Article
Immunology
Zhiyong Chen, Yiwen Xu, Miao Chen, Ran Cui, Yu-Hsun Wang, Sheng-Ming Dai, James Cheng-Chung Wei
Summary: The risk of cardiovascular diseases is significantly higher in patients with both psoriasis and gout, and gout independently increases the risk of CVD in psoriasis patients, regardless of traditional risk factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ujue Fresan, Marcela Guevara, Camino Trobajo-Sanmartin, Cristina Burgui, Carmen Ezpeleta, Jesus Castilla
Summary: The study found that, in the general population, individuals with cardiovascular, cerebrovascular, and chronic kidney diseases, rather than those with hypertension alone, should be considered as high-risk groups for COVID-19 hospitalization and severe COVID-19.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Hitoshi Terui, Yoshihide Asano
Summary: Psoriasis is a chronic inflammatory skin disease associated with a high prevalence of cardiovascular disease, obesity, dyslipidemia, hypertension, diabetes mellitus, and metabolic syndrome. Cardiovascular disease is the leading cause of morbidity and mortality in psoriasis patients. Biologics targeting inflammatory cytokines have shown efficacy in improving psoriasis and reducing the risk of cardiovascular disease. This review discusses the cardiovascular risk in psoriasis patients, the association between psoriatic inflammation and atherosclerosis, and the efficacy of biologics in reducing the risk of cardiovascular diseases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yi-Fen Lai, Ting-Yi Lin, Wu-Chien Chien, Chien-An Sun, Chi-Hsiang Chung, Yi-Hao Chen, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that patients with AS who have uveitis are at a significantly higher risk of developing acute myocardial infarction (AMI) compared to those without uveitis. Regardless of gender or age group, patients with uveitis in the AS population have an increased risk for AMI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Abbas Alshami, Nasam Alfraji, Steven Douedi, Swapnil Patel, Mohammad Hossain, Deborah Alpert, Dawn Calderon
Summary: Psoriasis, a chronic autoimmune disorder, is not significantly associated with non-ischemic dilated cardiomyopathy according to a large population-based study, despite its higher cardiovascular events and traditional atherosclerotic risk factors.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Oncology
Do Kyung Kim, Hye Sun Lee, Ju-Young Park, Jong Won Kim, Ji Soo Ha, Jae Heon Kim, Won Jae Yang, Kang Su Cho
Summary: The study found that ADT may reduce the risk of ischemic cardiovascular diseases, cardiovascular intervention, and cerebrovascular diseases in patients with prostate cancer. The duration of ADT is associated with this risk reduction.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Adrienne Clermont, Rodney Sufra, Jean Lookens Pierre, Michelle Nour Mourra, Elizabeth L. Fox, Vanessa Rouzier, Eliezer Dade, Stephano St-Preux, Joseph Inddy, Hilaire Erline, Fleurijean Pierre Obed, Lily D. Yan, Miranda Metz, Myung Hee Lee, Daniel W. Fitzgerald, Marie Marcelle Deschamps, Jean W. Pape, Margaret L. McNairy
Summary: Poor diets contribute to the high burden of noncommunicable diseases in Haiti, particularly among low-income adults. Inadequate intake of fruits and vegetables, high consumption of fried food and sugar-sweetened beverages, and the preference for adding salt and oil to meals are the key dietary patterns observed. Young males of low socioeconomic status present the highest risk. Public health campaigns targeting this population group, particularly household cooks, are necessary to address the growing NCD burden.
Article
Clinical Neurology
Yingyang Zhang, Xue Li, Vivien K. Y. Chan, Hao Luo, Sandra S. M. Chan, Gloria H. Y. Wong, Ian C. K. Wong, Terry Y. S. Lum
Summary: Longer exposure to depression is significantly associated with an increased risk of cardiovascular disease, particularly in women and individuals under 65.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Fangfang Zhang, Kuanhong Wang, Peixin Du, Wei Yang, Yazhou He, Tian Li, Zubing Mei
Summary: This meta-analysis indicates that cancer survivors have a relatively higher risk of stroke compared to cancer-free populations, especially among female survivors, younger individuals, and those with shorter cancer survival duration. Survivors are more prone to ischemic stroke. Due to substantial heterogeneity among the studies, caution is needed in interpreting the results.
Article
Multidisciplinary Sciences
Sangsoo Han, Jiwon Park, Sangun Nah, Hae-Dong Jang, Kyungdo Han, Jae-Young Hong
Summary: Underweight is an important modifiable risk factor for fractures. A large population cohort study found a significant association between the severity of underweight and fracture risk.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Yu-Yen Chen, Hsin-Hua Chen, Tzu-Chen Lo, Pesus Chou
Summary: This study used Taiwan's national health insurance research database to examine 195,125 patients with new-onset uveitis and found that these patients had a significantly higher risk of developing psoriasis or psoriatic arthritis compared to individuals without uveitis.
