Article
Dermatology
Linglin Zhang, Yutong Yang, Bo Wang, Yan Zhao, Peiru Wang, Jia Liu, Jiayi Yang, Yun Wu, Ting Lv, Ziyu Wei, Xiaojing Liu, Ruiping Wang, Harrison Wong, Qiang Ju, Lei Shi, Xiuli Wang
Summary: The study found that the overall effective rates of M-PDT for acne vulgaris were significantly higher than ISO at 1 month, but reversed 1 month after treatment. The time to achieve 50% lesion improvement in the M-PDT group was significantly less than the ISO group. Systemic side effects were more common in the ISO group, while side effects in the M-PDT group were limited to the skin.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Oncology
Peiru Wang, Bo Wang, Linglin Zhang, Xiaojing Liu, Lei Shi, Xiaojing Kang, Xia Lei, Kun Chen, Zhou Chen, Chengxin Li, Chunlei Zhang, Ping Tu, Meng Pan, Qiang Ju, Xiaoyong Man, Yan Lu, Nan Yu, Yuzhen Li, Huilan Zhu, Ruzhi Zhang, Juan Su, Shiqin Tao, Jianjun Qiao, Qiri Mu, Weihui Zeng, Zhiming Li, Ying Gao, Heng Gu, Xiuli Wang
Summary: Evidence suggests that 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) is clinically effective in managing acne vulgaris, particularly for moderate to severe and scar-prone acne. The efficacy and adverse reactions of ALA-PDT are determined by various therapeutic parameters. However, there is a lack of detailed clinical guideline for the application of ALA-PDT in acne treatment.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Morena Petrini, Silvia Di Lodovico, Giovanna Iezzi, Luigina Cellini, Domenico Tripodi, Adriano Piattelli, Simonetta D'Ercole
Summary: The use of a new gel containing aminolevulinic acid and red light (ALAD-PDI) was tested to counteract bacterial biofilm growth on different titanium implant surfaces. The study evaluated the antibacterial efficacy of ALAD-PDI against biofilm growth on several titanium surfaces. Results showed that ALAD-PDI significantly reduced bacterial colony-forming units (CFUs) and biofilm biomass on titanium surfaces, and effectively killed bacteria.
Article
Biochemical Research Methods
Chunlan Xu, Dan Yuan, Shi Cheng, Xiaoling Lan, Qian Wang, Xinyu Lin, Wei Liu
Summary: This study observed the fluorescence characteristics of acne inflammatory skin lesions in ALA-PDD and discussed its viability in evaluating these lesions and predicting subclinical skin lesions. The results showed that ALA-PDD is a feasible method for recognizing and evaluating inflammatory skin lesions, with advantages in predicting subclinical skin lesions.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Review
Polymer Science
Simonetta D'Ercole, Teocrito Carlesi, Tatiane Cristina Dotta, Tania Vanessa Pierfelice, Emira D'Amico, Domenico Tripodi, Giovanna Iezzi, Adriano Piattelli, Morena Petrini
Summary: The aim of this study was to discuss the use of 5-aminolevulinic acid with red LED light in endodontic treatment. It is reported that the persistence of microorganisms is the main cause of endodontic treatment failure. Photodynamic therapy has become a promising antimicrobial strategy for endodontic treatment, as it is easy to apply, quick, and does not allow microbial resistance. Recent studies have shown that the combination of 5-aminolevulinic acid and red LED light has good results against various types of bacteria, including Enterococuss faecalis. A case report showed a significant decrease in bacterial count after irrigation with a gel containing 5% of 5-aminolevulinic acid and subsequent irradiation with red LED light. The use of 5-aminolevulinic acid with red LED light is therefore concluded to be effective in endodontic treatment.
Article
Oncology
Qing-Yun Wu, Qian Zhang, Wen-Bo Bu, Fang Fang
Summary: This study reports a satisfying treatment result of acne conglobata through the use of 5-aminolevulinic acid photodynamic therapy and fractional carbon dioxide laser.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Chemistry, Multidisciplinary
Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin
Summary: A dual-organelle-targeted nanoparticle platform was developed for enhanced photodynamic therapy (PDT) of cancer. The platform grafted 5-aminolevulinic acid (ALA) to a Hf-12-based nanoscale metal-organic layer (Hf-MOL), which improved ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and trapped 5,15-di-p-benzoatoporphyrin (DBP) photosensitizers in lysosomes. By simultaneously exciting PpIX and DBP with light irradiation at 630 nm, synergistic enhancement of PDT efficacy was achieved through the damage to both mitochondria and lysosomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Dermatology
Yujie Zheng, Wen Fan, Li Jiang, Yan Lu
Summary: Sonophoresis can enhance the penetration of 5-ALA into the skin, improve the efficacy of PDT, facilitate earlier and more distinct localization of 5-ALA-PpIX in sebaceous glands, and enhance clinical improvement.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Lingyan Wang, Vipin Shankar Chelakkot, Nick Newhook, Stephanie Tucker, Kensuke Hirasawa
Summary: This study demonstrates that 5-ALA-PDT can induce inflammatory cell death in cancer cells and enhance anticancer immunity in vivo.
