Article
Oncology
Mahendra Pratap Kashyap, Rajesh Sinha, M. Shahid Mukhtar, Mohammad Athar
Summary: Advancements in cutting-edge technological tools and bioinformatics have revolutionized the understanding and research of cancer. This review focuses on the epigenetic regulation of non-melanoma skin cancer, emphasizing the roles of genetic mutations, epigenetic regulation, and novel therapeutic interventions in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Xin Yu, Yuli Cui, Xueqing Zhu, Hongjun Xu, Linfeng Li, Guangcheng Gao
Summary: The deregulation of miRNAs in vitiligo is associated with the development and progression of the disease and may serve as prognostic biomarkers. MiRNAs play a direct role in the pathogenesis of vitiligo and could potentially be targeted for therapy. However, further research is needed to fully understand the function and mechanism of deregulated miRNAs in vitiligo and establish their clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhiqiang Fang, Guorui Dou, Lin Wang
Summary: NAFLD is a chronic liver disorder closely associated with cardiovascular disease, obesity, and type 2 diabetes mellitus worldwide. Recent studies have found that miRNAs play crucial roles in the pathogenesis and progression of NAFLD, suggesting them as potential therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Linyinxue Dong, Xuechen Tian, Yunqi Zhao, Haohong Tu, Aloysius Wong, Yixin Yang
Summary: This systematic review discusses the roles of microRNAs (miRNAs) in melanoma immunotherapy, including regulating immune cell functions, affecting drug resistance, and influencing the effectiveness and adverse events of checkpoint inhibitors. It also explores the application of miRNAs in different immunotherapy approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Brunno Felipe R. Caetano, Beatrice Adrianne S. Jorge, Barbara Grasiele Mueller-Coan, Deilson Elgui de Oliveira
Summary: EBV is a gamma-herpesvirus linked to various human cancers, with its miRNAs modulating carcinogenesis and serving as potential markers for monitoring EBV-associated cancers.
Article
Cell Biology
Chunlei Liu, Xiujuan Qiu, Jun Gao, Zhifan Gong, Xiaogang Zhou, Haichao Luo, Xuerui Geng
Summary: The study aims to investigate the regulatory mechanism of SPI1 in melanoma. SPI1 was found to be highly expressed in melanoma cells and tissues. Its knockdown inhibited cell viability, metastasis, and glycolysis in melanoma cells. SPI1 was shown to directly target HK2, and the expression of HK2 was repressed upon SPI1 knockdown. Overexpression of HK2 counteracted the inhibitory effects of SPI1 knockdown on melanoma cell viability, metastasis, and glycolysis. The AKT1/mTOR pathway was found to be involved in the regulatory role of SPI1 in melanoma progression.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Soudeh Ghafouri-Fard, Mahdi Gholipour, Mohammad Taheri
Summary: miRNAs play a crucial role in the pathophysiological process of CAD, with up-regulated and down-regulated miRNAs associated with the development of CAD, which can be utilized for diagnostic and prognostic evaluation of CAD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Cristian Scheau, Carmen Draghici, Mihaela Adriana Ilie, Mihai Lupu, Iulia Solomon, Mircea Tampa, Simona Roxana Georgescu, Ana Caruntu, Carolina Constantin, Monica Neagu, Constantin Caruntu
Summary: Melanoma is an aggressive and fatal malignant tumor, with early diagnosis being curable but advanced stages having high mortality rates. Studies have focused on neuroendocrine factors' role in melanoma development, but there are still unknown features to uncover. Investigating how neuroendocrine factors influence melanoma's clinical course may lead to new biomedical research areas and therapeutic approaches.