Review
Immunology
Maria J. E. Visser, Gareth Tarr, Etheresia Pretorius
Summary: Psoriasis is a common inflammatory skin disorder driven by interleukin-17, with a multifactorial etiology and increased risk for multiple comorbid conditions, particularly cardiovascular disease. The presence of a hypercoagulable state in psoriatic patients may contribute to the association with cardiovascular disease. Inflammation and coagulation are closely related in the pathophysiology of Psoriasis and its comorbid conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
In Sun Ryou, Ju Young Kim, Hwa Yeon Park, Sohee Oh, Sehun Kim, Hwa Jung Kim
Summary: The study found that the risk of MACE incidence decreased in statin users, but increased for low-risk statin users, with no significant relationship identified for intermediate and borderline risk groups. The risk of MACE incidence decreased only in the high CVD risk group among statin users.
FRONTIERS IN MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Lu Liu, Saijin Cui, Meitong Liu, Xiangran Huo, Guoqiang Zhang, Na Wang
Summary: The study conducted an updated meta-analysis on cohort studies to investigate the relationship between psoriasis and adverse cardiovascular outcomes. The results showed that psoriasis is associated with various adverse cardiovascular outcomes, especially in severe patients. Psoriasis remains an independent risk factor for adverse cardiovascular outcomes and should receive more attention from clinicians.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Kathy Ming Feng, Wu-Chien Chien, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis could be a predictor of ACS in patients with AS. Both anterior uveitis and posterior segment involvement were associated with an increased risk of ACS in AS patients. Age, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, asthma, and systemic steroids were significant risk factors for ACS. The all-cause mortality was higher in the uveitis group compared to the non-uveitis group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Orthopedics
Matthew J. Dubiel, Joshua M. Kolz, Adam J. Tagliero, Dirk R. Larson, Hilal Maradit Kremers, Robert R. Cofield, John W. Sperling, Joaquin Sanchez-Sotelo
Summary: This study compared local and distant patients undergoing primary RSA, revealing that distant patients had longer operative times and were more likely to have had prior surgery, while local patients were older, more likely to have RSA for fracture, and had higher comorbidity scores and longer hospital stays.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Article
Orthopedics
Taghi Ramazanian, Shi Yan, Pouria Rouzrokh, Cody C. Wyles, Thomas J. O. Byrne, Michael J. Taunton, Hilal Maradit Kremers
Summary: This study compared HKA angle distribution in early and advanced knee osteoarthritis patients and found that patients undergoing total knee arthroplasty had a wider alignment distribution and more severe varus and valgus alignment. HKA angle was strongly associated with gender and body mass index.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Mario Hevesi, Cody C. C. Wyles, Pouria Rouzrokh, Bradley J. J. Erickson, Hilal Maradit-Kremers, David G. G. Lewallen, Michael J. J. Taunton, Robert T. T. Trousdale, Daniel J. J. Berry
Summary: This study aims to determine the optimal acetabular cup positioning during THA and investigate the effects of surgical approach on the topography of the acetabular safe zone and the risk of dislocation.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Celia C. Kamath, Thomas J. O'Byrne, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: Patients from low socioeconomic status (SES) neighborhoods undergoing total joint arthroplasty (TJA) have worse behavioral risk factors and higher comorbidity burden. Patients from rural communities generally have worse behavioral risk factors but are not significantly associated with comorbidities.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Pouria Rouzrokh, Bardia Khosravi, Quinn J. Johnson, Shahriar Faghani, Diana V. Vera Garcia, Bradley J. Erickson, Hilal Maradit Kremers, Michael J. Taunton, Cody C. Wyles
Summary: By utilizing deep-learning pipelines, we established an automated hip and pelvic radiography registry for total hip arthroplasty (THA) patients. The algorithms achieved high accuracy in determining radiograph appearance and measuring acetabular component angles. This efficient pipeline can be utilized by other institutions or registries for patient care and large-scale research.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Katrina L. Devick, Isabella Zaniletti, Dirk R. Larson, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: There are three common variable types in orthopedic research: confounders, colliders, and mediators. The decision to include or exclude a variable in an analysis should be based on its relationship with the exposure and outcome.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Orthopedics
