Article
Dermatology
Paola Lovato, Li Jiang, Josephine Hebsgaard, David A. Ewald, Hanne Norsgaard
Summary: In this study, the effects of a fixed-dose combination of Cal/BD foam and CP cream on Th17 cytokine secretion and epidermal differentiation were investigated. Cal/BD foam significantly inhibited Th17 cytokine secretion and improved the expression of epidermal differentiation markers, while CP cream reduced Th17 cytokine levels to a lesser extent and did not improve epidermal differentiation markers.
DERMATOLOGY AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Francesca Selmin, Silvia Franze, Antonella Casiraghi, Francesco Cilurzo
Summary: Psoriasis is a complex disease that requires lifelong treatment, and combination therapy can improve its safety and efficacy. Fixed-dose topical formulations can simplify treatment and improve patient compliance. This review provides an overview of Cal/BD fixed-dose combination products on the market and discusses the differences among different formulations.
Review
Dermatology
Yi Zhao, Akihiko Asahina, Pravit Asawanonda, Ma. Lorna Frez, Shinichi Imafuku, Dong Hyun Kim, Colin Theng, Liangchun Wang, Jiang An Zhang, Sameer Zimmo
Summary: This systematic review evaluated the global findings from clinical trials and real-world studies of topical calcipotriol and the two-compound formulation of calcipotriol and betamethasone dipropionate for mild-to-moderate plaque psoriasis. Following a critical review of the published data combined with expert opinion, clinical practice recommendations were agreed upon in order to assist healthcare providers.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Marjorie Heim, Marie Irondelle, Luc Duteil, Nathalie Cardot-Leccia, Stephane Rocchi, Thierry Passeron, Meri K. Tulic
Summary: Psoriasis is a chronic inflammatory disease that is difficult to control in the long term. The combination of topical treatment with steroids and vitamin D analogue foam has been shown to be efficient in managing the disease and reducing relapses. This study focuses on the effect of topical therapies on cellular infiltrate and cytokine profile in the lesional skin of psoriasis patients. The findings suggest that the combined Calcipotriol/Betamethasone foam treatment is effective in reducing cellular influx into lesional skin and is superior to other treatments.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Peripheral Vascular Disease
Natalie C. Ward, Revathy Carnagarin, Janis M. Nolde, Leslie Marisol Lugo-Gavidia, Justine Chan, Ancy Jose, Sandi Robinson, Anu Joyson, Markus P. Schlaich
Summary: This study found that serum acetate levels were significantly lower in patients with resistant hypertension, while propionate levels were lower and butyrate levels were higher in patients with essential hypertension. The number and class of antihypertensive drugs may influence the levels of short-chain fatty acids. This study identified a potential therapeutic target for patients with resistant hypertension for the first time.
JOURNAL OF HYPERTENSION
(2022)
Article
Dermatology
Roland Aschoff, Antonio Martorell, Tobias Anger, Diane Chayer, Anthony Bewley
Summary: Studies have shown the effectiveness of Cal/BD foam in treating moderate to severe plaque psoriasis. Data from 409 patients with beyond-mild psoriasis treated with Cal/BD foam were collected, with the foam being prescribed as monotherapy for most patients and considered effective. Research is needed to determine the optimal use of Cal/BD foam in these patients.
DERMATOLOGY AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Caitlin G. Purvis, Esther A. Balogh, Courtney E. Heron, Steven R. Feldman
Summary: Combining calcipotriol/BD provides better efficacy, safety, and ease of use compared to separate product monotherapies. Newer formulations also offer less messy vehicles, promoting improved adherence. However, further data is needed to determine cost-effectiveness and insurance coverage algorithms for this treatment option.