Article
Immunology
Yi Xu, Yongcheng He, Haofei Hu, Ricong Xu, Ying Liao, Xu Dong, Haiying Song, Xiaojie Chen, Jia Chen
Summary: The study found that the expression of miRNA-150-5p was significantly upregulated in the tonsils of patients in the GH-IgAN group, and was correlated with clinical data. This suggests that miRNA-150-5p may play an important role in the pathogenesis of IgAN.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daeun Choi, Jimin Kim, Jae Won Yang, Ji Hong Kim, Seoyeon Park, Jae Il Shin
Summary: Systemic lupus erythematosus is a chronic autoimmune disease with heterogeneous clinical presentation. Epigenetic factors, particularly microRNAs, have therapeutic potential in SLE pathogenesis. This review summarizes the current understanding of lupus pathogenesis, focusing on dysregulation of microRNAs in patients compared to healthy controls, as well as their potential pathogenic roles. Controversial microRNAs and future research directions are also discussed. Additionally, the importance of considering the specimen used to assess microRNA dysregulation in studies is emphasized.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Shilpi Singh, Waseem Raza, Shahnaz Parveen, Abha Meena, Suaib Luqman
Summary: miRNAs, as non-coding nucleotide sequences, play a crucial role in cancer development, with evidence suggesting that their deregulation is associated with tumorigenesis. Flavonoids are known to modulate miRNAs expression, potentially serving as chemopreventive agents by targeting miRNAs involved in cancer progression. While extensively studied in pre-clinical settings, more research is needed to explore the clinical implications of flavonoids in targeting miRNAs for cancer prevention and treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Jingyu Song, Jiaxin Wang, Kang Liu, Wenchao Xu, Taotao Sun, Jihong Liu
Summary: Erectile dysfunction, a common male sexual dysfunction disease, is predicted to affect 322 million individuals worldwide by 2025. The pathogenesis of ED is complex and current treatments options are limited. Recent studies have highlighted the significant role of miRNAs in ED, suggesting their potential as therapeutic targets for the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Lele Cong, Hongfeng Yang, Hongyan Sun, Miao Hao, Chenlu Liu, Yang Zheng, Xianling Cong, Rihua Jiang
Summary: circRNAs are key players in the pathogenesis of malignant melanoma, and they can serve as potential diagnostic, therapeutic, and prognostic biomarkers for advanced melanoma in clinical applications.
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION
(2022)
Review
Oncology
Gerardo Cazzato, Eliano Cascardi, Anna Colagrande, Teresa Lettini, Leonardo Resta, Cinzia Bizzoca, Francesca Arezzo, Vera Loizzi, Miriam Dellino, Gennaro Cormio, Nadia Casatta, Carmelo Lupo, Antonio Scillimati, Salvatore Scacco, Paola Parente, Lucia Lospalluti, Giuseppe Ingravallo
Summary: This article provides a systematic review of primary malignant melanoma of the esophagus (PMME) in terms of its history, epidemiology, treatment, and future research directions. PMME is an extremely rare form of esophageal cancer that has been subject to debate regarding its existence. Over time, more cases have been reported, increasing knowledge and paving the way for discussions on treatment. Currently, surgery remains the primary treatment approach, but new therapeutic strategies, such as nivolumab, are being explored. Future studies with large case series, including clinicopathological and molecular data, are needed to improve the outcome of PMME patients.
Review
Oncology
Vinitha Richard, Matthew G. Davey, Heidi Annuk, Nicola Miller, Roisin M. Dwyer, Aoife Lowery, Michael J. Kerin
Summary: Breast cancer is a heterogeneous disease model with various tumor subtypes, and microRNA profiling plays a significant role in precise classification, prediction of tumor progression, and risk stratification. By integrating protein, gene, and miRNA expression studies, a unique miRNA-based taxonomy is proposed as the gold standard for appropriate classification and separation of breast cancer for targeted therapy.
Review
Cell Biology
Raman Preet Kaur Gill, Jennifer Gantchev, Amelia Martinez Villarreal, Brandon Ramchatesingh, Elena Netchiporouk, Oleg E. Akilov, Niels odum, Robert Gniadecki, Sergei B. Koralov, Ivan V. Litvinov
Summary: Cutaneous T-cell lymphoma (CTCL) is a group of lymphoproliferative disorders caused by the infiltration of malignant T cells into the skin. Despite the challenges in diagnosis, studying cell lines and xenograft/GEMMs is crucial for advancing our understanding of the pathogenesis of CTCL.
