Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Biochemistry & Molecular Biology
Oriana Simonetti, Tiziana Bacchetti, Gianna Ferretti, Elisa Molinelli, Giulio Rizzetto, Luisa Bellachioma, Annamaria Offidani
Summary: The study revealed that children with atopic dermatitis (AD) have higher levels of lipid peroxidation and lower antioxidant defense, with abnormal activity of PON enzymes, indicating a relationship between oxidative stress and inflammation in AD patients.
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Francesco Borgia, Paolo Custurone, Lucia Peterle, Giovanni Pioggia, Sebastiano Gangemi
Summary: Epithelium-derived cytokines may represent a therapeutic opportunity for patients with atopic dermatitis and psoriasis, especially in itch control. These three cytokines are interconnected in both acute and chronic phases of these diseases, showing potential as target therapies or biomarkers of disease activity.
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Silvia Abigail Coavoy-Sanchez, Anderson Romerio Azevedo Cerqueira, Simone Aparecida Teixeira, Vincenzo Santagada, Giorgia Andreozzi, Angela Corvino, Antonia Scognamiglio, Rosa Sparaco, Giuseppe Caliendo, Beatrice Severino, Soraia Katia Pereira Costa, Luis Carlos Spolidorio, Marcelo Nicolas Muscara
Summary: Hydrogen sulfide (H2S) is produced in the skin and plays a role in inflammation, pruritus, cytoprotection, scarring, and angiogenesis. H2S-releasing Dex derivatives showed similar anti-inflammatory effects as Dex in a mouse model of atopic dermatitis (AD). The derivatives also prevented IL-4 elevation and oxidative modification of skin proteins, and one of them promoted endogenous H2S production and GPx activity without decreasing GR activity or causing hyperglycemia.
Article
Medicine, General & Internal
Sul-Hee Lee, Youin Bae, Young-Lip Park
Summary: This study found a negative correlation between serum adiponectin levels and disease severity and pruritus in AD patients. However, no significant effects were observed with biologic treatment for AD. Therefore, adiponectin may serve as a potential biomarker for severity assessment in AD.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Yasmin Bangash, Ammara Saleem, Muhammad Furqan Akhtar, Fareeha Anwar, Bushra Akhtar, Ali Sharif, Muhammad Imran Khan, Aslam Khan
Summary: This study found that PTN can alleviate the symptoms of atopic dermatitis by reducing inflammation, oxidative damage, and inflammatory cytokine expression in the skin of diseased animals. Therefore, PTN may be an effective drug for treating atopic dermatitis and other inflammatory skin disorders.
INFLAMMOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Ling Yu, Linfeng Li
Summary: Atopic dermatitis is a chronic inflammatory skin disease with a wide range of variations. Biomarkers play a crucial role in guiding personalized treatment. The development of technology has provided new insights into potential biomarkers, and non-invasive methods have been used to explore different profiles of patients' skin. Several potential biomarkers have been identified for AD diagnosis, disease severity monitoring, comorbidity prediction, and treatment effects evaluation.
FRONTIERS IN MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Roudin Sarama, Priya K. Matharu, Yousef Abduldaiem, Mab P. Correa, Cristiane D. Gil, Karin V. Greco
Summary: Psoriasis and Atopic Dermatitis are common inflammatory skin diseases with immune response dysregulation playing a crucial role in their pathogenesis. In vitro disease models have been widely used to study these conditions, but further development is needed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Youming Guo, Lingling Luo, Jing Zhu, Chengrang Li
Summary: Psoriasis and atopic dermatitis are inflammatory skin diseases with multiple causes and heterogeneity. Despite years of research, there is no cure, and the costs of caring for patients with these diseases are a significant burden on society. Integrating multiple omics datasets allows simultaneous analysis of genes, RNAs, chromatins, proteins, and metabolites, revealing networks between different molecular levels. This review discusses the latest developments in genomics, transcriptomics, proteomics, and metabolomics, and explores how they are used to identify biomarkers and understand the pathogenic mechanisms of these diseases. Finally, strategies for achieving multi-omics integration and the potential of integrative omics and systems biology in advancing our knowledge and treatment of psoriasis and atopic dermatitis are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Dengmei Xia, Yiyi Wang, Yue Xiao, Wei Li
Summary: Single-cell RNA sequencing (scRNA-seq) is a new technology that characterizes molecular heterogeneity at the single-cell level. It provides a deeper understanding of cell diversity in inflammatory skin diseases and sheds new light on cell-cell communication in disease responses. It holds promise as a tool in precision medicine for defining cell subsets with potential treatment targets and characterizing cell-specific responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Natsuko Saito-Sasaki, Yu Sawada
Summary: This review provides detailed information on the interactions among various S100 proteins in inflammatory diseases, highlighting the significant role of S100 proteins as important substances in the inflammatory process of skin tissues.
Article
Biochemistry & Molecular Biology
Alessio Ardizzone, Alberto Repici, Anna Paola Capra, Federica De Gaetano, Valentina Bova, Giovanna Casili, Michela Campolo, Emanuela Esposito
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease that mainly affects children. This study evaluated the effects of a cream formulation containing tempol in a murine model of AD. The results demonstrated that tempol reduced histological damage, mast cell infiltration, and improved skin barrier function by restoring tight junctions and filaggrin. Furthermore, tempol modulated inflammation and oxidative stress through the NF-κB/Nrf2 signaling pathways.
Article
Allergy
Helen He, Robert Bissonnette, Jianni Wu, Aisleen Diaz, Etienne Saint-Cyr Proulx, Catherine Maari, Carolyn Jack, Maudeline Louis, Yeriel Estrada, James G. Krueger, Ning Zhang, Ana B. Pavel, Emma Guttman-Yassky
Summary: This study utilized RNA-seq analysis of tape strips from lesional and nonlesional skin of patients with moderate-to-severe AD and psoriasis, revealing distinct immune and barrier signatures in the two diseases. The findings suggest the potential utility of tape strips as a minimally invasive alternative to biopsies for detecting disease biomarkers. Differences in gene expression profiles between AD and psoriasis highlight the unique pathophysiological mechanisms of these two skin disorders.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)