Article
Chemistry, Multidisciplinary
Shamsul Abedin, Yong Li, Abid Anjum Sifat, Khokan Roy, Eric O. Potma
Summary: This study addresses the challenges of stability and reproducibility in surface-enhanced coherent anti-Stokes Raman scattering (SE-CARS) by using nanoantennas made from high-index dielectric particles. The experimental results demonstrate enhanced molecular CARS signals observed at Si nanoantennas, which offer improved thermal stability compared to metallic counterparts.
Article
Instruments & Instrumentation
Nao Hirai, Yasuhiro Maeda, Kosuke Hashimoto, Bibin B. Andriana, Hiroko Matsuyoshi, Hidetoshi Sato
Summary: The study introduces a new type of CARS instrument with a double-wavelength-emission, background-free, electronically tuned Ti:sapphire laser (DW-ETL), which can provide stable CARS spectra for biological applications by controlling each laser pulse emission throughout the fingerprint region.
APPLIED SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Lei Ouyang, Tobias Meyer-Zedler, Kel-Meng See, Wei-Liang Chen, Fan-Cheng Lin, Denis Akimov, Sadaf Ehtesabi, Martin Richter, Michael Schmitt, Yu-Ming Chang, Stefanie Grafe, Jurgen Popp, Jer-Shing Huang
Summary: This study investigates the enhancement effect of plasmonic gratings in nonlinear surface-enhanced coherent anti-Stokes Raman scattering (SECARS) using the platform of plasmonic Doppler grating (PDG). The PDGs spatially separate the input and output enhancement, allowing for observation and comparison of overall enhancement from different combinations of individual input and output beams. The results indicate that enhancement in the pump and anti-Stokes beams plays a more critical role in the overall enhancement than that in the Stokes beam.
Article
Chemistry, Multidisciplinary
Nobuaki Oyamada, Hiro Minamimoto, Kei Murakoshi
Summary: This article discusses the use of plasmonic optical trapping to control the motion of small molecules at room temperature, demonstrating a method using plasmonic structures to achieve selective molecular condensation and create new adsorption isotherms.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Instruments & Instrumentation
Runfeng Li, Ruijun Lan, Dashan Dong, Hong Yang, Kebin Shi
Summary: The Bessel beam CARS spectroscopic method enhances spectral fidelity and signal-to-noise ratio in a turbulent environment, improving the measurement accuracy.
APPLIED SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Zhenzhen Chen, Zhewei Cai, Wenbo Liu, Zijie Yan
Summary: Optical tweezers can control the position and orientation of individual colloidal particles in solution, providing unique prospects for single-particle spectroscopy and microscopy. This perspective discusses the underlying principles, combinations, and applications of optical tweezers with different spectroscopy and microscopy techniques, as well as the challenges and opportunities for performing spectroscopy and microscopy on single nanoparticles with optical tweezers.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Analytical
Georgi Petrov, Rajan Arora, Vladoslav V. Yakovlev
Summary: The study demonstrated chemical imaging of calcifications in tissues using long wavelength excitation, with imaging and analysis performed 2 mm below the skin level in a model system. Applications to breast cancer diagnostics and imaging were discussed, along with methods to extend depth and improve spatial resolution in chemical imaging.
Article
Optics
Gwanjin Lee, Konkada Manattayil Jyothsna, Heejin Lim, Jonghoo Park, JaeDong Lee, Varun Raghunathan, Hyunmin Kim
Summary: In this study, a focus-engineered non-degenerate pumped coherent anti-Stokes Raman scattering (CARS) method using phase shaping, liquid lens focus control, and confocal detection is proposed for resolving non-fluorescent samples beyond the diffraction limit. The results show that non-degenerate pumped CARS achieved approximately 75% improvement in resolution compared to degenerate CARS.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Yujia Zhang, Minjian Lu, Zhendong Zhu, Yan Li, Haoyun Wei
Summary: Based on the enhancement factor of broadband SECARS excitation process, a novel Fano resonance plasmonic nanostructure is studied, which shows significant enhancement effect in a wide wavenumber region, covering most of the fingerprint region. This geometrically-tunable Fano plasmonic nanostructure provides a way to realize broadband-enhanced CARS, with potentials in single-molecular monitoring and high-selectivity biochemical detection.