Article
Dermatology
Kim A. Papp, Melinda J. Gooderham, Charles W. Lynde, Yves Poulin, Jennifer Beecker, Jan P. Dutz, Chih-Ho Hong, Robert Gniadecki, Mark G. Kirchhof, Catherine Maari, Ronald B. Vender
Summary: This article presents a methodological framework for developing practical and clinically relevant guidelines in situations where direct evidence is scarce or absent. By combining the best available evidence with structured expert opinion, the aim is to provide informative recommendations for complex clinical scenarios not adequately addressed by clinical trials.
DERMATOLOGY AND THERAPY
(2022)
Article
Hematology
Aishwarya Iyer, Dylan Hennessey, Robert Gniadecki
Summary: Mature T-cell lymphomas (TCLs) are rare hematologic cancers with poor prognosis. In this study, the researchers attempted to identify the cell of origin in TCLs by tracing the clonal history of the T cells using T-cell receptor (TCR) recombinations. They found that TCLs are initiated at the level of lymphoid precursor cells and have clonotypically diverse initiating cells. This finding provides important insights into the pathogenesis of TCLs.
Review
Dermatology
J. J. Wu, A. Kavanaugh, M. G. Lebwohl, R. Gniadecki, J. F. Merola
Summary: Psoriasis is a chronic inflammatory disorder that is often associated with comorbidities, particularly metabolic syndrome. The underlying pathophysiology of psoriasis and metabolic syndrome appears to involve genetic predispositions and inflammatory pathways. Biologic treatments for psoriasis may not only improve skin lesions but also reduce the risk of developing atherosclerosis and cardiovascular diseases.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Kim A. Papp, Jennifer Beecker, Curtis Cooper, Mark G. Kirchhof, Anton L. Pozniak, Juergen K. Rockstroh, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-Ho Hong, Charles W. Lynde, Catherine Maari, Yves Poulin, Ronald B. Vender, Sharon L. Walmsley
Summary: The study found that PLHIV who are diagnosed early and receive antiretroviral therapy can likely expect the same safety and efficacy for systemic psoriasis treatments as the general population.
DERMATOLOGY AND THERAPY
(2022)
Article
Medicine, General & Internal
Amy X. Du, Robert Gniadecki, Jan Storek, Mohamed Osman
Summary: Systemic sclerosis, also known as scleroderma, is an autoimmune disease characterized by fibrosis of the skin and internal organs, immune dysfunction, and vascular abnormalities. The exact cause is unknown, but it is associated with dysfunction of fibroblasts and damage to blood vessels, possibly triggered by DNA damage. Chemotherapeutic drugs and other agents that cause DNA damage may contribute to the development of systemic sclerosis.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
Lydia Ouchene, Anastasiya Muntyanu, Deborah Assayag, Evicka Veilleux, Andy Abril, Giovanni Ferrara, Elaine Yacyshyn, Christian A. Pineau, Elizabeth O'Brien, Murray Baron, Mohammed Osman, Robert Gniadecki, Elena Netchiporouk
Summary: This article introduces dermatologists to the noninfectious inflammatory skin diseases associated with pulmonary involvement and emphasizes the importance of screening and monitoring for lung disease in high-risk patients. It also highlights the need for dermatologists to recognize cutaneous manifestations of lung disease and refer patients to pulmonary specialists for appropriate treatment. The article emphasizes the common pulmonary complications and high mortality rates associated with autoimmune connective tissue diseases, sarcoidosis, vasculitis, and autoimmune blistering diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Dermatology
Melika Motamedi, Giovanni Ferrara, Elaine Yacyshyn, Mohammed Osman, Andy Abril, Samia Rahman, Elena Netchiporouk, Robert Gniadecki
Summary: Numerous inflammatory, neoplastic, and genetic skin disorders are associated with interstitial lung disease (ILD), the fibrosing inflammation of lung parenchyma that has significant morbidity and mortality. Therefore, the dermatologist plays a major role in the early detection and appropriate referral of patients at risk for ILD.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Computer Science, Interdisciplinary Applications
Marleine Azar, Francois Lagace, Anastasiya Muntyanu, Elena Netchiporouk, Youwen Zhou, Charles Lynde, Linda Moreau, Steve Mathieu, Denis Sasseville, Rachel Asiniwasis, Neil H. Shear, Robert Gniadecki, Elham Rahme, Ivan V. Litvinov
Summary: This study examined the relationship between h-index and academic rank, sex, and other factors in dermatology in Canada. The results showed an increase in female dermatologists and found no association between h-index and sex.