EXPERT OPINION ON PHARMACOTHERAPY
(2021)
Article
Dermatology
Roland Aschoff, Anthony Bewley, Annunziata Dattola, Clara De Simone, Mourad Lahfa, Mar Llamas-Velasco, Antonio Martorell, Mira Pavlovic, Michael Sticherling
Summary: The study highlights the challenges in treating patients with moderate psoriasis, and emphasizes the importance of patient preference and disease factors in treatment decisions. The consensus recommendations focus on the effectiveness of Cal/BD foam in monotherapy, as an add-on to non-biologic systemic therapies, and as an add-on to systemic biologics. They aim to improve treatment outcomes and provide practical guidance for healthcare providers treating patients with moderate psoriasis.
DERMATOLOGY AND THERAPY
(2021)
Article
Dermatology
Dimitrios Rigopoulos, Elisavet Lazaridou, Evangelia Papadavid, Sophia Georgiou, Vasiliki Chasapi, Konstantinos Sfaelos, George Cheliotis, Dimitrios Ioannides
Summary: The CELSUS study in Greece found that fixed combination calcipotriol/betamethasone aerosol foam is effective and brings satisfaction to psoriasis patients. The treatment success rate varied among different subgroups based on disease severity and previous treatment experience, with the highest success rate observed in treatment-naive patients with severe disease.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
David N. Adam, Marie Y. Jablonski Bernasconi, Henrik Thoning, Jashin J. Wu
Summary: Through a matching-adjusted indirect comparison, Cal/BD aerosol foam demonstrated significantly greater efficacy than HP/Taz lotion at 4 and 8 weeks, and had a more favorable safety profile up to 52 weeks. The proactive and reactive use of Cal/BD foam also had significant advantages over HP/Taz lotion in maintaining BSA and reducing adverse events.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Lejla Ramic, Paul Sator
Summary: Topical therapy is crucial in treating psoriasis, particularly in mild cases, and can be used in combination with UV and systemic therapy for moderate to severe cases. This article provides an overview of current therapeutic options, considering specific localizations, such as the scalp, face, intertriginous/genital areas, and palms/soles, as well as hyperkeratotic or inflammatory forms of the disease. The choice of active substances and formulations, as well as patient preferences and experiences, are important factors in increasing adherence to treatment. If topical therapy fails to yield satisfactory results, additional UV or systemic therapy should be considered.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Public, Environmental & Occupational Health
Campanati Anna, Marani Andrea, Giannoni Melania, Orciani Monia, Fabiani Francesco, Napolitano Rachele, Arnesano Marco, Tomasini Enrico Primo, Offidani Annamaria
Summary: The study demonstrates both clinical and subclinical efficacy of calcipotriol plus betamethasone dipropionate foam on psoriatic skin lesions, showing a significant reduction in inflammation and capillary density. Thermography and videocapillaroscopy may have future applications in evaluating the effects of psoriasis treatment.
HEALTH SCIENCE REPORTS
(2022)
Article
Dermatology
Seong Jin Jo, Chul-Jong Park, Chul Hwan Bang, Ki-Heon Jeong, Bong Seok Shin, Dong Hyun Kim, Hai-Jin Park, Byung-Soo Kim, Hae-Jun Song, Ju-Hee Lee, Sang Woong Youn
Summary: This study investigated the treatment outcomes and satisfaction of using Cal/BD foam for psoriasis vulgaris. The results showed that Cal/BD foam treatment improved the lesions and health-related quality of life of patients, with high global satisfaction and good tolerability and safety.
JOURNAL OF DERMATOLOGY
(2022)
Article
Environmental Sciences
Marta Kasprowicz-Furmanczyk, Joanna Czerwinska, Waldemar Placek, Agnieszka Owczarczyk-Saczonek
Summary: This study evaluated the effect of topical treatment with calcipotriol and betamethasone dipropionate foam on TRM markers in psoriasis. The results showed that this treatment significantly decreased the expression of TRM markers, especially in the epidermis.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Dermatology
Nagwa E. Abd Elazim, Ahmed Kamal, Reham M. Abdel Gaber, Eman Fathy, Heba E. M. EL-Deek
Summary: Follicular unit extraction (FUE) is an effective surgical treatment for stable vitiligo, with topical CBD as a successful adjuvant therapy targeting the immunological background. Dermoscopy plays an essential role in monitoring the repigmentation response.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