SCIENTIFIC REPORTS
(2023)
Article
Thermodynamics
Daniel R. Richardson, Sean P. Kearney, Daniel R. Guildenbecher
Summary: Accurate measurement of post-detonation fireball temperatures is crucial for understanding device performance. In this study, a hybrid fs-ps CARS instrument was used to measure temperatures in the fireball of a commercial detonator. Challenges such as light scattering from particulate matter and solid fragments were addressed using a new polarization scheme.
PROCEEDINGS OF THE COMBUSTION INSTITUTE
(2021)
Article
Chemistry, Analytical
Lili Zhang, Xiang Zou, Jing Huang, Jie Fan, Xiangjie Sun, Bohan Zhang, Bin Zheng, Chongyuan Guo, Deliang Fu, Lie Yao, Minbiao Ji
Summary: The study shows that label-free coherent nonlinear optical microscopy with combined SRS and SHG can reveal key diagnostic features of both normal and cancerous pancreatic tissues, providing potential for rapid intraoperative diagnosis of pancreatic cancer and predictive value for postoperative pancreatic fistula.
ANALYTICAL CHEMISTRY
(2021)
Article
Thermodynamics
Timothy Y. Chen, Christopher J. Kliewer, Benjamin M. Goldberg, Egemen Kolemen, Yiguang Ju
Summary: In this study, a model for the CH4 nu(1) Q-branch was developed for fs/ps CARS, enabling simultaneous temperature acquisition from the CH4 and N-2 vibrational Q-branches. Accurate measurements were achieved for both molecules' spectra, with temperatures corresponding well to differences ranging from 4 to 17%. Additionally, spatially resolved one-dimensional thermometry using the CH4 Q-branch demonstrated a spatial resolution of 40 pm.
COMBUSTION AND FLAME
(2021)
Article
Biochemical Research Methods
Hanlin Zhu, Chenran Xu, Vladislav V. Yakovlev, Delong Zhang
Summary: Researchers used time-resolved coherent anti-Stokes Raman scattering (T-CARS) spectroscopy to detect adulteration in cooking oil and understand the mechanisms of lipid oxidation. By overcoming the limitations of conventional Raman spectroscopy, they found that intra-molecular interactions in triglycerides significantly influence vibrational dephasing time. They observed that although initial dephasing times varied, they converged to a similar value after heating cycles. Notably, longer vibrational dephasing of the CH2 symmetric stretching mode was found to correlate with a higher lipid oxidation rate.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Optics
Xiaofeng Liu, Ying Wang, Shuang Li, Haixin Wang, Wenhui Fang, Nan Gong, Chenglin Sun, Zhiwei Men
Summary: In this study, stimulated Raman scattering (SRS) of deuteroxide was investigated using a pulsed Nd:YAG laser with a wavelength of 532 nm. The results showed that by adjusting various parameters, the intensity and energy conversion efficiency of Raman scattering could be effectively improved. This has important implications for the development of tunable Raman lasers.
OPTICS COMMUNICATIONS
(2022)
Review
Oncology
Jiabao Xu, Tong Yu, Christos E. Zois, Ji-Xin Cheng, Yuguo Tang, Adrian L. Harris, Wei E. Huang
Summary: Raman spectroscopy and imaging are label-free, non-destructive techniques used to study cellular metabolism at subcellular level. This review summarizes the applications of Raman-based methods in cancer metabolism and imaging, highlighting their contribution to understanding complex biological processes.