Article
Dermatology
Aaron M. M. Drucker, Omer Kleiner, Rachael Manion, Anie Philip, Jan Dutz, Kathleen Barnard, Julie Fradette, Lucie Germain, Robert Gniadecki, Ivan Litvinov, Sarvesh Logsetty, Morris Manolson, P. Regine Mydlarski, Vincent Piguet, Debbie Ward, Youwen Zhou, An-Wen Chan
Summary: The Skin Investigation Network of Canada (SkIN Canada) identified the top ten research priorities for nine key skin conditions through surveys, scoping reviews, and workshops, emphasizing the importance of involving patients and healthcare providers.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Article
Cell Biology
Robert Gniadecki, Sandra O'Keefe, Dylan Hennessey, Aishwarya Iyer
Summary: Ultraviolet radiation is a strong carcinogen responsible for most skin cancers. However, its role in the pathogenesis of mycosis fungoides (MF) is still controversial.
Article
Dermatology
Kim A. Papp, Barbara Melosky, Sandeep Sehdev, Sebastien J. Hotte, Jennifer R. Beecker, Mark G. Kirchhof, Irina Turchin, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Jo Lambert, Charles W. Lynde, Vimal H. Prajapati, Ronald B. Vender
Summary: Patients with previously treated solid tumors may have an increased risk of cancer recurrence when treated with systemic therapies for psoriasis, but for patients with a good cancer prognosis, treating psoriasis with systemic therapies may offer quality-of-life benefits.
DERMATOLOGY AND THERAPY
(2023)
Article
Oncology
Francois Lagace, Bibi Nuzha Noorah, Santina Conte, Lorena Alexandra Mija, Jasmine Chang, Leila Cattelan, Jonathan LeBeau, Joel Claveau, Irina Turchin, Wayne Gulliver, Robert Gniadecki, Elena Netchiporouk, Wilson H. Miller, Thomas G. Salopek, Elham Rahme, Sandra Pelaez, Ivan V. Litvinov
Summary: This study compared the differences in sun exposure, sun protection, and level of worry for cutaneous melanoma between high-incidence and low-incidence provinces in Atlantic Canada, as well as between different demographic groups. The findings identified significant differences across multiple variables, which will help guide future public health efforts in preventing and reducing the incidence of cutaneous melanoma in the communities.
Correction
Dermatology
Kim A. Papp, Jennifer Beecker, Curtis Cooper, Mark G. Kirchhof, Anton L. Pozniak, Juergen K. Rockstroh, Jan P. Dutz, Melinda J. Gooderham, Robert Gniadecki, Chih-ho Hong, Charles W. Lynde, Catherine Maari, Yves Poulin, Ronald B. Vender, Sharon L. Walmsley
DERMATOLOGY AND THERAPY
(2023)
Review
Oncology
Johanna Latzka, Chalid Assaf, Martine Bagot, Antonio Cozzio, Reinhard Dummer, Emmanuella Guenova, Robert Gniadecki, Emmilia Hodak, Constanze Jonak, Claus-Detlev Klemke, Robert Knobler, Stephen Morrris, Jan P. Nicolay, Pablo L. Ortiz-Romero, Evangelia Papadavid, Nicola Pimpinelli, Pietro Quaglino, Annamari Ranki, Julia Scarisbrick, Rudolf Stadler, Liisa Vakeva, Maarten H. Vermeer, Ulrike Wehkamp, Sean Whittaker, Rein Willemze, Franz Trautinger
Summary: This document provides an updated standard for the treatment of mycosis fungoides and Sezary syndrome (MF/SS), including treatment options for each disease stage. Skin-directed therapies are the most appropriate option for early-stage MF, while treatment options have expanded recently for advanced disease. Prognosis is still poor for most patients.
EUROPEAN JOURNAL OF CANCER
(2023)
