features.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett
Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Article
Neurosciences
Michelle M. Dunk, Ira Driscoll
Summary: This study investigates the relationship between total cholesterol and APOE-related AD risk. The results show that higher total cholesterol may be a significant contributor to AD risk, particularly in APOE4 carriers. These findings highlight a possible mechanism by which APOE confers AD risk and indicate the potential for AD risk modification through maintenance of healthy total cholesterol levels.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Cell Biology
Alexander M. Kulminski, Ethan Jain-Washburn, Elena Loiko, Yury Loika, Fan Feng, Irina Culminskaya, Alzheimer's Disease Neuroimaging Initiative Alzheimers Dis Neuroimaging Initiative
Summary: This study examined the associations of APOE alleles and polygenic profiles with cerebrospinal fluid and plasma biomarkers, revealing differential effects of specific alleles on different biomarkers.
Article
Behavioral Sciences
Nahid Zokaei, Alexander G. Board, Ellie Slavkova, Clare E. Mackay, Anna Christina Nobre, Masud Husain
Summary: The APOE gene is associated with individual cognitive health in aging, with the ε2 allele potentially protecting against Alzheimer's disease. Individuals carrying the ε2 allele show a significant memory advantage in short-term memory tasks, regardless of difficulty level and age, suggesting a phenotypical effect on cognition independent of later-life genetic effects.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
John Andersson, Anna Sundstrom, Maria Nordin, David Segersson, Bertil Forsberg, Rolf Adolfsson, Anna Oudin
Summary: This study aimed to investigate the association between PM2.5 exposure and dementia in a low exposure area, and the role of olfaction and the APOE epsilon 4 allele in these associations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Neurosciences
Sally Day, Stefanie Roberts, Nathalie H. Launder, Anita M. Y. Goh, Brian Draper, Alex Bahar-Fuchs, Samantha M. Loi, Kate Laver, Adrienne Withall, Monica Cations
Summary: Younger people with Alzheimer's disease (AD) have a worse prognosis in terms of faster cognitive decline compared to older individuals. More research is needed to determine the impact of symptom onset age in vascular dementia (VaD) and frontotemporal dementia (FTD), as well as functional decline in all types of dementias.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Cinzia Marchi, Maria Pia Adorni, Paolo Caffarra, Nicoletta Ronda, Marco Spallazzi, Federica Barocco, Daniela Galimberti, Franco Bernini, Francesca Zimetti
JOURNAL OF LIPID RESEARCH
(2019)
Letter
Clinical Neurology
Rita Di Censo, Carla Abdelnour, Frederic Blanc, Olivier Bousiges, Afina W. Lemstra, Inger van Steenoven, Marco Onofrj, Dag Aarsland, Laura Bonanni
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2020)
Article
Clinical Neurology
Alice Martini, Luca Weis, Roberta Schifano, Francesca Pistonesi, Eleonora Fiorenzato, Angelo Antonini, Roberta Biundo
JOURNAL OF NEURAL TRANSMISSION
(2020)
Article
Clinical Neurology
Salvatore Nigro, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Antonio Augimeri, Andrea Quattrone, Maurizio Morelli, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
MOVEMENT DISORDERS
(2020)
Review
Clinical Neurology
Alice Martini, Stefano Tamburin, Roberta Biundo, Luca Weis, Angelo Antonini, Clara Pizzolo, Giuseppe Leoni, Silvia Chimenton, Nicola M. J. Edelstyn
PARKINSONISM & RELATED DISORDERS
(2020)
Article
Clinical Neurology
Eleonora Fiorenzato, Angelo Antonini, Patrizia Bisiacchi, Luca Weis, Roberta Biundo
Summary: Asymmetric hemispheric loss of dopaminergic neurons in Parkinson's disease affects cognitive and motor performance differently, with greater motor severity associated with predominant right hemisphere nigrostriatal dopaminergic loss and more pronounced left hemisphere denervation affecting cognitive manifestations at onset and progression.
