Article
Allergy
Kazufumi Kunimura, Sayaka Akiyoshi, Takehito Uruno, Keisuke Matsubara, Daiji Sakata, Kenji Morino, Kenichiro Hirotani, Yoshinori Fukui
Summary: This study reveals the role of DOCK2 in MRGPRX2/B2-mediated MC degranulation and anaphylaxis. The results show that MRGPRB2-mediated Rac activation and PAK1 phosphorylation were impaired in DOCK2-deficient MCs, leading to severe attenuation of MC degranulation and anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Immunology
Graham A. Mackay, Nithya A. Fernandopulle, Jie Ding, Jeremy McComish, Paul F. Soeding
Summary: Acute anaphylaxis to small molecule drugs is believed to be predominantly antibody-mediated with IgE and IgG involvement, along with activation of mast cells and neutrophils. The MRGPRX2 receptor has also been identified as a potential trigger for anaphylactic reactions to various drugs, independent of antibody recognition. Understanding the role of MRGPRX2 in anaphylaxis could be crucial for future drug development and exploration as a potential drug target in broader clinical settings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Shiting Hu, Yonghui Zhang, Baowen Dang, Yuejing Wang, Guodong Zheng, Tao Zhang, Hongli An
Summary: Immunologic contact urticaria (ICU) is a type I hypersensitivity reaction mediated by allergen-specific immunoglobulin E (sIgE). Myricetin (Myr), a flavonoid, has anti-inflammatory properties. Myr treatment alleviated ICU symptoms, reduced IgE levels and inflammatory markers in mice. Myr inhibited mast cell activation and reduced calcium influx and degranulation in human mast cells. Myr exerted its effects through the PI3K/Akt/NF-kappa B signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Dermatology
Maria Lampinen, Eva Hagforsen, Simone Westrom, Anna Bergstrom, Kerstin Hamberg Levedahl, Aida Paivandy, Paola Lara-Valencia, Gunnar Pejler, Ola Rollman
Summary: This study evaluated the concept of depleting mast cells (MCs) in the skin lesions of mastocytosis patients by targeting their secretory granules. The results showed that the antimalarial drug mefloquine induced apoptosis of MCs and reduced their numbers in the skin.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Allergy
Mati Chuamanochan, Siri Chiewchanvit, Napatra Tovanabutra, Rujira Rujiwetpongstorn, Kulwadee Laosakul, Marcus Maurer
Summary: The first case of acute urticaria (AU) associated with dengue virus infection is described in this article, suggesting a possible association between dengue virus infection and AU.
ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Meitong Liu, Jing Lu, Yuelin Chen, Xiaolei Shi, YaZhuo Li, Shuting Yang, Jing Yu, Shuang Guan
Summary: The study revealed that sodium sulfite triggers pyroptosis, an inflammatory form of programmed cell death, in mast cells, leading to cell membrane rupture and degranulation. Reactive oxygen species and NLRP3 play crucial roles in this process.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Gerhard J. Molderings, Lawrence B. Afrin
Summary: This study comprehensively compiles a list of 390 mediators released by mast cells upon activation. These mediators can be secreted into the extracellular space and may still underestimate the actual number. The compilation can be used by physicians to gain clarity about mast cell mediators involved in patients with refractory symptoms.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Allergy
Sen Hee Tay, Amelia Santosa, Eugene Chen Howe Goh, Chun Xiang Xu, Lik Hang Wu, Mei Bigliardi-Qi, Leroy Sivappiragasam S. O. Pakkiri, Bernett Teck Kwong Lee, Chester Lee Drum, Paul Lorenz Bigliardi
Summary: This study is the first to combine both transcriptomic and metabolomic approaches in patients with NIUA, contributing to a deeper understanding of the pathogenesis of NIUA and potentially paving the way for a molecular diagnosis of NSAID hypersensitivity.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Plant Sciences
Ke Lv, Mingyue Li, Chenghong Sun, Yu Miao, Yan Zhang, Yang Liu, Jianshuang Guo, Qing Meng, Jingchun Yao, Guimin Zhang, Jing Li
Summary: This study investigated the effects of Jingfang granules on acute lung injury and its mechanisms. The results showed that Jingfang granules can attenuate pulmonary injury and inflammation by reducing the recruitment and activation of alveolar macrophages through the CD200-CD200R immunoregulatory signal axis. This provides an experimental basis for the clinical application of Jingfang granules in COVID-19.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Gyeongseo Suk, Do Hoon Kwon, Axel Roers, Soman N. Abraham, Hae Woong Choi
Summary: The pharmacological intervention of ORAI1 channel inhibition in mast cells shows promise as a therapeutic avenue for preventing peanut-induced anaphylaxis and acute diarrhea. ORAI1 inhibitors effectively suppress mast cell responses and ameliorate allergic reactions.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Haesoo Kim, Jeehee Jang, Min Ji Song, Chi-Hyun Park, Dong Hun Lee, Si-Hyung Lee, Jin Ho Chung
Summary: Photoaging is primarily caused by UV radiation, resulting in increased secretion of matrix metalloproteinases (MMPs) and collagen degradation. Our study reveals the critical role of senescent cells in photoaging and suggests that senolytic agents can attenuate photoaging and serve as potential strategies for its treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Allergy
Nan Wang, Jue Wang, Yongjing Zhang, Shiling Hu, Tianxiao Zhang, Yuanyuan Wu, Xiuzhen Sun, Tao Zhang, Shuanying Yang, Langchong He
Summary: The study investigated the relationship between Substance P (SP) and lung inflammation, as well as whether SP can directly trigger asthma. The results showed that SP levels were increased in serum samples of asthmatic patients, and SP induced Th2 lung inflammation in mice, which was dependent on mast cells.
