Journal
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
Volume 111, Issue 4, Pages 183-193Publisher
ELSEVIER TAIWAN
DOI: 10.1016/j.jfma.2011.09.024
Keywords
epidemiology; gastroenteritis; rotavirus; rotavirus vaccine
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Among children, rotaviruses are the most common cause of severe gastroenteritis worldwide and of diarrheal deaths in developing countries. Current vaccines (e.g., Rotarix, GlaxoSmithKline Biologicals; RotaTeq, Merck and Company) effectively reduce rotaviral gastroenteritis, emergency department visits, and hospitalizations. The tremendous burden of rotavirus-related diarrhea in children across the world continues to drive the remarkable pace of vaccine development. This review assesses the global epidemiological and economic burden of rotavirus diseases, summarizes the relevant principles of the development of rotavirus vaccines, and presents data on the efficacy and effectiveness of currently licensed vaccines in both developed and developing countries. Copyright (C) 2012, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
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