Article
Dermatology
Cathrine Helene Mohn, Hege S. Blix, Anja Maria Braend, Per Nafstad, Stale Nygard, Jon Anders Halvorsen
Summary: The literature on treatment patterns for paediatric atopic dermatitis (AD) is scarce. Using national registers, this study provides up-to-date, population-based prevalence estimates, predictors of risk and disease burden, and a comprehensive overview of treatment patterns and course for paediatric patients with AD.
DERMATOLOGY AND THERAPY
(2022)
Review
Environmental Sciences
Sukhbir Singh, Tapan Behl, Neelam Sharma, Ishrat Zahoor, Sridevi Chigurupati, Shivam Yadav, Mahesh Rachamalla, Aayush Sehgal, Tanveer Naved, Pritima, Sandeep Arora, Saurabh Bhatia, Ahmed Al-Harrasi, Syam Mohan, Lotfi Aleya, Simona Bungau
Summary: Atopic dermatitis is a common chronic skin disease that significantly impacts the lives of patients and their families. Currently, the main pharmacological treatment for atopic dermatitis is topical corticosteroids. However, delivering medications to deeper layers of the skin is challenging due to the skin's anatomy and barrier abnormalities in atopic dermatitis. Therefore, nanotechnology-based topical therapeutics have gained attention as they have the potential to increase drug diffusion and targeting, reducing adverse effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Allergy
Julian Matthewman, Kathryn E. Mansfield, Daniel Prieto-Alhambra, Amy R. Mulick, Liam Smeeth, Katherine E. Lowe, Richard J. Silverwood, Sinead M. Langan
Summary: This study found an association between atopic eczema and major osteoporotic fractures, and oral corticosteroid use explains only a small part of this association.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema, developed according to the EuroGuiDerm Guideline and Consensus Statement Development Manual, involves the participation of 29 experts from 12 European countries. The first part of the guideline provides general information, guidance, and detailed information on systemic treatment options, including conventional immunosuppressive drugs, biologics, and janus kinase inhibitors. The second part will cover other aspects of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Di Xu, Rainer Stengel, Pengfei Sun
Summary: This study aimed to evaluate whether the early use of emollients in infants can prevent atopic dermatitis. The results showed that there was no significant difference in the incidence rate of AD between the experimental and control groups. However, due to the variations in methods of emollient use, follow-up times, and sample sizes, a definitive conclusion could not be reached.
Review
Dermatology
Karlijn F. Van Halewijn, Thara Lahnstein, Arthur M. Bohnen, Pieter J. Van Den Berg, Suzanne Gma Pasmans, Patrick Je Bindels, Gijs Elshout
Summary: Guidelines for the management of atopic dermatitis vary in quality and therapeutic recommendations, particularly regarding the use of emollients and topical corticosteroids. Recommendations are often based on expert opinion rather than solid evidence.
EUROPEAN JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stefano Piazza, Giulia Martinelli, Andrea Magnavacca, Marco Fumagalli, Carola Pozzoli, Massimo Terno, Luisa Canilli, Marco Angarano, Nicole Maranta, Mario Dell'Agli, Enrico Sangiovanni
Summary: This study investigates the potential role of Hamamelis virginiana in controlling atopic dermatitis symptoms. The study finds that a standardized extract of Hamamelis virginiana inhibits the release of mediators involved in skin autoimmunity and allergy, and also counteracts the proliferation effects of IL-4, a key cytokine involved in atopic dermatitis. This work demonstrates the relevance of the whole phytocomplex of Hamamelis virginiana in controlling atopic dermatitis symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Tracey T. Sach, Stella Lartey, Charlotte R. Davies, Joanne H. Chalmers, Rachel E. Haines, Lucy A. Bradshaw, Alan S. Montgomery, Kim J. Thomas, Sara J. Brown, Matthew Ridd, Sandra J. Lawton, Mike Cork, Carsten Flohr, Eleanor Mitchell, Richard Swinden, Laura Wyatt, Stella Tarr, Susan Davies-Jones, Nicola M. Jay, Maeve R. Kelleher, Michael J. Perkin, Robert C. Boyle, Hywel Williams, BEEP Study Team
Summary: A study showed that enhancing skin barrier from birth might prevent eczema and food allergy. However, applying emollient daily for the first year of life in high-risk children does not appear cost-effective in preventing atopic eczema.
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Review
Biochemistry & Molecular Biology
Jamie Afghani, Claudia Traidl-Hoffmann, Philippe Schmitt-Kopplin, Matthias Reiger, Constanze Mueller
Summary: Atopic eczema is an inflammatory skin disorder that affects approximately 20% of children worldwide, and early onset can lead to other allergic diseases. Metabolomics can be used to observe the mechanisms of this disease and potentially discover new drug targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Astrid Herzum, Corrado Occella, Lodovica Gariazzo, Carlotta Pastorino, Gianmaria Viglizzo
Summary: Corticophobia, the fear of using topical corticosteroids, is becoming a more prevalent issue in industrialized countries, despite the proven safety of these medications for treating atopic dermatitis. This study found that factors such as milder or moderate disease severity, older age of patients, earlier disease onset, and previous healthcare professional consultations were associated with parental corticophobia. Additionally, severe parental corticophobia was significantly associated with a higher level of parental education and a greater impact on parental quality of life. Assessing the risk factors for corticophobia is crucial for developing educational programs that address the concerns of high-risk parents, in order to alleviate unfounded fears and improve treatment adherence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Dermatology
Nicole S. Stefanko, Victor L. Quan, Raj Chovatiya
Summary: This study investigates the diagnostic delay in an autoimmune skin disease. The use of C3d and C4d immunohistochemistry is found to be a valuable tool in the diagnosis of inflammatory skin diseases.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Anne Birgitte Simonsen, Jojo Biel-Nielsen Dietz, Jeanne Duus Johansen
Summary: This study aimed to explore the epidemiology, aetiology and severity of hand eczema (HE) among Danish adolescents. The study found a high prevalence of HE among Danish adolescents, raising concerns about this significant clinical problem.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Cathrine H. Mohn, Hege S. Blix, Anja Maria Braend, Per Nsfstad, Jon Anders Halvorsen
Summary: This study investigated isotretinoin therapy in patients with atopic dermatitis and compared the prevalence with individuals without atopic dermatitis nationwide. The results showed that more patients with atopic dermatitis were treated with isotretinoin than those without. Severe acne (isotretinoin therapy) was associated with atopic dermatitis at the population level in young adults.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Immunology
Paola Facheris, Jane Jeffery, Ester Del Duca, Emma Guttman-Yassky
Summary: Atopic dermatitis (AD) is a complex and heterogeneous inflammatory skin disease. Different phenotypes of AD based on patient characteristics have been defined, emphasizing the need for personalized treatment. Advances in understanding AD pathogenesis have led to an expansion in therapeutic options. Biomarkers in clinical studies are helping to clarify the role of cytokines and immune pathways in AD and enable personalized medicine. This review discusses changes in the understanding and treatment of AD, highlighting the scientific rationale behind targeted treatments and presenting recent clinical efficacy data.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