CLINICAL AND EXPERIMENTAL ALLERGY
(2022)
Article
Biochemistry & Molecular Biology
Seong-Ryeong Lim, Do-Wan Kim, Junghee Sung, Tae Hoon Kim, Chang-Hyung Choi, Sei-Jung Lee
Summary: Astaxanthin has antioxidant properties and can inhibit autophagic cell death induced by BPA in human dermal fibroblasts by suppressing ROS production and regulating kinase phosphorylation.
Article
Biochemistry & Molecular Biology
Jufang Jia, Mengnan Zeng, Denghui Zhu, Xinmian Jiao, Beibei Zhang, Ruolan Yang, Weisheng Feng, Xiaoke Zheng
Summary: This study demonstrates for the first time that EB-A can ameliorate allergic asthma by inhibiting mast cell activation and dendritic cell maturation, and the molecular mechanism of EB-A's anti-asthmatic activity might be mediated by inhibiting PAR2 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Mayra Ianhez, Selma R. P. S. Cerqueira, Ciro Martins Gomes, Carolina C. Talhari, Paulo R. Criado, Caio C. S. Castro, Paulo M. Ramos, Helio A. Miot
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2023)
Article
Mycology
Carla Pagliari, Luciane Kanashiro-Galo, Mirian Nacagami Sotto
Summary: This study investigated the presence and potential role of inflammasome elements in cutaneous lesions of Chromoblastomycosis. The results suggest that inflammasome-mediated response and pyroptosis may play a role in the immune response against fungal agents of CBM.
Letter
Dermatology
Cristina Marta Maria Laczynski, Carlos D'Apparecida Santos Machado Filho, Helio Amante Miot, Denise Maria Christofolini, Itatiana Ferreira Rodart, Paulo Ricardo Criado
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Review
Cell Biology
Paulo Ricardo Criado, Helio Amante Miot, Mayra Ianhez
Summary: This study aims to explore the biological and clinical spectrum of cutaneous manifestations involving tissue and/or systemic eosinophilia and distinct serum levels of IgE. A diagnostic approach for patients with elevated serum IgE level is provided, including conditions not related to atopic dermatitis. Clinical patterns of skin diseases associated with tissue eosinophilia are also listed to aid in diagnosis.
INFLAMMATION RESEARCH
(2023)
Article
Virology
Anna Claudia Calvielli Castelo Branco, Emily Araujo De Oliveira, Natalli Zanete Pereira, Ricardo Wesley Alberca, Amaro Nunes Duarte-Neto, Luiz Fernando Ferraz Da Silva, Fernanda Guedes Luiz, Naiura Vieira Pereira, Mirian Nacagami Sotto, Naiara Naiana Dejani, Patricia Helen Carvalho Rondo, Elyzabeth Avvad-Portari, Zilton Farias Meira De Vasconcelos, Alberto Jose da Silva Duarte, Tamiris Azamor, Maria Notomi Sato
Summary: The incidence of obesity is increasing worldwide, particularly in women, and this can affect pregnancy outcomes. During this period, viral infections pose a risk to the mother, placenta, and fetus. The Zika virus outbreak in Brazil has resulted in the congenital Zika syndrome (CZS) and devastating consequences such as microcephaly in newborns. This study examines the impact of maternal overweight/obesity on the expression of antiviral factors in the placental tissue of Zika-infected mothers.