Article
Optics
Andrew Banas, Stephen Daedalus Separa, Einstom Engay, Jesper Gluckstad
OPTICS COMMUNICATIONS
(2018)
Article
Optics
Einstom Engay, Ada-Ioana Bunea, Manto Chouliara, Andrew Banas, Jesper Gluckstad
Article
Nanoscience & Nanotechnology
Antonio Astorino, Jesper Gluckstad, Karsten Rottwitt
Article
Optics
Andrew Banas, Einstom Engay, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Gluckstad
OPTICS COMMUNICATIONS
(2019)
Article
Biochemical Research Methods
Ada-Ioana Bunea, Manto Chouliara, Stine Harloff-Helleber, Andrew R. Banas, Einstom L. Engay, Jesper Gluckstad
JOURNAL OF BIOMEDICAL OPTICS
(2019)
Review
Optics
Ada-Ioana Bunea, Jesper Gluckstad
LASER & PHOTONICS REVIEWS
(2019)
Article
Optics
Einstom Engay, Andrew Banas, Ada-Ioana Bunea, Stephen Daedalus Separa, Jesper Gluckstad
OPTICS COMMUNICATIONS
(2019)
Article
Optics
Andreas Erik Gejl Madsen, Rene Lynge Eriksen, Jesper Gluckstad
Summary: This study examines the use of a Convolutional Neural Network for generating digital holograms and compares it to state-of-the-art iterative methods. While the neural network outperforms the original GS algorithm in reconstruction quality, it lags behind in speed compared to modern optimized GS implementations.
OPTICS COMMUNICATIONS
(2022)
Article
Optics
Andreas Gejl Madsen, Jesper Gluckstad
Summary: This paper presents a novel approach called HoloTile for rapid and speckle-reduced hologram generation. HoloTile uses an analytic method to modify the Point Spread Function (PSF) of the holographic system into flat-top squares in order to prevent interference between adjacent random phase values. The PSF shape is determined by the inter-spectral spacing in the reconstruction plane, which is caused by tiling on the spatial light modulator. As a result, the final hologram is obtained by multiplying the once-calculated PSF shaping phase hologram with the tiled object holograms. HoloTile achieves speckle-reduced reconstructions and extremely fast hologram generation due to the high resolution of the object holograms.
OPTICS COMMUNICATIONS
(2022)
Article
Optics
Andreas Erik Gejl Madsen, Mohammad Aryaee Panah, Peter Emil Larsen, Frank Nielsen, Jesper Gluckstad
Summary: Digital holographic microscopy (DHM) is an imaging technique that reconstructs three-dimensional images from holographic data. This review paper provides an overview of on-axis DHM reconstruction methods, which can be classified into direct, iterative, and machine learning based algorithms. Direct methods are fast but suffer from noise and low contrast, while iterative methods improve accuracy and noise reduction at the cost of increased complexity. Machine learning based methods achieve similar results to iterative methods in less time, but require computational resources and training data.
OPTICS COMMUNICATIONS
(2023)
Proceedings Paper
Optics
Jesper Gluckstad
Summary: We propose the concept of Light Robotics, which involves using light-driven micro/nano robotic tools that can be manipulated and controlled like micro-drones in a three-dimensional space. To explore the full potential of this toolset in challenging microscopic geometries, a versatile and real-time reconfigurable light addressing method is required to dynamically track multiple tools and ensure continuous optimal light coupling.
COMPLEX LIGHT AND OPTICAL FORCES XVI
(2022)
Proceedings Paper
Optics
Andreas Gejl Madsen, Rene Eriksen, Jesper Gluckstad
Summary: This study compares a trained Convolutional Neural Network (CNN) with state-of-the-art iterative methods for digital hologram generation. The CNN outperforms the original Gerchberg-Saxton (GS) algorithm in terms of generation speed, but lags behind modern optimized GS implementations in terms of reconstruction quality.
COMPLEX LIGHT AND OPTICAL FORCES XVI
(2022)
Proceedings Paper
Optics
Andreas Gejl Madsen, Jesper Gluckstad
Summary: This paper explores the governing parameters of Gaussian to flat top beam shaping through simulation. It demonstrates the existence of optimal parameter values for a given beam shaping configuration, and the significant impact of deviation from these values on the homogeneity and precision of the output square. By performing a 3D parameter sweep, the best performing parameters are expressed in a single parameterized equation.
COMPLEX LIGHT AND OPTICAL FORCES XVI
(2022)
Proceedings Paper
Optics
Antonio Astorino, Andrew R. Banas, Karsten Rottwitt, Jesper Gluckstad
COMPLEX LIGHT AND OPTICAL FORCES XIII
(2019)
Article
Engineering, Electrical & Electronic
Ada-Ioana Bunea, Mogens Havsteen Jakobsen, Einstom Engay, Andrew R. Banas, Jesper Gluckstad
MICRO AND NANO ENGINEERING
(2019)