FRONTIERS IN ONCOLOGY
(2023)
Article
Infectious Diseases
Roberto Rossi, Lorena Rispoli, Michele Antonio Lopez, Andrea Netti, Morena Petrini, Adriano Piattelli
Summary: This paper reviews the results of using ALAD gel as a supportive therapy in the treatment of periodontal disease and peri-implantitis. The study found that the application of ALAD gel improved the condition of both teeth and implants, with no pain reported by the patients. Significant decreases in periodontal pocket depth were observed in periodontal disease patients after 3 and 6 months of treatment. For implant patients, the treatment was associated with decreases in periodontal pocket depth and bleeding on probing, but only the decrease in pocket depth was statistically significant.
Article
Polymer Science
Teocrito Carlesi, Tatiane Cristina Dotta, Tania Vanessa Pierfelice, Emira D'Amico, Stefania Lepore, Domenico Tripodi, Adriano Piattelli, Simonetta D'Ercole, Morena Petrini
Summary: In this ex vivo study, the effects of ALAD and red light on Enterococcus faecalis in infected root canals were evaluated. The results showed that 2.5% sodium hypochlorite had a good bactericidal effect on E. faecalis, while 1% sodium hypochlorite had no significant bactericidal effect. The combination of ALAD and red light had a significant bactericidal effect on E. faecalis.
Article
Oncology
Feng Li, Jia He, Ting Yang, Si Li, Li Liu, Qing Huang, Xi Duan
Summary: This article reports a case of a girl with refractory severe Kerion who was cured with 5-aminolevulinic acid-PDT, suggesting that PDT could be a potentially promising alternative treatment for cutaneous fungal infections.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Engineering, Biomedical
Yu-Tsung Chen, Yun-Jhen Lin, Chang-Cheng Chang, Po-Heng Liu, Yung-Hsueh Huang, Jia-Wei Shen, Meng-En Lu, Hsiu-Mei Chiang, Bor-Shyh Lin
Summary: This study investigated the effects of non-ablative Q-switched 1064-nm Nd:YAG laser-assisted 2% ALA-PDT on the treatment of acne vulgaris. The results showed that combined therapy can significantly improve sebum secretion and maintain its effectiveness for 24 weeks. However, the combined group had more severe melanin index and erythema index after treatment.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Polymer Science
Tania Vanessa Pierfelice, Emira D'Amico, Morena Petrini, Assunta Pandolfi, Camillo D'Arcangelo, Natalia Di Pietro, Adriano Piattelli, Giovanna Iezzi
Summary: This study evaluated the effects of a new photodynamic protocol (ALAD-PDT) on human gingival fibroblasts (HGF) and primary human osteoblasts (HOB). The results showed that ALAD-PDT had no cytotoxic effects and promoted cell proliferation.
Letter
Dermatology
N. van der Beek, K. Donne, P. Bjerring, H. A. M. Neumann
BRITISH JOURNAL OF DERMATOLOGY
(2015)
Letter
Dermatology
N. van der Beek, P. Bjerring, H. A. M. Neumann
BRITISH JOURNAL OF DERMATOLOGY
(2015)
Article
Dermatology
J. de Leeuw, Y. J. Assen, N. van der Beek, P. Bjerring, H. A. Martino Neumann
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2011)
Review
Dermatology
J. L. Klatte, N. van der Beek, P. M. J. H. Kemperman
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2015)
Article
Dermatology
Jaap de Leeuw, Nick van der Beek, W. Dieter Neugebauer, Peter Bjerring, H. A. Martino Neumann
LASERS IN SURGERY AND MEDICINE
(2009)
Article
Dermatology
Nick van der Beek, Jaap de Leeuw, Claire Demmendal, Peter Bjerring, H. A. Martino Neumann
LASERS IN SURGERY AND MEDICINE
(2012)
Article
Dermatology
J de Leeuw, N van der Beek, G Maierhofer, WD Neugebauer
EUROPEAN JOURNAL OF DERMATOLOGY
(2003)