Review
Dermatology
Helio Amante Miot, Paulo Ricardo Criado, Caio Cesar Silva de Castro, Mayra Ianhez, Carolina Talhari, Paulo Mueller Ramos
Summary: The JAK-STAT signaling pathway plays important roles in immune response, carcinogenesis, cell differentiation, division, and death. Drugs that interfere with different JAK-STAT signaling patterns have potential indications for various medical conditions. In dermatology, JAK-STAT pathway inhibitors have been primarily used for treating inflammatory or autoimmune diseases, but ongoing investigations are expanding their potential indications.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Review
Cell Biology
Paulo Ricardo Criado, Daniel Lorenzini, Helio Amante Miot, Roberto Bueno-Filho, Francisca Regina Oliveira Carneiro, Mayra Ianhez
Summary: This article provides an overview of a new class of drugs that can block important intracellular signaling pathways, thereby treating inflammatory, autoimmune, genetic, and neoplastic diseases. These drugs have significant implications for the treatment of dermatological diseases.
INFLAMMATION RESEARCH
(2023)
Article
Microbiology
Yasmin Pacheco Ribeiro, Luiz Fabio Magno Falcao, Vanessa Cavaleiro Smith, Jorge Rodrigues de Sousa, Carla Pagliari, Edna Cristina Santos Franco, Ana Cecilia Ribeiro Cruz, Janniffer Oliveira Chiang, Livia Caricio Martins, Juliana Abreu Lima Nunes, Fellipe Souza da Silva Vilacoert, Lais Carneiro dos Santos, Matheus Perini Furlaneto, Hellen Thais Fuzii, Marcos Virgilio Bertonsin Filho, Luccas Delgado da Costa, Maria Irma Seixas Duarte, Ismari Perini Furlaneto, Arnaldo Jorge Martins Filho, Tinara Leila de Souza Aarao, Pedro Fernando da Costa Vasconcelos, Juarez Antonio Simoes Quaresma
Summary: In this study, histopathological analysis of liver samples from 70 patients who died due to infections and complications of yellow fever, dengue fever, and chikungunya fever was conducted. The results showed significant differences in histopathological alterations between the control and infection groups, with a predominance of changes in the midzonal area in all three cases analyzed. Hepatic involvement in yellow fever cases showed more severe histopathological changes.
Article
Dermatology
Carla Pagliari, Luciane Kanashiro-Galo, Mirian Nacagami Sotto
Summary: This study aimed to identify the mechanisms of programmed cell death and inflammasome components in human oral mucosal lesions of paracoccidioidomycosis. The results showed increased expression of IL-1β, NLRP-1, caspase-1, and RIPK-3, suggesting the involvement of inflammasome complex in the immunopathogenesis of oral lesions in paracoccidioidomycosis.
Article
Allergy
Hanna Bonnekoh, Jannis Jelden-Thurm, Anastasiia Allenova, Yudi Chen, Ivan Cherrez-Ojeda, Inna Danilycheva, Irina Dorofeeva, Roberta Fachini Jardim Criado, Paulo Ricardo Criado, Asli Gelincik Akkor, Tomasz Hawro, Emek Kocaturk, Maryam Khoshkhui, Martin Metz, Iman Nasr, Michal Stec, Zuotao Zhao, Felix Aulenbacher, Pascale Salameh, Sabine Altrichter, Margarida Goncalo, Ana Gimenez-Arnau, Marcus Maurer, Karoline Krause, Pavel Kolkhir
Summary: Chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV) have some clinical features in common. This study aimed to identify the differences, similarities, and specific clinical features between these two disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Review
Allergy
Jonathan A. Bernstein, Navid Ziaie, Roberta Criado, Paulo Ricardo Criado, Stephanie Rea, Mark Davis
Summary: Chronic urticaria is a common condition characterized by intensely itchy wheals that last for at least 6 weeks. It can be either spontaneous or inducible, with specific triggers in the latter case. Angioedema, which is a localized swelling involving deep layers of the skin, can occur separately or in conjunction with chronic urticaria. Both conditions have multiple mimics, and it is important to consider a broad range of differential diagnoses to avoid incorrect diagnosis and ensure appropriate investigation, treatment, and prognosis for the patient.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Multidisciplinary Sciences
Carolina Talhari, Paulo R. Criado, Caio C. S. Castro, Mayra Ianhez, Paulo M. Ramos, Helio A. Miot
Summary: This study investigated the prevalence and risk factors for post-COVID manifestations up to 12 weeks after the onset of acute COVID-19. The majority of COVID-19 patients developed various post-COVID manifestations, with hair loss, fatigue, and neuropsychiatric symptoms being the most common. Female sex, myalgia, anosmia, and more severe disease were associated with multiple post-COVID manifestations.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Biotechnology & Applied Microbiology
Ana Carolina Caetano Jesus, Maria Cristina Goncalves Meniconi, Luciane Kanashiro Galo, Maria Irma Seixas Duarte, Mirian Nacagami Sotto, Carla Pagliari
Summary: HPV infection can lead to cervical diseases, and the STING protein plays an important role in this process. The function of Th17 cells depends on the tumor microenvironment.
INDIAN JOURNAL OF MICROBIOLOGY
(2023)