MOVEMENT DISORDERS
(2021)
Article
Genetics & Heredity
Marzia Pollazzon, Stefano Giuseppe Caraffi, Silvia Faccioli, Simonetta Rosato, Heidi Fodstad, Belinda Campos-Xavier, Emanuele Soncini, Giuseppina Comitini, Daniele Frattini, Teresa Grimaldi, Maria Marinelli, Davide Martorana, Antonio Percesepe, Silvia Sassi, Carlo Fusco, Giancarlo Gargano, Andrea Superti-Furga, Livia Garavelli
Summary: Arthrogryposis is a condition characterized by multiple congenital contractures affecting two or more areas of the body. This study identified the underlying pathogenic variants in individuals with arthrogryposis and found that prenatal findings were specific for one subtype. The phenotype of certain subtypes became more characteristic at later ages. Clinical evaluation combined with Next Generation Sequencing analysis may allow for early diagnosis and suggest a favorable prognosis in certain subtypes.
Review
Rheumatology
Giorgio Trivioli, Ana Marquez, Davide Martorana, Michelangelo Tesi, Andreas Kronbichler, Paul A. Lyons, Augusto Vaglio
Summary: Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and complex disease driven by the interaction of genetic and environmental factors, with genetic associations varying based on ANCA specificity and contributing to differences in clinical phenotype and treatment response.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Clinical Neurology
Eleonora Fiorenzato, Sadaf Moaveninejad, Luca Weis, Roberta Biundo, Angelo Antonini, Camillo Porcaro
Summary: This study suggests that the characteristics of cognitive decline in PD are changes in spontaneous neuronal activity and increased temporal complexity, involving the central executive network (CEN) and default mode network (DMN), possibly reflecting increased segregation of these networks. Therefore, we propose fractal dimension (FD) as a prognostic biomarker of PD-cognitive decline.
MOVEMENT DISORDERS
(2023)
Article
Health Care Sciences & Services
Roberto Di Marco, Francesca Pistonesi, Valeria Cianci, Roberta Biundo, Luca Weis, Lucrezia Tognolo, Alfonc Baba, Maria Rubega, Giovanni Gentile, Chiara Tedesco, Miryam Carecchio, Angelo Antonini, Stefano Masiero
Summary: The main objective of this study is to test the effect of thermal aquatic exercise on motor symptoms and quality of life in people with Parkinson's Disease. The study found that thermal aquatic exercise rehabilitation significantly improved balance and had positive effects on quality of life and psychological well-being.
Article
Clinical Neurology
Roberta Biundo, Luca Weis, Eleonora Fiorenzato, Francesca Pistonesi, Annachiara Cagnin, Alessandra Bertoldo, Mariagiulia Anglani, Diego Cecchin, Angelo Antonini
Summary: Amyloid deposition in Parkinson's disease and Lewy Body Diseases may exacerbate cognitive deficits, especially attention-executive and language dysfunctions, but the precise impact on cognitive symptoms and dementia progression remains debated, particularly in patients without significant amyloid deposits.
BRAIN COMMUNICATIONS
(2021)
Article
Clinical Neurology
Andrea Quattrone, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Maria G. Bianco, Roberta Vasta, Pier Paolo Arcuri, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: The measurement of third ventricle width can distinguish Parkinson's disease (PD) from progressive supranuclear palsy (PSP).
MOVEMENT DISORDERS
(2021)
Article
Oncology
Giovanni Innella, Cesare Rossi, Maria Romagnoli, Andrea Repaci, Davide Bianchi, Maria Elena Cantarini, Davide Martorana, Lea Godino, Andrea Pession, Antonio Percesepe, Uberto Pagotto, Daniela Turchetti
Article
Rheumatology
S. Farjadian, F. Bonatti, A. Soriano, M. Reina, A. Adorni, C. Graziano, M. Moghtaderi, A. Percesepe, G. Romeo, D. Martorana
Article
Rheumatology
F. Alberici, F. Bonatti, F. Maritati, M. L. Urban, G. Moroni, G. Emmi, A. Adorni, M. Reina, A. Vaglio, D. Martorana
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)