Minji K. Lee, Isabella Zaniletti, Dirk R. Larson, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: This paper provides an overview of the development, validation, and use of patient-reported outcomes (PROs) in orthopaedic research, along with practical guidelines for researchers and reviewers. It discusses considerations for conceptual framework, validity, reliability, factor analysis, and measurement of change using the Knee Injury and Osteoarthritis Outcome score (KOOS) as an example. The advantages of instruments developed based on item response theory and statistical analyses for PRO data collection are also described.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Isabella Zaniletti, Dirk R. Larson, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: Prediction models are commonly used in medicine to predict outcomes in treatment. However, their adoption in clinical practice, specifically in arthroplasty, is limited. This paper provides an overview of statistical concepts, practical steps, and the importance of robustly built and validated prediction models in arthroplasty research.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Isabella Zaniletti, Dirk R. Larson, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: Correlation in observational studies is often misconstrued as causation. While correlation is necessary to establish a causal relationship between two variables, correlations can also occur due to chance, reverse causality, or confounding. Orthopaedic researchers have several methods at their disposal to determine if observed correlations are causal, which depend on key study components such as design and data availability on confounders. In this article, we explain the main concepts surrounding correlation and causation using intuitive real-world examples from orthopaedic literature.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Dirk R. Larson, Isabella Zaniletti, David G. Lewallen, Daniel J. Berry, Hilal Maradit Kremers
Summary: Many arthroplasty research studies are based on nonrandomized, retrospective, registry-based cohorts, which may introduce treatment selection bias and confounding. Propensity scores can help balance cohort characteristics and minimize potential bias and confounding in nonrandomized studies. This article explains how propensity scores are created and provides examples of their application in the analysis of nonrandomized studies.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
J. R. Harmer, C. C. Wyles, S. Q. Duong, R. J. Morgan, H. Maradit-Kremers, M. P. Abdel
Summary: The study aims to investigate the prevalence of depressive and anxiety disorders prior to total hip and total knee arthroplasty and their impact on infection rates, revision rates, and reoperation rates. Data from a single academic medical center were analyzed and showed that depressive and anxiety disorders were common before both procedures and were associated with higher risks of infection, revision, reoperation, and patient dissatisfaction. These findings highlight the importance of mental health optimization in arthroplasty patients, similar to other preoperative factors such as diabetic control.
BONE & JOINT JOURNAL
(2023)
Article
Computer Science, Artificial Intelligence
Bardia Khosravi, Pouria Rouzrokh, Hilal Maradit Kremers, Dirk R. Larson, Quinn J. Johnson, Shahriar Faghani, Walter K. Kremers, Bradley J. Erickson, Rafael J. Sierra, Michael J. Taunton, Cody C. Wyles
Summary: This study developed a multimodal machine learning-based pipeline to predict the patient-specific risk of dislocation following primary total hip arthroplasty (THA). By combining imaging features and clinical characteristics, a multimodal survival model was built to predict the hazard of dislocation within 5 years. The results showed that the multimodal model outperformed the clinical-only model in terms of predictive accuracy, indicating its potential as a powerful tool for dislocation risk stratification and THA planning.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2022)
Article
Computer Science, Artificial Intelligence
Pouria Rouzrokh, Cody C. Wyles, Shyam J. Kurian, Taghi Ramazanian, Jason C. Cai, Qiao Huang, Kuan Zhang, Michael J. Taunton, Hilal Maradit Kremers, Bradley J. Erickson
Summary: This study developed a deep learning tool to automatically quantify femoral component subsidence after total hip arthroplasty. The tool showed accuracy and reliability compared to manual measurements by orthopedic surgeons.
RADIOLOGY-ARTIFICIAL INTELLIGENCE
(2022)
Article
Orthopedics
Cody C. Wyles, Hilal Maradit-Kremers, Dirk R. Larson, David G. Lewallen, Michael J. Taunton, Robert T. Trousdale, Mark W. Pagnano, Daniel J. Berry, Rafael J. Sierra
Summary: This study aims to develop a patient-specific risk assessment tool for dislocation following total hip arthroplasty (THA). Through evaluating thousands of THA cases, the study found that the dislocation risk varies based on patient-specific comorbidities and operative decisions. By developing a risk calculator and nomograms, it is possible to assess the individual's risk for dislocation and guide pre-operative decisions to reduce complications.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Orthopedics
Mohammadreza Chavoshi, Ghazaleh Soltani, Shekoufe Shafiei Zargar, Cody Clayton Wyles, Hilal Maradit Kremers, Pouria Rouzrokh
Summary: This study evaluated the diagnostic performance of standard physical examination maneuvers for developmental dysplasia of the hip (DDH) and found that these clinical examinations have high specificity but low sensitivity. If clinical examinations are required for screening, the combination of Ortolani-Barlow and limited hip abduction tests can provide higher sensitivity.
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
(2022)