Article
Clinical Neurology
Gemma Sullivan, Kadi Vaher, Manuel Blesa, Paola Galdi, David Q. Stoye, Alan J. Quigley, Michael J. Thrippleton, John Norrie, Mark E. Bastin, James P. Boardman
Summary: High breast milk exposure in preterm infants is associated with a cortical imaging phenotype that resembles that of term-born infants, and this effect appears to be dose-dependent.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Penny Lam, Brendan J. Mein, Ronald J. Benzie, John T. Ormerod, Kristy P. Robledo, Emily J. Hibbert, Ralph K. Nanan
Summary: This study analyzed the effects of maternal diabetes mellitus and body mass index on central and peripheral fat accrual in large for gestational age offspring. The results showed that diabetes mellitus was associated with increased abdominal and mid-thigh fat accumulation in fetuses, independent of BMI.
Article
Pediatrics
Marie Camerota, Elisabeth C. McGowan, Brian S. Carter, Jennifer Check, Lynne M. Dansereau, Sheri A. DellaGrotta, Jennifer B. Helderman, Julie A. Hofheimer, Charles R. Neal, T. Michael O'Shea, Steven L. Pastyrnak, Lynne M. Smith, Barry M. Lester
Summary: This study found that prenatal risk phenotypes are associated with neurobehavioral impairment in children born very preterm. Infants born to mothers in the psychological risk group had increased risk of dysregulated neurobehavior at discharge and motor delay and externalizing problems at 24 months. Infants born to mothers in the physical risk group had increased risk of motor delay at 24 months.
JOURNAL OF PEDIATRICS
(2023)
Article
Endocrinology & Metabolism
Xiao Song Liu, Xiu Juan Su, Guo Hua Li, Shi Jia Huang, Yang Liu, Han Xiang Sun, Qiao Ling Du
Summary: This study found an association between FT4 and birth weight as well as birth weight discordance in twins, while TSH was not associated with birth weight. These findings have implications for obstetricians in preventing birth weight discordance in twin pregnancies.
Article
Medical Laboratory Technology
Xiaoxue Wang, Yudong Pu, Shiwei Ai, Haixia Liu, Shuzhen He, Zhilan Li, Yuhui Dang
Summary: This study found that mercury exposure is associated with preeclampsia and adverse birth outcomes. Pregnant women with higher levels of mercury in their blood are more likely to develop mild and severe preeclampsia, as well as have low birth weight and preterm birth.
CLINICA CHIMICA ACTA
(2022)
Article
Psychology, Developmental
Adelar Pedro Franz, Arthur Caye, Barbara Calil Lacerda, Flavia Wagner, Rita C. Silveira, Renato Soibelmann Procianoy, Carlos Renato Moreira-Maia, Luis Augusto Rohde
Summary: The study developed an individualized risk calculator for ADHD in VP/VLBW newborns, which showed good performance in identifying high-risk children at 6 years old. This tool could offer more effective early intervention compared to traditional approaches.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Wenzheng Zhou, Xin Ming, Yunping Yang, Yaqiong Hu, Ziyi He, Hongyan Chen, Yannan Li, Jin Cheng, Xiaojun Zhou
Summary: This study explores the association between maternal exposure to ambient air pollutants and the risk of very low birth weight (VLBW), and identifies the sensitive exposure time window. The results suggest that high levels of PM2.5, PM10, NO2, and O3 during pregnancy may increase the risk of VLBW, especially during the first and second trimester. Therefore, reducing the risk of early maternal exposure to ambient air pollution is necessary.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Nutrition & Dietetics
Mahtab Matin, Aziz Homayouni-Rad, Manizheh Mostafa-Gharehbaghi, Mojgan Mirghafourvand, Sakineh Mohammad-Alizadeh-Charandabi
Summary: Oral probiotic administration of Lacticaseibacillus paracasei to breastfeeding mothers of VLBW infants or to the infants can reduce infant TSB level but has no significant effect on weight gain.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Pediatrics
Dustin D. Flannery, Erika M. Edwards, Karen M. Puopolo, Jeffrey D. Horbar
Summary: This study investigated the epidemiology and microbiology of early-onset sepsis (EOS) among very preterm infants from 2018 to 2019. The findings revealed an incidence rate of 13.5 per 1000 very preterm births, with Escherichia coli and group B Streptococcus being the most common pathogens. Infected infants had longer hospital stays and lower survival rates, emphasizing the need for novel preventive strategies.
Article
Medicine, General & Internal
Charlotte Greer, Sarah L. Harris, Richard Troughton, Philip D. Adamson, John Horwood, Chris Frampton, Brian A. Darlow
Summary: Being born preterm and at very low birth weight is associated with increased cardiopulmonary disorders in childhood and potential late cardiac effects, including right ventricular remodeling and occult pulmonary hypertension as survivors age. In a population-based study, young adults born PT at VLBW exhibited smaller RV dimensions compared to normal-weight term-born controls, with slightly reduced RV function detected using strain imaging. Birth weight and gestational age were related to these differences, highlighting the potential importance of echocardiographic strain imaging in detecting RV function disparities in this population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Nasenien Nourkami-Tutdibi, Erol Tutdibi, Theresa Faas, Gudrun Wagenpfeil, Elizabeth S. Draper, Samantha Johnson, Marina Cuttini, Rym El Rafei, Anna-Veera Seppaenen, Jan Mazela, Rolf Felix Maier, Alexandra Nuytten, Henrique Barros, Carina Rodrigues, Jennifer Zeitlin, Michael Zemlin
Summary: The study found that maternal advanced age does not have a significant impact on mortality and morbidity of very preterm infants. Even though older mothers may face greater pregnancy risks, the outcomes for VPT infants born to AMA and vAMA mothers did not differ from those born to younger mothers.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Sapna Virdi, Nafisa M. Jadavji
Summary: Folate plays a critical role in pregnancy and deficiency can lead to offspring neurodevelopmental defects. This review examines clinical and preclinical studies to explore the impact of folate deficiency on offspring neurodevelopment and brain function.
Article
Multidisciplinary Sciences
Matthias W. Wagner, Delvin So, Ting Guo, Lauren Erdman, Min Sheng, S. Ufkes, Ruth E. Grunau, Anne Synnes, Helen M. Branson, Vann Chau, Manohar M. Shroff, Birgit B. Ertl-Wagner, Steven P. Miller
Summary: This study aims to predict adverse neurodevelopmental outcomes in very preterm neonates. By using brain MRI and extracting radiomic features, it was found that radiomic features outperformed clinical variables in predicting motor outcomes, and combining the two improved predictive performance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Avinash S. Patil, Chad A. Grotegut, Nilesh W. Gaikwad, Shelley D. Dowden, David M. Haas
Summary: Plasma levels of DOC and 16 alpha-OHP in early gestation, combined with patient demographic and clinical data, can predict significant neonatal morbidity, neonatal length of stay, and the risk for very preterm delivery. Validation studies are needed to confirm these findings. Early identification of pregnancies at risk for preterm delivery and neonatal morbidity can lead to timely multidisciplinary care and improved perinatal outcomes.
Article
Pediatrics
Hermano A. L. Rocha, Christopher R. Sudfeld, Alvaro J. M. Leite, Marcia M. T. Machado, Sabrina G. M. O. Rocha, Jocileide S. Campos, Anamaria C. e Silva, Luciano L. Correia
Summary: The first 1000 days of life are critical for child development, and factors during pregnancy and neonatal care have a significant impact on later developmental outcomes. Children whose mothers did not receive folic acid supplementation during pregnancy or who were born with low birth weight tended to have lower developmental scores.